公开(公告)号：US5342959A

公开(公告)日：1994-08-30

申请号：US102658

申请日：1993-08-05

Applicant: Vladimir Genukh Beylin ,  Anthony D. Sercel ,  Howard D. H. Showalter ,  Gerald E. Adams ,  Edward M. Fielden ,  Matthew A. Naylor ,  Ian J. Stratford

Inventor： Vladimir Genukh Beylin ,  Anthony D. Sercel ,  Howard D. H. Showalter ,  Gerald E. Adams ,  Edward M. Fielden ,  Matthew A. Naylor ,  Ian J. Stratford

IPC: A61K31/415 ,  A61P43/00 ,  C07D233/91 ,  C07D403/06 ,  C07D413/06 ,  C07F7/18 ,  C07D233/61

CPC classification number: C07D403/06 ,  C07D233/91 ,  C07D413/06

Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.

Abstract translation: 描述了用作放射增敏剂或具有式（IMAGE）的化学敏化剂的手性化合物，其中X是用于制备这些化合物的卤素或中间体，以及制备这些化合物的新方法。

公开(公告)号：US5543527A

公开(公告)日：1996-08-06

申请号：US443548

申请日：1995-05-18

Applicant: Vladimir G. Beylin ,  Anthony D. Sercel ,  Howard D. H. Showalter ,  Gerald E. Adams ,  Edward M. Fielden ,  Matthew A. Naylor ,  Ian J. Stratford

Inventor： Vladimir G. Beylin ,  Anthony D. Sercel ,  Howard D. H. Showalter ,  Gerald E. Adams ,  Edward M. Fielden ,  Matthew A. Naylor ,  Ian J. Stratford

IPC: A61K31/415 ,  A61P43/00 ,  C07D233/91 ,  C07D403/06 ,  C07D413/06 ,  C07F7/18 ,  C07D413/02 ,  C07D403/02

CPC classification number: C07D403/06 ,  C07D233/91 ,  C07D413/06

Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.

Abstract translation: 描述了用作放射增敏剂或具有式（IMAGE）的化学敏化剂的手性化合物，其中X是用于制备这些化合物的卤素或中间体，以及制备这些化合物的新方法。

公开(公告)号：US5481000A

公开(公告)日：1996-01-02

申请号：US359226

申请日：1994-12-19

Applicant: Vladimir G. Beylin ,  Anthony D. Sercel ,  Howard D. H. Showalter ,  Gerald E. Adams ,  Edward M. Fielden ,  Matthew A. Naylor ,  Ian J. Stratford

Inventor： Vladimir G. Beylin ,  Anthony D. Sercel ,  Howard D. H. Showalter ,  Gerald E. Adams ,  Edward M. Fielden ,  Matthew A. Naylor ,  Ian J. Stratford

IPC: A61K31/415 ,  A61P43/00 ,  C07D233/91 ,  C07D403/06 ,  C07D413/06 ,  C07F7/18 ,  C07D233/64

CPC classification number: C07D403/06 ,  C07D233/91 ,  C07D413/06

Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.

Abstract translation: 描述了用作放射增敏剂或具有式（IMAGE）的化学敏化剂的手性化合物，其中X是用于制备这些化合物的卤素或中间体，以及制备这些化合物的新方法。

公开(公告)号：US07144995B2

公开(公告)日：2006-12-05

申请号：US10382754

申请日：2003-03-06

Applicant: Dean S. Wise ,  Anthony D. Sercel ,  Kee-Yong Jung ,  David A. Berry ,  John B. Randolph ,  Robert L. Somers ,  Hugh Mackie

Inventor： Dean S. Wise ,  Anthony D. Sercel ,  Kee-Yong Jung ,  David A. Berry ,  John B. Randolph ,  Robert L. Somers ,  Hugh Mackie

IPC: C07G3/00 ,  C07H21/00 ,  C12Q1/68

CPC classification number: C07D487/04 ,  C07H19/14 ,  C07H19/23

Abstract: A fluorescent nitrogenous base and nucleosides including the fluorescent nitrogenous base are provided. Nucleosides including the fluorescent nitrogenous base are capable of Watson-Crick base pairing with naturally occurring nucleosides. The nucleosides including the fluorescent nitrogenous base have many uses including but not limited to use in probes, in the synthesis of nucleic acids, and in investigating nucleic acid interactions with other nucleic acids and/or with proteins.

Abstract translation: 提供荧光含氮碱和包含荧光含氮碱的核苷。 包括荧光含氮碱基的核苷可与Watson-Crick碱基与天然存在的核苷配对。 包括荧光含氮碱基的核苷具有许多用途，包括但不限于在探针中使用，在核酸的合成中，以及调查与其它核酸和/或蛋白质的核酸相互作用。

公开(公告)号：US4806654A

公开(公告)日：1989-02-21

申请号：US149103

申请日：1988-02-11

Applicant: Vladimir G. Beylin ,  Om P. Goel ,  Anthony D. Sercel ,  Howard D. H. Showalter

Inventor： Vladimir G. Beylin ,  Om P. Goel ,  Anthony D. Sercel ,  Howard D. H. Showalter

IPC: C07D491/048 ,  A61K31/415 ,  A61P31/04 ,  A61P35/02 ,  C07D495/04 ,  C07D495/06 ,  C07D513/08 ,  C07D517/08 ,  C07D491/06

CPC classification number: C07D495/06

Abstract: Improved processes for producing substituted benzo(chalcogeno)[4,3,2-cd] indazoles. The processes produce compounds in higher yields and of greater purity by using a novel sequence of acylation chemistry and easily removed protecting groups. The compounds produced have antibacterial, antifungal, antileukemic, and antitumor activity.

公开(公告)号：US4604390A

公开(公告)日：1986-08-05

申请号：US738195

申请日：1985-05-24

Applicant: Edward F. Elslager ,  Leslie M. Werbel ,  Daniel F. Ortwine ,  Donald F. Worth ,  Howard D. H. Showalter ,  David B. Capps ,  Ellen M. Berman ,  Vlad E. Gregor ,  Anthony D. Sercel

Inventor： Edward F. Elslager ,  Leslie M. Werbel ,  Daniel F. Ortwine ,  Donald F. Worth ,  Howard D. H. Showalter ,  David B. Capps ,  Ellen M. Berman ,  Vlad E. Gregor ,  Anthony D. Sercel

IPC: C07C205/38 ,  C07C391/02 ,  C07D311/86 ,  C07D335/16 ,  C07D345/00 ,  C07D491/06 ,  C07D495/06 ,  C07D517/06 ,  A61K31/415 ,  A61K31/54

CPC classification number: C07D491/06 ,  C07C205/38 ,  C07C243/00 ,  C07C323/00 ,  C07C391/02 ,  C07D311/86 ,  C07D335/16 ,  C07D345/00 ,  C07D495/06 ,  C07D517/06 ,  C07D517/08

Abstract: Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines.Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.

Abstract translation: 取代的2H- [1]苯并吡喃并[4,3,2-cd]吲唑，2H- [1]苯并噻喃并[4,3,2-cd]吲唑和2H- [1]苯并硒[4,3,2-cd ]吲唑已经证明了对广谱革兰氏阳性和革兰氏阴性细菌，酵母和真菌的药理活性，以及​​针对L1210和P388鼠白血病细胞系的活性。 还公开了含有化合物的药物组合物和在治疗细菌或真菌感染和抑制哺乳动物肿瘤生长的方法中使用该化合物的方法。