公开(公告)号：US20230113788A1

公开(公告)日：2023-04-13

申请号：US17907793

申请日：2021-02-26

Applicant: BERTIS INC

Inventor： Hyeon Seok SHIN ,  Sung Soo KIM

IPC: G06N5/04

Abstract: The present invention provides a system for predicting the spectral profile of a peptide, wherein the spectrum of a sample to be checked can be efficiently analyzed by machine learning properties of the peptide and generating training data for predicting the spectral profile.

公开(公告)号：US20240043937A1

公开(公告)日：2024-02-08

申请号：US18268858

申请日：2021-08-26

Applicant: BERTIS INC

Inventor： Sangwon LEE ,  Jingi BAE ,  Dowoon NAM ,  Daehee HWANG ,  Jin-Young JANG ,  Cheolju LEE ,  Sungho SHIN ,  Min-Sik KIM

IPC: C12Q1/6886 ,  C12Q1/6806

CPC classification number: C12Q1/6886 ,  C12Q1/6806 ,  G01N2800/56 ,  G01N2800/7028

Abstract: The present invention relates to a method of determining the subtype of a pancreatic ductal adenocarcinoma patient through proteogenomic analysis of PDAC. The method of determining the subtype of pancreatic cancer according to one embodiment of the present invention comprises steps of: (1) pulverizing a pancreatic ductal adenocarcinoma lesion tissue isolated from a pancreatic ductal adenocarcinoma patient; (2) obtaining a peptide sample for the patient by extracting and digesting proteins from the lesion tissue; (3) measuring the expression levels of representative genes of pancreatic ductal adenocarcinoma subtypes 1 to 6 from the peptide sample for the patient; and (4) determining the subtype of the pancreatic ductal adenocarcinoma patient by comparing the expression levels of the representative genes of pancreatic ductal adenocarcinoma subtypes 1 to 6.

公开(公告)号：US20250102506A1

公开(公告)日：2025-03-27

申请号：US18722482

申请日：2023-03-30

Applicant: BERTIS INC

Inventor： Sungsoo KIM ,  Youngmin PARK ,  Hyeonseok SHIN ,  Seungman HAN ,  Dongyoung NOH

IPC: G01N33/574 ,  G01N33/573 ,  G01N33/68 ,  G16B20/00

Abstract: The present invention relates to a method of diagnosing cancer using proteins (or fragments thereof), which are specifically expressed in cancer, or genes encoding the proteins. According to the present invention, specific proteins and fragments thereof useful for cancer diagnosis are discovered among blood proteins, and they may be used as diagnostic biomarkers to diagnose in particular breast cancer simply and accurately at an early stage, thereby significantly lowering the mortality rate of patients with related diseases.

公开(公告)号：US20240053309A1

公开(公告)日：2024-02-15

申请号：US18270528

申请日：2021-04-28

Applicant: BERTIS INC

Inventor： Sejun SONG ,  Sungsoo KIM ,  Hyeonseok SHIN

IPC: G01N30/86 ,  G01N30/72 ,  G06N3/045

CPC classification number: G01N30/8693 ,  G01N30/7233 ,  G06N3/045 ,  G01N2030/027

Abstract: The present invention relates, with respect to liquid chromatograph-mass spectrometry (LC-MS), to a technique for predicting retention time of samples and thereby accurately separating signals of samples having mass that are close to each other to improve multiplexity of quantitative measurements.

公开(公告)号：US20230074311A1

公开(公告)日：2023-03-09

申请号：US17793158

申请日：2020-01-15

Applicant: BERTIS INC

Inventor： Sung Soo KIM ,  Seung Man HAN

IPC: G01N33/574

Abstract: The present invention relates to a composition capable of cancer diagnosis, a diagnostic kit comprising same, and a method for providing information for cancer diagnosis using the composition. When a biomarker of the present invention is used, it is possible to accurately and conveniently diagnose cancer, particularly breast cancer, in an early stage, and furthermore, it is possible to diagnose the stage of cancer and predict therapeutic responsiveness or post-treatment prognosis.

公开(公告)号：US20220268776A1

公开(公告)日：2022-08-25

申请号：US17625531

申请日：2020-07-09

Applicant: BERTIS INC

Inventor： Youngsoo KIM ,  Yoseop KIM ,  Minsoo SON ,  Jin-Young JANG

IPC: G01N33/574 ,  G01N30/72 ,  G01N33/68 ,  G16B40/10 ,  G06N20/10 ,  G06N3/04

Abstract: The present invention relates to a biomarker for diagnosing pancreatic cancer and use thereof. The marker according to the present application can significantly predict or determine, through a 14-multimarker panel, the onset likelihood, early diagnosis, and severity of pancreatic cancer or precancerous lesions of pancreatic cancer, and can be used in research on the tumorigenesis of pancreatic cancer.

公开(公告)号：US20240011979A1

公开(公告)日：2024-01-11

申请号：US18251919

申请日：2022-10-27

Applicant: BERTIS INC.

Inventor： Sung Soo KIM ,  Jaehong LEE

IPC: G01N33/543 ,  G01N33/68

CPC classification number: G01N33/543 ,  G01N33/6848

Abstract: The present disclosure relates to a composition for detecting or measuring an analyte and an analysis method using the composition. In particular, efficiency and performance of sample analysis may be greatly improved through the composition and analysis method of the present disclosure.

公开(公告)号：US20230236158A1

公开(公告)日：2023-07-27

申请号：US18157219

申请日：2023-01-20

Applicant: Korea University Research and Business Foundation ,  BERTIS INC.

Inventor： Sang-Won LEE ,  Chaewon KANG

IPC: G01N30/20 ,  G01N30/34

CPC classification number: G01N30/20 ,  G01N30/34 ,  G01N2030/027

Abstract: Disclosed are a mutually independent dual online liquid chromatography device and a control method thereof. The mutually independent dual online liquid chromatography device according to the present disclosure includes a first pump configured to inject a first solvent or a mixed solution containing the first solvent and a second solvent; a second pump configured to inject the first solvent or the mixed solution containing the first solvent and the second solvent; a sample inlet valve to which the first pump and a sample injector configured to inject a sample are connected; a first column valve to which a first sample separation column is connected; a second column valve to which a second sample separation column is connected; and a column selection valve to which the second pump is connected, and interposed between the sample inlet valve, and the first column valve and the second column valve to inject the sample fed from the sample inlet valve onto any one of the first sample separation column and the second sample separation column to separate and analyze the sample in one sample separation column while allowing for wash and equilibration, sample injection and isocratic elution of the other sample separation column.