利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.016 秒)

    Medical device for vessel compatibility during high pressure infusion
    1.
    发明授权
    Medical device for vessel compatibility during high pressure infusion 失效
    用于高压输注期间血管相容性的医疗装置

    公开(公告)号：US07938799B2

    公开(公告)日：2011-05-10

    申请号：US11780885

    申请日：2007-07-20

    申请人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

    发明人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

    IPC分类号： A61M31/00 ,  A61M37/00

    CPC分类号： A61M29/02 ,  A61B17/12022 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12131 ,  A61B17/12172 ,  A61B2017/1205 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1095

    摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

    摘要翻译： 本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。 根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。 可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。 这允许递送具有降低治疗部位损伤风险的治疗剂。 本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

    Balloon catheter having an oscillating tip configuration
    2.
    发明授权
    Balloon catheter having an oscillating tip configuration 有权
    气球导管具有摆动尖端构造

    公开(公告)号：US06264630B1

    公开(公告)日：2001-07-24

    申请号：US09219802

    申请日：1998-12-23

    申请人： Timothy J. Mickley ,  Chad G. Harris

    发明人： Timothy J. Mickley ,  Chad G. Harris

    IPC分类号： A61M2900

    CPC分类号： A61M25/104 ,  A61B17/22012 ,  A61M25/0043 ,  A61M25/0054 ,  A61M25/1006 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/1079 ,  A61M2025/1093

    摘要： A catheter is disclosed which includes an over-the-wire type balloon catheter, with a guide wire, wherein the catheter incorporates an axially movable inner tubular member which extends proximally through a proximal manifold lumen. The inner tubular member extends distally beyond the distal end of the outer tubular member with the balloon member distal waist affixed to the inner tubular member proximate the distal end. The catheter incorporates axial tension members which function to transmit force to the distal tip when the movable inner tubular member is oscillated axially. The axial tension members are preferably a plurality of wires, each having a proximal end affixed to the outside diameter of the inner tubular member proximate the manifold, and each having a distal end affixed to the outside diameter of the inner tubular member a substantial distance distal of the manifold. When the inner tubular member is pulled proximally, energy is stored in the catheter, which when the inner is released, forces the distal tip forward with added force from the distal point of attachment of the axial tension members. An actuator and a valve assembly are preferably included.

    摘要翻译： 公开了一种导管，其包括具有导丝的超线型气囊导管，其中所述导管包括沿近侧延伸通过近端歧管内腔的可轴向移动的内部管状构件。 内部管状构件向远侧延伸超过外部管状构件的远端，球囊构件远端腰部靠近远端固定到内部管状构件。 该导管包括轴向张力构件，当可移动的内部管状构件轴向摆动时，该张力构件用于将力传递到远侧末端。 轴向张力构件优选地是多个线，每个线具有固定到靠近歧管的内部管状构件的外径的近端，并且每个具有固定到内部管状构件的外径的远端，远端远离 的歧管。 当内部管状构件被向近侧拉动时，能量被存储在导管中，当内部被释放时，其能够通过来自轴向张力构件的远端附接点的附加力向前推动远侧末端。 优选地包括致动器和阀组件。

    Catheter having a variable length balloon and method of using the same
    3.
    发明授权
    Catheter having a variable length balloon and method of using the same 失效
    具有可变长度球囊的导管及其使用方法

    公开(公告)号：US5961536A

    公开(公告)日：1999-10-05

    申请号：US950520

    申请日：1997-10-14

    申请人： Timothy J. Mickley ,  Steven P. Mertens ,  Christopher R. Larson ,  Chad G. Harris ,  John H. Carlson, II

    发明人： Timothy J. Mickley ,  Steven P. Mertens ,  Christopher R. Larson ,  Chad G. Harris ,  John H. Carlson, II

    IPC分类号： A61F2/958 ,  A61M25/10

    CPC分类号： A61M25/10 ,  A61M2025/1068

    摘要： A variable length balloon catheter is provided. The balloon catheter includes a catheter shaft having a distal portion, a balloon and an adjustment device. The balloon is in fluid communication with a distal end of the catheter shaft. The adjustment device includes an outer sleeve and an attachment structure. The outer sleeve is configured to be generally co-axially received over the distal portion of the catheter shaft and includes a distal end configured to restrict inflation proximal the distal end. Further, the outer sleeve is configured such that at least a portion of the outer sleeve is slidable relative to the distal portion of the catheter shaft such that a distal end of the outer sleeve relative to the balloon can be varied. The attachment structure is similarly disposed at the distal portion of the catheter shaft and is configured to selectively secure at least a portion of the outer sleeve to the distal portion of the catheter shaft such that the outer sleeve will not move upon inflation of the balloon.

    摘要翻译： 提供可变长度的球囊导管。 气囊导管包括具有远端部分的导管轴，球囊和调节装置。 气囊与导管轴的远端流体连通。 调节装置包括外套筒和附接结构。 外套管被构造成大致同轴地容纳在导管轴的远侧部分上，并且包括构造成限制近端近端的充气的远端。 此外，外套筒构造成使得外套筒的至少一部分相对于导管轴的远端部分可滑动，使得外套筒相对于球囊的远端可以改变。 附接结构类似地设置在导管轴的远端部分处，并被构造成选择性地将外套筒的至少一部分固定到导管轴的远端部分，使得外套筒在气囊膨胀时不会移动。

    VARIABLE STIFFNESS DIRECT INJECTION SYSTEM
    4.
    发明申请
    VARIABLE STIFFNESS DIRECT INJECTION SYSTEM 审中-公开
    可变刚度直接注射系统

    公开(公告)号：US20100076403A1

    公开(公告)日：2010-03-25

    申请号：US12604983

    申请日：2009-10-23

    申请人： Chad G. HARRIS ,  Timothy J. MICKLEY

    发明人： Chad G. HARRIS ,  Timothy J. MICKLEY

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0105 ,  A61M25/0041 ,  A61M25/0152

    摘要： A direct injection system with a small diameter that can be easily placed at a desired treatment location is provided, where the system comprises an outer guide catheter having a predefined bend at the distal end. For example, the outer guide catheter may be no larger than a 7 Fr catheter. According to the invention, various mechanisms may be used to alter the curvature of the predefined bend in the catheter, allowing an operator to easily place the distal end of an injection catheter at a desired treatment location. Alternatively, the injection catheter itself has a predefined bend at the distal end, wherein the curvature can be adjusted by adjusting the position of the injection catheter within a guide catheter.

    摘要翻译： 提供了一种具有小直径的直接注射系统，其可以容易地放置在期望的治疗位置，其中系统包括在远端具有预定弯曲的外导向导管。 例如，外引导导管可以不大于7Fr导管。 根据本发明，可以使用各种机构来改变导管中的预定弯曲的曲率，从而允许操作者容易地将注射导管的远端放置在期望的治疗位置。 或者，注射导管本身在远端处具有预定的弯曲部，其中可以通过调节引导导管内的注射导管的位置来调节曲率。

    Catheter with sensor tips, tool and device and methods of use of same
    5.
    发明授权
    Catheter with sensor tips, tool and device and methods of use of same 有权
    导管带传感器尖端，工具和装置及其使用方法

    公开(公告)号：US07565208B2

    公开(公告)日：2009-07-21

    申请号：US11037342

    申请日：2005-01-19

    申请人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

    发明人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

    IPC分类号： A61N1/02

    CPC分类号： A61B5/4839 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/6885 ,  A61M25/0084

    摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.

    摘要翻译： 一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。 注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。 通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。 如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

    Variable depth injection device and method
    8.
    发明授权
    Variable depth injection device and method 失效
    可变深度注射装置及方法

    公开(公告)号：US07678077B2

    公开(公告)日：2010-03-16

    申请号：US10781775

    申请日：2004-02-20

    申请人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley

    发明人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley

    IPC分类号： A61M5/00

    CPC分类号： A61M25/0606 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0084 ,  A61M2025/0089

    摘要： An apparatus for the injection of therapeutic and other agents at a target site within a patient's body. A catheter including a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also including a second elongated shaft slidingly disposed in the first elongated shaft, the second elongated shaft having a distal end and a proximal and a lumen extending therebetween. The catheter further including a third elongated shaft disposed in and attached to the second elongate shaft, the third elongated shaft to move in a one-to-one relationship with the first elongated shaft and the second elongated shaft to maintain a predetermined needle deployment length as each are subjected to various bend configurations.

    摘要翻译： 用于在患者体内的靶位置注射治疗剂和其它药剂的装置。 一种导管，其包括具有远端和近端的第一细长轴和在其间延伸的内腔。 导管还包括滑动地设置在第一细长轴中的第二细长轴，第二细长轴具有远端和近端以及在其间延伸的内腔。 所述导管还包括设置在所述第二细长轴中并连接到所述第二细长轴的第三细长轴，所述第三细长轴与所述第一细长轴和所述第二细长轴以一对一关系移动，以将预定的针展开长度保持为 每个都经受各种弯曲构造。

    MEDICAL DEVICE FOR VESSEL COMPATIBILITY DURING HIGH PRESSURE INFUSION
    10.
    发明申请
    MEDICAL DEVICE FOR VESSEL COMPATIBILITY DURING HIGH PRESSURE INFUSION 失效
    高压输液过程中血管相容性的医疗装置

    公开(公告)号：US20080039786A1

    公开(公告)日：2008-02-14

    申请号：US11780885

    申请日：2007-07-20

    申请人： Samuel J. EPSTEIN ,  Toby FREYMAN ,  Chad G. HARRIS ,  Timothy J. MICKLEY

    发明人： Samuel J. EPSTEIN ,  Toby FREYMAN ,  Chad G. HARRIS ,  Timothy J. MICKLEY

    IPC分类号： A61M25/10

    CPC分类号： A61M29/02 ,  A61B17/12022 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12131 ,  A61B17/12172 ,  A61B2017/1205 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1095

    摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

    摘要翻译： 本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。 根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。 可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。 这允许递送具有降低治疗部位损伤风险的治疗剂。 本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。