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    Sprayer device with aerosol functionality—flairosol
    2.
    发明授权
    Sprayer device with aerosol functionality—flairosol 有权

    公开(公告)号：US11660624B2

    公开(公告)日：2023-05-30

    申请号：US17336710

    申请日：2021-06-02

    Applicant: DISPENSING TECHNOLOGIES B.V.

    Inventor： Wilhelmus Johannes Joseph Maas ,  Petrus Lambertus Wilhelmus Hurkmans ,  Aaron S. Haleva

    IPC: B05B9/00 ,  B05B9/08 ,  B05B11/00 ,  B05B11/10

    CPC classification number: B05B9/0822 ,  B05B9/0883 ,  B05B11/0027 ,  B05B11/00446 ,  B05B11/1011

    Abstract: In exemplary embodiments of the present invention, Flair® based aerosol-type devices can be provided. Such devices utilize a combination of Flair® technology, pre-compression valves and aerosol like pressurization of the dispensed liquid. Such a dispensing device has a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a reservoir and fills the pressure chamber with that liquid as a user operates the trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve. In a dispensing head a valve is provided to regulate the strength of the flow and preclude leakage. Once the liquid is sufficiently pressurized, it can be dispensed by a user opening an activation valve, such as by pressing on an activation button, and spray can be abruptly stopped by a user ceasing to push on such button. Or, for example, in alternate embodiments without an activation button, once the liquid is sufficiently pressurized, continuous spray occurs until the pressure chamber is emptied. By repeatedly pumping the trigger before the pressure chamber is fully emptied, continuous spray can be achieved. By designing the input volume to be amply greater than the volume of the pressure chamber, continuous spray with fewer pumping strokes can be implemented.

    Discharging device
    3.
    发明授权
    Discharging device 有权

    公开(公告)号：US09700907B2

    公开(公告)日：2017-07-11

    申请号：US12925543

    申请日：2010-10-22

    Applicant: Juergen Greiner-Perth ,  Matthias Wochele ,  Peter Stadelhofer

    Inventor： Juergen Greiner-Perth ,  Matthias Wochele ,  Peter Stadelhofer

    IPC: B65D35/56 ,  B05B11/00

    CPC classification number: B05B11/00412 ,  B05B11/0039 ,  B05B11/00442 ,  B05B11/00446 ,  B05B11/3026 ,  B05B11/3032 ,  B05B11/3035 ,  B05B11/3047

    Abstract: A discharging device for liquids.The invention relates to a discharging device for liquids, more particularly for pharmaceutical liquids, comprising a delivery device (10), a liquid storage receptical (20) communicating with an input (10a) of the delivery device for storage of the liquid (30), and a discharge orifice (12) which communicates with an outlet (10b) of said delivery device,and the liquid storage receptical (20) is at least in part in the form of a dimensionally flexible liquid-containing bag (20) and the liquid storage receptical (20) is disposed in a buffer chamber of constant volume (42).To prevent air from escaping from the buffer chamber (42), provision is made for the buffer chamber to be sealed by a protective housing from the environment (1) in a gas-tight manner, for the buffer chamber to communicate with the environment through at least one capillary passageway for the purpose of pressure compensation, or for the buffer chamber (42) to communicate with the environment (1) via a balancing passageway for the purpose of pressure compensation, while a valve (70) which opens in dependence on the pressure differential is disposed in this balancing passageway.

    Pump systems and methods for storing and dispensing a plurality of precisely measured unit-doses of imiquimod cream
    5.
    发明授权
    Pump systems and methods for storing and dispensing a plurality of precisely measured unit-doses of imiquimod cream 有权
    用于存储和分配多个精确测量的单位剂量咪喹莫特乳膏的泵系统和方法

    公开(公告)号：US09072876B2

    公开(公告)日：2015-07-07

    申请号：US12875787

    申请日：2010-09-03

    Applicant: Michael T. Nordsiek ,  Kodumudi S. Balaji

    Inventor： Michael T. Nordsiek ,  Kodumudi S. Balaji

    IPC: G01F11/00 ,  A61M35/00 ,  A61K9/00 ,  A61K9/06 ,  A61K31/4745 ,  A61K47/10 ,  B05B11/00

    CPC classification number: A61M35/003 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/4745 ,  A61K47/10 ,  B05B11/0037 ,  B05B11/0038 ,  B05B11/00416 ,  B05B11/00446 ,  B05B11/3001 ,  B05B11/3042 ,  B05B11/3047

    Abstract: The present invention is directed to airless storage and dispensing systems that include a pump or dispensing package pre-filled with a topical semi-solid imiquimod pharmaceutical formulation (“pump systems”) and methods for storing and dispensing from the pump systems a plurality of precisely measured and uniform unit doses of a topical semi-solid imiquimod pharmaceutical formulation, and more particularly to pump systems, pre-filled with a topical imiquimod pharmaceutical cream and methods for delivering multiple precisely measured unit doses of a topical imiquimod pharmaceutical cream, and methods for using a controlled delivery pump system to store and dispense a plurality of consistent and precisely measured unit doses of a topical imiquimod pharmaceutical cream for use in topically treating a dermal and mucosal-associated condition, such as, external genital warts and/or perianal warts (EGWs), actinic keratosis or actinic keratoses (AK or AKs) and superficial basal cell carcinoma (sBCC).

    Abstract translation: 本发明涉及无空气储存和分配系统，其包括预先填充有局部半固体咪喹莫特药物制剂（“泵系统”）的泵或分配包装以及用于从泵系统存储和分配多个精确的 测量和均匀单位剂量的局部半固体咪喹莫特药物制剂，更具体地涉及预先填充有局部咪喹莫特药物霜剂的泵系统和用于递送多个精确测量的单位剂量的局部咪喹莫特药物霜剂的方法，以及用于 使用受控递送泵系统来存储和分配多个一致和精确测量的单位剂量的局部咪喹莫特药物霜，用于局部治疗皮肤和粘膜相关病症，例如外部生殖器疣和/或肛周疣（ EGW），光化性角化病或光化性角化病（AK或AK）和浅表性基底细胞癌 noma（sBCC）。

    PUMP SYSTEMS AND METHODS FOR STORING AND DISPENSING A PLURALITY OF PRECISELY MEASURED UNIT-DOSES OF IMIQUIMOD CREAM
    6.
    发明申请
    PUMP SYSTEMS AND METHODS FOR STORING AND DISPENSING A PLURALITY OF PRECISELY MEASURED UNIT-DOSES OF IMIQUIMOD CREAM 有权
    用于储存和分配多种精确测量的IMIQUIMOD CREAM单位的泵系统和方法

    公开(公告)号：US20120035556A1

    公开(公告)日：2012-02-09

    申请号：US12875787

    申请日：2010-09-03

    Applicant: Michael T. Nordsiek ,  Kodumudi S. Balaji

    Inventor： Michael T. Nordsiek ,  Kodumudi S. Balaji

    IPC: A61M35/00

    CPC classification number: A61M35/003 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/4745 ,  A61K47/10 ,  B05B11/0037 ,  B05B11/0038 ,  B05B11/00416 ,  B05B11/00446 ,  B05B11/3001 ,  B05B11/3042 ,  B05B11/3047

    Abstract: The present invention is directed to airless storage and dispensing systems that include a pump or dispensing package pre-filled with a topical semi-solid imiquimod pharmaceutical formulation (“pump systems”) and methods for storing and dispensing from the pump systems a plurality of precisely measured and uniform unit doses of a topical semi-solid imiquimod pharmaceutical formulation, and more particularly to pump systems, pre-filled with a topical imiquimod pharmaceutical cream and methods for delivering multiple precisely measured unit doses of a topical imiquimod pharmaceutical cream, and methods for using a controlled delivery pump system to store and dispense a plurality of consistent and precisely measured unit doses of a topical imiquimod pharmaceutical cream for use in topically treating a dermal and mucosal-associated condition, such as, external genital warts and/or perianal warts (EGWs), actinic keratosis or actinic keratoses (AK or AKs) and superficial basal cell carcinoma (sBCC).

    Abstract translation: 本发明涉及无空气储存和分配系统，其包括预先填充有局部半固体咪喹莫特药物制剂（“泵系统”）的泵或分配包装以及用于从泵系统存储和分配多个精确的 测量和均匀单位剂量的局部半固体咪喹莫特药物制剂，更具体地涉及预先填充有局部咪喹莫特药物霜剂的泵系统和用于递送多个精确测量的单位剂量的局部咪喹莫特药物霜剂的方法，以及用于 使用受控递送泵系统来存储和分配多个一致和精确测量的单位剂量的局部咪喹莫特药物霜，用于局部治疗皮肤和粘膜相关病症，例如外部生殖器疣和/或肛周疣（ EGW），光化性角化病或光化性角化病（AK或AK）和浅表性基底细胞癌 noma（sBCC）。

    Cartridge for a liquid
    7.
    发明授权
    Cartridge for a liquid 有权
    墨盒用于液体

    公开(公告)号：US07802568B2

    公开(公告)日：2010-09-28

    申请号：US11232896

    申请日：2005-09-23

    Applicant: Joachim Eicher ,  Johannes Geser ,  Matthias Hausmann ,  Michael Schyra ,  Gilbert Wuttke ,  Andreas Fiol ,  Heinrich Kladders ,  Dieter Hochrainer ,  Bernd Zierenberg

    Inventor： Joachim Eicher ,  Johannes Geser ,  Matthias Hausmann ,  Michael Schyra ,  Gilbert Wuttke ,  Andreas Fiol ,  Heinrich Kladders ,  Dieter Hochrainer ,  Bernd Zierenberg

    IPC: A61M11/00 ,  A61M15/00

    CPC classification number: B05B11/0054 ,  A61M15/0065 ,  B05B11/0008 ,  B05B11/00412 ,  B05B11/0044 ,  B05B11/00444 ,  B05B11/00446

    Abstract: For meteredly dispensing a liquid over a period of several months from a container which can be stored over a long period of time, the need is for a container which is practically diffusion-tight and in which the liquid does not come into contact with the ambient atmosphere. The cartridge according to the invention is a three-shell container comprising a collapsible bag which contains the liquid, a container which is stable in respect of shape and a stiff metal casing. The cartridge can be releasably connected to a dispensing device. The cartridge can be provided with a micro-opening with which the time for pressure equalisation between the cartridge and the ambient atmosphere can be adjusted. The cartridge is suitable for aqueous and for alcoholic liquids which contain a pharmaceutically active substance. The liquid in the cartridge is protected from external influences. The cartridge can be used in an atomiser for producing an inhalable aerosol for the treatment of illnesses.

    Abstract translation: 对于可以长时间储存​​的容器在几个月的时间内计量分配液体，需要一种几乎不扩散的容器，其中液体不会与环境接触 大气层。 根据本发明的墨盒是一种三壳容器，其包括容纳液体的可折叠袋，相对于形状稳定的容器和刚性金属外壳。 盒可以可释放地连接到分配装置。 墨盒可以设置有微孔，可以调节墨盒和环境大气之间的压力均衡时间。 该药筒适用于含有药物活性物质的水溶液和含酒精液体。 保护盒中的液体免受外部影响。 墨盒可用于雾化器中，用于产生用于治疗疾病的可吸入气雾剂。

    Manually-actuated metering pump
    8.
    发明授权
    Manually-actuated metering pump 有权
    手动启动计量泵

    公开(公告)号：US07481336B2

    公开(公告)日：2009-01-27

    申请号：US10538362

    申请日：2003-11-15

    Applicant: Laurent Arghyris ,  Patrice Puviland ,  Jean-Philippe Taberlet

    Inventor： Laurent Arghyris ,  Patrice Puviland ,  Jean-Philippe Taberlet

    IPC: B65D88/54

    CPC classification number: B05B11/3004 ,  B05B11/00412 ,  B05B11/0044 ,  B05B11/00442 ,  B05B11/00444 ,  B05B11/00446 ,  B05B11/0072 ,  B05B11/3074

    Abstract: The invention relates to a manually-actuated metering pump of simple design, which is intended for a rigid container. The inventive metering pump is of the dual valve type, comprising a lower inlet valve and an upper ejection valve which are disposed at the input and output respectively of a metering chamber which is slidably mounted on the lower valve. Moreover, said lower valve is fixed to a hollow tube which communicates with the inside of the container. The invention can be used for dispensing fluid products.

    Abstract translation: 本发明涉及一种简单设计的手动致动计量泵，其用于刚性容器。 本发明的计量泵是双阀型的，包括下入口阀和上排出阀，它们分别设置在可滑动地安装在下阀上的计量室的输入和输出端。 此外，所述下阀固定到与容器的内部连通的中空管。 本发明可用于分配流体产品。

    Pressure compensation device for a two-part container
    9.
    发明授权
    Pressure compensation device for a two-part container 有权
    用于两部分集装箱的压力补偿装置

    公开(公告)号：US07090093B2

    公开(公告)日：2006-08-15

    申请号：US10815531

    申请日：2004-04-01

    Applicant: Dieter Hochrainer ,  Bernd Zierenberg ,  Heinrich Kladders ,  Martin Essing ,  Gilbert Wuttke ,  Matthias Hausmann ,  Joachim Eicher

    Inventor： Dieter Hochrainer ,  Bernd Zierenberg ,  Heinrich Kladders ,  Martin Essing ,  Gilbert Wuttke ,  Matthias Hausmann ,  Joachim Eicher

    IPC: B67D5/42 ,  B65D1/32

    CPC classification number: B65D83/0055 ,  B05B11/00412 ,  B05B11/0044 ,  B05B11/00444 ,  B05B11/00446

    Abstract: For medical fluids, two-part containers are used which consist of an inner container and an outer container which is impenetrable to diffusion. The inner container collapses when the fluid is removed. For the purposes of pressure compensation between the gaseous space, disposed between the inner- and outer containers, and the surroundings of the two-part container, a pressure compensation device is required by means of which at the same time the loss of fluid through diffusion from the collapsible inner container is kept as little as possible. To that end, at least one channel is used which communicates the gas-filled intermediate space with the surroundings of the two-part container. The time constant for compensation of a pressure differential of a few millibars is within the region of quite a few hours. It is obtained by selecting the length of the channel and channel cross-section. The, at least one, channel can be produced individually, or a plurality of channels can be present in the form of pores in an open-pore sintered material or in a permeable membrane. The pressure compensation device permits storage of the two-part container for many years, and use for many weeks as fluid is being removed in portion-wise manner. During these times, the quantity of fluid in the inner container, or the concentration thereof changes substantially less than with the use of a known two-part container.

    Abstract translation: 对于医疗流体，使用两部分容器，其由内部容器和不容易扩散的外部容器组成。 当流体被移除时，内部容器塌陷。 为了在设置在内部和外部容器之间的气体空间与两部分容器的周围之间的压力补偿之间进行压力补偿，需要压力补偿装置，同时通过该压力补偿装置损失流体通过扩散 从可折叠的内部容器保持尽可能少。 为此，使用至少一个通道将气体填充的中间空间与两部分容器的周围环境连通。 补偿几毫巴压力差的时间常数在不到几个小时的时间内。 通过选择通道和通道横截面的长度来获得。 可以单独制造至少一个通道，或者多个通道可以以开孔烧结材料或渗透膜中的孔的形式存在。 压力补偿装置可以容纳两部分容器的存放多年，并且以分段方式移除流体使用多个星期。 在这些时间内，内部容器中的流体量或其浓度变化明显小于使用已知的两部分容器。

    Device for packaging and dispensing a product, with manual pump and an air intake filter
    10.
    发明授权
    Device for packaging and dispensing a product, with manual pump and an air intake filter 有权
    用于包装和分配产品的装置，具有手动泵和进气过滤器

    公开(公告)号：US06354469B1

    公开(公告)日：2002-03-12

    申请号：US09581275

    申请日：2000-09-01

    Applicant: Jacques Pozzi

    Inventor： Jacques Pozzi

    IPC: B67D558

    CPC classification number: B05B11/0037 ,  B05B11/00442 ,  B05B11/00444 ,  B05B11/00446

    Abstract: The device comprises a rigid container, a manual pump mounted on the container for dispensing in unit doses the product contained in the container and a filter for filtering outside air entering the container when the pump is actuated. The pump has no air intake in the container and the filter is arranged in an air intake passage provided in the base of the container, which is injection-moulded. The invention is useful for packaging and dispensing of fluids, in particular liquids, which need to be maintained germ-free.

    Abstract translation: 该装置包括刚性容器，安装在容器上的手动泵，用于以包含在容器中的产品的单位剂量分配，以及用于当泵被致动时过滤进入容器的外部空气的过滤器。 泵在容器中没有进气口，并且过滤器布置在设置在容器的基部中的进气通道中，该进气通道被注射成型。 本发明可用于包装和分配需要保持无菌的流体，特别是液体。

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