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    BIODEGRADABLE FIBRE AND ITS PROCESS OF MANUFACTURE
    2.
    发明申请
    BIODEGRADABLE FIBRE AND ITS PROCESS OF MANUFACTURE 审中-公开
    生物可变光纤及其制造工艺

    公开(公告)号：US20120202398A1

    公开(公告)日：2012-08-09

    申请号：US13497209

    申请日：2010-10-21

    Applicant: Colin Marshall ,  Jamie Moffat

    Inventor： Colin Marshall ,  Jamie Moffat

    IPC: C08L1/12 ,  D03D15/00 ,  D01F6/18

    CPC classification number: A24D3/068 ,  A24D3/10 ,  B29C48/05 ,  D01F2/00 ,  D01F2/02 ,  D01F2/28 ,  Y10T442/30

    Abstract: The present invention concerns a biodegradable fibre comprising composite filaments of cellulose and cellulose acetate, and a process for making such a fibre comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibres. The invention also concerns materials made from such a fibre, and garments or soft furnishings made from such a material.

    Abstract translation: 本发明涉及包含纤维素和乙酸纤维素的复合长丝的生物可降解纤维，以及制备这种纤维的方法，包括提供溶液涂料，所述溶液涂料包含离子液体中的纤维素和乙酸纤维素的混合物或N-甲基吗啉酮-N-氧化物 （NMMO），并将共混物旋转浇铸成质子溶剂以产生纤维。 本发明还涉及由这种纤维制成的材料，以及由这种材料制成的衣服或软的家具。

    3,7-diamino-10H-phenothiazine salts and their use
    3.
    发明授权
    3,7-diamino-10H-phenothiazine salts and their use 有权
    3,7-二氨基-10H-吩噻嗪盐及其用途

    公开(公告)号：US07888350B2

    公开(公告)日：2011-02-15

    申请号：US12294599

    申请日：2007-03-28

    Applicant: Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    Inventor： Claude Michel Wischik ,  Janet Elizabeth Rickard ,  Charles Robert Harrington ,  David Horsley ,  John Mervyn David Storey ,  Colin Marshall ,  James Peter Sinclair ,  Thomas Craven Baddeley

    IPC: C07D279/18 ,  A61K31/5415

    CPC classification number: A61K31/5415 ,  C07D279/20 ,  C07D279/22 ,  C09B21/00 ,  Y02A50/393 ,  Y02A50/411

    Abstract: This invention pertains generally to the field of phenothiazine compounds, and more particularly to certain stably reduced phenothiazine compounds, specifically, certain 3,7 diamino-10H-phenothiazine (DAPTZ) compounds of the following formula wherein: each of R1 and R9 is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R3NA and R3NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of R7NA and R7NB is independently selected from: —H; C1-4alkyl; C2-4alkenyl; and halogenated C1-4alkyl; each of HX1 and HX2 is independently a protic acid; and pharmaceutically acceptable salts, solvates, and hydrates thereof. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease, and also as prodrugs for the corresponding oxidized thioninium drugs (for example, methythioninium chloride, MTC).

    Abstract translation: 本发明一般涉及吩噻嗪化合物领域，更具体地涉及某些稳定还原的吩噻嗪化合物，具体地，下列通式的某些3,7-二氨基-10H-吩噻嗪（DAPTZ）化合物其中：R 1和R 9各自独立地选自 从：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R3NA和R3NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; R7NA和R7NB中的每一个独立地选自：-H; C 1-4烷基; C2-4烯基; 和卤代C 1-4烷基; HX1和HX2各自独立地是质子酸; 及其药学上可接受的盐，溶剂化物和水合物。 这些化合物可用作药物，例如用于治疗tau蛋白病如阿尔茨海默氏病，以及作为相应的氧化硫堇药物（例如氯化甲硫氨酸，MTC）的前药。

    LOW EMISSIVITY FILM
    4.
    发明申请
    LOW EMISSIVITY FILM 有权
    低电感膜

    公开(公告)号：US20100173145A1

    公开(公告)日：2010-07-08

    申请号：US12601246

    申请日：2008-05-21

    Applicant: Colin Marshall ,  Paul Watters

    Inventor： Colin Marshall ,  Paul Watters

    IPC: B32B27/20 ,  B32B15/02 ,  B32B27/06 ,  B32B27/40 ,  B32B23/08

    CPC classification number: C08J7/047 ,  C08J2475/00 ,  C08K3/08 ,  C09D5/38 ,  C09D7/70 ,  Y10T428/249978 ,  Y10T428/25 ,  Y10T428/273 ,  Y10T428/31544 ,  Y10T428/31609 ,  Y10T428/31678

    Abstract: The present invention concerns a functional film material comprising a substrate layer and a coating layer, the coating layer comprising a block copolymeric binder and a particulate metal pigment therein, the ratio of pigment to binder in the coating layer being selected with reference to the coat weight to provide the functional film material with an emissivity of less than 0.5, and the substrate and coating layer being selected to provide the film with a VWTR (ambient) in excess 400 gm−2d−1 bar−1.

    Abstract translation: 本发明涉及一种包括基材层和涂层的功能性薄膜材料，所述涂层包含嵌段共聚物粘合剂和其中的颗粒状金属颜料，所述涂层中的颜料与粘合剂的比率是根据涂层重量来选择的 以提供功能薄膜材料的发射率小于0.5，并且选择衬底和涂层以使膜具有超过400gm-2d-1bar-1的VWTR（环境）。

    Methods of treatment of a tauopathy condition comprising the use of thioninium compounds
    5.
    发明授权
    Methods of treatment of a tauopathy condition comprising the use of thioninium compounds 有权
    包括使用硫铊化合物的tau病变病况的治疗方法

    公开(公告)号：US07737138B2

    公开(公告)日：2010-06-15

    申请号：US11391675

    申请日：2006-03-29

    Applicant: Claude M. Wischik ,  Janet E. Rickard ,  Charles R. Harrington ,  David Horsley ,  John M. D. Storey ,  Colin Marshall ,  James P. Sinclair ,  Han Wan Tan

    Inventor： Claude M. Wischik ,  Janet E. Rickard ,  Charles R. Harrington ,  David Horsley ,  John M. D. Storey ,  Colin Marshall ,  James P. Sinclair ,  Han Wan Tan

    IPC: A61K31/5415

    CPC classification number: C09B19/02 ,  C07D279/18

    Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

    Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文中称为“二氨基吩噻嗪鎓化合物”）的方法，包括氯化铁偶氮（MTC）（ 也称为亚甲基蓝）。 在一个实施方案中，该方法包括以下步骤：按顺序：亚硝基化（NOS）; 亚硝酰还原（NR）; 硫代磺酸形成（TSAF）; 氧化偶合（OC）; Cr（VI）还原（CR）; 两性离子中间体（IAPOZI）的分离和纯化; 闭环（RC）; 氯化物盐形成（CSF）; 一种：硫化物处理（ST）; 二甲基二硫代氨基甲酸酯处理（DT）; 碳酸盐处理（CT）; 乙二胺四乙酸处理（EDTAT）; 有机萃取（OE）; 和重结晶（RX）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及治疗和诊断方法等，例如对于tau蛋白病 ，阿尔茨海默病（AD），皮肤癌，黑素瘤，病毒性疾病，细菌性疾病或原生动物疾病。

    Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
    6.
    发明申请
    Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC) 有权
    二氨基吩噻嗪鎓化合物的化学合成和纯化方法，包括甲基硫堇（MTC）

    公开(公告)号：US20060287523A1

    公开(公告)日：2006-12-21

    申请号：US11391675

    申请日：2006-03-29

    Applicant: Claude Wischik ,  Janet Rickard ,  Charles Harrington ,  David Horsley ,  John Storey ,  Colin Marshall ,  James Sinclair ,  Han Tan

    Inventor： Claude Wischik ,  Janet Rickard ,  Charles Harrington ,  David Horsley ,  John Storey ,  Colin Marshall ,  James Sinclair ,  Han Tan

    IPC: C07D279/18

    CPC classification number: C09B19/02 ,  C07D279/18

    Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

    Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文中称为“二氨基吩噻嗪鎓化合物”）的方法，包括氯化铁偶氮（MTC）（ 也称为亚甲基蓝）。 在一个实施方案中，该方法包括以下步骤：按顺序：亚硝基化（NOS）; 亚硝酰还原（NR）; 硫代磺酸形成（TSAF）; 氧化偶合（OC）; Cr（VI）还原（CR）; 两性离子中间体（IAPOZI）的分离和纯化; 闭环（RC）; 氯化物盐形成（CSF）; 一种：硫化物处理（ST）; 二甲基二硫代氨基甲酸酯处理（DT）; 碳酸盐处理（CT）; 乙二胺四乙酸处理（EDTAT）; 有机萃取（OE）; 和重结晶（RX）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及治疗和诊断方法等，例如对于tau蛋白病 ，阿尔茨海默病（AD），皮肤癌，黑素瘤，病毒性疾病，细菌性疾病或原生动物疾病。

    Biodegradable composites
    7.
    发明授权
    Biodegradable composites 有权
    可生物降解复合材料

    公开(公告)号：US08833376B2

    公开(公告)日：2014-09-16

    申请号：US13497220

    申请日：2010-09-17

    Applicant: Colin Marshall ,  Jamie Moffat

    Inventor： Colin Marshall ,  Jamie Moffat

    IPC: A24D3/06 ,  D01F2/28 ,  D01F2/00 ,  B29C47/00 ,  A24D3/10 ,  D01F2/02

    CPC classification number: A24D3/068 ,  A24D3/10 ,  B29C47/0014 ,  D01F2/00 ,  D01F2/02 ,  D01F2/28 ,  Y10T442/30

    Abstract: The present invention concerns a biodegradable cigarette filter tow comprising composite filaments of cellulose and cellulose acetate, and a process for making such a filter tow comprising providing a solution dope comprising a blend of cellulose and cellulose acetate in an ionic liquid or in N-methylmorphilone-N-oxide (NMMO), and spinning casting the blend into a protic solvent to generate fibers or films, and converting the fibers or films into cigarette filter tow. The invention also concerns cigarette filters and cigarettes made from such a filter tow.

    Abstract translation: 本发明涉及一种包括纤维素和乙酸纤维素的复合长丝的可生物降解的香烟过滤丝束，以及制备这种过滤丝束的方法，包括提供溶液涂料，该溶液涂料包含离子液体中的纤维素和乙酸纤维素的混合物或N-甲基吗啉酮 - N-氧化物（NMMO），并将共混物纺丝成质子溶剂以产生纤维或膜，并将纤维或膜转化为香烟过滤丝束。 本发明还涉及由这种过滤丝束制成的香烟过滤嘴和香烟。

    CIGARETTE FILTER
    8.
    发明申请
    CIGARETTE FILTER 审中-公开
    香烟过滤器

    公开(公告)号：US20120192883A1

    公开(公告)日：2012-08-02

    申请号：US13384982

    申请日：2010-08-05

    Applicant: Paul Watters ,  Colin Marshall

    Inventor： Paul Watters ,  Colin Marshall

    IPC: A24D3/04 ,  A24D3/06

    CPC classification number: A24B15/28 ,  A24C5/56 ,  A24D1/02 ,  A24D3/04 ,  A24D3/06 ,  A24D3/068

    Abstract: The present invention concerns an at least partially transparent cigarette filter tipping film comprising a biodegradable substrate, and softener in an amount of less than 25% by weight of the biodegradable substrate, and a cigarette filter comprising a filtration material encased in a cylinder of the said tipping film.

    Abstract translation: 本发明涉及一种至少部分透明的卷烟过滤嘴，其包括可生物降解的基质和小于生物降解性基质重量的25重量％的软化剂，以及卷烟过滤嘴，其包括被包封在所述 翻转胶片

    METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INVOLVING THE USE OF PERSULFATE OXIDANTS
    9.
    发明申请
    METHODS OF CHEMICAL SYNTHESIS OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INVOLVING THE USE OF PERSULFATE OXIDANTS 有权
    涉及使用聚氨酯氧化物的二氨基苯并嗪化合物的化学合成方法

    公开(公告)号：US20120058995A1

    公开(公告)日：2012-03-08

    申请号：US13318907

    申请日：2010-05-11

    Applicant: Christopher Paul Larch ,  John Mervyn David Storey ,  Craig Williamson ,  Colin Marshall ,  Steven John Kemp

    Inventor： Christopher Paul Larch ,  John Mervyn David Storey ,  Craig Williamson ,  Colin Marshall ,  Steven John Kemp

    IPC: A61K31/5415 ,  C07C309/01 ,  A61P33/02 ,  A61P35/00 ,  A61P31/12 ,  A61P31/04 ,  C07D279/18 ,  A61P25/28

    CPC classification number: C07D279/18 ,  C07C381/02

    Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the e//i method comprises the steps of in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thio sulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD).

    Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文称为“二氨基吩噻嗪鎓化合物”）的方法，包括甲基硫堇（MTC） ）（也称为亚甲基蓝）。 在一个实施方案中，所述方法包括以下步骤：如下所示的硫代磺酸形成（TSAF），其中所述反应在硫代硫酸盐和氧化剂存在下进行，所述硫酸硫酸盐和氧化剂是或包含过硫酸盐 氧化偶联（OC）; 和闭环（RC）。 所得到的化合物和包含它们的组合物（例如片剂，胶囊剂）可用于治疗和诊断等方法，例如tau蛋白病或阿尔茨海默病（AD）。

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