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公开(公告)号：US20100099941A1
公开(公告)日：2010-04-22
申请号：US12646258
申请日：2009-12-23
Applicant: Yousef Haik , Ching-Jen Chen
Inventor： Yousef Haik , Ching-Jen Chen
IPC: A61N2/00
Abstract: Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.
Abstract translation: 提供磁性纳米颗粒组合物，其提供用于磁加热的固有温度调节剂，特别用于磁疗热疗医疗。 组合物包括居里温度为40至46℃，优选约42℃的磁性纳米颗粒，并且还可包括聚合物材料和任选的药物或放射增敏剂。 提供了对有需要的患者进行热疗治疗的方法，包括向患者施用包含居里温度在40至46℃之间的磁性纳米颗粒的组合物; 并将患者中的磁性纳米颗粒暴露于有效地在纳米颗粒中产生滞后热的交变磁场。
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公开(公告)号：US07081489B2
公开(公告)日：2006-07-25
申请号：US10215306
申请日：2002-08-08
Applicant: Ching-Jen Chen , Yousef Haik , Jhunu Chatterjee
Inventor： Ching-Jen Chen , Yousef Haik , Jhunu Chatterjee
IPC: C08K9/10
CPC classification number: B01J13/06
Abstract: Polymeric nanoencapsulation methods, which combine sonication and nonsolvent temperature induced crystallization, are provided. The steps include (a) providing active agent nanoparticles having an average diameter between about 5 and about 100 nm; (b) treating said active agent nanoparticles (e.g., a superparamagnetic material) with an anionic surfactant to form modified active agent nanoparticles; (c) mixing the modified active agent nanoparticles with a solution of a polymer in a solvent at a first temperature, which is greater than the melting temperature of the polymer and less than the boiling point of the solvent to form a first mixture, said mixing comprising the use of sonication; (d) mixing a non-solvent with the first mixture to form a second mixture, the non-solvent being a non-solvent for the solvent and for the polymer and having a boiling point greater than the melting temperature of the polymer; (e) sonicating the second mixture to form an emulsion; and (f) cooling the emulsion to a second temperature and at a rate effective to precipitate polymeric nanoparticles comprising the polymer with the modified active agent nanoparticles dispersed therein.
Abstract translation: 提供了结合超声处理和非溶剂温度诱导结晶的聚合纳米包封方法。 这些步骤包括（a）提供平均直径在约5至约100nm之间的活性剂纳米颗粒; （b）用阴离子表面活性剂处理所述活性剂纳米颗粒（例如超顺磁材料）以形成改性的活性剂纳米颗粒; （c）在第一温度下将改性的活性剂纳米颗粒与聚合物在溶剂中的溶液混合，所述第一温度大于聚合物的熔融温度并低于溶剂的沸点以形成第一混合物，所述混合 包括使用超声处理; （d）将非溶剂与第一混合物混合以形成第二混合物，所述非溶剂是溶剂和聚合物的非溶剂，并且具有大于聚合物熔点的沸点; （e）超声处理第二混合物以形成乳液; 和（f）将乳液冷却至第二温度并且以有效沉淀包含聚合物的聚合物纳米颗粒与其中分散有改性活性剂纳米颗粒的速率冷却。
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公开(公告)号：USD470385S1
公开(公告)日：2003-02-18
申请号：US29141318
申请日：2001-05-04
Applicant: Ching-Jen Chen
Designer： Ching-Jen Chen
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公开(公告)号：US4703674A
公开(公告)日：1987-11-03
申请号：US895114
申请日：1986-08-11
Applicant: Ching-Wen Chen , Ching-Jen Chen
Inventor： Ching-Wen Chen , Ching-Jen Chen
Abstract: An electrical pliers includes two posterior arms and two anterior arms overlapped and pivoted together, the posterior arms serving as handles and the anterior arms acting as jaw members. In the anterior arms are mounted wire stripping jaw members and wire clamping jaw members which extend transversely and partly out of the respective anterior arms. When the handles are depressed to approach one another, movable jaw members are moved to fixed jaw members in a direction parallel to a longitudinal axis of the pliers so as to clamp and cut the insulation layer of a wire, and then the anterior arms open to remove the cut portion of the insulation layer.
Abstract translation: 电钳包括两个后臂和两个前臂重叠并枢转在一起，后臂用作手柄，前臂用作颌部件。 在前臂中安装有线剥离钳口构件和线夹紧钳口构件，其横向地和部分地从相应的前臂延伸。 当把手被压下以相互接近时，可移动的钳口构件沿平行于钳子的纵向轴线的方向移动到固定的钳口构件，以便夹紧和切割线的绝缘层，然后前臂开口 去除绝缘层的切割部分。
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公开(公告)号：US4571764A
公开(公告)日：1986-02-25
申请号：US700713
申请日：1985-02-12
Applicant: Ching-Wen Chen , Ching-Jen Chen
Inventor： Ching-Wen Chen , Ching-Jen Chen
CPC classification number: H02G1/1212 , H01R43/05
Abstract: The double-sided plier with parts including a pair of handle bars, a body, a T member slideable relative to the body member, in which the T member has portions confronting a straight upper edge of the body and therebetween the stripping cutter and the terminal pressing member are mounted with respect to the two sides of the transverse section of the T member, their functions can be effected when operating the handle bars. The body is formed with notches extended inwardly from two side thereof, a fixed tool member and a movable tool member associated therewith are provided with shearing surfaces pressing surfaces which extend across the notches respectively, the fixed tool member and the movable tool member are mounted in a manner that they can be driven by the handle bars with a pivoting motion to cutting wires or pressing either isolated or bare terminals of wires.
Abstract translation: 所述双面钳具有包括一对把手杆，主体，相对于主体构件可滑动的T构件的部件，其中，T构件具有面对主体的直的上边缘的部分，以及剥离刀具和终端 按压构件相对于T构件的横截面的两侧安装，当操作把手时可以实现它们的功能。 主体形成有从其两侧向内延伸的凹口，固定工具构件和与其相关联的可移动工具构件设置有分别延伸穿过凹口的剪切表面按压表面，固定工具构件和可移动工具构件安装在 它们可以由手柄带动旋转运动来切割电线或按压电线的隔离或裸露端子。
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Patent Agency Ranking
公开(公告)号：US07308815B2
公开(公告)日：2007-12-18
申请号：US11335535
申请日：2006-01-20
Applicant: Ching-Jen Chen
Inventor： Ching-Jen Chen
IPC: H01R43/042
CPC classification number: H01R43/042 , Y10T29/5151 , Y10T29/53226
Abstract: A terminal crimping pliers is provided, which is designed with a simple structure, and is used to improve the disadvantages of the conventional terminal crimping pliers, such as being difficult to be grasped and difficult for forces applied thereon. The terminal crimping pliers can be extended with a small angle, through a vertical stopping slot combined with two stopping slots with oblique angles, and the terminal crimping pliers can be held closed with a small force.
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公开(公告)号：US06989196B2
公开(公告)日：2006-01-24
申请号：US10676406
申请日：2003-10-01
Applicant: Jhunu Chatterjee , Yousef Haik , Ching-Jen Chen
Inventor： Jhunu Chatterjee , Yousef Haik , Ching-Jen Chen
CPC classification number: B01J13/14 , Y10T428/2989
Abstract: Microencapsulation methods and products are provided. The method includes forming, at a first temperature, a emulsion which comprises aqueous microdroplets, including the agent (e.g., a magnetic material or drug) and a cross-linkable matrix material (e.g., a protein such as albumin), dispersed in a hydrophobic continuous phase comprising an oil and an oil-soluble surfactant, the first temperature being below the temperature effective to initiate cross-linking of the matrix material, and then heating the emulsion to a temperature and for a time effective to cause the matrix material to self-crosslink, to form microparticles comprising the agent encapsulated by the crosslinked matrix material.
Abstract translation: 提供微胶囊化方法和产品。 所述方法包括在第一温度下，形成包含水分微滴的乳液，所述微滴包括分散在疏水性的水性微滴中，所述微滴包括所述试剂（例如，磁性材料或药物）和可交联的基质材料（例如蛋白质如白蛋白） 连续相包含油和油溶性表面活性剂，第一温度低于有效引发基质材料交联的温度，然后将乳液加热至有效使基质材料自身的温度 交联，以形成包含由交联基质材料包封的试剂的微粒。
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公开(公告)号：US20050249817A1
公开(公告)日：2005-11-10
申请号：US11125488
申请日：2005-05-10
Applicant: Yousef Haik , Ching-Jen Chen
Inventor： Yousef Haik , Ching-Jen Chen
Abstract: Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include the steps of administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles.
Abstract translation: 提供磁性纳米颗粒组合物，其提供用于磁加热的固有温度调节剂，特别用于磁疗热疗医疗。 组合物包括居里温度为40至46℃，优选约42℃的磁性纳米颗粒，并且还可包括聚合物材料和任选的药物或放射增敏剂。 提供了对有需要的患者进行热疗治疗的方法，其包括向患者施用包含居里温度为40至46℃的磁性纳米颗粒的组合物的步骤; 并将患者中的磁性纳米颗粒暴露于有效地在纳米颗粒中产生滞后热的交变磁场。
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公开(公告)号：US20050239948A1
公开(公告)日：2005-10-27
申请号：US10831493
申请日：2004-04-23
Applicant: Yousef Haik , Jhunu Chatterjee , Ching-Jen Chen
Inventor： Yousef Haik , Jhunu Chatterjee , Ching-Jen Chen
CPC classification number: B82Y30/00 , B29C67/24 , B29K2105/18 , B29K2995/0005 , B29K2995/0008 , Y10S977/842 , Y10S977/845
Abstract: Methods are provided for aligning carbon nanotubes and for making a composite material comprising aligned carbon nanotubes. The method for aligning carbon nanotubes comprises adsorbing magnetic nanoparticles to carbon nanotubes dispersed in a fluid medium to form a magnetic particle-carbon nanotube composite in the fluid medium; and exposing the composite to a magnetic field effective to align the nanotubes in the fluid medium. The method for making a composite material comprising aligned carbon nanotubes comprises (1) adsorbing magnetic nanoparticles to carbon nanotubes to form a magnetic particle-carbon nanotube composite; (2) dispersing the magnetic particle-carbon nanotube composite in a fluid matrix material to form a mixture; (3) exposing the mixture to a magnetic field effective to align the nanotubes in the mixture; and (4) solidifying the fluid matrix material to form a nanotube/matrix material composite comprising the aligned nanotubes which remain aligned in the absence of said magnetic field.
Abstract translation: 提供了用于对准碳纳米管和制备包含对准的碳纳米管的复合材料的方法。 用于对准碳纳米管的方法包括将磁性纳米颗粒吸附到分散在流体介质中的碳纳米管上，以在流体介质中形成磁性颗粒 - 碳纳米管复合材料; 并将复合材料暴露于有效地将纳米管对准流体介质中的磁场。 制备包含排列碳纳米管的复合材料的方法包括（1）将磁性纳米颗粒吸附到碳纳米管上以形成磁性颗粒 - 碳纳米管复合材料; （2）将磁性颗粒 - 碳纳米管复合物分散在流体基质材料中以形成混合物; （3）将混合物暴露于有效地使纳米管在混合物中对准的磁场; 和（4）固化所述流体基质材料以形成纳米管/基体材料复合材料，其包含在没有所述磁场的情况下保持对准的排列的纳米管。
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公开(公告)号：US6129848A
公开(公告)日：2000-10-10
申请号：US461586
申请日：1999-12-16
Applicant: Ching-Jen Chen , Yousef Haik , Vinay M. Pai
Inventor： Ching-Jen Chen , Yousef Haik , Vinay M. Pai
IPC: G01N33/553 , A61K35/14 , A61M1/02 , B01D20060101 , B01D35/06 , B01D43/00 , B03C20060101 , B03C1/00 , B03C1/035 , B03C1/28 , G01N33/543
CPC classification number: B03C1/288 , B03C1/035 , G01N33/54326
Abstract: A magnetic system and apparatus having a multi-dimensional gradient for continuous, on-line separation of components from a mixture of chemical entities which comprises at least one separation chamber with a plurality of channels and a plurality of magnets, and a method is provided for continuously and magnetically separating and treating components of a mixture of chemical entities using a multi-dimensional gradient.
Abstract translation: 一种具有多维梯度的磁性系统和装置，用于从包括至少一个具有多个通道的分离室和多个磁体的化学实体的混合物的连续，在线分离组件，以及一种方法， 使用多维梯度连续地和磁性地分离和处理化学实体的混合物的组分。
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