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    Compact tampon applicator with snap-action hinged panels
    1.
    发明授权
    Compact tampon applicator with snap-action hinged panels 失效
    紧凑型棉条涂抹器，具有快动铰链面板

    公开(公告)号：US4911687A

    公开(公告)日：1990-03-27

    申请号：US234856

    申请日：1988-08-22

    申请人： A. Eugene Stewart ,  Joseph Albora

    发明人： A. Eugene Stewart ,  Joseph Albora

    IPC分类号： A61F13/26 ,  A61F13/34

    CPC分类号： A61F13/34 ,  A61F13/263

    摘要： A compact and short tampon applicator is formed of an outer barrel which surrounds a tampon-holding inner tubular plunger which is slidable within the outer barrel. A portion of the wall of the plunger defines a pair of hinged panels which snap into the interior of the plunger in response to an inwardly directed radial force. This inward force is supplied by a tab on the barrel, once the plunger has been retracted sufficiently out of the barrel to register the hinged panels with the tab. The applicator is readied for use by retracting the plunger rearwardly behind the tampon, sufficiently to cause the hinged panels to engage the tab on the inner surface of the barrel to snap into the plunger. After insertion of the barrel into the catamenial canal, the plunger is pressed inward, back into the barrel, to enable its inwardly snapped panels to engage the rear of the tampon and to eject the tampon through the front of the barrel.

    摘要翻译： 紧凑且短的棉塞施用器由外筒形成，外筒围绕保持内管柱塞，其可在外筒内滑动。 柱塞的壁的一部分限定了一对铰链板，其响应于向内的径向力而卡入柱塞的内部。 一旦柱塞已经被充分地从筒中退出以将铰链板与突片对准，则该向内的力由筒上的突片供应。 通过使塞子在棉塞后方缩回柱塞以使铰链板与筒体内表面上的接头接合以卡入到柱塞中，使得施加器准备好使用。 在将筒插入月经通道之后，柱塞被向内压入到筒中，使得其向内卡扣的面板能够与棉塞的后部接合并且通过筒的前部喷出棉塞。

    Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same
    3.
    发明申请
    Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same 审中-公开
    包含扩展结合口袋的糖皮质激素受体配体结合结构域的结构和使用其的方法

    公开(公告)号：US20070020684A1

    公开(公告)日：2007-01-25

    申请号：US10600751

    申请日：2003-06-20

    申请人： Randy Bledsoe ,  Millard Lambert ,  Valerie Montana ,  Eugene Stewart ,  H. Xu

    发明人： Randy Bledsoe ,  Millard Lambert ,  Valerie Montana ,  Eugene Stewart ,  H. Xu

    IPC分类号： G01N33/53 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50 ,  C07K14/705

    CPC分类号： C07K14/721 ,  A61K38/00 ,  C07K2299/00 ,  G01N2333/723

    摘要： A solved three-dimensional crystal structure of a glucocorticord receptor (GR) α ligand binding domain polypeptide is disclosed, in the form of a crystalline glucocorticord receptor α ligand binding domain polypeptide in complex with the ligand fluticasone propionate (FP) and a peptide derived from the co-activator TIF2. The GR/FP/TIF2 structure includes an expanded binding pocket not seen in other GR structures. Methods of designing steroid and non-steroid modulators of the biological activity of GR and other nuclear receptors (NRs) are also disclosed. In another aspect of the present invention homology models of androgen receptor (AR), progesterone receptor (PR) and mineralcorticoid receptor (MR) are disclosed, as well as methods of forming homology models for other NRs. Methods of forming a soluble GR/FP/TIF2 complex are also disclosed.

    摘要翻译： 糖配糖体受体（GR）α配体结合域多肽的解决三维晶体结构以与配体氟替卡松丙酸酯（FP）复合的结晶性糖皮质激素受体α配体结合域多肽的形式和衍生自 共激活剂TIF2。 GR / FP / TIF2结构包括在其他GR结构中未见的扩展的绑定袋。 还公开了GR和其他核受体（NR）的生物活性的类固醇和非类固醇调节剂的设计方法。 在本发明的另一方面，公开了雄激素受体（AR），孕酮受体（PR）和盐皮质激素受体（MR）的同源性模型，以及形成其他NR的同源性模型的方法。 还公开了形成可溶性GR / FP / TIF2复合物的方法。

    Mutations in the mineralocorticoid receptor ligand binding domain polypeptide that permit structural determination of low affinity ligand complexes and screening methods employing same
    4.
    发明申请
    Mutations in the mineralocorticoid receptor ligand binding domain polypeptide that permit structural determination of low affinity ligand complexes and screening methods employing same 审中-公开
    允许结构测定低亲和力配体复合物的盐皮质激素受体配体结合域多肽的突变和使用其的筛选方法

    公开(公告)号：US20070219348A1

    公开(公告)日：2007-09-20

    申请号：US11377502

    申请日：2006-03-16

    申请人： Christopher Apolito ,  Randy Bledsoe ,  Millard Lambert ,  Kevin Madauss ,  Thomas Stanley ,  Eugene Stewart ,  Shawn Williams

    发明人： Christopher Apolito ,  Randy Bledsoe ,  Millard Lambert ,  Kevin Madauss ,  Thomas Stanley ,  Eugene Stewart ,  Shawn Williams

    IPC分类号： C07K14/715 ,  G06F19/00

    CPC分类号： C07K14/721

    摘要： An isolated mineralocorticoid receptor (MR) polypeptide, or functional portion thereof, having one or more mutations that alter the solubility or crystal-forming properties and confer the ability to generate soluble protein complexes with the MR and ligands that only weakly bind the native polypeptide, and a polynucleotide encoding it are disclosed. Representative mutations are C808S and S810L substitutions. Expression of the MR polypeptide in E. coli is also provided. A solved three-dimensional crystal structure of an MR ligand binding domain polypeptide is also disclosed, along with a crystalline form of the MR ligand binding domain polypeptide. Methods of modeling one or more molecular interactions of a native NR with a ligand having low affinity for the native NR utilizing a mutated MR, designing modulators of the biological activity of MR and other nuclear receptor, steroid receptor and glucocorticoid receptor polypeptides and nuclear receptor, steroid receptor and glucocorticoid receptor ligand binding domain polypeptides are also disclosed.

    摘要翻译： 具有一个或多个突变的分离的盐皮质激素受体（MR）多肽或其功能部分，所述突变改变溶解度或结晶形成性质并赋予与MR和仅仅弱结合天然多肽的配体产生可溶性蛋白质复合物的能力， 并公开了编码它的多核苷酸。 代表性突变是C808S和S810L取代。 还提供了MR多肽在大肠杆菌中的表达。 还公开了MR配体结合结构域多肽的解决的三维晶体结构以及MR配体结合结构域多肽的结晶形式。 使用天然NR与天然NR的亲和力低的配体的天然NR的一个或多个分子相互作用建模的方法，设计MR和其他核受体，类固醇受体和糖皮质激素受体多肽和核受体的生物活性的调节剂， 类固醇受体和糖皮质激素受体配体结合域多肽也被公开。

    Independent victim data buffer and probe buffer release control utilzing control flag
    8.
    发明授权
    Independent victim data buffer and probe buffer release control utilzing control flag 失效
    独立的受害者数据缓冲区和探针缓冲区释放控制利用控制标志

    公开(公告)号：US6061765A

    公开(公告)日：2000-05-09

    申请号：US957505

    申请日：1997-10-24

    申请人： Stephen Van Doren ,  Simon C. Steely, Jr. ,  Robert Eugene Stewart ,  James Bernard Keller

    发明人： Stephen Van Doren ,  Simon C. Steely, Jr. ,  Robert Eugene Stewart ,  James Bernard Keller

    IPC分类号： G06F12/08 ,  G06F12/00

    CPC分类号： G06F12/0815 ,  G06F12/0822

    摘要： In accordance with the present invention, a method and apparatus is provided for storing victim data evicted from a cache and for satisfying pending requests or probe messages that target victim data, using a set of victim data buffers coupled to a central processing unit of a computer system. Storage locations referred to as a "victim valid bit" and a "probe valid bit" are associated with each victim data buffer in the computer system to indicate a release condition for the coupled victim data buffer. With such an arrangement, the victim data buffer can be deallocated when the victim valid bit and the probe valid bit have both been cleared.

    摘要翻译： 根据本发明，提供了一种方法和装置，用于存储从高速缓存中移出的受害者数据，并且使用耦合到计算机的中央处理单元的一组受害者数据缓冲器来满足目标受害者数据的待决请求或探测消息 系统。 称为“受害者有效位”的存储位置和“探测有效位”与计算机系统中的每个受害者数据缓冲器相关联，以指示耦合的受害者数据缓冲器的释放条件。 通过这样的配置，当受害者有效位和探测有效位都被清除时，可以释放受害者数据缓冲区。

    Garniture belt
    10.
    发明授权
    Garniture belt 失效
    附件带

    公开(公告)号：US3983761A

    公开(公告)日：1976-10-05

    申请号：US626482

    申请日：1975-10-28

    申请人： Emory Eugene Stewart

    发明人： Emory Eugene Stewart

    IPC分类号： A24C5/00 ,  A24C5/18 ,  D03D15/00 ,  F16G1/00 ,  A24C1/00 ,  B65G15/30

    CPC分类号： D03D1/0094 ,  A24C5/1857 ,  D02G3/28 ,  D02G3/38 ,  D03D15/00 ,  D03D15/0027 ,  D03D3/04 ,  F16G1/00 ,  D10B2201/02 ,  D10B2331/02 ,  D10B2331/04 ,  D10B2505/00

    摘要： An endless woven garniture tape or belt for cigarette making machines comprising a combination of natural, chemically modified, and synthetic fibers in a unique blend and arrangement which possesses properties that result in superior wear life performance without sacrificing other performance criteria. The warp is made from combed sak cotton fiber threads, with a multiplicity of such threads mercerized and plied together to form each warp thread. The filling threads are made up of a multifilament synthetic core wrapped with cotton fiber with a multiplicity of such wrapped threads plied together to form each filling thread. Endless belts made according to this invention have a wear life approximating three times the normal wear life of conventional belts used on cigarette making machines.

    摘要翻译： 一种用于香烟制造机器的环形编织带或带，其独特的混合和布置包括天然，化学改性和合成纤维的组合，其具有在不牺牲其他性能标准的情况下产生优异的磨损寿命性能的性质。 经纱由精梳的棉花棉纤维线制成，多个这样的丝线丝光并合并在一起形成每根经线。 填充线由用棉纤维包裹的复丝合成纤维制成，多个这样的缠绕线组合在一起以形成每个填充线。 根据本发明制造的无限带的磨损寿命接近于在卷烟机上使用的常规带的正常磨损寿命的三倍。