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1.发明授权Glycoconjugates and use thereof as vaccine against Shigella flexneri serotype 3a and X 有权糖缀合物及其用作针对志贺氏菌志贺氏菌血清型3a和X的疫苗公开(公告)号：US08815239B2
公开(公告)日：2014-08-26
申请号：US12663454
申请日：2008-05-16
申请人： Laurence Mulard , Julien Boutet , Catherine Guerreiro , Farida Nato , Philippe Sansonetti , Armelle Phalipon
发明人： Laurence Mulard , Julien Boutet , Catherine Guerreiro , Farida Nato , Philippe Sansonetti , Armelle Phalipon
IPC分类号： A61K39/395 , A61K39/112 , A61P31/04 , C12N15/13
CPC分类号： C07K16/1228 , A61K47/646 , C07H1/00 , C07H3/04 , C07H3/06 , C07H5/04
摘要： The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
摘要翻译： 本发明涉及衍生自富含志贺氏菌志贺氏菌血清型3a和X的表位的糖的化合物及其制备疫苗组合物的用途。 更具体地，本发明的主题涉及包含下文所述的寡糖或多糖的新型糖缀合化合物，涉及将这些寡糖或多糖和糖缀合物合成的方法，这些寡糖或多糖的衍生物用于含有它们的组合物，还涉及 使用糖缀合物进行疫苗接种。 最后，本发明涉及使用一种或多种寡糖或多糖或其结合物诊断志贺氏杆菌感染的方法。
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2.发明申请GLYCOCONJUGATES AND USE THEREOF AS VACCINE AGAINST SHIGELLA FLEXNERI SEROTYPE 3A AND X 有权甘氨酸和其作为抗真菌剂的抗菌肽3A和X公开(公告)号：US20100239584A1
公开(公告)日：2010-09-23
申请号：US12663454
申请日：2008-05-16
申请人： Laurence Mulard , Julien Boutet , Catherine Guerreiro , Farida Nato , Philippe Sansonetti , Armelle Phalipon
发明人： Laurence Mulard , Julien Boutet , Catherine Guerreiro , Farida Nato , Philippe Sansonetti , Armelle Phalipon
IPC分类号： C07K16/12 , C07H1/00 , C07K14/00 , A61K39/112 , C12N15/13 , C12N15/63 , C12N15/85 , C12N5/10 , A01K67/027 , A01H5/00 , A61K39/395 , A61P31/04
CPC分类号： C07K16/1228 , A61K47/646 , C07H1/00 , C07H3/04 , C07H3/06 , C07H5/04
摘要： The present invention relates to compounds derived from sugars which reproduce the epitopes of Shigella flexneri serotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing a Shigella flexneri infection using one or more oligosaccharides or polysaccharides or conjugates thereof.
摘要翻译： 本发明涉及衍生自富含志贺氏菌志贺氏菌血清型3a和X的表位的糖的化合物及其制备疫苗组合物的用途。 更具体地，本发明的主题涉及包含下文所述的寡糖或多糖的新型糖缀合化合物，涉及将这些寡糖或多糖和糖缀合物合成的方法，这些寡糖或多糖的衍生物用于含有它们的组合物，还涉及 使用糖缀合物进行疫苗接种。 最后，本发明涉及使用一种或多种寡糖或多糖或其结合物诊断志贺氏杆菌感染的方法。
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3.发明申请Targeting the histone code as a bacterial strategy for selectively modulating gene expression 审中-公开将组蛋白代码作为选择性调节基因表达的细菌策略公开(公告)号：US20070077254A1
公开(公告)日：2007-04-05
申请号：US11521546
申请日：2006-09-15
IPC分类号： A61K39/00 , G01N33/574
CPC分类号： A61K38/164 , A61K38/45 , A61K39/0283 , A61K2039/521 , C07K14/4702 , C07K14/4703 , C07K14/4747 , C07K14/5421 , C07K14/5434 , C12N9/1205 , C12N9/16 , Y02A50/476
摘要： The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
摘要翻译： 志贺氏菌志贺氏菌的ospF基因编码磷酸酶，其是新一类磷酸酶的成员。 OspF磷酸酶通过直接蛋白修饰或转录下调抑制几种蛋白质的活性。 这些蛋白质包括MAP激酶，IL-8，CCL20，IL-12，AP1，CREB，RPA p32和BCL2相关蛋白。 提供了使用OspF磷酸酶治疗疾病的方法，用于鉴定调节OspF磷酸酶活性的药剂的方法，用于鉴定模拟OspF磷酸酶活性的药剂的方法，以及包含OspF磷酸酶的免疫原性组合物。 还提供了含有灭活的ospF基因的志贺氏菌志贺菌菌株。
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4.发明授权Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri 有权糖缀合物及其作为抵抗志贺氏菌感染的潜在疫苗的用途公开(公告)号：US08124380B2
公开(公告)日：2012-02-28
申请号：US10563221
申请日：2004-07-02
申请人： Armelle Phalipon , Farida Nato , Laurence Mulard , Philippe Sansonetti , Françoise Baleux , Frédéric Belot , Cyrille Grandjean
发明人： Armelle Phalipon , Farida Nato , Laurence Mulard , Philippe Sansonetti , Françoise Baleux , Frédéric Belot , Cyrille Grandjean
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
摘要翻译： 共轭分子包含与载体共价结合的寡糖或多糖，并且其用作针对S.Flexneri感染的潜在疫苗。
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5.发明申请Targeting the Histone Code as a Bacterial Strategy for Selectively Modulating Gene Expression 失效针对组蛋白代码作为选择性调节基因表达的细菌策略公开(公告)号：US20090324646A1
公开(公告)日：2009-12-31
申请号：US11992155
申请日：2006-09-15
CPC分类号： A61K38/164 , A61K38/45 , A61K39/0283 , A61K2039/521 , C07K14/4702 , C07K14/4703 , C07K14/4747 , C07K14/5421 , C07K14/5434 , C12N9/1205 , C12N9/16 , Y02A50/476
摘要： The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
摘要翻译： 志贺氏菌志贺氏菌的ospF基因编码磷酸酶，其是新一类磷酸酶的成员。 OspF磷酸酶通过直接蛋白修饰或转录下调抑制几种蛋白质的活性。 这些蛋白质包括MAP激酶，IL-8，CCL20，IL-12，AP1，CREB，RPA p32和BCL2相关蛋白。 提供了使用OspF磷酸酶治疗疾病的方法，用于鉴定调节OspF磷酸酶活性的药剂的方法，用于鉴定模拟OspF磷酸酶活性的药剂的方法，以及包含OspF磷酸酶的免疫原性组合物。 还提供了含有灭活的ospF基因的志贺氏菌志贺菌菌株。
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6.发明申请Targeting the histone code as a bacterial strategy for selectively modulating gene expression 审中-公开将组蛋白代码作为选择性调节基因表达的细菌策略公开(公告)号：US20100322974A1
公开(公告)日：2010-12-23
申请号：US12318108
申请日：2008-12-22
IPC分类号： A61K39/02 , A61K38/46 , C12N9/14 , C12Q1/42 , A61P35/00 , A61P37/06 , A61P29/00 , C12N1/20 , C12N15/53 , A61P31/04
CPC分类号： A61K38/164 , A61K38/45 , A61K39/0283 , A61K2039/521 , C07K14/4702 , C07K14/4703 , C07K14/4747 , C07K14/5421 , C07K14/5434 , C12N9/1205 , C12N9/16 , Y02A50/476
摘要： The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
摘要翻译： 志贺氏菌志贺氏菌的ospF基因编码磷酸酶，其是新一类磷酸酶的成员。 OspF磷酸酶通过直接蛋白修饰或转录下调抑制几种蛋白质的活性。 这些蛋白质包括MAP激酶，IL-8，CCL20，IL-12，AP1，CREB，RPA p32和BCL2相关蛋白。 提供了使用OspF磷酸酶治疗疾病的方法，用于鉴定调节OspF磷酸酶活性的药剂的方法，用于鉴定模拟OspF磷酸酶活性的药剂的方法，以及包含OspF磷酸酶的免疫原性组合物。 还提供了含有灭活的ospF基因的志贺氏菌志贺菌菌株。
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7.发明申请Glycoconjugates and Their Use as Potential Vaccines Against Infection by Shigella Flexneri 有权糖缀合物及其作为潜在疫苗用于志贺氏菌感染的疫苗公开(公告)号：US20080112951A1
公开(公告)日：2008-05-15
申请号：US10563221
申请日：2004-07-02
申请人： Armelle Phalipon , Farida Nato , Laurence Mulard , Philippe Sansonetti , Francoise Baleux , Frederic Belot , Cyrille Grandjean
发明人： Armelle Phalipon , Farida Nato , Laurence Mulard , Philippe Sansonetti , Francoise Baleux , Frederic Belot , Cyrille Grandjean
IPC分类号： A61K39/40 , A01H5/00 , A01K67/027 , C07H21/00 , C07K14/00 , C07K2/00 , C12N15/63 , C12Q1/04 , C12N5/10 , C12N1/00 , C07K16/12 , C07H3/00 , A61P31/04 , A61K39/385
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
摘要翻译： 共轭分子包含与载体共价结合的寡糖或多糖，并且其用作针对S.Flexneri感染的潜在疫苗。
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8.发明授权Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions 失效模拟病原微生物的表面多糖抗原的免疫原性多肽，其获得方法及其在疫苗组合物中的应用公开(公告)号：US06528061B1
公开(公告)日：2003-03-04
申请号：US09144280
申请日：1998-08-31
申请人： Armelle Phalipon , Philippe Sansonetti , Franco Felici , Riccardo Cortese , Jean Pierre Kraehenbuhl
发明人： Armelle Phalipon , Philippe Sansonetti , Franco Felici , Riccardo Cortese , Jean Pierre Kraehenbuhl
IPC分类号： A01N6300
CPC分类号： C12Q1/025 , A61K39/00 , A61K2039/525 , C07K14/25 , C07K16/1228 , C07K2317/34 , G01N33/56911 , G01N33/56983 , G01N2333/25 , Y02A50/476
摘要： A purified immunogenic polypeptide comprises an epitope unit recognized by a protective monoclonal antibody having a high affinity and a high specificity for a surface polysaccharide of a pathogenic microorganism of bacterial, viral, or fungal origin. The polypeptide is capable of inducing an immune response in vivo against the pathogenic microorganism. The immune response confers protection in mice against challenge with the virulent microorganisms.
摘要翻译： 纯化的免疫原性多肽包含由对细菌，病毒或真菌来源的病原微生物的表面多糖具有高亲和力和高特异性的保护性单克隆抗体识别的表位单元。 该多肽能够在体内诱导针对病原微生物的免疫应答。 免疫应答赋予小鼠免受有毒微生物攻击的保护作用。
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9.发明授权Glycoconjugates and their use as potential vaccines against infection by Shigella flexneri 有权糖缀合物及其作为抵抗志贺氏菌感染的潜在疫苗的用途公开(公告)号：US09446109B2
公开(公告)日：2016-09-20
申请号：US13325511
申请日：2011-12-14
申请人： Armelle Phalipon , Farida Nato , Laurence Mulard , Philippe Sansonetti , Françoise Baleux , Frédéric Belot , Cyrille Grandjean
发明人： Armelle Phalipon , Farida Nato , Laurence Mulard , Philippe Sansonetti , Françoise Baleux , Frédéric Belot , Cyrille Grandjean
IPC分类号： C12P19/00 , C12P19/12 , C07K1/00 , A61K39/112 , A61K47/48 , C07K16/12 , G01N33/563 , G01N33/569 , C07H3/06 , C08B37/00 , A61K39/00
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
摘要翻译： 共轭分子包含与载体共价结合的寡糖或多糖，并且其用作针对S.Flexneri感染的潜在疫苗。
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10.发明申请GLYCOCONJUGATES AND THEIR USE AS POTENTIAL VACCINES AGAINST INFECTION BY SHIGELLA FLEXNERI 有权谷氨酸钠及其作为潜在的疫苗使用，可以通过SHIGELLA FLEXNERI感染公开(公告)号：US20140161793A2
公开(公告)日：2014-06-12
申请号：US13325511
申请日：2011-12-14
申请人： Armelle PHALIPON , Farida NATO , Laurence MULARD , Philippe SANSONETTI , Francoise BALEUX , Frederic BELOT , Cyrille GRANDJEAN
发明人： Armelle PHALIPON , Farida NATO , Laurence MULARD , Philippe SANSONETTI , Francoise BALEUX , Frederic BELOT , Cyrille GRANDJEAN
IPC分类号： A61K39/112 , C07K16/12 , C08B37/00 , C07H3/06
CPC分类号： A61K39/0283 , A61K47/557 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6031 , A61K2039/6037 , A61K2039/625 , C07H3/06 , C07K16/1228 , C07K2317/565 , C08B37/006 , G01N33/563 , G01N33/56916 , Y02A50/476
摘要： A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri.
摘要翻译： 共轭分子包含与载体共价结合的寡糖或多糖，并且其用作针对S.Flexneri感染的潜在疫苗。
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