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    INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC
    1.
    发明申请
    INHALER FOR THE ADMINISTRATION OF AN ANTICHOLINERGIC 审中-公开
    吸入抗真菌药物的药物

    公开(公告)号：US20140116435A1

    公开(公告)日：2014-05-01

    申请号：US14133914

    申请日：2013-12-19

    申请人： Bernd ZIERENBERG

    发明人： Bernd ZIERENBERG

    IPC分类号： A61M15/00 ,  A61K31/46

    CPC分类号： A61M15/0041 ,  A61K9/0075 ,  A61K9/145 ,  A61K31/439 ,  A61M15/0021 ,  A61M15/0026 ,  A61M15/0028 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0075 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/75

    摘要： An inhalation kit comprising: (a) an inhaler displaying a flow resistance of about 0.01 to 0.1, √{square root over (kPa)} min/L; and (b) an inhalable powder comprising tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 to 500 μm, and a method of administering an inhalable powder containing tiotropium in admixture with a physiologically acceptable excipient with an average particle size of between 10 pm to 500 μm, the method comprising actuating an inhaler a flow resistance of about 0.01 to 0.1 √{square root over (kPa)} min/L containing the inhalable powder.

    摘要翻译： 一种吸入试剂盒，包括：（a）显示约0.01至0.1，{{平方根（kPa）} min / L的流动阻力的吸入器; 和（b）包含噻托溴铵的可吸入粉末，其与平均粒径为10-500μm的生理上可接受的赋形剂混合，以及将含有噻托溴铵的可吸入粉末与生理上可接受的赋形剂的平均粒径 介于10μm至500μm之间的方法，该方法包括使吸入器的流动阻力为含有可吸入粉末的约0.01至0.1√（平方根（kPa）} min / L）。

    Cartridge for a liquid
    4.
    发明授权
    Cartridge for a liquid 有权
    墨盒用于液体

    公开(公告)号：US07802568B2

    公开(公告)日：2010-09-28

    申请号：US11232896

    申请日：2005-09-23

    申请人： Joachim Eicher ,  Johannes Geser ,  Matthias Hausmann ,  Michael Schyra ,  Gilbert Wuttke ,  Andreas Fiol ,  Heinrich Kladders ,  Dieter Hochrainer ,  Bernd Zierenberg

    发明人： Joachim Eicher ,  Johannes Geser ,  Matthias Hausmann ,  Michael Schyra ,  Gilbert Wuttke ,  Andreas Fiol ,  Heinrich Kladders ,  Dieter Hochrainer ,  Bernd Zierenberg

    IPC分类号： A61M11/00 ,  A61M15/00

    CPC分类号： B05B11/0054 ,  A61M15/0065 ,  B05B11/0008 ,  B05B11/00412 ,  B05B11/0044 ,  B05B11/00444 ,  B05B11/00446

    摘要： For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.

    摘要翻译： 对于可以长时间储存​​的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触 大气层。 根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。 盒可以可释放地连接到分配装置。 墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。 该药筒适用于含有药物活性物质的水溶液和含酒精液体。 保护盒中的液体免受外部影响。 墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。

    Pressure compensation device for a two-part container
    7.
    发明授权
    Pressure compensation device for a two-part container 有权
    用于两部分集装箱的压力补偿装置

    公开(公告)号：US07090093B2

    公开(公告)日：2006-08-15

    申请号：US10815531

    申请日：2004-04-01

    申请人： Dieter Hochrainer ,  Bernd Zierenberg ,  Heinrich Kladders ,  Martin Essing ,  Gilbert Wuttke ,  Matthias Hausmann ,  Joachim Eicher

    发明人： Dieter Hochrainer ,  Bernd Zierenberg ,  Heinrich Kladders ,  Martin Essing ,  Gilbert Wuttke ,  Matthias Hausmann ,  Joachim Eicher

    IPC分类号： B67D5/42 ,  B65D1/32

    CPC分类号： B65D83/0055 ,  B05B11/00412 ,  B05B11/0044 ,  B05B11/00444 ,  B05B11/00446

    摘要： For medical fluids, two-part containers are used which consist of an inner container and an outer container which is impenetrable to diffusion. The inner container collapses when the fluid is removed. For the purposes of pressure compensation between the gaseous space, disposed between the inner- and outer containers, and the surroundings of the two-part container, a pressure compensation device is required by means of which at the same time the loss of fluid through diffusion from the collapsible inner container is kept as little as possible. To that end, at least one channel is used which communicates the gas-filled intermediate space with the surroundings of the two-part container. The time constant for compensation of a pressure differential of a few millibars is within the region of quite a few hours. It is obtained by selecting the length of the channel and channel cross-section. The, at least one, channel can be produced individually, or a plurality of channels can be present in the form of pores in an open-pore sintered material or in a permeable membrane. The pressure compensation device permits storage of the two-part container for many years, and use for many weeks as fluid is being removed in portion-wise manner. During these times, the quantity of fluid in the inner container, or the concentration thereof changes substantially less than with the use of a known two-part container.

    摘要翻译： 对于医疗流体，使用两部分容器，其由内部容器和不容易扩散的外部容器组成。 当流体被移除时，内部容器塌陷。 为了在设置在内部和外部容器之间的气体空间与两部分容器的周围之间的压力补偿之间进行压力补偿，需要压力补偿装置，同时通过该压力补偿装置损失流体通过扩散 从可折叠的内部容器保持尽可能少。 为此，使用至少一个通道将气体填充的中间空间与两部分容器的周围环境连通。 补偿几毫巴压力差的时间常数在不到几个小时的时间内。 通过选择通道和通道横截面的长度来获得。 可以单独制造至少一个通道，或者多个通道可以以开孔烧结材料或渗透膜中的孔的形式存在。 压力补偿装置可以容纳两部分容器的存放多年，并且以分段方式移除流体使用多个星期。 在这些时间内，内部容器中的流体量或其浓度变化明显小于使用已知的两部分容器。

    Needle-less injector of miniature type
    10.
    发明授权
    Needle-less injector of miniature type 有权

    公开(公告)号：US06689092B2

    公开(公告)日：2004-02-10

    申请号：US09797001

    申请日：2001-03-02

    申请人： Bernd Zierenberg ,  Ralph Christian Reimholz ,  Knut Elbers ,  Stefan Henke ,  Joachim Eicher ,  Johannes Geser

    发明人： Bernd Zierenberg ,  Ralph Christian Reimholz ,  Knut Elbers ,  Stefan Henke ,  Joachim Eicher ,  Johannes Geser

    IPC分类号： H61M530

    CPC分类号： A61M5/30 ,  A61M5/204 ,  A61M5/3145 ,  A61M5/31531 ,  A61M2005/3104 ,  A61M2005/3128 ,  A61M2205/7545

    摘要： Needle-less injectors for liquids are known in many different forms which are adapted to different conditions of use. The needle-less injector according to the invention is in the form of a hand-held unit. It includes a locking stressing mechanism, an energy-storing spring (36), a hollow plunger (37) displaceable in a cylinder (38) and a nozzle (39). At its one end, the hollow plunger is provided with a valve body (42). The supply container (44) for the liquid is arranged within the housing. When the locking stressing mechanism is stressed by rotation of the two housing portions (31, 32) relative to each other the hollow plunger (37) is drawn out of the cylinder (38); at the same time the amount of liquid required for an injection is conveyed out of the supply container (44) through the plunger into the pump chamber (43). After the locking stressing mechanism is triggered the amount of liquid is expelled from the pump chamber through the nozzle. The needle-less injector can be safely and easily handled, even by unskilled persons. It is used for the intracutaneous injection of a medicament-bearing liquid into biological tissue, for the injection of an active substance-bearing liquid into a plant, or for the injection of a liquid through a membrane into the space behind the membrane.