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    Microencapsulated bioactive agents and method of making
    2.
    发明授权
    Microencapsulated bioactive agents and method of making 失效
    微囊化生物活性剂及其制备方法

    公开(公告)号：US06387399B1

    公开(公告)日：2002-05-14

    申请号：US09079766

    申请日：1998-05-15

    Applicant: Dennis R. Morrison ,  Benjamin Mosier

    Inventor： Dennis R. Morrison ,  Benjamin Mosier

    IPC: A61K948

    CPC classification number: A61K9/5073 ,  A61K9/1277 ,  A61K9/5089 ,  A61K41/0028 ,  B01F13/0059 ,  B01J13/06 ,  C30B7/00

    Abstract: Microcapsules prepared by encapsulating an aqueous solution of a protein, drug or other bioactive substance inside a semi-permeable membrane by are disclosed. The microcapsules are formed by interfacial coacervation under conditions where the shear forces are limited to 0-100 dynes/cm2 at the interface. By placing the microcapsules in a high osmotic dewatering solution, the protein solution is gradually made saturated and then supersaturated, and the controlled nucleation and crystallization of the protein is achieved. The crystal-filled microcapsules prepared by this method can be conveniently harvested and stored while keeping the encapsulated crystals in essentially pristine condition due to the rugged, protective membrane. Because the membrane components themselves are x-ray transparent, large crystal-containing microcapsules can be individually selected, mounted in x-ray capillary tubes and subjected to high energy x-ray diffraction studies to determine the 3-D structure of the protein molecules. Certain embodiments of the microcapsules of the invention have composite polymeric outer membranes which are somewhat elastic, water insoluble, permeable only to water, salts, and low molecular weight molecules and are structurally stable in fluid shear forces typically encountered in the human vascular system.

    Abstract translation: 公开了通过将半透膜中的蛋白质，药物或其它生物活性物质的水溶液包封而制备的微胶囊。 微胶囊通过界面凝聚在界面处的剪切力限制在0-100达因/厘米2的条件下形成。 通过将微胶囊置于高渗透脱水溶液中，使蛋白质溶液逐渐饱和，然后过饱和，并实现蛋白质的受控成核和结晶。 通过这种方法制备的晶体填充的微胶囊可以方便地收获和储存，同时保持包封的晶体基本上原始状态由于坚固的保护膜。 因为膜组分本身是x射线透明的，所以可以单独选择大晶体的微胶囊，安装在x射线毛细管中，并进行高能X射线衍射研究以确定蛋白质分子的3-D结构。 本发明的微胶囊的某些实施方案具有复合聚合物外膜，其具有弹性，水不溶性，仅对水，盐和低分子量分子是可渗透的，并且在人血管系统中通常遇到的流体剪切力中结构稳定。

    Method of forming fire retardant insulating material from plastic foam scrap and the resultant product
    3.
    发明授权
    Method of forming fire retardant insulating material from plastic foam scrap and the resultant product 失效
    从塑料泡沫废料和所得产品形成阻燃绝缘材料的方法

    公开(公告)号：US4714715A

    公开(公告)日：1987-12-22

    申请号：US837185

    申请日：1986-03-07

    Applicant: Benjamin Mosier

    Inventor： Benjamin Mosier

    IPC: C08J9/35 ,  B29C39/10 ,  B29C65/04 ,  B29C67/16

    CPC classification number: C08J9/35 ,  C08J2361/00 ,  Y10S264/02 ,  Y10S264/07

    Abstract: Fire retardant polystyrene insulating material is manufactured from expandable polystyrene scrap in admixture with a phenol-formaldehyde or melamine-formaldehyde resin in resole form, the resin containing a blowing agent and a surfactant. The insulating material is formed from the scrap-resin mix by applying dielectric heating to foam the resin, and cure the foamed resin to a closed cell structure.

    Abstract translation: 阻燃聚苯乙烯绝缘材料由可发泡聚苯乙烯废料与酚醛树脂或三聚氰胺甲醛树脂混合制成，树脂含有发泡剂和表面活性剂。 绝缘材料由废树脂混合物形成，通过施加电介质加热来使树脂发泡，并将泡沫树脂固化成闭孔结构。

    Mold and mildew removal composition and method of manufacture
    4.
    发明授权
    Mold and mildew removal composition and method of manufacture 失效
    模具和霉菌去除组合物及其制造方法

    公开(公告)号：US4097395A

    公开(公告)日：1978-06-27

    申请号：US759747

    申请日：1977-01-17

    Applicant: Dan E. Posey ,  Benjamin Mosier

    Inventor： Dan E. Posey ,  Benjamin Mosier

    IPC: C11D3/20 ,  C11D3/48 ,  C11D11/00 ,  C11D17/00 ,  C11D3/065

    CPC classification number: C11D3/48 ,  C11D1/83 ,  C11D11/0094 ,  C11D3/06 ,  C11D3/2034 ,  C11D3/2079

    Abstract: A concentrate for producing a reactive mixture which mold and mildew cannot tolerate and which removes mold and mildew from a surface without scrubbing. The primary active ingredients of the concentrate consist essentially of acetic acid, sodium metasilicate, sodium tripolyphosphate, sodium alkyl benzene sulfonate, and sodium-o-phenylphenolate. A surfactant such as polyethoxylated nonyl phenol can be included to increase the solubility of the phenolate in aqueous solution. An improved method of preparing the concentrate in a manner to prevent formation of silica gel includes adding the acetic acid last, and a three stage mixing procedure. The mold and mildew is removed by mixing the concentrate with water and bleach, and thereafter spraying the mixture onto an area to be treated.

    Abstract translation: 用于生产模具和霉变不能耐受的反应性混合物的浓缩物，并且从表面除去霉菌和霉变而不进行洗涤。 浓缩物的主要活性成分基本上由乙酸，偏硅酸钠，三聚磷酸钠，烷基苯磺酸钠和邻苯基苯酚钠组成。 可以包括表面活性剂如聚乙氧基化壬基酚以增加酚盐在水溶液中的溶解度。

    Method for determining the three-dimensional structure of a protein
    6.
    发明授权
    Method for determining the three-dimensional structure of a protein 有权
    确定蛋白质三维结构的方法

    公开(公告)号：US06676964B2

    公开(公告)日：2004-01-13

    申请号：US09774168

    申请日：2001-01-26

    Applicant: Dennis R. Morrison ,  Benjamin Mosier

    Inventor： Dennis R. Morrison ,  Benjamin Mosier

    IPC: A61K948

    CPC classification number: A61K9/5073 ,  A61K9/1277 ,  A61K9/5089 ,  A61K41/0028 ,  B01F13/0059 ,  B01J13/06 ,  C30B7/00

    Abstract: Microcapsules prepared by encapsulating an aqueous solution of a protein, drug or other bioactive substance inside a semi-permeable membrane by are disclosed. The microcapsules are formed by interfacial coacervation under conditions where the shear forces are limited to 0-100 dynes/cm2 at the interface. By placing the microcapsules in a high osmotic dewatering solution, the protein solution is gradually made saturated and then supersaturated, and the controlled nucleation and crystallization of the protein is achieved. The crystal-filled microcapsules prepared by this method can be conveniently harvested and stored while keeping the encapsulated crystals in essentially pristine condition due to the rugged, protective membrane. Because the membrane components themselves are x-ray transparent, large crystal-containing microcapsules can be individually selected, mounted in x-ray capillary tubes and subjected to high energy x-ray diffraction studies to determine the 3-D structure of the protein molecules. Certain embodiments of the microcapsules of the invention have composite polymeric outer membranes which are somewhat elastic, water insoluble, permeable only to water, salts, and low molecular weight molecules and are structurally stable in fluid shear forces typically encountered in the human vascular system.

    Abstract translation: 公开了通过将半透膜中的蛋白质，药物或其它生物活性物质的水溶液包封而制备的微胶囊。 微胶囊在界面处的剪切力限制在0-100达因/厘米2的条件下通过界面凝聚形成。 通过将微胶囊置于高渗透脱水溶液中，使蛋白质溶液逐渐饱和，然后过饱和，并实现蛋白质的受控成核和结晶。 通过这种方法制备的晶体填充的微胶囊可以方便地收获和储存，同时保持包封的晶体基本上原始状态由于坚固的保护膜。 因为膜组分本身是x射线透明的，所以可以单独选择大晶体的微胶囊，安装在x射线毛细管中，并进行高能X射线衍射研究以确定蛋白质分子的3-D结构。 本发明的微胶囊的某些实施方案具有复合聚合物外膜，其具有弹性，水不溶性，仅对水，盐和低分子量分子是可渗透的，并且在人血管系统中通常遇到的流体剪切力中结构稳定。

    Microencapsulated bioactive agents and method of making
    7.
    发明授权
    Microencapsulated bioactive agents and method of making 有权
    微囊化生物活性剂及其制备方法

    公开(公告)号：US06558698B2

    公开(公告)日：2003-05-06

    申请号：US09733391

    申请日：2000-12-06

    Applicant: Dennis R. Morrison ,  Benjamin Mosier

    Inventor： Dennis R. Morrison ,  Benjamin Mosier

    IPC: A61K948

    CPC classification number: A61K9/5073 ,  A61K9/1277 ,  A61K9/5089 ,  A61K41/0028 ,  B01F13/0059 ,  B01J13/06 ,  C30B7/00

    Abstract: The invention is directed to microcapsules encapsulating an aqueous solution of a protein, drug or other bioactive substance inside a semi-permeable membrane. The microcapsules are formed by interfacial coacervation where shear forces are limited to 0-100 dynes per square centimeter. The resulting uniform microcapsules can then be subjected to dewatering in order to cause the internal solution to become supersaturated with the dissolved substance. This dewatering allows controlled nucleation and crystallization of the dissolved substance. The crystal-filled microcapsules can be stored, keeping the encapsulated crystals in good condition for further direct use in x-ray crystallography or as injectable formulations of the dissolved drug, protein or other bioactive substance.

    Abstract translation: 本发明涉及将蛋白质，药物或其他生物活性物质的水溶液包封在半透膜内的微胶囊。 微胶囊通过界面凝聚形成，其中剪切力限制在0-100达因/平方厘米。 然后将得到的均匀的微胶囊进行脱水，以使内部溶液变得与溶解的物质过饱和。 该脱水允许溶解物质的受控成核和结晶。 可以储存晶体填充的微胶囊，保持包封的晶体处于良好状态，以进一步直接用于x射线晶体学或作为溶解药物，蛋白质或其他生物活性物质的可注射制剂。

    Microencapsulation and electrostatic processing method
    8.
    发明授权
    Microencapsulation and electrostatic processing method 失效
    微胶囊化和静电处理方法

    公开(公告)号：US6103271A

    公开(公告)日：2000-08-15

    申请号：US79770

    申请日：1998-05-15

    Applicant: Dennis R. Morrison ,  Benjamin Mosier

    Inventor： Dennis R. Morrison ,  Benjamin Mosier

    IPC: A61K9/127 ,  A61K9/50 ,  A61K9/52 ,  A61K41/00 ,  B01J13/06

    CPC classification number: A61K9/1277 ,  A61K41/0028 ,  A61K9/5073 ,  A61K9/5089 ,  B01J13/06 ,  B01F13/0059 ,  Y10T428/2985 ,  Y10T428/2989

    Abstract: Methods are provided for forming spherical multilamellar microcapsules having alternating hydrophilic and hydrophobic liquid layers, surrounded by flexible, semi-permeable hydrophobic or hydrophilic outer membranes which can be tailored specifically to control the diffusion rate. The methods of the invention rely on low shear mixing and liquid-liquid diffusion process and are particularly well suited for forming microcapsules containing both hydrophilic and hydrophobic drugs. These methods can be carried out in the absence of gravity and do not rely on density-driven phase separation, mechanical mixing or solvent evaporation phases. The methods include the process of forming, washing and filtering microcapsules. In addition, the methods contemplate coating microcapsules with ancillary coatings using an electrostatic field and free fluid electrophoresis of the microcapsules. The microcapsules produced by such methods are particularly useful in the delivery of pharmaceutical compositions.

    Abstract translation: 提供用于形成具有交替的亲水和疏水液体层的球形多层微胶囊的方法，其被柔性的，半渗透的疏水或亲水外膜包围，其可以专门用于控制扩散速率。 本发明的方法依赖于低剪切混合和液 - 液扩散方法，特别适用于形成含有亲水和疏水药物的微胶囊。 这些方法可以在不存在重力的情况下进行，不依赖于密度驱动的相分离，机械混合或溶剂蒸发阶段。 所述方法包括形成，洗涤和过滤微胶囊的过程。 此外，该方法考虑使用静电场和微胶囊的自由流动电泳涂覆具有辅助涂层的微胶囊。 通过这些方法制备的微胶囊特别可用于药物组合物的递送。

    In situ activation of microcapsules
    9.
    发明授权
    In situ activation of microcapsules 失效
    微胶囊的原位活化

    公开(公告)号：US6099864A

    公开(公告)日：2000-08-08

    申请号：US79741

    申请日：1998-05-15

    Applicant: Dennis R. Morrison ,  Benjamin Mosier

    Inventor： Dennis R. Morrison ,  Benjamin Mosier

    IPC: A61K9/127 ,  A61K9/50 ,  A61K9/52 ,  A61K41/00 ,  B01J13/06

    CPC classification number: A61K9/5073 ,  A61K41/0028 ,  A61K9/1277 ,  A61K9/5089 ,  B01J13/06 ,  B01F13/0059 ,  Y10S514/951 ,  Y10T428/2984 ,  Y10T428/2985

    Abstract: Disclosed are microcapsules comprising a polymer shell enclosing two or more immiscible liquid phases in which a drug, or a prodrug and a drug activator are partitioned into separate phases, or prevented from diffusing out of the microcapsule by a liquid phase in which the drug is poorly soluble. Also disclosed are methods of using the microcapsules for in situ activation of drugs, where upon exposure to an appropriate energy source the internal phases mix and the drug is activated in situ.

    Abstract translation: 公开了包含聚合物壳的微胶囊，其包封两个或多个不混溶的液相，其中药物或前药和药物活化剂被分隔成分开的相，或者通过其中药物不良的液相阻止从微胶囊中扩散出来 易溶。 还公开了使用微胶囊原位激活药物的方法，其中当暴露于合适的能量源时，内相混合并且药物在原位激活。

    Microcapsules and methods for making
    10.
    发明授权
    Microcapsules and methods for making 失效
    微胶囊和制造方法

    公开(公告)号：US5827531A

    公开(公告)日：1998-10-27

    申请号：US349169

    申请日：1994-12-02

    Applicant: Dennis R. Morrison ,  Benjamin Mosier

    Inventor： Dennis R. Morrison ,  Benjamin Mosier

    IPC: A61K9/127 ,  A61K9/50 ,  A61K9/52 ,  A61K41/00 ,  B01J13/06

    CPC classification number: A61K9/5089 ,  A61K41/0028 ,  A61K9/1277 ,  A61K9/5073 ,  B01J13/06 ,  B01F13/0059 ,  Y10T428/2985 ,  Y10T428/2989

    Abstract: Methods of forming multi-lamellar microcapsules having alternating layers of hydrophilic and hydrophobic immiscible liquid phases have been developed using different polymer/solvent systems. The methods use liquid-liquid diffusion and simultaneous lateral phase separation, controlled by proper timed-sequence exposures of immiscible phases and low shear mixing, to form narrow size distributions of spherical, multilamellar microcapsules. The use of special formulations of solubilized drugs, surfactants, and polymeric co-surfactants in aqueous vehicles which are dispersed in hydrocarbon solvents containing small quantities of oil, low molecular weight co-surfactants and glycerides that are aqueous insoluble enables the formation of unique microcapsules which can carry large amounts of pharmaceuticals in both aqueous and non-aqueous solvent compartments. The liquid microcapsules are quickly formed in a single step and can include a polymeric outer "skin" which protects the microcapsules during physical manipulation or exposure to high shear forces. Water-in-oil and oil-in-water microcapsules have been formed both in 1.times.g and in microgravity, which contain several types of drugs co-encapsulated within different fluid compartments inside the same microcapsule. Large, spherical multi-lamellar microcapsules have been formed including a cytotoxic drug co-encapsulated with a radiocontrast medium which has advantages for chemoembolization of vascular tumors. In certain cases, crystals of the drug form inside the microcapsules providing zero-order and first order, sustained drug release kinetics.

    Abstract translation: 已经开发了使用不同聚合物/溶剂体系形成具有亲水和疏水不混溶液相交替层的多层薄膜的方法。 该方法使用液 - 液扩散和同时横向相分离，通过适当的定时序列暴露于不混溶相和低剪切混合来控制，以形成球形，多层微胶囊的窄尺寸分布。 在水性载体中使用分散在含有少量油的低分子量辅助表面活性剂和甘油酯的烃溶剂中的水溶性载体中的特殊配方使得形成独特的微胶囊 可以在水性和非水性溶剂隔室中携带大量的药物。 液体微胶囊在单一步骤中快速形成，并且可以包括在物理操作或暴露于高剪切力期间保护微胶囊的聚合物外部“皮肤”。 油包水和水包油微囊已经以1xg和微重力形成，其中包含几种类型的药物共同包封在同一微囊内的不同流体隔室内。 已经形成了大的球形多层微胶囊，其包括与放射性对照介质共同包封的细胞毒性药物，其具有用于血管肿瘤化学栓塞的优点。 在某些情况下，微胶囊内的药物晶体提供零级和一级，持续的药物释放动力学。

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