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公开(公告)号：US09200047B2
公开(公告)日：2015-12-01
申请号：US13028953
申请日：2011-02-16
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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2.发明授权Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof 失效分离的与HLA分子结合的非肽和十肽及其用途公开(公告)号：US07713714B2
公开(公告)日：2010-05-11
申请号：US10758673
申请日：2004-01-16
摘要： A method for inducing proliferation of cytolytic T cells is described.
摘要翻译： 描述了诱导溶细胞T细胞增殖的方法。
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公开(公告)号：US20060189001A1
公开(公告)日：2006-08-24
申请号：US10565315
申请日：2004-07-21
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： C07H21/04 , C12P21/06 , G01N33/543 , C07K14/74
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US20060051772A1
公开(公告)日：2006-03-09
申请号：US10936888
申请日：2004-09-09
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
CPC分类号： C07K14/4748 , A61K38/00 , C07K16/2833 , C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.
摘要翻译： 本发明描述了由SSX-4肿瘤相关基因编码的HLA II类结合肽，以及编码与其相关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-4基因表达为特征的病症的方法和产品。
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公开(公告)号：US20050079553A1
公开(公告)日：2005-04-14
申请号：US10937794
申请日：2004-09-09
申请人： Maha Ayyoub , Danila Valmori
发明人： Maha Ayyoub , Danila Valmori
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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6.发明授权Isolated nucleic acid molecules which encode peptides that bind to HLA molecules, and uses thereof 有权编码与HLA分子结合的肽的分离的核酸分子及其用途公开(公告)号：US07344879B2
公开(公告)日：2008-03-18
申请号：US09789649
申请日：2001-02-21
摘要： Nucleic acid molecules which encode decapeptides which are defined by an HLA-A2 binding motif are disclosed. Also disclosed are expression vectors which include these nucleic acid molecules.
摘要翻译： 公开了编码由HLA-A2结合基序定义的十肽的核酸分子。 还公开了包括这些核酸分子的表达载体。
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公开(公告)号：US06384190B1
公开(公告)日：2002-05-07
申请号：US09461083
申请日：1999-12-14
IPC分类号： A01N3734
摘要： Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.
摘要翻译： 公开了结合HLA分子并引发溶细胞T细胞增殖的非肽和十肽。 十肽终止于缬氨酸，并限制在其前三个氨基酸位置。 还公开了其它有用的壬肽。
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8.发明授权Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof 失效分离的与HLA分子结合的非肽和十肽及其用途
公开(公告)号：US06025470A
公开(公告)日：2000-02-15
申请号：US880963
申请日：1997-06-23
摘要： Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.
摘要翻译： 公开了结合HLA分子并引发溶细胞T细胞增殖的非肽和十肽。 十肽终止于缬氨酸，并限制在其前三个氨基酸位置。 还公开了其它有用的壬肽。
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公开(公告)号：US20110293648A1
公开(公告)日：2011-12-01
申请号：US13192759
申请日：2011-07-28
申请人： MAHA AYYOUB , DANILA VALMORI
发明人： MAHA AYYOUB , DANILA VALMORI
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与肽有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US20110144186A1
公开(公告)日：2011-06-16
申请号：US13028953
申请日：2011-02-16
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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