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13 条记录 (耗时 0.014 秒)

    Method of detecting gene polymorphism
    2.
    发明申请
    Method of detecting gene polymorphism 审中-公开
    检测基因多态性的方法

    公开(公告)号：US20060234230A1

    公开(公告)日：2006-10-19

    申请号：US10516038

    申请日：2003-05-29

    申请人： Yusuke Nakamura ,  Akihiro Sekine ,  Aritoshi Iida ,  Susumu Saito

    发明人： Yusuke Nakamura ,  Akihiro Sekine ,  Aritoshi Iida ,  Susumu Saito

    IPC分类号： C12Q1/68 ,  C07H21/04

    CPC分类号： C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6837 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2561/113

    摘要： A method for detecting a genetic polymorphism(s) in a gene encoding cytochrome P450 using as oligonucleotide probes and/or oligonucleotide primers at least one sequence selected from the group consisting of an at least 13 nucleotide sequence within any of the nucleotide sequences as shown in SEQ ID NOS: 1 through 215, said at least 13 nucleotide sequence containing the 21st nucleotide, or a sequence complementary to said at least 13 nucleotide sequence.

    摘要翻译： 用于使用寡核苷酸探针和/或寡核苷酸引物检测编码细胞色素P450的基因中的遗传多态性的方法，所述寡核苷酸探针和/或寡核苷酸引物至少一个选自下列任一核苷酸序列中的至少13个核苷酸序列的序列，如 SEQ ID NO：1至215，所述至少13个核苷酸序列含有第21个核苷酸，或与所述至少13个核苷酸序列互补的序列。

    Method of judging inflammatory disease
    5.
    发明授权
    Method of judging inflammatory disease 失效
    炎症性疾病的诊断方法

    公开(公告)号：US07754422B2

    公开(公告)日：2010-07-13

    申请号：US10523723

    申请日：2003-08-08

    申请人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    发明人： Toshihiro Tanaka ,  Yozo Ohnishi ,  Koichi Ozaki ,  Aritoshi Iida ,  Yusuke Nakamura ,  Masatsugu Hori

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The object of the present invention is to determine inflammatory diseases such as myocardial infarction by identifying single nucleotide polymorphisms (SNPs) associated with myocardial infarction and utilizing these SNPs. The present invention provides a method for determining an inflammatory disease, which comprises detecting at least one gene polymorphism existing in at least one gene selected from the group consisting of a lymphotoxin-α (LT-α) gene, an I Kappa B-like (IKBL) gene, and a BAT1 gene; an oligonucleotide used in said method; a kit for diagnosing an inflammatory disease which comprises said oligonucleotide; and use thereof. The present invention further provides a method for treating an inflammatory disease; and a method for screening for a therapeutic agent for an inflammatory disease.

    摘要翻译： 本发明的目的是通过鉴定与心肌梗塞相关的单核苷酸多态性（SNP）和利用这些SNP来确定诸如心肌梗死的炎性疾病。 本发明提供了一种测定炎性疾病的方法，该方法包括检测至少一种存在于选自淋巴毒素-α（LT-α）基因，IκB样（LT-α） IKBL）基因和BAT1基因; 所述方法中使用的寡核苷酸; 用于诊断包含所述寡核苷酸的炎性疾病的试剂盒; 及其用途。 本发明还提供一种治疗炎性疾病的方法; 以及筛选炎性疾病治疗剂的方法。