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    Lactobacilli harboring aggregation gene as a vaccine delivery vehicle
    6.
    发明授权
    Lactobacilli harboring aggregation gene as a vaccine delivery vehicle 失效
    携带凝集基因作为疫苗递送载体的乳杆菌

    公开(公告)号：US6100388A

    公开(公告)日：2000-08-08

    申请号：US39773

    申请日：1998-03-16

    申请人： Ivan Casas ,  Hans Jonsson ,  Bo Mollstam ,  Stefan Roos

    发明人： Ivan Casas ,  Hans Jonsson ,  Bo Mollstam ,  Stefan Roos

    IPC分类号： A61K39/00 ,  C07K14/335 ,  C07K14/47 ,  C12N15/74 ,  C07H21/04 ,  C07H21/00 ,  C07H21/02

    CPC分类号： C07K14/4727 ,  C07K14/335 ,  C12N15/746 ,  A61K39/00 ,  C07K2319/00

    摘要： Live vaccines and methods for preparing the vaccines useful in protecting a host from infection by a pathogenic microorganism are provided. Vaccines are prepared from live Lactobacillus cells which have been transformed using DNA technology to express heterologous antigens of pathogenic microorganisms or other suitable biological material. Genes encoding antigenic determinants pathogenic in the mammalian gastrointestinal tract are inserted into expression cassettes and fused with genes encoding an aggregation factor and/or a mucin binding factor. The inserted genes are shown to transform L. reuteri cells. The aggregation enhancing and mucin binding genes have been isolated and sequenced. The vaccine can be ingested orally in a pharmaceutical carrier or in milk products.

    摘要翻译： 提供了用于制备用于保护宿主免受致病微生物感染的疫苗的活疫苗和方法。 使用DNA技术转化的活乳杆菌细胞制备疫苗以表达病原微生物或其他合适的生物材料的异源抗原。 编码在哺乳动物胃肠道中致病的抗原决定簇的基因插入表达盒中，并与编码聚集因子和/或粘蛋白结合因子的基因融合。 插入的基因显示转化罗伊氏乳杆菌细胞。 聚集增强和粘蛋白结合基因已被分离和测序。 该疫苗可以在药物载体或乳制品中口服摄取。

    Stabilized bacterial formulation
    8.
    发明授权
    Stabilized bacterial formulation 有权
    稳定细菌配方

    公开(公告)号：US08114397B2

    公开(公告)日：2012-02-14

    申请号：US12590313

    申请日：2009-11-05

    申请人： Bengt Bjorksten ,  Bo Mollstam

    发明人： Bengt Bjorksten ,  Bo Mollstam

    IPC分类号： A01N63/00

    CPC分类号： G01N33/6863 ,  A23L33/135 ,  A23Y2220/71 ,  A61K35/747 ,  C12Q1/025 ,  G01N33/6869 ,  G01N2333/335 ,  G01N2333/495

    摘要： Selected strains of Lactobacillus and products containing cells of the selected strains to improve breast milk for feeding to babies, more precisely to increase the levels of the anti-inflammatory cytokine IL10 in the milk and reduce the risk that the feeding baby will develop allergies and simultaneously reduce the cause and thereby the amount of TGF-beta-2 in the milk, thus resulting in reduced risk for the lactating mother to develop mastitis.

    摘要翻译： 选定的乳杆菌菌株和含有所选菌株细胞的产品，以改善母乳喂养婴儿，更准确地提高乳中抗炎细胞因子IL10的水平，并降低喂养婴儿会产生过敏和同时发生的风险 减少牛奶中的原因，从而降低牛奶中TGF-β-2的量，从而导致哺乳期母亲发生乳腺炎的风险降低。

    Stabilized bacterial formulation
    9.
    发明申请
    Stabilized bacterial formulation 有权
    稳定细菌配方

    公开(公告)号：US20100129336A1

    公开(公告)日：2010-05-27

    申请号：US12590313

    申请日：2009-11-05

    申请人： Bengt Bjorksten ,  Bo Mollstam

    发明人： Bengt Bjorksten ,  Bo Mollstam

    IPC分类号： A61K45/00 ,  C12N1/20 ,  A61P43/00

    CPC分类号： G01N33/6863 ,  A23L33/135 ,  A23Y2220/71 ,  A61K35/747 ,  C12Q1/025 ,  G01N33/6869 ,  G01N2333/335 ,  G01N2333/495

    摘要： Selected strains of Lactobacillus and products containing cells of the selected strains to improve breast milk for feeding to babies, more precisely to increase the levels of the anti-inflammatory cytokine IL10 in the milk and reduce the risk that the feeding baby will develop allergies and simultaneously reduce the cause and thereby the amount of TGF-beta-2 in the milk, thus resulting in reduced risk for the lactating mother to develop mastitis.

    摘要翻译： 选定的乳杆菌菌株和含有所选菌株细胞的产品，以改善母乳喂养婴儿，更准确地提高乳中抗炎细胞因子IL10的水平，并降低喂养婴儿会产生过敏和同时发生的风险 减少牛奶中的原因，从而降低牛奶中TGF-β-2的量，从而导致哺乳期母亲发生乳腺炎的风险降低。