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公开(公告)号：US5980705A
公开(公告)日：1999-11-09
申请号：US942354
申请日：1997-10-01
IPC分类号： A61B5/0408 , A61B5/0478 , A61B5/0492 , C25B11/00 , C25B11/04 , G01N27/30
CPC分类号： G01N27/30
摘要： Nitric oxide-specific electrodes are useful for in situ detection of nitric oxide in biomedical applications and have at least a surface region thereof which is capable of forming complexes with nitric oxide, for example, nitrosyl complexes. The nitric oxide complexes formed at the surface of the electrodes apparently increase the concentration of nitric oxide available for detection, thereby leading to significantly improved relative responses as compared to other known nitric oxide electrode materials. Most preferably, the electrode has at least an exterior surface region which contains ruthenium and/or at least one oxide of ruthenium. The electrodes are advantageously conditioned in saline solution at +675 mV for about two hours.
摘要翻译： 一氧化氮特异性电极可用于在生物医学应用中原位检测一氧化氮，并且至少具有能与一氧化氮形成复合物的表面区域，例如亚硝酰基络合物。 在电极表面形成的一氧化氮络合物明显增加可用于检测的一氧化氮的浓度，从而与其它已知的一氧化氮电极材料相比，显着提高了相对响应。 最优选地，电极具有至少一个包含钌和/或至少一种钌氧化物的外表面区域。 电极有利地在盐水溶液中+675mV处理约2小时。
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公开(公告)号：US06287452B1
公开(公告)日：2001-09-11
申请号：US09399371
申请日：1999-09-20
IPC分类号： G01N2726
CPC分类号： G01N27/30
摘要： Nitric oxide-specific electrodes are useful for in situ detection of nitric oxide in biomedical applications and have at least a surface region thereof which is capable of forming complexes with nitric oxide, for example, nitrosyl complexes. The nitric oxide complexes formed at the surface of the electrodes apparently increase the concentration of nitric oxide available for detection, thereby leading to significantly improved relative responses as compared to other known nitric oxide electrode materials. Most preferably, the electrode has at least an exterior surface region which contains ruthenium and/or at least one oxide of ruthenium. The electrodes are advantageously conditioned in saline solution at +675 mV for about two hours.
摘要翻译： 一氧化氮特异性电极可用于生物医学应用中一氧化氮的原位检测，并且至少具有能与一氧化氮形成复合物的表面区域，例如亚硝酰基络合物。 在电极表面形成的一氧化氮络合物明显增加可用于检测的一氧化氮的浓度，从而与其它已知的一氧化氮电极材料相比，显着提高了相对响应。 最优选地，电极具有至少一个包含钌和/或至少一种钌氧化物的外表面区域。 电极有利地在盐水溶液中+675mV处理约2小时。
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3.发明授权
公开(公告)号：US5282467A
公开(公告)日：1994-02-01
申请号：US930002
申请日：1992-08-13
CPC分类号： A61B5/02007 , A61B5/02416 , A61B5/1455
摘要： A non-invasive method for detecting deep venous thrombosis in a human body wherein changes are effected in the amount of deoxyhemoglobin in the body limb by trapping blood in the venous system for a determinate time period and then releasing the trapped blood in the venous system. During the period that the changes in the amount of deoxyhemoglobin are effected, first and second light sources emit light of two selected wavelengths which penetrate into the deep venous system of the body limb so that the reflectance contributions can be used to measure changes in the flow and amount of deoxyhemoglobin and to thereby detect the presence or absence of deep venous thrombosis.
摘要翻译： 一种用于检测人体深静脉血栓形成的非侵入性方法，其中通过将静脉系统中的血液捕获确定的时间段，然后释放静脉系统中的被捕获的血液，从而在身体肢体中进行脱氧血红蛋白的量的变化。 在脱氧血红蛋白量的变化期间，第一和第二光源发射穿透身体肢体的深静脉系统的两个选定波长的光，使得反射率贡献可用于测量流动的变化 和脱氧血红蛋白的量，从而检测是否存在深静脉血栓形成。
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4.发明授权公开(公告)号：US06472390B1
公开(公告)日：2002-10-29
申请号：US09986807
申请日：2001-11-13
IPC分类号： A61K31535
CPC分类号： A61K31/21 , A61K31/223 , A61K31/5377
摘要： Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a therapeutically effective amount of a nitric oxide (NO) donor which is insufficient to acutely lower mean arterial blood pressure or pulmonary artery pressure by more than 10%. In one subgenus, NO donor is administered to modify red blood cell membrane receptors to prevent red blood cells from causing vasoconstriction. A related method which allows increased dosage of NO donor without acutely lowering mean arterial blood pressure comprises administering the NO donor into an artery of the patient. In another method, patients having a cardiovascular syndrome, or who are at risk for such, are administered a therapeutically effective amount of thiol which does not acutely affect blood pressure to a significant degree.
摘要翻译： 患有与包含半胱氨酸的蛋白质相关的平滑肌或疾病的病变状况或患有这种风险的患者的患者被给予治疗有效量的一氧化氮（NO）供体，其不足以急性降低平均动脉血 压力或肺动脉压力超过10％。 在一个亚属中，施用NO供体以修饰红细胞膜受体以防止红细胞引起血管收缩。 允许NO供体的增加剂量而不急性降低平均动脉血压的相关方法包括将NO供体施用到患者的动脉中。 在另一种方法中，具有心血管综合征或有风险的患者给予治疗有效量的硫酸盐，所述硫醇在很大程度上不会急剧影响血压。
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5.发明授权Method and apparatus for intravascularly measuring oxidative metabolism in body organs and tissues 失效用于血管内测量身体器官和组织中的氧化代谢的方法和装置
公开(公告)号：US5161531A
公开(公告)日：1992-11-10
申请号：US846284
申请日：1992-03-03
CPC分类号： A61K49/00 , A61B5/0086 , A61B5/02 , A61B5/14551
摘要： A method and apparatus for measuring oxidative metabolism in an internal organ or tissue of interest wherein a percutaneous intravascular approach is utilized to bring a light-transmitting and receiving scope into contact with the site to be assessed. The tip of the scope is adapted so that the light-transmitting optical fiber(s) and light-receiving optical fiber(s) are in divergent relationship so as to increase the photon pathlength through the tissue of interest to provide optical information from a substantial volume of tissue relative thereto.
摘要翻译： 用于测量感兴趣的内部器官或组织中的氧化代谢的方法和装置，其中使用经皮血管内途径使透光和接收范围与要评估的部位接触。 范围的尖端被适配成使得光传输光纤和光接收光纤处于发散关系，以便通过感兴趣的组织增加光子路径长度，以从实质的方向提供光学信息 相对于其组织的体积。
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6.发明授权Apparatus for intravascularly measuring oxidative metabolism in body organs and tissues 失效用于血管内测量身体器官和组织中的氧化代谢的装置
公开(公告)号：US5127408A
公开(公告)日：1992-07-07
申请号：US582756
申请日：1990-09-14
CPC分类号： A61K49/00 , A61B5/0086
摘要： A method and apparatus for measuring oxidative metabolism in an internal organ or tissue of interest wherein a percutaneous intravascular approach is utilized to bring a light-transmitting and receiving scope into contact with the site to be assessed. The tip of the scope is adapted so that the light-transmitting optical fiber(s) and light-receiving optical fiber(s) are in divergent relationship so as to increase the photon pathlength through the tissue of interest to provide optical information from a substantial volume of tissue relative thereto.
摘要翻译： 用于测量感兴趣的内部器官或组织中的氧化代谢的方法和装置，其中使用经皮血管内途径使透光和接收范围与要评估的部位接触。 范围的尖端被适配成使得光传输光纤和光接收光纤处于发散关系，以便通过感兴趣的组织增加光子路径长度，以从实质的方向提供光学信息 相对于其组织的体积。
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7.发明申请Non-Invasive Diagnostic Device for Early Detection of Infection and Inflammation and Methods of Use 审中-公开用于早期检测感染和炎症的非侵入性诊断装置和使用方法公开(公告)号：US20140039280A1
公开(公告)日：2014-02-06
申请号：US13957205
申请日：2013-08-01
IPC分类号： A61B5/00
CPC分类号： A61B5/412 , A61B5/082 , A61B5/14546 , A61B5/1477 , A61B5/443
摘要： The present disclosure provides, in part, a self-contained, point-of-care device for the early detection of infection, or other pathologic conditions that can lead to system inflammation, by the detection of the endogenous gaseous mediator nitric oxide (NO.) and methods of use.
摘要翻译： 本公开部分地通过检测内源性气体介体一氧化氮（NO。）来部分地提供用于早期检测感染或其它可能导致系统炎症的病理状况的独立的点护理装置。 ）和使用方法。
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公开(公告)号：US06964984B2
公开(公告)日：2005-11-15
申请号：US10608120
申请日：2003-06-30
申请人： Jonathan S. Stamler , Robert J. Lefkowitz , Erin J. Whalen , Walter J. Koch , Claude A. Piantadosi
发明人： Jonathan S. Stamler , Robert J. Lefkowitz , Erin J. Whalen , Walter J. Koch , Claude A. Piantadosi
IPC分类号： A61K45/00 , A61K20060101 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/21 , A61K31/223 , A61K31/5377 , A61K38/00 , A61K38/05 , A61K38/06 , A61P1/00 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61K31/13
CPC分类号： A61K31/21 , A61K31/19 , A61K31/223 , A61K31/5377 , A61K38/063
摘要： Desensitization of receptors that control disease is prevented by inhibiting G-protein receptor kinases. This has applicability, e.g., for patients with heart failure or on a left ventricular heart device or a heart pump after surgery or about to undergo surgery and at high risk for a cardiac event or on an opiate or addicted to opiate or with cystic fibrosis or rheumatoid arthritis.
摘要翻译： 通过抑制G蛋白受体激酶来防止控制疾病的受体的脱敏。 这具有适用性，例如对于患有心力衰竭的患者或手术后左心室心脏装置或心脏泵，或即将进行手术并且心脏事件或鸦片剂或阿片剂或成瘾患有高胆固醇或囊性纤维化的患者，或 类风湿关节炎。
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9.发明授权
公开(公告)号：US5512270A
公开(公告)日：1996-04-30
申请号：US299316
申请日：1994-08-31
IPC分类号： A61K9/12 , A61K9/06 , A61K9/08 , A61K31/765 , A61K31/77 , A61K31/775 , A61K47/10 , A61P9/00 , A61P11/00 , A61P11/12 , A61P43/00 , A61K31/045
CPC分类号： A61K31/775 , A61K31/765 , A61K31/77 , Y10S514/828 , Y10S514/851 , Y10S514/887
摘要： The present invention relates to use of alkylaryl polyether alcohol polymers as antioxidants to suppress certain oxidant chemical reactions that cause tissue injury and disease in mammals. Disclosed is a method of inhibiting oxidants using alkylaryl polyether alcohol polymers. More particularly, disclosed is a method for the treatment of mammalian disease entities related to overproduction of partially reduced oxygen species comprising administering to a mammal a treatment effective amount of an alkylaryl polyether alcohol polymer. The mammalian disease entities include, but are not limited to, myocardial infarction, stroke, adult respiratory distress syndrome, oxygen toxicity of the lung, lung injury from asbestos, Parkinson's disease, thermal and solar burns of the skin, and injury to the gastrointestinal tract from nonsteroidal anti-inflammatory agents.
摘要翻译： 本发明涉及使用烷基芳基聚醚醇聚合物作为抗氧化剂以抑制在哺乳动物中引起组织损伤和疾病的某些氧化剂化学反应。 公开了使用烷基芳基聚醚醇聚合物抑制氧化剂的方法。 更具体地，公开了一种用于治疗与部分还原氧物质过量产生有关的哺乳动物疾病实体的方法，包括向哺乳动物施用有效量的烷基芳基聚醚醇聚合物。 哺乳动物疾病实体包括但不限于心肌梗塞，中风，成人呼吸窘迫综合征，肺的氧毒性，来自石棉的肺损伤，帕金森病，皮肤的热和太阳灼伤以及对胃肠道的损伤 来自非甾体抗炎剂。
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10.发明授权
公开(公告)号：US5474760A
公开(公告)日：1995-12-12
申请号：US219770
申请日：1994-03-29
IPC分类号： A61K9/12 , A61K9/06 , A61K9/08 , A61K31/765 , A61K31/77 , A61K31/775 , A61K47/10 , A61P9/00 , A61P11/00 , A61P11/12 , A61P43/00
CPC分类号： A61K31/775 , A61K31/765 , A61K31/77 , Y10S514/828 , Y10S514/851 , Y10S514/887
摘要： A method and medicament for the inhibition of oxidants comprising administering a treatment effective amount of alkylaryl polyether alcohol polymers to a chemical or biologic system in need thereof. The medicament is preferably administered by aerosolization into the mammalian respiratory system. The medicament may also be applied to the mammalian skin. Preferably, the medicament includes a physiologically acceptable carrier which may be selected from the group consisting of physiologically buffered saline, isotonic saline, normal saline, petrolatum based ointments and U.S.P. cold cream.
摘要翻译： 用于抑制氧化剂的方法和药物，包括将有效量的烷基芳基聚醚醇聚合物施用于有需要的化学或生物体系。 药物优选通过气雾化给予哺乳动物呼吸系统。 药物也可以施用于哺乳动物皮肤。 优选地，药物包括生理上可接受的载体，其可以选自生理缓冲盐水，等渗盐水，生理盐水，凡士林基软膏和U.S.P。 冷奶油
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