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公开(公告)号：US20120052048A1
公开(公告)日：2012-03-01
申请号：US13148009
申请日：2010-02-05
申请人： Miguel Ängelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Sara Ferreira Llorente Grancho Lourenço
发明人： Miguel Ängelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Sara Ferreira Llorente Grancho Lourenço
IPC分类号： A61K35/76 , C07K14/005 , A61K38/16 , A61P31/04 , A01N37/18 , C07H21/00 , C12Q1/70 , C12Q1/18 , A01N63/00 , C12N7/00 , A01P1/00
CPC分类号： A61K35/76 , A61K9/0014 , A61K9/0073 , A61K38/00 , A61K45/06 , C07K14/005 , C12N7/00 , C12N9/6489 , C12N2795/00032 , C12N2795/10021 , C12N2795/10022 , C12N2795/10032 , C12N2795/14021 , C12N2795/14022 , C12N2795/14032 , G01N33/56911
摘要： The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophages F1245/05, F168/08, F170/08, F770/05, F197/08, F86/06, F87s/06 and F91a/06, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophages and/or isolated polypeptides and methods for the treatment and prevention of bacterial infection, either alone or in combination with other antibacterial therapies, e.g., antibiotics or other phage therapies.
摘要翻译： 本发明涉及用于治疗和控制细菌感染的噬菌体治疗领域。 特别地，本发明涉及新型噬菌体F1245 / 05，F168 / 08，F170 / 08，F770 / 05，F197 / 08，F86 / 06，F87s / 06和F91a / 06，其分离的多肽， 一种或多种新的噬菌体和/或分离的多肽和用于治疗和预防细菌感染的方法，单独或与其它抗菌疗法（例如抗生素或其它噬菌体疗法）结合使用。
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公开(公告)号：US08563504B2
公开(公告)日：2013-10-22
申请号：US13122190
申请日：2009-10-09
申请人： Miguel Ângelo da Costa Garcia , Madalena Maria Vilela Pimentel , Carlos Jorge Sousa de São José
发明人： Miguel Ângelo da Costa Garcia , Madalena Maria Vilela Pimentel , Carlos Jorge Sousa de São José
IPC分类号： A01N37/18
CPC分类号： C12N9/503 , C07K2319/00 , C12N2795/10311 , C12N2795/10322
摘要： The present invention is directed to isolated and chimeric polypeptides of bacteriophage origin having antibiotic activity and use thereof in the treatment and control of bacterial infections. Specifically, the present invention is directed to the use of a novel antibacterial polypeptide derived from bacteriophage F87s/06 and chimeric constructs thereof, and their use for the treatment and control of infections caused by gram-positive bacteria, including Staphylococcus aureus.
摘要翻译： 本发明涉及具有抗生素活性的噬菌体来源的分离和嵌合多肽及其在治疗和控制细菌感染中的用途。 具体而言，本发明涉及来自噬菌体F87s / 06及其嵌合构建体的新型抗菌多肽及其用于治疗和控制由革兰氏阳性菌（包括金黄色葡萄球菌）引起的感染的用途。
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公开(公告)号：US09222077B2
公开(公告)日：2015-12-29
申请号：US13823519
申请日：2011-09-19
申请人： Miguel Ângelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Ana Raquel Martins Barbosa
发明人： Miguel Ângelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Ana Raquel Martins Barbosa
CPC分类号： A61K35/76 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/007 , A61K31/505 , A61K31/7056 , A61K38/14 , A61K38/47 , A61K38/48 , A61K45/06 , C12N7/00 , C12N9/2462 , C12N9/503 , C12N2795/00022 , C12N2795/00031 , C12N2795/00032 , Y02A50/473
摘要： The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophage F387/08, F391/08, F394/08, F488/08, F510/08, F44/10, and F125/10, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophage and/or isolated polypeptides, as well as to methods for the treatment and prevention of bacterial infections using same, either alone or in combination with other antibacterial therapies, e.g., antibiotics and/or other phage therapies.
摘要翻译： 本发明涉及用于治疗和控制细菌感染的噬菌体治疗领域。 特别地，本发明涉及新型噬菌体F387 / 08，F391 / 08，F394 / 08，F488 / 08，F510 / 08，F44 / 10和F125 / 10，其分离的多肽，包含一种或多种 的新型噬菌体和/或分离的多肽，以及单独或与其它抗菌疗法（例如抗生素和/或其它噬菌体疗法）组合治疗和预防细菌感染的方法。
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公开(公告)号：US20140079671A1
公开(公告)日：2014-03-20
申请号：US13823519
申请日：2011-09-19
申请人： Miguel Ângelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Ana Raquel Martins Barbosa
发明人： Miguel Ângelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Ana Raquel Martins Barbosa
CPC分类号： A61K35/76 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/007 , A61K31/505 , A61K31/7056 , A61K38/14 , A61K38/47 , A61K38/48 , A61K45/06 , C12N7/00 , C12N9/2462 , C12N9/503 , C12N2795/00022 , C12N2795/00031 , C12N2795/00032 , Y02A50/473
摘要： The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophage F387/08, F391/08, F394/08, F488/08, F510/08, F44/10, and F125/10, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophage and/or isolated polypeptides, as well as to methods for the treatment and prevention of bacterial infections using same, either alone or in combination with other antibacterial therapies, e.g., antibiotics and/or other phage therapies.
摘要翻译： 本发明涉及用于治疗和控制细菌感染的噬菌体治疗领域。 特别地，本发明涉及新型噬菌体F387 / 08，F391 / 08，F394 / 08，F488 / 08，F510 / 08，F44 / 10和F125 / 10，其分离的多肽，包含一种或多种 的新型噬菌体和/或分离的多肽，以及单独或与其它抗菌疗法（例如抗生素和/或其它噬菌体疗法）组合治疗和预防细菌感染的方法。
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公开(公告)号：US20110230393A1
公开(公告)日：2011-09-22
申请号：US13122190
申请日：2009-10-09
申请人： Miguel Angelo Da Costa Garcia , Madalena Maria Vilela Pimentel , Carlos Jorge Sousa de São José
发明人： Miguel Angelo Da Costa Garcia , Madalena Maria Vilela Pimentel , Carlos Jorge Sousa de São José
CPC分类号： C12N9/503 , C07K2319/00 , C12N2795/10311 , C12N2795/10322
摘要： The present invention is directed to isolated and chimeric polypeptides of bacteriophage origin having antibiotic activity and use thereof in the treatment and control of bacterial infections. Specifically, the present invention is directed to the use of a novel antibacterial polypeptide derived from bacteriophage F87s/06 and chimeric constructs thereof, and their use for the treatment and control of infections caused by gram-positive bacteria, including Staphylococcus aureus.
摘要翻译： 本发明涉及具有抗生素活性的噬菌体来源的分离和嵌合多肽及其在治疗和控制细菌感染中的用途。 具体而言，本发明涉及来自噬菌体F87s / 06及其嵌合构建体的新型抗菌多肽及其用于治疗和控制由革兰氏阳性菌（包括金黄色葡萄球菌）引起的感染的用途。
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公开(公告)号：US09134312B2
公开(公告)日：2015-09-15
申请号：US13148009
申请日：2010-02-05
申请人： Miguel Ängelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Sara Ferreira Llorente Grancho Lourenço
发明人： Miguel Ängelo Da Costa Garcia , Carlos Jorge Sousa De São José , Clara Isabel Rodrigues Leandro , Filipa Maria Rodrigues Pardal Dias Antunes Marçal Da Silva , Sara Ferreira Llorente Grancho Lourenço
IPC分类号： A61K39/00 , C07K14/005 , C12N7/00 , A01N63/00 , G01N33/569 , A61K35/76 , A61K45/06 , C12N9/64 , A61K38/00
CPC分类号： A61K35/76 , A61K9/0014 , A61K9/0073 , A61K38/00 , A61K45/06 , C07K14/005 , C12N7/00 , C12N9/6489 , C12N2795/00032 , C12N2795/10021 , C12N2795/10022 , C12N2795/10032 , C12N2795/14021 , C12N2795/14022 , C12N2795/14032 , G01N33/56911
摘要： The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophages F1245/05, F168/08, F170/08, F770/05, F197/08, F86/06, F87s/06 and F91a/06, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophages and/or isolated polypeptides and methods for the treatment and prevention of bacterial infection, either alone or in combination with other antibacterial therapies, e.g., antibiotics or other phage therapies.
摘要翻译： 本发明涉及用于治疗和控制细菌感染的噬菌体治疗领域。 特别地，本发明涉及新型噬菌体F1245 / 05，F168 / 08，F170 / 08，F770 / 05，F197 / 08，F86 / 06，F87s / 06和F91a / 06，其分离的多肽， 一种或多种新的噬菌体和/或分离的多肽和用于治疗和预防细菌感染的方法，单独或与其它抗菌疗法（例如抗生素或其它噬菌体疗法）结合使用。
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