公开(公告)号：US09364593B2

公开(公告)日：2016-06-14

申请号：US13618071

申请日：2012-09-14

申请人： Mark W. McBride ,  David A. Boger ,  Robert L. Campbell ,  Gregory P. Dillon ,  Stephen A. Hambric ,  Robert F. Kunz ,  Boris Leschinsky ,  Thomas M. Mallison ,  James P. Runt ,  Justin M. Walsh

发明人： Mark W. McBride ,  David A. Boger ,  Robert L. Campbell ,  Gregory P. Dillon ,  Stephen A. Hambric ,  Robert F. Kunz ,  Boris Leschinsky ,  Thomas M. Mallison ,  James P. Runt ,  Justin M. Walsh

IPC分类号： A61M1/12 ,  A61M1/10 ,  F04D3/00 ,  F04D29/18 ,  F04D29/24

CPC分类号： A61M1/1012 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1017 ,  A61M1/102 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  A61M2205/0266 ,  B33Y80/00 ,  F04D3/00 ,  F04D3/02 ,  F04D29/181 ,  F04D29/247 ,  F04D29/528 ,  F04D29/542 ,  F05B2240/311 ,  F05B2280/5001

摘要： An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be part of a pump for pumping fluids, such as blood, and may include a cannula having a proximal portion with a fixed diameter, and a distal portion with an expandable diameter. The impeller may reside in the expandable portion of the cannula. The cannula may have a compressed diameter which allows it to be inserted percutaneously into a patient. Once at a desired location, the expandable portion of the cannula may be expanded and the impeller expanded to the deployed configuration. A flexible drive shaft may extend through the cannula for rotationally driving the impeller within the patient.

摘要翻译： 叶轮包括轮毂和由轮毂支撑的叶片。 叶轮具有存储构造，其中叶片被压缩，使得其远端朝向轮毂移动，以及展开构型，其中叶片远离轮毂延伸。 叶轮可以是用于泵送诸如血液的泵的泵的一部分，并且可以包括具有固定直径的近端部分和具有可扩张直径的远侧部分的套管。 叶轮可以驻留在套管的可膨胀部分中。 套管可以具有压缩直径，其允许其经皮插入患者体内。 一旦在期望的位置，插管的可扩张部分可以膨胀并且叶轮膨胀到展开构型。 柔性驱动轴可以延伸穿过套管以在患者体内旋转地驱动叶轮。

公开(公告)号：US08795323B2

公开(公告)日：2014-08-05

申请号：US13351257

申请日：2012-01-17

申请人： Boris Leschinsky

发明人： Boris Leschinsky

IPC分类号： A61B17/00

CPC分类号： A61B17/1355 ,  A61B5/022 ,  A61B5/026 ,  A61B5/1491 ,  A61B5/6831 ,  A61B5/685 ,  A61B17/085 ,  A61B2017/00084 ,  A61B2562/0271 ,  A61F7/007

摘要： A dual mode automatic device for delivery of remote ischemic preconditioning treatment includes a cuff and a controller configured to deliver a first regular treatment protocol or a second extended treatment protocol. Switching to an extended treatment protocol may be done by an operator for selected groups of patients such as elderly or patients with diabetes. Automatic determination of the best mode is also disclosed. Optimal delivery of remote ischemic preconditioning treatment in this individualized patient-specific manner provides strong ischemic protection to a greater number of patients.

摘要翻译： 用于递送远程缺血预处理治疗的双模式自动装置包括袖套和被配置为递送第一常规治疗方案或第二扩展治疗方案的控制器。 切换到扩展治疗方案可以由操作者对所选择的患者组例如老年人或糖尿病患者进行。 还公开了自动确定最佳模式。 以个性化的患者特异性方式优化远端缺血预处理治疗，为更多的患者提供强大的缺血保护。

公开(公告)号：US20130184745A1

公开(公告)日：2013-07-18

申请号：US13351257

申请日：2012-01-17

申请人： Boris Leschinsky

发明人： Boris Leschinsky

IPC分类号： A61B17/135

CPC分类号： A61B17/1355 ,  A61B5/022 ,  A61B5/026 ,  A61B5/1491 ,  A61B5/6831 ,  A61B5/685 ,  A61B17/085 ,  A61B2017/00084 ,  A61B2562/0271 ,  A61F7/007

摘要： A dual mode automatic device for delivery of remote ischemic preconditioning treatment includes a cuff and a controller configured to deliver a first regular treatment protocol or a second extended treatment protocol. Switching to an extended treatment protocol may be done by an operator for selected groups of patients such as elderly or patients with diabetes. Automatic determination of the best mode is also disclosed. Optimal delivery of remote ischemic preconditioning treatment in this individualized patient-specific manner provides strong ischemic protection to a greater number of patients.

摘要翻译： 用于递送远程缺血预处理治疗的双模式自动装置包括袖套和被配置为递送第一常规治疗方案或第二扩展治疗方案的控制器。 切换到扩展治疗方案可以由操作者对所选择的患者组例如老年人或糖尿病患者进行。 还公开了自动确定最佳模式。 以个性化的患者特异性方式优化远端缺血预处理治疗，为更多的患者提供强大的缺血保护。

公开(公告)号：US20120172655A1

公开(公告)日：2012-07-05

申请号：US13343617

申请日：2012-01-04

申请人： Robert L. Campbell ,  Keif Fitzgerald ,  William James Harrison ,  Boris Leschinsky ,  Thomas M. Mallison ,  Mark W. McBride ,  Adam Roslund ,  Daniel A. Walters ,  Phyllis Yuen

发明人： Robert L. Campbell ,  Keif Fitzgerald ,  William James Harrison ,  Boris Leschinsky ,  Thomas M. Mallison ,  Mark W. McBride ,  Adam Roslund ,  Daniel A. Walters ,  Phyllis Yuen

IPC分类号： A61M1/10 ,  A61M25/00

CPC分类号： A61M25/04 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  A61M2025/0024 ,  A61M2025/0096

摘要： Disclosed herein are heart pumps that include a catheter assembly and that can be applied percutaneously. Some embodiments include a locking device that prevents components of the catheter assembly from being separated when in use. The catheter assembly can include an expandable tip. In some embodiments, the catheter assembly includes a housing having a wall structure, a portion of which can have a bulbuous shape or can be deformable. In other embodiments, the housing can be configured to reduce fluttering or deflection of the housing and/or to maintain a gap between the housing and an impeller blade disposed therein.

摘要翻译： 本文公开了包括导管组件并且可以经皮应用的心脏泵。 一些实施例包括锁定装置，其防止导管组件的组件在使用时被分离。 导管组件可包括可扩张尖端。 在一些实施例中，导管组件包括具有壁结构的壳体，其一部分可具有球形形状或可变形。 在其他实施例中，壳体可以被配置为减少壳体的颤动或偏转和/或在壳体和设置在其中的叶轮叶片之间保持间隙。

公开(公告)号：US20110236210A1

公开(公告)日：2011-09-29

申请号：US13072624

申请日：2011-03-25

申请人： Mark W. McBride ,  Thomas M. Mallison ,  Gregory P. Dillon ,  Robert L. Campbell ,  David A. Boger ,  Stephen A. Hambric ,  Robert F. Kunz ,  James P. Runt ,  Justin M. Walsh ,  Boris Leschinsky

发明人： Mark W. McBride ,  Thomas M. Mallison ,  Gregory P. Dillon ,  Robert L. Campbell ,  David A. Boger ,  Stephen A. Hambric ,  Robert F. Kunz ,  James P. Runt ,  Justin M. Walsh ,  Boris Leschinsky

IPC分类号： F04D29/26

CPC分类号： F04D29/181 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  B63B2231/42 ,  B63H1/26 ,  B63H11/08 ,  F04D3/00 ,  F04D3/02 ,  F04D19/02 ,  F04D29/026 ,  F04D29/247 ,  F04D29/382 ,  F04D29/526 ,  F04D29/528 ,  F05D2210/11 ,  F05D2250/51 ,  F05D2250/52 ,  F05D2300/43 ,  Y10S415/90 ,  Y10T29/49229

摘要： An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

摘要翻译： 叶轮包括轮毂和由轮毂支撑的多个叶片，叶片布置成至少两个叶片排。 叶轮具有展开构造，其中叶片远离轮毂延伸，并且存储构造，其中至少一个叶片径向压缩，例如通过将叶片朝向毂折叠。 叶轮还可以具有这样的操作构造，其中当处于展开构型时，在叶轮旋转时，至少一些叶片从展开构型变形。 一个或多个叶片的外边缘可以具有小翼，并且叶片的基部可以具有相关联的压痕以便于叶片的折叠。

公开(公告)号：US20090060743A1

公开(公告)日：2009-03-05

申请号：US12157267

申请日：2008-06-09

申请人： Mark W. McBride ,  Thomas M. Mallison ,  Gregory P. Dillon ,  Robert L. Campbell ,  David A. Boger ,  Stephen A. Hambric ,  Robert F. Kunz ,  James P. Runt ,  Justin M. Walsh ,  Boris Leschinsky

发明人： Mark W. McBride ,  Thomas M. Mallison ,  Gregory P. Dillon ,  Robert L. Campbell ,  David A. Boger ,  Stephen A. Hambric ,  Robert F. Kunz ,  James P. Runt ,  Justin M. Walsh ,  Boris Leschinsky

IPC分类号： B64C11/28

CPC分类号： F04D29/181 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1024 ,  A61M1/1034 ,  A61M1/122 ,  A61M1/125 ,  B63B2231/42 ,  B63H1/26 ,  B63H11/08 ,  F04D3/00 ,  F04D3/02 ,  F04D19/02 ,  F04D29/026 ,  F04D29/247 ,  F04D29/382 ,  F04D29/526 ,  F04D29/528 ,  F05D2210/11 ,  F05D2250/51 ,  F05D2250/52 ,  F05D2300/43 ,  Y10S415/90 ,  Y10T29/49229

摘要： An impeller includes a hub, and a plurality of blades supported by the hub, the blades being arranged in at least two blade rows. The impeller has a deployed configuration in which the blades extend away from the hub, and a stored configuration in which at least one of the blades is radially compressed, for example by folding the blade towards the hub. The impeller may also have an operational configuration in which at least some of the blades are deformed from the deployed configuration upon rotation of the impeller when in the deployed configuration. The outer edge of one or more blades may have a winglet, and the base of the blades may have an associated indentation to facilitate folding of the blades.

摘要翻译： 叶轮包括轮毂和由轮毂支撑的多个叶片，叶片布置成至少两个叶片排。 叶轮具有展开构造，其中叶片远离轮毂延伸，并且存储构造，其中至少一个叶片径向压缩，例如通过将叶片朝向毂折叠。 叶轮还可以具有这样的操作构造，其中当处于展开构型时，在叶轮旋转时，至少一些叶片从展开构型变形。 一个或多个叶片的外边缘可以具有小翼，并且叶片的基部可以具有相关联的压痕以便于叶片的折叠。

公开(公告)号：US06602270B2

公开(公告)日：2003-08-05

申请号：US09928843

申请日：2001-08-13

申请人： Boris Leschinsky ,  Robert B. Schock

发明人： Boris Leschinsky ,  Robert B. Schock

IPC分类号： A61M2510

CPC分类号： A61M25/10 ,  A61M1/1008 ,  A61M1/106 ,  A61M1/1072 ,  A61M1/1086 ,  A61M1/125 ,  A61M1/127 ,  A61M2025/0002

摘要： A reduced size IAB catheter system comprising an IAB catheter disposed within a tube serving both as a insertion sheath and as a reinforcement tube. The tube is preferably disposed about the entire catheter up to the balloon membrane. The catheter remains disposed within the tube during therapy.

摘要翻译： 减小尺寸的IAB导管系统，其包括设置在同时用作插入鞘的管内和作为加强管的IAB导管。 管优选地围绕整个导管设置直到球囊膜。 在治疗过程中导管保持置于管内。

公开(公告)号：US5817001A

公开(公告)日：1998-10-06

申请号：US863232

申请日：1997-05-27

申请人： Boris Leschinsky ,  Jonathan R. Williams

发明人： Boris Leschinsky ,  Jonathan R. Williams

IPC分类号： A61M1/10

CPC分类号： A61M1/106 ,  A61M1/1062 ,  A61M1/1065 ,  A61M1/1072

摘要： An intra-aortic balloon pump includes an overdrive system for inflating the intra-aortic balloon with a working gas and deflating the balloon more rapidly. A substantially constant inflation pressure is applied to the working gas for a predetermined time to substantially fully inflate the balloon to a working pressure. The inflation pressure is then reduced to a pressure which is substantially equal to the working pressure so as to maintain the balloon in the inflated condition and prevent its overinflation. Subsequently, a substantially constant deflation pressure is applied to the working gas and is held for a predetermined time to substantially fully deflate the balloon to a desired end deflation pressure. The deflation pressure is then increased to a pressure which is substantially equal to the end deflation pressure so as to maintain the balloon in the deflated condition and ready the system for the next inflation cycle.

摘要翻译： 主动脉内气囊泵包括用于用工作气体充气主动脉内球囊并且更快速地使气囊膨胀的过驱动系统。 将基本上恒定的充气压力施加到工作气体预定时间，以使气囊基本上完全充气至工作压力。 然后将充气压力降低到基本上等于工作压力的压力，以便将球囊保持在充气状态并防止其过度充气。 随后，将基本上恒定的放气压力施加到工作气体并保持预定时间，以将气囊基本上完全放气至期望的端部放气压力。 然后将放气压力增加到基本上等于末端放气压力的压力，以便将气囊保持在放气状态，并为下一个充气循环准备系统。

公开(公告)号：US20190060542A1

公开(公告)日：2019-02-28

申请号：US15692345

申请日：2017-08-31

申请人： William C. Altman ,  Boris Leschinsky

发明人： William C. Altman ,  Boris Leschinsky

IPC分类号： A61M1/12 ,  A61M1/10

摘要： The present invention includes a method and device for the minimally invasive implantation in a heart of a deployable device through a left thoracotomy or subxiphoid incision.

公开(公告)号：US08753283B2

公开(公告)日：2014-06-17

申请号：US13362039

申请日：2012-01-31

申请人： Boris Leschinsky

发明人： Boris Leschinsky

IPC分类号： A61B5/02 ,  A61B17/00

CPC分类号： A61H9/0092 ,  A61B5/02208 ,  A61B5/02225 ,  A61B5/02233 ,  A61B17/12109 ,  A61B17/12136 ,  A61B17/135 ,  A61B17/1355 ,  A61B2017/00199 ,  A61H1/006 ,  A61H9/0078 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5071 ,  A61H2230/30

摘要： Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient's hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

摘要翻译： 公开了用于远端缺血预处理和血压监测的单膀胱或双膀胱装置以及在进行缺血预处理治疗期间用于检测收缩压和舒张压的各种示波器和其他方法。 本发明的装置和方法提供了在最低有效袖带压力下输送缺血预处理，同时密切监测患者的血液动力学。 有利地，本发明的装置允许在相同的肢体上进行缺血预处理和血压监测。 本发明装置的一次性电池供电版本对于急性心肌梗塞，急性中风或急性创伤患者的紧急使用特别有用。 描述了用于经皮干预和血管密封设置的附加装置配置。