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公开(公告)号：US08609703B2
公开(公告)日：2013-12-17
申请号：US13544312
申请日：2012-07-09
CPC分类号： C07D209/20 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , C07D209/18 , C07D401/12 , C07D403/12
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20130011923A1
公开(公告)日：2013-01-10
申请号：US13544312
申请日：2012-07-09
IPC分类号： C12N5/07
CPC分类号： C07D209/20 , A61K31/404 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , C07D209/18 , C07D401/12 , C07D403/12
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（CFTR）及其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20080071095A1
公开(公告)日：2008-03-20
申请号：US11841646
申请日：2007-08-20
申请人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07C215/76 , C07C69/96 , C07D209/14 , C07D209/16 , C07D311/76
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20060074075A1
公开(公告)日：2006-04-06
申请号：US11165818
申请日：2005-06-24
申请人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： A61K31/55 , A61K31/5415 , A61K31/538 , A61K31/5377 , A61K31/496 , A61K31/4747 , A61K31/4709 , A61K31/4704 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US07495103B2
公开(公告)日：2009-02-24
申请号：US11165818
申请日：2005-06-24
申请人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D215/38 , A61K31/44
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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