公开(公告)号：US4738929A

公开(公告)日：1988-04-19

申请号：US942556

申请日：1986-12-18

申请人： Blanche D. Graham ,  Josefino B. Tunac

发明人： Blanche D. Graham ,  Josefino B. Tunac

IPC分类号： C07D241/46 ,  C12P17/12 ,  C12N1/20 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07D241/46 ,  C12P17/12 ,  Y10S435/886

摘要： Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate anti-microbial and antineoplastic activity.A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

摘要翻译： 衍生自6-甲酰基-4,7,9-三羟基-1-吩嗪甲酸，甲酯的酸，酯，亚胺酸，亚胺酯和亚胺酰胺，得自6-甲酰基-4,7,9-三羟基-8- 甲基-1-吩嗪甲酸甲酯显示出抗微生物和抗肿瘤活性。 纯化的链霉菌链霉菌NRRL 15738的菌株能够从含有可同化碳源的发酵液中分离得到6-甲酰基-4,7,9-三羟基-8-甲基-1-吩嗪甲酸甲酯， 氮。

公开(公告)号：US4657909A

公开(公告)日：1987-04-14

申请号：US743321

申请日：1985-06-10

申请人： Christopher F. Bigge ,  Edward F. Elslager ,  James C. French ,  Blanche D. Graham ,  Gerard C. Hokanson ,  Stephen W. Mamber ,  Tim A. Smitka ,  Josefino B. Tunac ,  John H. Wilton

发明人： Christopher F. Bigge ,  Edward F. Elslager ,  James C. French ,  Blanche D. Graham ,  Gerard C. Hokanson ,  Stephen W. Mamber ,  Tim A. Smitka ,  Josefino B. Tunac ,  John H. Wilton

IPC分类号： C12N1/20 ,  A61K31/495 ,  A61P31/04 ,  A61P35/00 ,  C07D241/46 ,  C12P17/12 ,  C12R1/465 ,  C07D401/12 ,  C07D403/12

CPC分类号： C12R1/465 ,  C07D241/46 ,  C12P17/12 ,  Y10S435/886

摘要： Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.

摘要翻译： 衍生自6-甲酰基-4,7,9-三羟基-1-吩嗪甲酸，甲酯的酸，酯，亚胺酸，亚胺酯和亚胺酰胺，得自6-甲酰基-4,7,9-三羟基-8- 甲基-1-吩嗪羧酸甲酯显示出抗菌和抗肿瘤活性。 纯化的链霉菌链霉菌NRRL 15738的菌株能够从含有可同化碳源的发酵液中分离得到6-甲酰基-4,7,9-三羟基-8-甲基-1-吩嗪甲酸甲酯， 氮。

公开(公告)号：US4495286A

公开(公告)日：1985-01-22

申请号：US497875

申请日：1983-05-25

申请人： Josefino B. Tunac ,  William E. Dobson ,  Blanche D. Graham

发明人： Josefino B. Tunac ,  William E. Dobson ,  Blanche D. Graham

IPC分类号： C07C59/42 ,  C07D309/32 ,  C07F9/113 ,  C07F9/655 ,  C12N1/20 ,  C12P9/00 ,  C12P17/06 ,  C12R1/465

CPC分类号： C12R1/465 ,  C07C59/42 ,  C07D309/32 ,  C07F9/113 ,  C07F9/6552 ,  C12N1/20 ,  C12P17/06 ,  C12P9/00 ,  Y10S435/886

摘要： A biologically pure culture of the microorganism Streptomyces pulveraceus subspecies fostreus ATCC 31906 is provided. Strain 31906 is capable of producing the CL 1565 antibiotic complex in a recoverable quantity upon cultivation in an aqueous nutrient medium containing assimilable sources of nitrogen and carbon. The CL 1565 antibiotic complex includes CL 1565-A, -B and -T sodium salt compounds that in dosage form are useful antibiotics and antitumor agents.

摘要翻译： 提供微生物链霉菌亚种Fastreus ATCC 31906的生物学纯培养物。 菌株31906能够在含有可同化氮源和碳源的含水养分培养基中培养时产生可回收量的CL 1565抗生素复合物。 CL 1565抗生素复合物包括CL 1565-A，-B和-T钠盐化合物，其剂型是有用的抗生素和抗肿瘤剂。