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    METHOD AND SYSTEM OF MICROFLUIDIC IMMUNOASSAY USING MAGNETIC BEADS
    3.
    发明申请
    METHOD AND SYSTEM OF MICROFLUIDIC IMMUNOASSAY USING MAGNETIC BEADS 审中-公开
    使用磁珠的微流感免疫法的方法和系统

    公开(公告)号：US20150198593A1

    公开(公告)日：2015-07-16

    申请号：US14597999

    申请日：2015-01-15

    申请人： Andrew Barry ,  Laurel Provencher ,  Seth Cohen ,  I-Jane Chen ,  Jun Yan ,  Jingjing Wang

    发明人： Andrew Barry ,  Laurel Provencher ,  Seth Cohen ,  I-Jane Chen ,  Jun Yan ,  Jingjing Wang

    IPC分类号： G01N33/561

    CPC分类号： G01N33/561 ,  G01N27/447 ,  G01N33/5302 ,  G01N33/54326

    摘要： A microfluidic Western blot method and system including a microfluidic western blot method for immunoassay of proteins, the method including introducing a sample including the proteins onto a chip; electrophoretically separating the proteins; binding the separated proteins to beads to form protein-attached beads, the beads being magnetic; flowing the protein-attached beads into a magnetic holding region; applying a magnetic field to the magnetic holding region to fix the protein-attached beads in place within the magnetic holding region; binding primary antibodies to target proteins on the protein-attached beads; binding secondary antibodies to the bound primary antibodies; and detecting the bound secondary antibodies.

    摘要翻译： 一种微流体Western印迹方法和系统，包括用于蛋白质免疫测定的微流体蛋白质印迹法，该方法包括将包含蛋白质的样品引入到芯片上; 电泳分离蛋白质; 将分离的蛋白质与珠粒结合以形成附着蛋白的珠粒，珠粒是磁性的; 将附着蛋白的珠子流入磁性保持区域; 将磁场施加到磁性保持区域以将附着蛋白质的珠子固定在磁性保持区域内的适当位置; 结合初次抗体与蛋白质连接珠上的靶蛋白; 结合第一抗体的结合二抗; 并检测结合的二抗。

    FORWARD-CHAINING INFERENCING
    4.
    发明申请
    FORWARD-CHAINING INFERENCING 有权
    前向链接感染

    公开(公告)号：US20050240546A1

    公开(公告)日：2005-10-27

    申请号：US10908495

    申请日：2005-05-13

    申请人： Andrew Barry

    发明人： Andrew Barry

    IPC分类号： G06F17/00 ,  G06N5/02 ,  G06N5/04

    CPC分类号： G06N5/046

    摘要： A method is disclosed of forward-chaining inferencing in a rulebased system having a rulebase and a set of input facts, wherein new facts are inferred in accordance with variations to the rules or the input facts, the method including: developing a computerized database containing a fact dependency tree for indicating which facts are used to produce other facts in accordance with respective rules in the rulebase; sequentially ordering the facts in the fact dependency tree to produce a serialized fact dependency tree wherein for any given fact in the sequence, all facts which are used to produce that fact are facts which are earlier in the sequence than is the given fact, and ordering the rules in the rulebase in accordance with the facts produced thereby to produce a serialized rulebase wherein the rules are in the same sequential order as the facts in the serialized fact dependency tree

    摘要翻译： 公开了一种在具有规则库和一组输入事实的基于规则的系统中的前向链接推理的方法，其中根据规则或输入事实的变化来推断新事实，该方法包括：开发包含 事实依赖树，用于根据规则库中的相应规则指示哪些事实用于产生其他事实; 在事实依赖关系树中顺序排序事实以产生序列化的事实依赖性树，其中对于序列中的任何给定的事实，用于产生该事实的所有事实都是序列中的事实，而不是给定的事实，以及排序 规则库中的规则根据由此产生的事实产生序列化规则库，其中规则与序列化事实依赖树中的事实处于相同的顺序

    Time-based programming and computation
    6.
    发明授权
    Time-based programming and computation 有权
    基于时间的编程和计算

    公开(公告)号：US08145587B2

    公开(公告)日：2012-03-27

    申请号：US12036461

    申请日：2008-02-25

    申请人： Andrew Barry

    发明人： Andrew Barry

    IPC分类号： G06F17/00 ,  G06N5/02

    CPC分类号： G06F9/451

    摘要： A computer implemented method and system for calculating changepoints in a rule-based environment. At least one time-based value is created from at least one date value, and combined with at least one changepoint value to calculate changepoints. The changepoints are then formatted, and a report is generated and output for display to the user in plain language. In another aspect, a value is assigned to a time-based parameter and combined with a changepoint value to calculate changepoints.

    摘要翻译： 用于计算基于规则的环境中的变化点的计算机实现的方法和系统。 从至少一个日期值创建至少一个基于时间的值，并与至少一个变化点值组合以计算变化点。 然后格式化变化，并生成报告并输出以用简单的语言显示给用户。 另一方面，将值分配给基于时间的参数，并与变化点值组合以计算变化点。

    Forward-chaining inferencing
    8.
    发明授权
    Forward-chaining inferencing 有权
    前向链接引用

    公开(公告)号：US07418434B2

    公开(公告)日：2008-08-26

    申请号：US10908495

    申请日：2005-05-13

    申请人： Andrew Barry

    发明人： Andrew Barry

    IPC分类号： G06F17/00 ,  G06N5/02

    CPC分类号： G06N5/046

    摘要： A method is disclosed of forward-chaining inferencing in a rulebased system having a rulebase and a set of input facts, wherein new facts are inferred in accordance with variations to the rules or the input facts, the method including: developing a computerized database containing a fact dependency tree for indicating which facts are used to produce other facts in accordance with respective rules in the rulebase; sequentially ordering the facts in the fact dependency tree to produce a serialized fact dependency tree wherein for any given fact in the sequence, all facts which are used to produce that fact are facts which are earlier in the sequence than is the given fact, and ordering the rules in the rulebase in accordance with the facts produced thereby to produce a serialized rulebase wherein the rules are in the same sequential order as the facts in the serialized fact dependency tree.

    摘要翻译： 公开了一种在具有规则库和一组输入事实的基于规则的系统中的前向链接推理的方法，其中根据规则或输入事实的变化来推断新事实，该方法包括：开发包含 事实依赖树，用于根据规则库中的相应规则指示哪些事实用于产生其他事实; 在事实依赖关系树中顺序排序事实以产生序列化的事实依赖性树，其中对于序列中的任何给定的事实，用于产生该事实的所有事实都是序列中的事实，而不是给定的事实，以及排序 根据由此产生的事实，规则库中的规则产生序列化规则库，其中规则与序列化事实依赖关系树中的事实处于相同的顺序。

    Non-linear junction detector
    9.
    发明授权
    Non-linear junction detector 失效
    非线性结检测器

    公开(公告)号：US06897777B2

    公开(公告)日：2005-05-24

    申请号：US10467507

    申请日：2002-02-11

    申请人： Steven John Holmes ,  Andrew Barry Stephen

    发明人： Steven John Holmes ,  Andrew Barry Stephen

    IPC分类号： G01V3/12 ,  G08B13/14

    CPC分类号： G01V3/12

    摘要： A target junction is illuminated with energy at a fundamental RF frequency and reflections from the non-linear junction are analyzed to determine the type of junction detected. The power output level of a transmitter emitting the illuminating signal is automatically controlled so as to drive the signal strength of the received signals towards a predetermined value, e.g. a minimum threshold value. An indication of the current received signal strength, adjusted by a factor so as to compensate for any automatic adaptation in the actual transmitter power output level, may be provided to an operator.

    摘要翻译： 目标结点以基频RF频率的能量照射，并且分析来自非线性结的反射以确定检测到的结的类型。 发射发光信号的发射机的功率输出电平被自动控制，以将接收到的信号的信号强度驱动到预定值，例如。 最小阈值。 可以向操作者提供当前接收信号强度的指示，其被调整为因子以补偿实际发射机功率输出电平中的任何自动适配。