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    SYSTEM, METHOD AND PROGRAM FOR PHARMACOKINETIC PARAMETER PREDICTION OF PEPTIDE SEQUENCE BY MATHEMATICAL MODEL
    2.
    发明申请
    SYSTEM, METHOD AND PROGRAM FOR PHARMACOKINETIC PARAMETER PREDICTION OF PEPTIDE SEQUENCE BY MATHEMATICAL MODEL 审中-公开
    用数学模型进行药代动力学参数预测的系统，方法与程序

    公开(公告)号：US20100121791A1

    公开(公告)日：2010-05-13

    申请号：US12513279

    申请日：2007-05-28

    申请人： Sang-Kee Kang ,  Min-Kyung Kim ,  Min-Kook Kim ,  Jun-Hyoung Kim ,  Jae-Min Shin ,  Cheol-Heui Yun ,  Ho-Kyoung Rhee ,  Dong-Hyun Jung ,  Eun-Kyoung Jung ,  Seung-Hoon Choi ,  Yun-Jaie Choi ,  Jin-Huk Choi

    发明人： Sang-Kee Kang ,  Min-Kyung Kim ,  Min-Kook Kim ,  Jun-Hyoung Kim ,  Jae-Min Shin ,  Cheol-Heui Yun ,  Ho-Kyoung Rhee ,  Dong-Hyun Jung ,  Eun-Kyoung Jung ,  Seung-Hoon Choi ,  Yun-Jaie Choi ,  Jin-Huk Choi

    IPC分类号： G06F15/18 ,  G06F17/10 ,  G06G7/60

    CPC分类号： G16B15/00 ,  G16B40/00

    摘要： The present invention relates to the system, method and program for the pharmacokinetic parameter prediction of peptide sequence by the mathematical model.The present invention is comprising the steps of acquiring a variety of peptide sequence having specific features by the experimental technique; acquiring, on the basis of the sequence, a variety of peptide sequences lacking the specific features; storing the acquired peptide sequences as each set respectively, followed by randomly extracting peptide sequences in the constant ratio to divide into a training set and a test set of mathematical model; allowing individual peptide sequence descriptor values and an activity value; training the set of training peptide by mathematical model; predicting pharmacokinetic parameter of the set of test peptide by the trained mathematical model; and validating the trained mathematical model. The present invention is useful because the pharmacokinetic parameter of peptide sequence, which are necessary for oral drug delivery, can be predicted in advance by not an experiment, but the program-storage medium, and cost and time can be reduced compared to an experiment as a result.

    摘要翻译： 本发明涉及通过数学模型对肽序列的药代动力学参数预测的系统，方法和程序。 本发明包括通过实验技术获得具有特定特征的各种肽序列的步骤; 在序列的基础上获得缺乏特定特征的多种肽序列; 分别存储获得的肽序列，然后以恒定比例随机提取肽序列，以分成训练集和数学模型的测试集合; 允许单个肽序列描述符值和活性值; 通过数学模型训练一套训练肽; 通过训练数学模型预测该组测试肽的药代动力学参数; 并验证训练有素的数学模型。 本发明是有用的，因为口服药物递送所必需的肽序列的药代动力学参数可以通过实验预先预测，但与实验相比可以减少程序储存培养基，并且可以降低成本和时间 结果。

    Electrolyte for lithium battery and lithium battery comprising same
    5.
    发明申请
    Electrolyte for lithium battery and lithium battery comprising same 有权
    锂电池用电解液和包含锂电池的锂电池

    公开(公告)号：US20060127776A1

    公开(公告)日：2006-06-15

    申请号：US11265779

    申请日：2005-11-01

    申请人： Dae-Yup Shin ,  Dong-Hyun Jung ,  Soo-Jin Park ,  Kyoung-Han Yew ,  Hyun-Jeong Lim

    发明人： Dae-Yup Shin ,  Dong-Hyun Jung ,  Soo-Jin Park ,  Kyoung-Han Yew ,  Hyun-Jeong Lim

    IPC分类号： H01M10/40 ,  H01M4/58 ,  H01M4/40

    CPC分类号： H01M10/0567 ,  H01M10/052 ,  H01M10/0568 ,  H01M10/0569

    摘要： The electrolyte for a lithium battery includes a non-aqueous organic solvent, a lithium salt, and an additive of the following Formula 1: wherein, X and Y are the same or different from each other and selected from O, S, CR2, or NR, where here R is H, a halogen, or an alkyl having a carbon number of less than or equal to 8, or neighboring alkyl groups are combined to each other to form a cycle or hetero cycle, and both X and Y are not oxygen (O), Ra to Rd are the same or different from each other and selected from H, a halogen, an alkoxy group having a carbon number of less than or equal to 8, or an unsaturated or saturated alkyl group having a carbon number of less than or equal to 8, or neighboring alkyl groups are combined to each other to form a cycle or hetero cycle, and at least one of Ra to Rd is a halogen.

    摘要翻译： 用于锂电池的电解质包括非水有机溶剂，锂盐和下式1的添加剂：其中X和Y彼此相同或不同，并且选自O，S，CR NR 2或NR，其中R为H，卤素或碳数小于或等于8的烷基或相邻的烷基彼此结合形成一个环或杂环 ，并且X和Y都不是氧（O），R a至R d彼此相同或不同，并且选自H，卤素，烷氧基 具有小于或等于8的碳数或碳数小于或等于8的不饱和或饱和烷基或相邻烷基的基团彼此组合以形成循环或异质循环，以及 R a至R d中的至少一个为卤素。

    APPARATUS FOR PRODUCING U3O8 POWDER
    7.
    发明申请
    APPARATUS FOR PRODUCING U3O8 POWDER 有权
    用于生产U3O8粉末的装置

    公开(公告)号：US20120063964A1

    公开(公告)日：2012-03-15

    申请号：US12972471

    申请日：2010-12-18

    申请人： DONG HYUN JUNG ,  Seung Jae Lee ,  Joon Ro Lee ,  Beom Jae Lee ,  Kyeong Lak Jeon ,  Jung Min Suh ,  Keun Min Kim ,  Myoung Ho Oh ,  Doo Lae Jeong ,  Nam Kyu Joo

    发明人： DONG HYUN JUNG ,  Seung Jae Lee ,  Joon Ro Lee ,  Beom Jae Lee ,  Kyeong Lak Jeon ,  Jung Min Suh ,  Keun Min Kim ,  Myoung Ho Oh ,  Doo Lae Jeong ,  Nam Kyu Joo

    IPC分类号： G21C1/00

    CPC分类号： C01G43/01 ,  F27B17/0016 ,  F27D5/0031

    摘要： In an apparatus for producing U3O8 powder, the apparatus has an oxidation reactor including an interior space, a scrap box loaded with UO2 sintered pellets to be oxidized and introduced into the interior space of the oxidation reactor, an impact generating unit applying an impact to the scrap box to dissipate heat generated by the oxidation of the UO2 sintered pellets in the oxidation reactor, and a control unit controlling an oxidation process. The apparatus for producing U3O8 powder allows the heat generated by the oxidation of the UO2 sintered pellets in the oxidation reactor to be uniformly dissipated by the impact generating unit, thus producing U3O8 powder having a larger specific surface area which can be used to obtain a sintered UO2 pellet with a larger and more stable grain size of increased quality.

    摘要翻译： 在用于生产U3O8粉末的装置中，该装置具有包括内部空间的氧化反应器，装载有待氧化并引入氧化反应器的内部空间的UO2烧结颗粒的废料箱，对冲击产生单元施加冲击 废气箱以消散由氧化反应器中的UO2烧结颗粒氧化产生的热量，以及控制氧化过程的控制单元。 用于制造U3O8粉末的装置允许由氧化反应器中的UO2烧结颗粒的氧化产生的热量被冲击产生单元均匀地消散，从而产生具有较大比表面积的U3O8粉末，其可用于获得烧结 UO2颗粒具有更大更稳定的粒度提高的质量。

    Electrolyte for lithium battery and lithium battery comprising same
    10.
    发明授权
    Electrolyte for lithium battery and lithium battery comprising same 有权
    锂电池用电解液和包含锂电池的锂电池

    公开(公告)号：US07482099B2

    公开(公告)日：2009-01-27

    申请号：US11259940

    申请日：2005-10-26

    申请人： Dae-Yup Shin ,  Dong-Hyun Jung ,  Soo-Jin Park ,  Kyoung-Han Yew ,  Hyun-Jeong Lim

    发明人： Dae-Yup Shin ,  Dong-Hyun Jung ,  Soo-Jin Park ,  Kyoung-Han Yew ,  Hyun-Jeong Lim

    IPC分类号： H01M10/40

    CPC分类号： H01M10/0565 ,  H01M6/168 ,  H01M10/0525 ,  H01M10/0566 ,  H01M10/0567

    摘要： The electrolyte for a lithium battery includes a non-aqueous organic solvent, a lithium salt, and an additive of the following Formula 1: wherein, X is O, S, CR2 or NR, where here R is H, a halogen, or an alkyl having a carbon number of less than or equal to 8, or neighboring alkyl groups are combined to each other to form a cycle or hetero cycle,Y1, and Y2 are the same or different from each other and selected from O, S, CR2, and NR, where here R is H, a halogen, or an alkyl having a carbon number of less than or equal to 8, or neighboring alkyl groups are combined to each other to form a cycle or hetero cycle,Y3 is S, CR2, or NR, where here R is H, a halogen, or an alkyl having a carbon number of less than or equal to 8, or neighboring alkyl groups are combined to each other to form a cycle or hetero cycle, andRa to Rd are the same or different from each other and selected from H, a halogen, an alkoxy group having a carbon number of less than or equal to 8, or an unsaturated or saturated alkyl group having a carbon number of less than or equal to 8, neighboring alkyl groups are combined to each other to form a cycle or hetero cycle.

    摘要翻译： 用于锂电池的电解质包括非水有机溶剂，锂盐和下式1的添加剂：其中X是O，S，CR 2或NR，其中R是H，卤素或 碳数小于或等于8的烷基或相邻的烷基彼此组合以形成循环或异质循环，Y1和Y2彼此相同或不同，并且选自O，S，CR2 和NR，其中R为H，卤素或碳数小于或等于8的烷基或相邻的烷基彼此结合形成一个环或杂环，Y 3为S，CR 2 或NR，其中R为H，卤素或碳数小于或等于8的烷基或相邻的烷基彼此结合形成一个循环或异质循环，Ra至Rd为 相同或不同，选自H，卤素，碳数小于或等于8的烷氧基，或不饱和或不饱和的 碳数小于或等于8的饱和烷基，相邻的烷基彼此组合以形成循环或异质循环。