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    Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development
    1.
    发明授权
    Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development 有权
    孤立的澳大利亚珊瑚礁荧光蛋白和用于癌症药物开发的基于细胞的激酶或磷酸酶平台

    公开(公告)号：US08709981B2

    公开(公告)日：2014-04-29

    申请号：US13496574

    申请日：2010-09-16

    申请人： David Gruber ,  Hung-Teh Kao ,  Vincent Pieribone

    发明人： David Gruber ,  Hung-Teh Kao ,  Vincent Pieribone

    IPC分类号： C40B40/10

    CPC分类号： C07K14/43504 ,  C07K2319/60 ,  C12Q1/485 ,  G01N2333/43504

    摘要： The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are also provided. For example, methods to detect protein-protein interactions, to develop novel fluorescent reagents, to monitor cellular events, as well as cell-based methods for screening for kinase or phosphatase inhibitors, are set forth. Kits to carry out the methods of the invention are also taught.

    摘要翻译： 本发明涉及新型分离的荧光蛋白，其变体，以及编码该荧光蛋白的多核苷酸。 还提供了制备和使用多肽和多核苷酸的方法。 例如，阐述了检测蛋白质 - 蛋白质相互作用，开发新型荧光试剂，监测细胞事件以及用于筛选激酶或磷酸酶抑制剂的基于细胞的方法的方法。 还教导了实施本发明方法的试剂盒。

    Rice flour compositions
    2.
    发明申请
    Rice flour compositions 有权
    米粉成分

    公开(公告)号：US20050053715A1

    公开(公告)日：2005-03-10

    申请号：US10913002

    申请日：2004-08-06

    申请人： Maria Dolores-Martinez-Serna Villagran ,  Marko Stojanovic ,  David Gruber ,  David Chang

    发明人： Maria Dolores-Martinez-Serna Villagran ,  Marko Stojanovic ,  David Gruber ,  David Chang

    IPC分类号： A21D2/36 ,  A21D10/00 ,  A23K1/18 ,  A23L1/10 ,  A23L1/164 ,  A23L1/217

    CPC分类号： A21D2/362 ,  A23K50/40 ,  A23L7/117 ,  A23L7/13 ,  A23L7/198 ,  A23L19/19

    摘要： Rice flour compositions having a Peak Viscosity of from about 4 RVU to about 130 RVU. In one embodiment, the rice flour compositions have a Final Viscosity of from about 4 RVU to about 220 RVU. Preferably, the compositions have a WAI of from about 2.6 to about 9. In a preferred embodiment, the Peak Viscosity of the rice flour compositions is ≦about 55(WAI)-145. The compositions can be used to produce food products such as fabricated sheeted snacks, extruded products, sauces, coatings for fried foods, dog foods, dog biscuits, baby foods and breads. The preferred doughs formed from the inventive rice flour composition are sheetable and elastic, and fabricated snacks made from the doughs have the desired taste and texture characteristics. A dry blend for a preferred fabricated snack comprises from about 2% to about 100%, preferably from about 3% to about 33%, most preferably from about 4% to about 17%, of the rice flour composition.

    摘要翻译： 具有约4RVU至约130RVU的峰值粘度的米粉组合物。 在一个实施方案中，米粉组合物具有约4RVU至约220RVU的最终粘度。 优选地，组合物的WAI为约2.6至约9.在优选实施方案中，米粉组合物的峰值粘度为约55（WAI）-145。 组合物可用于生产食品，例如制成的薄片小吃，挤压产品，调味酱，油炸食品涂料，狗食，狗饼干，婴儿食品和面包。 由本发明的米粉组合物形成的优选面团是可成形和弹性的，并且由面团制成的制作的小吃具有期望的味道和质地特征。 用于优选制成的小吃的干混合物包含米粉组合物的约2％至约100％，优选约3％至约33％，最优选约4％至约17％。

    Bio-amplifier for sensing the bio-electric field of fish
    3.
    发明授权
    Bio-amplifier for sensing the bio-electric field of fish 失效
    用于感测鱼类生物电场的生物放大器

    公开(公告)号：US5307052A

    公开(公告)日：1994-04-26

    申请号：US871741

    申请日：1992-04-21

    申请人： Frank P. Harrison ,  David Gruber

    发明人： Frank P. Harrison ,  David Gruber

    IPC分类号： G01N33/18 ,  G08B23/00

    CPC分类号： G01N33/186

    摘要： The present invention provides a bio-amplifier in a water quality system. The bio-amplifier detects and amplifies a ventilatory behavior of a fish. The ventilatory behavior is converted to a signal. The signal is an instantaneous determination of the quality of water being tested.

    摘要翻译： 本发明提供一种水质系统中的生物放大器。 生物放大器检测并放大鱼的通气行为。 通气行为被转换为信号。 信号是对被测试水质的瞬时确定。

    Monitoring tank modules and array for use with biological sensors
    8.
    发明授权
    Monitoring tank modules and array for use with biological sensors 失效
    监控油箱模块和阵列，用于生物传感器

    公开(公告)号：US5140855A

    公开(公告)日：1992-08-25

    申请号：US611653

    申请日：1990-11-13

    申请人： David Gruber

    发明人： David Gruber

    IPC分类号： A01K63/04 ,  C02F3/00 ,  C02F3/32 ,  G01N33/18

    CPC分类号： A01K63/04 ,  C02F3/006 ,  C02F3/327 ,  G01N33/186 ,  Y02W10/18

    摘要： A monitoring tank for fish used as biological sensors wherein water being monitored for quality and toxins continuously flows. Extraneous noise is mostly eliminated by suitable grounding. Aluminum racks with slide guides support the multiple monitorin tanks for each access to the monitoring tanks. The water is discharged from the monitoring tanks into drain trays located under the aluminum racks.

    摘要翻译： 用作生物传感器的鱼的监测罐，其中监测质量和毒素的水持续流动。 外来噪音大多被适当的接地消除。 具有滑动导轨的铝制支架可以为每个进入监控箱的多个监视器舱提供支持。 水从监控箱排放到位于铝制机架下方的排水盘中。

    Sequencing means for photocopying processes
    9.
    发明授权
    Sequencing means for photocopying processes 失效
    复印过程的排序方法

    公开(公告)号：US4712907A

    公开(公告)日：1987-12-15

    申请号：US794129

    申请日：1985-11-01

    申请人： Joseph Weinberger ,  Gary S. Bricault ,  David Gruber ,  Eleonora Rakover

    发明人： Joseph Weinberger ,  Gary S. Bricault ,  David Gruber ,  Eleonora Rakover

    IPC分类号： G03G15/04 ,  G03G15/00

    CPC分类号： G03G15/04018

    摘要： An electrophotographic printing machine for reproducing an original document with a copy thereof having additional indicia thereon. A means such as a movable occluder bar is used to mask a region of photoconductive member from the illuminating means to prevent discharge at that region. Then a means to discharge selectively the masked region reocrds a latent image corresponding to the additional indicia.

    摘要翻译： 一种电子照相印刷机，用于再现具有其上附加标记的副本的原始文件。 使用诸如可移动封堵器杆的装置来遮蔽来自照明装置的光电导部件的区域，以防止在该区域的放电。 然后，选择性地放电被掩蔽区域的手段使对应于附加标记的潜像重新放纵。