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    Transport protein which is used to introduce chemical compounds into nerve cells
    4.
    发明授权
    Transport protein which is used to introduce chemical compounds into nerve cells 有权
    用于将化学物质引入神经细胞的运输蛋白质

    公开(公告)号：US08293230B2

    公开(公告)日：2012-10-23

    申请号：US11661849

    申请日：2005-09-06

    申请人： Andreas Rummel

    发明人： Andreas Rummel

    IPC分类号： A61K38/48

    CPC分类号： C07K14/33 ,  A61K8/64 ,  A61K8/66 ,  A61K38/00 ,  A61K38/4893 ,  A61Q19/00 ,  A61Q19/08 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

    摘要： The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof.

    摘要翻译： 本发明涉及可通过改变由肉毒梭菌形成的神经毒素的重链获得的转运蛋白。 该蛋白与天然神经毒素具有较高的亲和力特异性结合神经细胞。 本发明还涉及生产运输蛋白的方法，编码运输蛋白的核酸，含运输蛋白的药物和化妆品组合物及其用途。

    CARRIER FOR TARGETING NERVE CELLS
    6.
    发明申请
    CARRIER FOR TARGETING NERVE CELLS 有权

    公开(公告)号：US20130315888A1

    公开(公告)日：2013-11-28

    申请号：US13867740

    申请日：2013-04-22

    申请人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    发明人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    IPC分类号： C12N9/52

    CPC分类号： C12N9/52 ,  A61K38/00 ,  C07K14/33 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

    摘要： The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragm assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.

    MEANS AND METHODS FOR DETERMINING CLOSTRIDIAL NEUROTOXINS
    9.
    发明申请
    MEANS AND METHODS FOR DETERMINING CLOSTRIDIAL NEUROTOXINS 审中-公开
    用于确定封闭神经毒素的方法和方法

    公开(公告)号：US20140287433A1

    公开(公告)日：2014-09-25

    申请号：US14233740

    申请日：2012-07-18

    申请人： Oliver Weingart ,  Marc Avondet ,  Martin Loessner ,  Andreas Rummel ,  Frank Gessler

    发明人： Oliver Weingart ,  Marc Avondet ,  Martin Loessner ,  Andreas Rummel ,  Frank Gessler

    IPC分类号： G01N33/573

    CPC分类号： G01N33/573 ,  G01N33/5432 ,  G01N2333/33 ,  G01N2333/952

    摘要： This invention relates to a method of determining presence, amount and/or activity of a clostridial neurotoxin in a sample, the method comprising or consisting of the following steps: (a) bringing said sample into contact with a liposome, said liposome comprising (aa) at least one receptor on its outer surface, said receptor being capable of binding said neurotoxin and comprising or consisting of (i) a glycolipid and (ii) a peptide or protein; and (ab) a substrate in its interior, said substrate (i) being cleavable by the peptidase comprised in said neurotoxin and (ii) generating a detectable signal upon cleavage, said detectable signal preferably being generated by (1) the donor of a FRET pair, said donor exhibiting increased fluorescence upon cleavage by said peptidase, (2) a luminescent compound formed upon said cleavage, or (3) an enzyme formed upon said cleavage; and (b) determining whether an increase in signal occurs as compared to the absence of said sample, wherein such increase is indicative of the presence of said neurotoxin and/or the degree of such increase is indicative of the amount and/or activity of said neurotoxin in said sample.

    摘要翻译： 本发明涉及一种测定样品中梭菌神经毒素的存在，量和/或活性的方法，所述方法包括或由以下步骤组成：（a）使所述样品与脂质体接触，所述脂质体包含（aa ）在其外表面上的至少一个受体，所述受体能够结合所述神经毒素并且包含（i）糖脂和（ii）肽或蛋白质或由其组成; 和（ab）其内部的底物，所述底物（i）可由包含在所述神经毒素中的肽酶切割，和（ii）在切割时产生可检测信号，所述可检测信号优选通过（1）FRET的供体产生 所述供体在所述肽酶切割时表现出增加的荧光，（2）在所述切割时形成的发光化合物，或（3）在所述切割时形成的酶; 和（b）确定与不存在所述样品相比是否发生信号增加，其中这种增加指示所述神经毒素的存在和/或这种增加的程度指示所述神经毒素的量和/或活性 所述样品中的神经毒素。

    Use of methane, methane and hydrogen, or natural gas for pyrolysis gas
    10.
    发明授权
    Use of methane, methane and hydrogen, or natural gas for pyrolysis gas 失效
    甲烷，甲烷和氢气或天然气用于热解气体的使用

    公开(公告)号：US4605487A

    公开(公告)日：1986-08-12

    申请号：US654813

    申请日：1984-09-26

    申请人： Wolfgang Michel ,  Heinz Paul ,  Andreas Rummel ,  Gero Seher ,  Manfred Ossowski ,  Irmtrud Heberlein ,  Dieter Kostler ,  Frank Wilhelm

    发明人： Wolfgang Michel ,  Heinz Paul ,  Andreas Rummel ,  Gero Seher ,  Manfred Ossowski ,  Irmtrud Heberlein ,  Dieter Kostler ,  Frank Wilhelm

    IPC分类号： C10B49/10 ,  C10G1/02 ,  F02B3/06 ,  C10G1/00

    CPC分类号： C10B49/10 ,  C10G1/02 ,  F02B3/06 ,  Y10S208/951

    摘要： Method for the production of liquid products, particularly, tar, from organic bulk materials.The invention relates to a method, whereby in an apparatus in one or a multiple of refining stages, organic bulk goods are refined to economically significant base materials, so that they are suitable, either directly or indirectly, for the production of gasifier or diesel fuel.The technical object is to utilize a fluidizing medium, with the help of which it is possible to produce, in a reaction chamber, an increased yield of liquid products, especially tar.According to the invention, the problem is solved by supplying a hydrocarbonaceous gas, especially a gas containing methane and hydrogen, as a fluidizing medium in the individual refining stages, whereby, under the particular refining conditions, there results a decrease of the portion of methane and hydrogen, and a comparative increase of the portion of the liquid product, especially of the portion of tar. Furthermore, the portion of the components which boil easier, short-chained hydrocarbons, are significantly increased in the produced liquid product.

    摘要翻译： 从有机散装材料生产液体产品，特别是焦油的方法。 本发明涉及一种方法，其中在一个或多个精炼阶段的装置中，将有机散装货物精炼成经济上重要的基础材料，使得它们直接或间接适用于生产气化器或柴油 。 技术目的是利用流化介质，借助它可以在反应室中产生液体产物，尤其是焦油的产量增加。 根据本发明，通过在单个精炼阶段中提供含烃气体，特别是含有甲烷和氢气的气体作为流化介质来解决问题，由此在特定的精炼条件下，导致甲烷部分的减少 和氢气，以及液体产物的一部分，特别是焦油部分的比较增加。 此外，在所生产的液体产品中部分沸腾更容易的短链烃的部分显着增加。