Method for predicting responses to PDE4 inhibitors using biomarkers
    1.
    发明申请
    Method for predicting responses to PDE4 inhibitors using biomarkers 审中-公开
    使用生物标志物预测PDE4抑制剂反应的方法

    公开(公告)号:US20050033521A1

    公开(公告)日:2005-02-10

    申请号:US10640470

    申请日:2003-08-12

    IPC分类号: A61B5/00 G06F19/00

    摘要: Methods for predicting effectiveness of a PDE4 inhibitor are described. In one embodiment, a method includes administering a β2-agonist to a patient having asthma and applying a measurement to the patient to determine a treated result of the measurement. The measurement is configured to evaluate effectiveness of the β2-agonist for the patient. The method also includes predicting effectiveness of the PDE4 inhibitor for the patient based on the treated result of the measurement.

    摘要翻译: 描述了预测PDE4抑制剂有效性的方法。 在一个实施方案中,一种方法包括向患有哮喘的患者施用β2-激动剂,并向患者施加测量以确定治疗的测量结果。 该测量被配置为评估患者的β2-激动剂的有效性。 该方法还包括基于治疗的测量结果预测PDE4抑制剂对患者的有效性。

    Endoscopic Instrument
    2.
    发明申请
    Endoscopic Instrument 有权
    内窥镜仪器

    公开(公告)号:US20140121460A1

    公开(公告)日:2014-05-01

    申请号:US14063460

    申请日:2013-10-25

    IPC分类号: A61B1/005

    摘要: Endoscopic instrument with a control element, an instrument shaft, an adjustment element, a pull element and an actuator, and also with an intermediate element which is operatively connected to the control element and to the adjustment element, wherein the intermediate element has a first portion and a second portion, the first portion is connected to the second portion, the second portion has a greater bending resistance than the first portion, and the first portion has a measurement element for measuring a flexion of the first portion, wherein the adjustment element has a first abutment device, which defines a first movement range of the first portion relative to the adjustment element, and a second abutment device, which defines a second movement range of the second portion relative to the adjustment element, and the first movement range is smaller than the second movement range.

    摘要翻译: 具有控制元件,仪器轴,调节元件,拉动元件和致动器的内窥镜仪器,以及可操作地连接到控制元件和调节元件的中间元件,其中中间元件具有第一部分 以及第二部分,所述第一部分连接到所述第二部分,所述第二部分具有比所述第一部分更大的抗弯曲性,并且所述第一部分具有用于测量所述第一部分的屈曲的测量元件,其中所述调节元件具有 第一邻接装置,其限定第一部分相对于调节元件的第一移动范围;以及第二邻接装置,其限定第二部分相对于调节元件的第二移动范围,并且第一移动范围较小 比第二运动范围。

    Endoscopic Instrument
    3.
    发明申请
    Endoscopic Instrument 有权
    内窥镜仪器

    公开(公告)号:US20140221751A1

    公开(公告)日:2014-08-07

    申请号:US14174999

    申请日:2014-02-07

    IPC分类号: A61B1/005

    摘要: Endoscopic instrument with a control element, an instrument shaft, an adjustment element, a pull element, an actuator, an intermediate element which is operatively connected to the control element and to the adjustment element such that a force applied to the control element by the user can be transmitted to the adjustment element via the intermediate element in order to move the adjustment element, a detection device for detecting a torsion of the intermediate element, and an abutment device, which defines a free rotatory movement range of the control element relative to the adjustment element.

    摘要翻译: 具有控制元件,仪器轴,调节元件,拉动元件,致动器,可操作地连接到控制元件和调节元件的中间元件的内窥镜仪器,使得由用户施加到控制元件的力 可以经由中间元件传递到调节元件,以便移动调节元件,用于检测中间元件的扭转的检测装置和限定控制元件相对于该中间元件的自由旋转移动范围的抵接装置 调整元素

    Defining virtual patient populations
    4.
    发明申请
    Defining virtual patient populations 审中-公开
    定义虚拟患者人群

    公开(公告)号:US20070026365A1

    公开(公告)日:2007-02-01

    申请号:US11346990

    申请日:2006-02-03

    IPC分类号: G09B19/00

    摘要: The invention encompasses methods, including computer-implemented methods, of defining a virtual patient population and mapping the virtual patient population to a population of real patients. The invention utilizes virtual measures from one or more virtual patients, and data representative of multiple real subjects in a sample population, such as data collected from patients in a clinical trial or epidemiological study of a real population. The invention includes evaluating the similarity between the virtual patients and the real subjects, and assigning prevalences to the virtual patients based on the evaluation. The similarity can be assessed using some or all of the virtual measures of the virtual patients and some or all of the data obtained for the real subjects. Any of various goodness-of-fit measures can be used to evaluate the similarity or to help identify prevalences. The virtual patient population is defined as the virtual patients according to their respective prevalences.

    摘要翻译: 本发明涵盖包括计算机实现的方法,定义虚拟患者人群并将虚拟患者人群映射到真实病人群体的方法。 本发明利用来自一个或多个虚拟患者的虚拟测量,以及代表样本群体中的多个实际受试者的数据,例如在临床试验或对真实人群的流行病学研究中从患者收集的数据。 本发明包括评估虚拟患者与实际受试者之间的相似性,并根据评估将流行率分配给虚拟患者。 可以使用虚拟患者的一些或全部虚拟测量以及为真实对象获得的部分或全部数据来评估相似性。 可以使用任何适合度的措施来评估相似性或帮助确定流行率。 虚拟患者群体根据各自的流行率定义为虚拟患者。