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公开(公告)号：US4657909A
公开(公告)日：1987-04-14
申请号：US743321
申请日：1985-06-10
申请人： Christopher F. Bigge , Edward F. Elslager , James C. French , Blanche D. Graham , Gerard C. Hokanson , Stephen W. Mamber , Tim A. Smitka , Josefino B. Tunac , John H. Wilton
发明人： Christopher F. Bigge , Edward F. Elslager , James C. French , Blanche D. Graham , Gerard C. Hokanson , Stephen W. Mamber , Tim A. Smitka , Josefino B. Tunac , John H. Wilton
IPC分类号： C12N1/20 , A61K31/495 , A61P31/04 , A61P35/00 , C07D241/46 , C12P17/12 , C12R1/465 , C07D401/12 , C07D403/12
CPC分类号： C12R1/465 , C07D241/46 , C12P17/12 , Y10S435/886
摘要： Acids, esters, imine acids, imine esters, and imine amides derived from 6-formyl-4,7,9-trihydroxy-1-phenazinecarboxylic acid, methyl ester and from 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester demonstrate antimicrobial and antineoplastic activity.A purified strain of Streptomyces galanosa, NRRL 15738, is capable of producing 6-formyl-4,7,9-trihydroxy-8-methyl-1-phenazinecarboxylic acid, methyl ester in isolable quantities from a fermentation broth containing assimilable sources of carbon and nitrogen.
摘要翻译： 衍生自6-甲酰基-4,7,9-三羟基-1-吩嗪甲酸，甲酯的酸，酯，亚胺酸，亚胺酯和亚胺酰胺，得自6-甲酰基-4,7,9-三羟基-8- 甲基-1-吩嗪羧酸甲酯显示出抗菌和抗肿瘤活性。 纯化的链霉菌链霉菌NRRL 15738的菌株能够从含有可同化碳源的发酵液中分离得到6-甲酰基-4,7,9-三羟基-8-甲基-1-吩嗪甲酸甲酯， 氮。
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公开(公告)号：US4530835A
公开(公告)日：1985-07-23
申请号：US512088
申请日：1983-07-08
CPC分类号： C12P1/06
摘要： A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors.Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds.The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.
摘要翻译： 确定为ATCC 39363的放线菌的纯化分离物能够产生具有针对移植肿瘤的活性的含硫抗生素化合物的复合物。 抗生素化合物CL-1577A和CL-1577B及其密切相关的同系物通过在需氧条件下培养分离物ATCC 39363，在含有可同化碳源和氮的来源的培养基中培养，直到产生大量的CL-1577复合物，随后 分离复合物或一种或多种化合物。 还公开了抗生素化合物CL-1577A，CL-1577B，它们的同系物和包含这些物质的药物组合物和合适的载体。
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公开(公告)号：US4436750A
公开(公告)日：1984-03-13
申请号：US432467
申请日：1982-10-04
IPC分类号： C07D493/20 , C07D493/22 , C12P17/18 , A61K31/365
CPC分类号： C07D493/20 , C07D493/22 , C12P17/181
摘要： The present invention relates to the novel trichothecenes, 12'-hydroxyverrucarin J and iso-satratoxin H, and a fermentation process for the production of said compounds.The invention also relates to pharmaceutical compositions comprising said compounds and methods for using said compositions.
摘要翻译： 本发明涉及新颖的单端孢霉烯，12'-羟基芸香碱J和异硫酸素毒素H，以及用于生产所述化合物的发酵方法。 本发明还涉及包含所述化合物的药物组合物和使用所述组合物的方法。
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公开(公告)号：US5457119A
公开(公告)日：1995-10-10
申请号：US273079
申请日：1994-07-08
IPC分类号： A61K31/40 , A01N43/38 , A01N43/90 , A61K31/403 , A61P31/04 , A61P35/00 , C07D209/56 , C07D209/70 , C07D209/80 , C07D491/06 , C07D491/08 , C12N1/12 , C12P17/08 , C12P17/10 , C12P17/18 , C12R1/89 , A61K31/275 , C07D209/94 , C07D405/02
CPC分类号： C07D209/56 , A01N43/38 , A01N43/90 , C07D209/80 , C07D491/06 , C12N1/12 , C12P17/10 , C12P17/18 , Y10S435/822 , Y10S435/946
摘要： New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
摘要翻译： 称为A89271A-F和I的新的hapalindole型生物碱是抗真菌剂和抗肿瘤剂。 提供了通过培养蓝绿藻Fischerella ambigua ATCC 55210制备它们和制备hapalindoles G和H的方法。 还提供了通过培养蓝绿藻Hapalosiphon hibernicus ATCC 55225和这种藻类的生物学纯培养物来制备A89271因子B和F的方法。 还提供了抑制真菌生长和易感性肿瘤治疗的方法和组合物。
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公开(公告)号：US5366890A
公开(公告)日：1994-11-22
申请号：US135931
申请日：1993-10-13
IPC分类号： A61K31/40 , A01N43/38 , A01N43/90 , A61K31/403 , A61P31/04 , A61P35/00 , C07D209/56 , C07D209/70 , C07D209/80 , C07D491/06 , C07D491/08 , C12N1/12 , C12P17/08 , C12P17/10 , C12P17/18 , C12R1/89 , C12N1/20
CPC分类号： C07D209/56 , A01N43/38 , A01N43/90 , C07D209/80 , C07D491/06 , C12N1/12 , C12P17/10 , C12P17/18 , Y10S435/822 , Y10S435/946
摘要： New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
摘要翻译： 称为A89271A-F和I的新的hapalindole型生物碱是抗真菌剂和抗肿瘤剂。 提供了通过培养蓝绿藻Fischerella ambigua ATCC 55210制备它们和制备hapalindoles G和H的方法。 还提供了通过培养蓝绿藻Hapalosiphon hibernicus ATCC 55225和这种藻类的生物学纯培养物来制备A89271因子B和F的方法。 还提供了抑制真菌生长和易感性肿瘤治疗的方法和组合物。
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6.发明授权
公开(公告)号：US5292647A
公开(公告)日：1994-03-08
申请号：US984078
申请日：1992-11-30
IPC分类号： C12N1/20 , A61K31/7048 , A61P33/00 , C12P1/06 , C12P17/08 , C12P17/18 , C12P19/62 , C12R1/465 , A01N43/02 , C12P17/02
CPC分类号： C12R1/465 , C12P19/623
摘要： A new microorganism, Streptomyces avermitilis subspecies niger NRRL 21005, and processes using the microorganism for producing known avermectins are provided.
摘要翻译： 提供了一种新的微生物，阿维链霉菌亚种Niger NRRL 21005，以及使用微生物生产已知的除虫菌素的方法。
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公开(公告)号：US4870185A
公开(公告)日：1989-09-26
申请号：US908746
申请日：1986-09-18
申请人： Rosanne Bonjouklian , Richard E. Moore , Jon S. Mynderse , Gregory M. L. Patterson , Tim A. Smitka
发明人： Rosanne Bonjouklian , Richard E. Moore , Jon S. Mynderse , Gregory M. L. Patterson , Tim A. Smitka
IPC分类号： A61K31/425 , A61K31/40 , A61K31/403 , A61K31/404 , A61P31/04 , A61P31/10 , C07D209/14 , C07D209/58 , C07D209/90 , C07D405/04 , C07D513/06 , C07D513/10 , C12P17/10 , C12P17/16 , C12P17/18 , C12R1/91
CPC分类号： C07D405/04 , C07D209/14 , C07D209/90 , C07D513/10 , C12P17/10 , C12P17/185
摘要： New alkaloids called hapalindoles J-Q and T-V, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.
摘要翻译： 提供了称为hapalindoles J-Q和T-V的新生物碱，其为抗菌和抗真菌剂，以及通过培养蓝绿藻Hapalosiphon fontinalis ATCC 39694制备这些生物碱的方法。
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8.发明授权
公开(公告)号：US5292650A
公开(公告)日：1994-03-08
申请号：US946501
申请日：1992-09-16
IPC分类号： A61K31/40 , A01N43/38 , A01N43/90 , A61K31/403 , A61P31/04 , A61P35/00 , C07D209/56 , C07D209/70 , C07D209/80 , C07D491/06 , C07D491/08 , C12N1/12 , C12P17/08 , C12P17/10 , C12P17/18 , C12R1/89 , C12P17/16
CPC分类号： C07D209/56 , A01N43/38 , A01N43/90 , C07D209/80 , C07D491/06 , C12N1/12 , C12P17/10 , C12P17/18 , Y10S435/822 , Y10S435/946
摘要： New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
摘要翻译： 称为A89271A-F和I的新的hapalindole型生物碱是抗真菌剂和抗肿瘤剂。 提供了通过培养蓝绿藻Fischerella ambigua ATCC 55210制备它们和制备hapalindoles G和H的方法。 还提供了通过培养蓝绿藻Hapalosiphon hibernicus ATCC 55225和这种藻类的生物学纯培养物来制备A89271因子B和F的方法。 还提供了抑制真菌生长和易感性肿瘤治疗的方法和组合物。
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