公开(公告)号：US07214384B2

公开(公告)日：2007-05-08

申请号：US10445642

申请日：2003-05-27

Applicant: Ronald N. Zuckermann ,  Chin-Yi Huang ,  John E. Murphy ,  Tetsuo Uno

Inventor： Ronald N. Zuckermann ,  Chin-Yi Huang ,  John E. Murphy ,  Tetsuo Uno

IPC: A61K9/127 ,  C08K5/20 ,  C12N15/00 ,  C07C231/00

CPC classification number: C12N15/87 ,  A61K47/645

Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

Abstract translation: 根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。 本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送到靶位点的载体。 特别地，本发明化合物有利于促进将多核苷酸递送至细胞。 本发明还提供了用于制备与递送载体​​复合的多核苷酸的稳定制剂的方法。

公开(公告)号：US20060079459A1

公开(公告)日：2006-04-13

申请号：US11302208

申请日：2005-12-14

Applicant: Bao-Lu Chen ,  Chin-Yi Huang

Inventor： Bao-Lu Chen ,  Chin-Yi Huang

IPC: A61K38/54

CPC classification number: A61K9/0014 ,  A61K38/57 ,  A61K47/12 ,  A61K47/18 ,  A61K47/183 ,  C07K14/8114

Abstract: Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and an antioxidant can lead to a significant improvement in the storage life of TFPI or TFPI variant compositions. The solubilizing agent and antioxidant substantially counteract the effects of TFPI or TFPI variant degradation through aggregation and oxidation.

Abstract translation: 组织因子途径抑制剂（TFPI）或TFPI变体的稳定含水组合物包含增溶剂，抗氧化剂和缓冲液。 增溶剂和抗氧化剂的组合可导致TFPI或TFPI变体组合物的储存寿命的显着改善。 增溶剂和抗氧化剂通过聚集和氧化基本上抵消了TFPI或TFPI变体降解的作用。

公开(公告)号：US20050081222A1

公开(公告)日：2005-04-14

申请号：US10682743

申请日：2003-10-08

Applicant: Chin-Yi Huang

Inventor： Chin-Yi Huang

IPC: G11B17/04 ,  G11B17/03 ,  G11B33/02

CPC classification number: G11B17/0515

Abstract: A slot-in type optical disk-loading apparatus includes first and second housings defining a disk slot. When a large diameter optical disk is inserted into the slot so that it is supported on a roller, a motor is activated to rotate the roller so as to move the optical disk rearwardly. The large diameter optical disk pushes two front limiting members away from each other so that two rear limiting members are removed from a disk path, thereby permitting the large diameter optical disk to move rearwardly into a disk holder unit along the disk path through a space between the front limiting members. When a small diameter optical disk is inserted into the slot, it is moved rearwardly into the disk holder unit through the space between the front limiting members and a space between the rear limiting members.

Abstract translation: 插入式光盘加载装置包括限定盘槽的第一和第二壳体。 当将大直径光盘插入槽中使其被支撑在辊上时，电动机被启动以使辊旋转，以使光盘向后移动。 大直径光盘将两个前限制构件彼此远离，使得两个后限制构件从盘路径移除，从而允许大直径光盘沿着盘路径向后移动到盘保持器单元中， 前限制成员。 当小直径光盘插入槽中时，其通过前限制构件之间的空间和后限制构件之间的空间向后移动到盘保持器单元中。

公开(公告)号：US06680506B2

公开(公告)日：2004-01-20

申请号：US10231505

申请日：2002-08-30

Applicant: Yun Chang ,  Chin-Yi Huang

Inventor： Yun Chang ,  Chin-Yi Huang

IPC: H01L2976

CPC classification number: H01L27/11521 ,  H01L21/28273 ,  H01L27/115 ,  H01L29/42324

Abstract: Methods are provided for forming a contoured floating gate for use in a floating gate memory cell. One method includes forming a floating gate that has a polysilicon layer over a substrate; forming oxide layers on opposing sides of the floating gate, the oxide layer having a vertical thickness greater than a vertical thickness of the floating gate; forming a spacer layer over the oxide layers and the floating gate; removing a portion of the spacer layer such that a top surface of the floating gate positioned laterally toward a middle region of the floating gate is exposed; and removing a portion of the floating gate underlying the exposed top surface of the middle region to form the contoured floating gate.

Abstract translation: 提供了用于形成用于浮动栅极存储单元的轮廓浮动栅极的方法。 一种方法包括形成在衬底上具有多晶硅层的浮置栅极; 在所述浮置栅极的相对侧上形成氧化物层，所述氧化物层具有大于所述浮动栅极的垂直厚度的垂直厚度; 在所述氧化物层和所述浮动栅极上形成间隔层; 去除间隔层的一部分，使得横向朝向浮动栅极的中间区域定位的浮动栅极的顶表面被暴露; 以及移除位于中间区域的暴露顶表面下方的浮动栅极的一部分以形成轮廓浮动栅极。

公开(公告)号：US06197332B1

公开(公告)日：2001-03-06

申请号：US09132808

申请日：1998-08-12

Applicant: Ronald N. Zuckermann ,  Chin-Yi Huang ,  John E. Murphy ,  Tetsuo Uno

Inventor： Ronald N. Zuckermann ,  Chin-Yi Huang ,  John E. Murphy ,  Tetsuo Uno

IPC: A61K9127

CPC classification number: C12N15/87 ,  A61K47/645

Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

Abstract translation: 根据本发明，提供了脂质共轭聚酰胺化合物及其相关组合物和方法。 本发明的脂质偶联的聚酰胺化合物特别可用作将生物活性剂递送到靶位点的载体。 特别地，本发明化合物有利于促进将多核苷酸递送至细胞。 本发明还提供了用于制备与递送载体​​复合的多核苷酸的稳定制剂的方法。

公开(公告)号：USD381774S

公开(公告)日：1997-07-29

申请号：US44826

申请日：1995-10-02

Applicant: Chin-Yi Huang

Designer： Chin-Yi Huang

公开(公告)号：USD380064S

公开(公告)日：1997-06-17

申请号：US44828

申请日：1995-10-02

Applicant: Chin-Yi Huang

Designer： Chin-Yi Huang

公开(公告)号：US20110059079A1

公开(公告)日：2011-03-10

申请号：US12875083

申请日：2010-09-02

Applicant: SUSAN JOYCE BABUKA ,  CHIN-YI HUANG ,  MINGXIANG LI

Inventor： SUSAN JOYCE BABUKA ,  CHIN-YI HUANG ,  MINGXIANG LI

IPC: A61K39/395 ,  A61K39/40 ,  A61P31/04 ,  A61P29/00

CPC classification number: G01N30/36 ,  A61K39/39591 ,  A61K2039/507 ,  C07K16/1282 ,  G01N25/20 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/394 ,  Y02A50/401 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/466 ,  Y02A50/469

Abstract: This invention relates to stable formulations of multiple antibodies comprising a plurality of antibodies and an effective amount of a succinate buffer wherein the pH of the formulation is between about 4.5 and about 7.0.

Abstract translation: 本发明涉及包含多种抗体和有效量的琥珀酸盐缓冲液的多种抗体的稳定制剂，其中制剂的pH为约4.5至约7.0。

公开(公告)号：US20080276767A1

公开(公告)日：2008-11-13

申请号：US11968307

申请日：2008-01-02

Applicant: Chin-Yi Huang

Inventor： Chin-Yi Huang

IPC: B25B7/16 ,  B25B7/02

CPC classification number: B25B7/02 ,  B25B7/123 ,  B25B13/00

Abstract: A pair of pliers include a fixed handle, a fixed jaw secured to the fixed handle and provided with a first toothed clamping portion and a first holding recess, a movable jaw pivotally mounted on the fixed handle and provided with a second toothed clamping portion and a second holding recess, and a movable handle pivotally mounted on the movable jaw. Thus, the pliers are used to operate a pipe by the second toothed clamping portion and the first toothed clamping portion and to operate a nut or screw by the second holding recess and the first holding recess, so that the pliers can be used to operate workpieces of two different types.

Abstract translation: 一对钳子包括固定手柄，固定在固定手柄上并具有第一齿形夹紧部分和第一保持凹口的固定夹爪，可枢转地安装在固定手柄上并具有第二齿形夹持部分和 第二保持凹部和可枢转地安装在可动夹爪上的可动手柄。 因此，钳子用于通过第二齿形夹持部分和第一齿形夹持部分操作管道，并且通过第二保持凹部和第一保持凹部操作螺母或螺钉，使得钳子可用于操作工件 的两种不同类型。

公开(公告)号：US06576514B2

公开(公告)日：2003-06-10

申请号：US09683213

申请日：2001-12-03

Applicant: Chen-Chin Liu ,  Chin-Yi Huang ,  Weng-Hsing Huang

Inventor： Chen-Chin Liu ,  Chin-Yi Huang ,  Weng-Hsing Huang

IPC: H01L21336

CPC classification number: H01L27/11521 ,  H01L21/76819 ,  H01L27/115 ,  H01L29/66545

Abstract: A semiconductor wafer includes a substrate, a polysilicon layer, and a sacrificial layer on the polysilicon layer. A dielectric layer is formed to cover the substrate and the sacrificial layer. A portion of the dielectric layer is removed to expose an upper portion of the sidewalls of the sacrificial layer. A passivation layer is formed on the surface of the dielectric layer and contacts the exposed sidewalls of the sacrificial layer. The passivation layer and the dielectric layer positioned over the sacrificial layer are removed down to a predetermined height by CMP. The dielectric layer is removed from the sacrificial layer, followed by removing the passivation layer and removing the sacrificial layer. A recess is thus formed with the polysilicon layer as the bottom of the recess and the remaining dielectric layer as the walls. Finally, another polysilicon layer is formed on the semiconductor wafer to form a floating gate.

Abstract translation: 半导体晶片包括多晶硅层上的衬底，多晶硅层和牺牲层。 形成介电层以覆盖基板和牺牲层。 去除介电层的一部分以暴露牺牲层的侧壁的上部。 在电介质层的表面上形成钝化层并与牺牲层的暴露的侧壁接触。 位于牺牲层上的钝化层和电介质层通过CMP被去除到预定的高度。 从牺牲层去除电介质层，然后去除钝化层并去除牺牲层。 因此形成凹槽，其中多晶硅层作为凹槽的底部，剩余的电介质层作为壁。 最后，在半导体晶片上形成另一个多晶硅层，形成浮栅。