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1.发明授权Methods for forming small-volume electrical contacts and material manipulations with fluid microchannels 有权用流体微通道形成小容量电触点和材料操作的方法公开(公告)号：US08083915B2
公开(公告)日：2011-12-27
申请号：US11875031
申请日：2007-10-19
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流动，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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2.发明授权公开(公告)号：US07931790B2
公开(公告)日：2011-04-26
申请号：US11875019
申请日：2007-10-19
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microehannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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3.发明授权Microfluidic systems and methods for transport and lysis of cells and analysis of cell lysate 有权微流体系统和细胞运输和裂解方法以及细胞裂解液的分析公开(公告)号：US07419575B2
公开(公告)日：2008-09-02
申请号：US10858096
申请日：2004-06-01
IPC分类号： G01N27/453 , C12M1/33 , C12N13/00
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/0487 , C12N1/066 , C12N13/00 , G01N27/44743
摘要： Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.
摘要翻译： 公开了微流体系统和方法，其适于运输和裂解测试样品的细胞组分用于分析。 公开的使用电场破裂细胞膜的微流体系统和方法引起非常快速的裂解，从而最小化持续的细胞活性并导致细胞过程分析的更高精度。
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4.发明授权Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate 失效微流体系统和细胞的运输和裂解方法以及细胞裂解物的分析公开(公告)号：US06783647B2
公开(公告)日：2004-08-31
申请号：US10041821
申请日：2001-10-19
IPC分类号： G01N27447
CPC分类号： B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/0487 , C12N1/066 , C12N13/00 , G01N27/44743
摘要： Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods, which employ an electric field to rupture the cell membrane, cause unusually rapid lysis, thereby minimizing continued cellular activity and resulting in greater accuracy of analysis of cell processes.
摘要翻译： 公开了微流体系统和方法，其适于运输和裂解测试样品的细胞组分用于分析。 公开的使用电场破裂细胞膜的微流体系统和方法引起非常快速的裂解，从而最小化持续的细胞活性并导致细胞过程分析的更高精度。
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5.发明授权公开(公告)号：US06685809B1
公开(公告)日：2004-02-03
申请号：US09244914
申请日：1999-02-04
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
IPC分类号： G01N27447
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流动，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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6.发明申请Methods for Forming Small-Volume Electrical Contacts and Material Manipulations With Fluid Microchannels 有权用流体微通道形成小体积电触头和材料操作的方法公开(公告)号：US20090032399A1
公开(公告)日：2009-02-05
申请号：US11875031
申请日：2007-10-19
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
IPC分类号： G01N27/447
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流动，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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7.发明申请公开(公告)号：US20080272000A1
公开(公告)日：2008-11-06
申请号：US11875027
申请日：2007-10-19
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流动，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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8.发明申请公开(公告)号：US20120273702A1
公开(公告)日：2012-11-01
申请号：US13265174
申请日：2010-04-19
IPC分类号： F16K31/02
CPC分类号： B01L3/50273 , B01L3/502707 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , B01L2400/0605 , B01L2400/0661
摘要： Disclosed are electroactive polymer actuators and their use on microfluidic devices. Such actuators can comprise an electrode, an electroactive polymer, and a fluid-conducting channel. The electroactive polymer can be at least partially disposed between the electrode and the fluid-conducting channel. Furthermore, methods for creating a hydrodynamic force in a microfluidic device are disclosed by creating a potential difference across an electroactive polymer disposed on the microfluidic device.
摘要翻译： 公开了电活性聚合物致动器及其在微流体装置上的应用。 这种致动器可以包括电极，电活性聚合物和导流通道。 电活性聚合物可以至少部分地设置在电极和导液通道之间。 此外，通过在布置在微流体装置上的电活性聚合物上产生电位差来公开在微流体装置中产生流体动力的方法。
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9.发明授权公开(公告)号：US07909973B2
公开(公告)日：2011-03-22
申请号：US11875027
申请日：2007-10-19
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microchannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流动，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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10.发明申请公开(公告)号：US20080128279A1
公开(公告)日：2008-06-05
申请号：US11875019
申请日：2007-10-19
申请人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
发明人： Stephen C. Jacobson , J. Michael Ramsey , Christopher T. Culbertson , William B. Whitten , Robert S. Foote
IPC分类号： G01N27/447
CPC分类号： B01D57/02 , B01D61/422 , B01D61/427 , B01D61/445 , B01L3/50273 , B01L3/502753 , B01L2200/10 , B01L2300/0816 , B01L2400/0415 , B01L2400/0418 , B01L2400/049 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44791
摘要： A microfabricated device employing a bridging membrane and methods for electrokinetic transport of a liquid phase biological or chemical material using the same are described. The bridging membrane is deployed in or adjacent to a microchannel and permits either ionic current flow or the transport of gas species, while inhibiting the bulk flow of material. The use of bridging membranes in accordance with this invention is applicable to a variety of processes, including electrokinetically induced pressure flow in a region of a microehannel that is not influenced by an electric field, sample concentration enhancement and injection, as well as improving the analysis of materials where it is desired to eliminate electrophoretic bias. Other applications of the bridging membranes according to this invention include the separation of species from a sample material, valving of fluids in a microchannel network, mixing of different materials in a microchannel, and the pumping of fluids.
摘要翻译： 描述了使用桥接膜的微制造装置和使用其的液相生物或化学材料的电动转运方法。 桥接膜部署在微通道中或邻近微通道，并允许离子电流流动或气体物质的输送，同时抑制材料的大量流动。 根据本发明的桥接膜的使用适用于各种工艺，包括不受电场影响的微通道区域中的电动感应压力流，样品浓度增强和注入，以及改进分析 需要消除电泳偏压的材料。 根据本发明的桥接膜的其它应用包括物质与样品材料的分离，微通道网络中的流体阀门，微通道中的不同材料的混合以及流体的泵送。
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