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    Golf Ball Placement Apparatus
    1.
    发明申请
    Golf Ball Placement Apparatus 审中-公开
    高尔夫球放置装置

    公开(公告)号：US20100190563A1

    公开(公告)日：2010-07-29

    申请号：US12695741

    申请日：2010-01-28

    申请人： Craig A. SMITH

    发明人： Craig A. SMITH

    IPC分类号： A63B69/36

    CPC分类号： A63B57/0006 ,  A63B2210/50

    摘要： A golf ball placement apparatus, for holding and dispensing golf balls onto a tee automatically, comprises a base assembly, a hollow cylinder body attached to the base assembly, and a control arm attached to the base assembly and rotatable through a hinge point. The hollow cylinder body has an open end at top to allow multiple golf balls to be loaded and an open end at bottom to allow a bottom golf ball from said multiple golf balls to be dispensed. When the control arm is rotated downward, the bottom golf ball is forced onto the control arm for setting right onto a tee on the ground. When the control arm is lifted back to the initial up-position, another bottom golf ball from the multiple golf balls is scooped into the scoop ready for next dispensing.

    摘要翻译： 用于将高尔夫球自动保持和分配到三通上的高尔夫球放置装置包括基座组件，连接到基座组件的中空圆柱体，以及连接到基座组件并可通过铰链点旋转的控制臂。 中空圆柱体在顶部具有开口端，以允许多个高尔夫球被装载，底部的开口端允许来自所述多个高尔夫球的底部高尔夫球被分配。 当控制臂向下旋转时，底部高尔夫球被迫到控制臂上，用于设置在地面上的三通上。 当控制臂被提回到初始向上位置时，将来自多个高尔夫球的另一个底部高尔夫球舀入勺子中准备下一次分配。

    IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR
    2.
    发明申请
    IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR 审中-公开
    免疫组化及其用途

    公开(公告)号：US20090117112A1

    公开(公告)日：2009-05-07

    申请号：US12246291

    申请日：2008-10-06

    申请人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    发明人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P37/02

    CPC分类号： C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

    摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

    摘要翻译： 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

    Method of printing secure documents
    6.
    发明授权
    Method of printing secure documents 失效
    打印安全文件的方法

    公开(公告)号：US5983065A

    公开(公告)日：1999-11-09

    申请号：US898824

    申请日：1997-07-23

    申请人： Jeffrey J. Folkins ,  Michael M. Shahin ,  Craig A. Smith ,  Michael A. Parisi ,  Lingappa K. Mestha

    发明人： Jeffrey J. Folkins ,  Michael M. Shahin ,  Craig A. Smith ,  Michael A. Parisi ,  Lingappa K. Mestha

    IPC分类号： B41M3/14 ,  G03G21/04 ,  H04N1/00

    CPC分类号： H04N1/00795 ,  B41M3/14 ,  G03G21/043 ,  H04N1/00883 ,  H04N1/00925

    摘要： A method including:providing a facility with at least one controlled access electronic printing machine;printing original documents with the controlled access electronic printing machine, wherein printed images formed thereby arise from marking materials containing at least one photoactive additive;equipping all uncontrolled access reprographic devices within the facility with a secure illumination source capable of exposing an object document with sufficient intensity to activate the photoactive additive; andilluminating the object document with the secure illumination source of the uncontrolled access reprographic device, wherein the object documents having original document images printed thereon cannot be copied or scanned in a normal copy or scan illumination interval.

    摘要翻译： 一种方法，包括：向设施提供至少一个受控访问电子打印机; 用受控访问电子印刷机打印原始文件，其中形成的印刷图像由含有至少一种光活性添加剂的标记材料产生; 为设备内的所有不受控制的访问复制设备装备一个安全的照明源，能够以足够的强度曝光目标文件来激活光活性添加剂; 并且用不受控制的访问复制设备的安全照明源照亮对象文档，其中在其上打印有原始文档图像的对象文档不能以正常复印或扫描照明间隔被复制或扫描。

    Isolated viral protein TNF antagonists
    7.
    发明授权
    Isolated viral protein TNF antagonists 失效
    分离的病毒蛋白TNF拮抗剂

    公开(公告)号：US5464938A

    公开(公告)日：1995-11-07

    申请号：US292549

    申请日：1994-08-18

    申请人： Craig A. Smith ,  Raymond G. Goodwin

    发明人： Craig A. Smith ,  Raymond G. Goodwin

    IPC分类号： A61K38/00 ,  C07K14/065

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2710/24022

    摘要： Isolated viral proteins, and pharmaceutical compositions made therefrom, are disclosed which are capable of binding to cytokines, thereby functioning as cytokine antagonists. Also disclosed are processes for preparing isolated vital protein cytokine antagonists.

    摘要翻译： 公开了分离的病毒蛋白质和由其制备的药物组合物，其能够结合细胞因子，从而起细胞因子拮抗剂的作用。 还公开了制备分离的重要蛋白质细胞因子拮抗剂的方法。

    Manual sorter
    9.
    发明授权
    Manual sorter 失效
    手动分拣机

    公开(公告)号：US4011952A

    公开(公告)日：1977-03-15

    申请号：US541543

    申请日：1975-01-16

    申请人： Craig A. Smith ,  Leonard Schachner

    发明人： Craig A. Smith ,  Leonard Schachner

    IPC分类号： B65H29/60 ,  B07C7/02 ,  B41L43/10 ,  B65H31/24 ,  B65H39/10 ,  B65H39/11 ,  G03G15/00 ,  G06K17/00 ,  B42F7/10

    CPC分类号： B65H39/10 ,  B07C7/02 ,  B65H31/24

    摘要： A manual sorter and reproducing machine including the sorter. The sorter has a plurality of sheet receiving bins arranged one behind the other from front to back. The bins include sheet supporting surfaces which are oriented to provide efficient sheet stacking and jogging as well as ease of use and operator convenience. The sorter is adapted to be positioned adjacent the sheet output device of the machine with its front to back direction being transverse to the direction in which sheets are generally fed into or removed from the sheet output device.

    摘要翻译： 包括分拣机的手动分拣机和再现机。 分拣机具有从前到后一个彼此相邻布置的多个纸张接收箱。 箱体包括板支撑表面，其被定向以提供有效的纸张堆叠和点动以及易于使用和操作者便利。 分拣机适于定位在机器的纸张输出装置附近，其前后方向横向于纸张通常被输送到纸张输出装置或从纸张输出装置移除的方向。

    CD47 related compositions and methods for treating immunological diseases and disorders
    10.
    发明授权
    CD47 related compositions and methods for treating immunological diseases and disorders 有权
    CD47相关组合物和治疗免疫疾病和病症的方法

    公开(公告)号：US08377448B2

    公开(公告)日：2013-02-19

    申请号：US12687334

    申请日：2010-01-14

    申请人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Peter Probst

    发明人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Peter Probst

    IPC分类号： A61K39/00

    CPC分类号： C07K14/70596 ,  C07K2319/30

    摘要： Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.

    摘要翻译： 本文提供的是包含与Fc多肽融合的CD47细胞外结构域或其变体的融合多肽。 根据本文所述的方法，融合多肽可用于治疗受试者的免疫疾病或病症。 融合多肽能够抑制免疫细胞的免疫反应性，抑制促炎细胞因子的产生，包括抑制免疫复合物诱导的细胞因子产生。