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公开(公告)号：US09427483B2
公开(公告)日：2016-08-30
申请号：US14679520
申请日：2015-04-06
CPC分类号： A61K51/0478 , A61K51/1093
摘要： The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.
摘要翻译： 本发明涉及一系列稳定的放射性同位素三硫醇复合物，其提供用于以低浓度存在的放射性同位素的直接络合的简化途径。 在某些实施方案中，复合物含有被配置成将放射性同位素三硫醇复合物与靶向载体缀合的连接结构域。 本发明还涉及将放射性同位素与三硫醇化合物连接以形成放射性同位素三硫醇络合物的新方法。 本发明的放射性同位素三硫醇复合物可用于各种应用，包括核医学中的诊断和/或治疗。
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公开(公告)号：US20110277592A1
公开(公告)日：2011-11-17
申请号：US13127743
申请日：2009-11-06
申请人： Cathy S. Cutler , Stacy L. Wilder , Mary F. Embree
发明人： Cathy S. Cutler , Stacy L. Wilder , Mary F. Embree
IPC分类号： C22B59/00
CPC分类号： C22B3/42 , B01D15/362 , C22B3/24 , C22B59/00 , G21F9/12 , Y02P10/234
摘要： A method for separating a lanthanide from a mixture containing at least one other lanthanide is provided. In particular, an HPLC and liquid separation method using a chromatographic column for separating a lanthanide from a mixture containing at least one other lanthanide is provided.
摘要翻译： 提供了从含有至少一种其他镧系元素的混合物中分离镧系元素的方法。 特别地，提供了使用色谱柱从含有至少一种其它镧系元素的混合物中分离镧系元素的HPLC和液体分离方法。
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公开(公告)号：US20150283274A1
公开(公告)日：2015-10-08
申请号：US14679520
申请日：2015-04-06
CPC分类号： A61K51/0478 , A61K51/1093
摘要： The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.
摘要翻译： 本发明涉及一系列稳定的放射性同位素三硫醇复合物，其提供用于以低浓度存在的放射性同位素的直接络合的简化途径。 在某些实施方案中，复合物含有被配置成将放射性同位素三硫醇复合物与靶向载体缀合的连接结构域。 本发明还涉及将放射性同位素与三硫醇化合物连接以形成放射性同位素三硫醇复合物的新方法。 本发明的放射性同位素三硫醇复合物可用于各种应用，包括核医学中的诊断和/或治疗。
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公开(公告)号：US20130108525A1
公开(公告)日：2013-05-02
申请号：US13566447
申请日：2012-08-03
CPC分类号： C22B11/04 , C01G55/00 , C01G55/004 , G21G1/001 , G21G1/06 , G21G2001/0094
摘要： A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
摘要翻译： 提供了从含有锇和至少一种其它附加金属的混合物中分离出锇的量的方法。 特别地，提供了用于形成和捕获OsO 4从含有锇和至少一种其它附加金属的混合物分离锇的方法。
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公开(公告)号：US09593052B2
公开(公告)日：2017-03-14
申请号：US14958185
申请日：2015-12-03
CPC分类号： C07B59/004 , C07F9/74
摘要： The present invention provides radioactive arsenic complexes useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.
摘要翻译： 本发明提供可用于诊断和治疗应用的放射性砷络合物和形成这些砷络合物的方法。
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公开(公告)号：US10087503B2
公开(公告)日：2018-10-02
申请号：US15352304
申请日：2016-11-15
IPC分类号： C22B34/00 , C22B3/00 , C22B61/00 , C01G47/00 , C01G55/00 , G21G1/00 , G21G1/10 , C22B7/00 , C25C1/06
摘要： A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
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公开(公告)号：US08241393B2
公开(公告)日：2012-08-14
申请号：US11219497
申请日：2005-09-02
IPC分类号： B22F9/24
CPC分类号： B22F9/24 , A61K47/62 , A61K47/6923 , A61K47/6929 , A61K49/0002 , A61K49/0428 , A61K51/1244 , B22F1/0018 , B82Y5/00 , B82Y30/00
摘要： An example embodiment of a method for making gold nanoparticles includes steps of reacting a gold salt with a phosphino amino acid. Example phosphino amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphino group. In an example method of the invention, the gold nanoparticles may be produced in timer periods of less than about 3 minutes, and at temperatures of less than about 30° C. Other methods of the invention are directed to methods for stabilizing gold nanoparticles, and to methods for making gold nanochains.
摘要翻译： 制备金纳米颗粒的方法的示例性实施方案包括使金盐与膦基氨基酸反应的步骤。 实例的膦基氨基酸包括三聚体，具体实例是含有一个膦基的三聚氨基酸缀合物。 在本发明的一个示例性方法中，金纳米颗粒可以在小于约3分钟的定时周期内和小于约30℃的温度下制备。本发明的其它方法涉及稳定金纳米颗粒的方法，以及 制作金纳米线的方法。
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公开(公告)号：US20170058381A1
公开(公告)日：2017-03-02
申请号：US15352304
申请日：2016-11-15
CPC分类号： C22B34/00 , C01G47/00 , C01G55/00 , C01G55/001 , C01G55/004 , C22B7/001 , C22B7/006 , C22B7/009 , C22B11/04 , C22B11/042 , C22B61/00 , C25C1/06 , G21G1/001 , G21G1/10 , G21G2001/0073 , Y02P10/214
摘要： A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.
摘要翻译： 提供了从含有锇和至少一种其它附加金属的混合物中分离出锇的量的方法。 特别地，提供了用于形成和捕获OsO 4从含有锇和至少一种其它附加金属的混合物分离锇的方法。
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公开(公告)号：US20160083408A1
公开(公告)日：2016-03-24
申请号：US14958185
申请日：2015-12-03
IPC分类号： C07F9/74
CPC分类号： C07B59/004 , C07F9/74
摘要： The present invention provides radioactive arsenic complexes useful in diagnostic and therapeutic applications and methods for forming those arsenic complexes.
摘要翻译： 本发明提供可用于诊断和治疗应用的放射性砷络合物和形成这些砷络合物的方法。
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10.发明申请GUM ARABIC COATED 198GOLD RADIOACTIVE NANOPARTICLES FOR CANCER THERAPY 审中-公开用于癌症治疗的阿拉伯胶囊198Gold放射性纳米颗粒公开(公告)号：US20120134918A1
公开(公告)日：2012-05-31
申请号：US13293827
申请日：2011-11-10
CPC分类号： A61K51/1244 , B82Y5/00 , B82Y15/00
摘要： The invention provides a cancer therapeutic and imaging agent comprising a solution containing Gum Arabic coated 198Au nanoparticles. The Gum Arabic coated 198Au nanoparticles have been demonstrated experimentally shown to have a surprising efficacy for a single dose direct injection, reducing tumors in analog mice by 82% over a short period of time. The particles of the invention have a believed optimal size for therapy and imaging applications, and can be used as a theranostic agent in the treatment of needle accessible cancers. The invention also provides a method for forming Gum Arabic coated 198Au nanoparticles. A gold foil is irradiated to produce 198Au foil. The foil is dissolved to form radioactive gold salt. The salt is dried, and then reconstituted to form a 198Au nanoparticle precursor. The precursor is reduced with a reducing agent in an aqueous solution including Gum Arabic to form Gum Arabic coated 198Au nanoparticles.
摘要翻译： 本发明提供一种癌症治疗和显像剂，其包含含有阿拉伯胶的198Au纳米颗粒的溶液。 实验证明，阿拉伯胶包覆的198Au纳米颗粒在单次剂量直接注射中具有令人惊奇的功效，在短时间内将模拟小鼠的肿瘤减少82％。 本发明的颗粒具有用于治疗和成像应用的相信最佳尺寸，并且可以用作治疗针可及性癌症的治疗剂。 本发明还提供了一种形成阿拉伯胶的198Au纳米颗粒的方法。 照射金箔以产生198Au箔。 将箔溶解形成放射性金盐。 将盐干燥，然后重构形成198Au纳米颗粒前体。 在包含阿拉伯胶的水溶液中用还原剂还原前体以形成阿拉伯胶包覆的198Au纳米颗粒。
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