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公开(公告)号：US06641816B1
公开(公告)日：2003-11-04
申请号：US09720466
申请日：2001-03-09
IPC分类号： A61K3912
CPC分类号： A61K39/39 , A61K35/768 , A61K39/12 , A61K39/145 , A61K39/21 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/555 , A61K2039/55505 , A61K2039/55516 , A61K2039/55522 , A61K2039/70 , C12N2710/24032 , C12N2710/24043 , C12N2740/15034 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16134
摘要： The invention relates to a method for enhancing the specific immune response against an immunogenic compound which comprises administering the immunogenic compound together with a poxvirus recombinant and a vaccinal antigen, which is not a poxvirus. The immunological material may be any biological material useful as a vaccine e.g., a polypeptide characteristic of a pathogenic microorganism or associated with a tumoral disorder, a DNA plasmid encoding a peptide or a polypeptide characteristic of a pathogenic microorganism or a tumor-associated antigen, or an hapten coupled to a carrier molecule. The poxvirus may be a live, attenuated or inactivated virus or a recombinant virus. Recombinant virus may encode a heterologous polypeptide such as chemokines, cytokines or co-immunostimulatory molecules or an homologous polypeptide, which is immunologically cross reactive with the immunogenic polypeptide or peptide.
摘要翻译： 本发明涉及增强针对免疫原性化合物的特异性免疫应答的方法，其包括将免疫原性化合物与不是痘病毒的痘病毒重组体和疫苗抗原一起施用。 免疫学材料可以是用作疫苗的任何生物材料，例如病原微生物特征的多肽或与肿瘤病症有关的多肽，编码病原微生物或肿瘤相关抗原特征的肽或多肽的DNA质粒，或 与载体分子偶联的半抗原。 痘病毒可以是活的，减毒的或灭活的病毒或重组病毒。 重组病毒可以编码与免疫原性多肽或肽免疫交叉反应的异源多肽，例如趋化因子，细胞因子或共免疫刺激分子或同源多肽。
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公开(公告)号：US07871807B2
公开(公告)日：2011-01-18
申请号：US12238740
申请日：2008-09-26
申请人： Catherine Gerdil , Catherine Moste , Isabelle Legastelois , Michel Joseph Marie Bublot , Francois-Xavier Le Gros
发明人： Catherine Gerdil , Catherine Moste , Isabelle Legastelois , Michel Joseph Marie Bublot , Francois-Xavier Le Gros
IPC分类号： C12N7/00 , C12N7/02 , C12N7/04 , A61K39/145
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/55 , C12N7/00 , C12N2710/24143 , C12N2760/16134 , C12N2760/16161
摘要： The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs, d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus, and e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus.
摘要翻译： 本发明涉及一种生产流感病毒的方法，其中：a）通过向母鸡施用流感疫苗来免疫母鸡，b）在免疫的母鸡的一个或多个卵中触发胚胎发生，c）感染一个或多个被胚胎的 将鸡蛋通过将鸡流感病毒接种到卵的尿囊腔中，d）在允许复制病毒的温度和湿度条件下孵育一种或多种感染的含胚卵，以及e）收获所述一种或多种孵化蛋的尿囊液 含有病毒。
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3.发明授权Vaccine composition against influenza, with synergic effects, containing influenza virus core as an additive 失效针对流行性感冒的疫苗组合，具有协同作用，含有流感病毒核心作为添加剂
公开(公告)号：US5741493A
公开(公告)日：1998-04-21
申请号：US375224
申请日：1995-01-19
IPC分类号： A61K39/145 , A61K39/39 , A61K39/00 , A61K38/00 , C12N7/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55511 , A61K2039/55516 , A61K2039/55566 , A61K2039/55588 , C12N2760/16134
摘要： The use, when preparing a vaccine composition containing a standard influenza virus vaccine, of an additive which consists of a core or core fraction of at least one influenza virus, especially a fraction containing protein M; and a vaccine composition thereby obtained. The use of said additive improves the vaccine's effectiveness.
摘要翻译： 在制备含有标准流感病毒疫苗的疫苗组合物时，使用由至少一种流感病毒的核心或核心部分，特别是含有蛋白质M的级分组成的添加剂的用途; 和由此获得的疫苗组合物。 所述添加剂的使用提高了疫苗的有效性。
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公开(公告)号：US09005623B2
公开(公告)日：2015-04-14
申请号：US12246803
申请日：2008-10-07
IPC分类号： A61K39/42 , A61K39/145 , A61K39/21 , G01N33/53 , C07K16/10 , A61K31/737 , G01N33/569
CPC分类号： C07K16/1018 , A61K31/737 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The invention relates to a flu virus hemagglutinin-specific monoclonal antibody which recognizes an antigenic structure present both on the H1 and H3 subtypes of the hemagglutinins of type A flu viruses and on the hemagglutinin of type B flu viruses. Within type B flu viruses, the antigenic structure is present on the hemagglutinins of type B flu viruses belonging to the B/Victoria group and/or to the B/Yagamata group.
摘要翻译： 本发明涉及一种流感病毒血凝素特异性单克隆抗体，其识别存在于A型流感病毒的血凝素的H1和H3亚型以及B型流感病毒的血凝素上的抗原结构。 在B型流感病毒中，抗原结构存在于属于B /维多利亚组和/或B / Yagamata组的B型流感病毒的血细胞凝集素上。
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公开(公告)号：US20110212129A1
公开(公告)日：2011-09-01
申请号：US12962375
申请日：2010-12-07
申请人： Catherine Gerdil , Catherine Moste , Isabelle Legastelois , Michel Marie Joseph Bublot , François-Xavier Le Gros
发明人： Catherine Gerdil , Catherine Moste , Isabelle Legastelois , Michel Marie Joseph Bublot , François-Xavier Le Gros
IPC分类号： A61K39/145 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/55 , C12N7/00 , C12N2710/24143 , C12N2760/16134 , C12N2760/16161
摘要： The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs, d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus, and e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus.
摘要翻译： 本发明涉及一种生产流感病毒的方法，其中：a）通过向母鸡施用流感疫苗来免疫母鸡，b）在免疫的母鸡的一个或多个卵中触发胚胎发生，c）感染一个或多个被胚胎的 将鸡蛋通过将鸡流感病毒接种到卵的尿囊腔中，d）在允许复制病毒的温度和湿度条件下孵育一种或多种感染的含胚卵，以及e）收获所述一种或多种孵化蛋的尿囊液 含有病毒。
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公开(公告)号：US20090092620A1
公开(公告)日：2009-04-09
申请号：US12246803
申请日：2008-10-07
CPC分类号： C07K16/1018 , A61K31/737 , C12N2760/16111 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The invention relates to a flu virus hemagglutinin-specific monoclonal antibody which recognizes an antigenic structure present both on the H1 and H3 subtypes of the hemagglutinins of type A flu viruses and on the hemagglutinin of type B flu viruses. Within type B flu viruses, the antigenic structure is present on the hemagglutinins of type B flu viruses belonging to the B/Victoria group and/or to the B/Yagamata group.
摘要翻译： 本发明涉及一种流感病毒血凝素特异性单克隆抗体，其识别存在于A型流感病毒的血凝素的H1和H3亚型以及B型流感病毒的血凝素上的抗原结构。 在B型流感病毒中，抗原结构存在于属于B /维多利亚组和/或B / Yagamata组的B型流感病毒的血细胞凝集素上。
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公开(公告)号：US20090081255A1
公开(公告)日：2009-03-26
申请号：US12238740
申请日：2008-09-26
申请人： Michel Marie Joseph Bublot , Francois-Xavier Le Gros , Catherine Gerdil , Catherine Moste , Isabelle Legastelois
发明人： Michel Marie Joseph Bublot , Francois-Xavier Le Gros , Catherine Gerdil , Catherine Moste , Isabelle Legastelois
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/00 , A61K39/12 , A61K2039/5252 , A61K2039/5256 , A61K2039/55 , C12N7/00 , C12N2710/24143 , C12N2760/16134 , C12N2760/16161
摘要： The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs, d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus, and e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus.
摘要翻译： 本发明涉及一种生产流感病毒的方法，其中：a）通过向母鸡施用流感疫苗来免疫母鸡，b）在免疫的母鸡的一个或多个卵中触发胚胎发生，c）感染一个或多个被胚胎的 将禽流感病毒接种到卵的尿囊腔中，d）在允许复制病毒的温度和湿度条件下孵育一种或多种受感染的含胚卵，以及e）收获一种或多种孵育的蛋的尿囊液 含有病毒。
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