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    IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR
    2.
    发明申请
    IMMUNOMODULATORY COMPOSITIONS AND USES THEREFOR 审中-公开
    免疫组化及其用途

    公开(公告)号：US20090117112A1

    公开(公告)日：2009-05-07

    申请号：US12246291

    申请日：2008-10-06

    申请人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    发明人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P37/02

    CPC分类号： C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

    摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

    摘要翻译： 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

    CD47 related compositions and methods for treating immunological diseases and disorders
    3.
    发明授权
    CD47 related compositions and methods for treating immunological diseases and disorders 有权
    CD47相关组合物和治疗免疫疾病和病症的方法

    公开(公告)号：US08377448B2

    公开(公告)日：2013-02-19

    申请号：US12687334

    申请日：2010-01-14

    申请人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Peter Probst

    发明人： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Peter Probst

    IPC分类号： A61K39/00

    CPC分类号： C07K14/70596 ,  C07K2319/30

    摘要： Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.

    摘要翻译： 本文提供的是包含与Fc多肽融合的CD47细胞外结构域或其变体的融合多肽。 根据本文所述的方法，融合多肽可用于治疗受试者的免疫疾病或病症。 融合多肽能够抑制免疫细胞的免疫反应性，抑制促炎细胞因子的产生，包括抑制免疫复合物诱导的细胞因子产生。

    Immunomodulatory compositions and uses therefor
    7.
    发明申请
    Immunomodulatory compositions and uses therefor 审中-公开
    免疫调节组合物及其用途

    公开(公告)号：US20070134234A1

    公开(公告)日：2007-06-14

    申请号：US11541449

    申请日：2006-09-29

    申请人： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    发明人： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C12N5/06 ,  C12P21/08

    CPC分类号： C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

    摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

    摘要翻译： 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

    Methods and vectors for expressing siRNA
    10.
    发明申请
    Methods and vectors for expressing siRNA 审中-公开
    用于表达siRNA的方法和载体

    公开(公告)号：US20050233994A1

    公开(公告)日：2005-10-20

    申请号：US10826130

    申请日：2004-04-16

    申请人： Ajamete Kaykas ,  Randall Moon

    发明人： Ajamete Kaykas ,  Randall Moon

    IPC分类号： A61K48/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/85 ,  C12Q1/68

    CPC分类号： C12N15/85 ,  C12N15/63

    摘要： In a first aspect, the invention provides expression vectors comprising: (a) a first RNA polymerase III promoter operably associated with a first RNA polymerase III termination signal and (b) a second RNA polymerase III promoter operably associated with a second RNA polymerase III termination signal, wherein the first and second RNA polymerase III promoters are oriented to promote bidirectional transcription of an insert disposed between the first and the second RNA polymerase III termination signals. In other aspects, the invention provide methods for using these expression vectors for inhibiting expression of target genes, for determining the effect of siRNAs on biological processes, and for identifying siRNAs that affect biological processes.

    摘要翻译： 在第一方面，本发明提供表达载体，其包含：（a）可操作地与第一RNA聚合酶III终止信号相关的第一RNA聚合酶III启动子和（b）与第二RNA聚合酶III终止子可操作地相关的第二RNA聚合酶III启动子 信号，其中所述第一和第二RNA聚合酶III启动子被定向以促进设置在所述第一和第二RNA聚合酶III终止信号之间的插入物的双向转录。 在其它方面，本发明提供了使用这些表达载体抑制靶基因表达，确定siRNA对生物学过程的影响以及鉴定影响生物学过程的siRNA的方法。