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公开(公告)号：US20210331030A1
公开(公告)日：2021-10-28
申请号：US16331087
申请日：2018-12-21
申请人： Todd Anthony Person
发明人： Todd Anthony Person
IPC分类号： A63B22/00 , A63B22/06 , A63B22/20 , A63B21/068
摘要： A muscle strengthening system is provided having a functional core endurance training device and a pair of rolling blocks for supporting the functional core endurance training device. Each rolling block in the pair of rolling blocks includes an elongated opening for receiving a wheel of the functional core endurance training device. Additionally, each rolling block in the pair of rolling blocks includes a pair of rollers, a stabilizer and a bumper guard for grounding the surface of the wheels of the functional core endurance training device allowing the wheels to spin with increased intensity. Optionally, an individual may utilize a stationary foot pedestal or a wheeled foot pedestal that provides for both the strengthening of the muscles of the individual while simultaneously stimulating an endurance building effect on the muscular and fascial systems of the body, all of which is achieved with minimal to no impact/pounding on the joints.
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公开(公告)号：US11351410B2
公开(公告)日：2022-06-07
申请号：US16331087
申请日：2018-12-21
申请人： Todd Anthony Person
发明人： Todd Anthony Person
IPC分类号： A63B21/068 , A63B22/06 , A63B22/20 , A63B22/00
摘要： A muscle strengthening system is provided having a functional core endurance training device and a pair of rolling blocks for supporting the functional core endurance training device. Each rolling block in the pair of rolling blocks includes an elongated opening for receiving a wheel of the functional core endurance training device. Additionally, each rolling block in the pair of rolling blocks includes a pair of rollers, a stabilizer and a bumper guard for grounding the surface of the wheels of the functional core endurance training device allowing the wheels to spin with increased intensity. Optionally, an individual may utilize a stationary foot pedestal or a wheeled foot pedestal that provides for both the strengthening of the muscles of the individual while simultaneously stimulating an endurance building effect on the muscular and fascial systems of the body, all of which is achieved with minimal to no impact/pounding on the joints.
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公开(公告)号：US08808982B2
公开(公告)日：2014-08-19
申请号：US12962498
申请日：2010-12-07
申请人： Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
发明人： Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
CPC分类号： C12N5/0696 , A61K38/1709 , A61K38/1816 , A61K38/44 , A61K38/465 , A61K38/50 , A61K48/005 , A61K48/0075 , C07K14/47 , C07K14/4712 , C07K14/505 , C12N9/0075 , C12N9/22 , C12N9/78 , C12N15/117 , C12N15/85 , C12N15/87 , C12N2310/17 , C12N2310/335 , C12N2320/30 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/02 , C12Y114/13039 , C12Y301/04012 , C12Y305/04004
摘要： The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mRNA that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mRNA was introduced, and compositions therefor. For example, the present invention provides mRNA molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells.
摘要翻译： 本发明涉及用于改变真核细胞分化状态的方法，所述方法包括将编码一种或多种重编程因子的mRNA引入细胞并将细胞维持在其中细胞存活的条件下，并将导入 表达足够量的细胞并足够的时间产生与引入mRNA的细胞相比表现出改变的分化状态的细胞及其组合物。 例如，本发明提供mRNA分子及其用于将人体细胞重编程为多能干细胞的方法。
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4.发明申请RNA PREPARATIONS COMPRISING PURIFIED MODIFIED RNA FOR REPROGRAMMING CELLS 有权包含用于转染细胞的纯化的修饰的RNA的RNA制备公开(公告)号：US20110143397A1
公开(公告)日：2011-06-16
申请号：US12962468
申请日：2010-12-07
申请人： Katalin Kariko , Drew Weissman , Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
发明人： Katalin Kariko , Drew Weissman , Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
CPC分类号： C12N5/0602 , A61K48/0041 , A61K48/005 , A61K48/0075 , C07K14/47 , C07K14/4712 , C07K14/505 , C12N5/0696 , C12N15/117 , C12N15/67 , C12N2310/17 , C12N2310/33 , C12N2310/3341 , C12N2501/40
摘要： The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs.
摘要翻译： 本发明提供使用包含编码iPS细胞诱导因子的单链mRNA的纯化RNA制备物重编程体细胞的组合物和方法。 纯化的RNA制剂优选基本上不含RNA污染物分子，其可以：i）激活体细胞中的免疫应答，ii）降低体细胞中单链mRNA的表达，和/或iii）活性RNA传感器 在体细胞中。 在某些实施方案中，纯化的RNA制剂基本上不含部分mRNA，双链RNA，未封端的RNA分子和/或单链连续的mRNA。
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公开(公告)号：US09012219B2
公开(公告)日：2015-04-21
申请号：US12962468
申请日：2010-12-07
申请人： Katalin Kariko , Drew Weissman , Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
发明人： Katalin Kariko , Drew Weissman , Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
IPC分类号： C12N5/00 , C12N5/02 , C12Q1/68 , A61K48/00 , C07K14/47 , C07K14/505 , C12N15/117 , C12N15/67
CPC分类号： C12N5/0602 , A61K48/0041 , A61K48/005 , A61K48/0075 , C07K14/47 , C07K14/4712 , C07K14/505 , C12N5/0696 , C12N15/117 , C12N15/67 , C12N2310/17 , C12N2310/33 , C12N2310/3341 , C12N2501/40
摘要： The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs.
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公开(公告)号：US20110143436A1
公开(公告)日：2011-06-16
申请号：US12962498
申请日：2010-12-07
申请人： Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
发明人： Gary Dahl , Anthony Person , Judith Meis , Jerome Jendrisak
CPC分类号： C12N5/0696 , A61K38/1709 , A61K38/1816 , A61K38/44 , A61K38/465 , A61K38/50 , A61K48/005 , A61K48/0075 , C07K14/47 , C07K14/4712 , C07K14/505 , C12N9/0075 , C12N9/22 , C12N9/78 , C12N15/117 , C12N15/85 , C12N15/87 , C12N2310/17 , C12N2310/335 , C12N2320/30 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2506/02 , C12Y114/13039 , C12Y301/04012 , C12Y305/04004
摘要： The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mRNA encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mRNA that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mRNA was introduced, and compositions therefor. For example, the present invention provides mRNA molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells.
摘要翻译： 本发明涉及用于改变真核细胞分化状态的方法，所述方法包括将编码一种或多种重编程因子的mRNA引入细胞并将细胞维持在其中细胞存活的条件下，并将导入 表达足够量的细胞并足够的时间产生与引入mRNA的细胞相比表现出改变的分化状态的细胞及其组合物。 例如，本发明提供mRNA分子及其用于将人体细胞重编程为多能干细胞的方法。
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