-
公开(公告)号：US08691760B2
公开(公告)日：2014-04-08
申请号：US13147406
申请日：2010-02-02
Applicant: Dan Frenkel , Adi Kopelevich , Veronica Lifshitz , Tali Benromano , Nofit Borenstein
Inventor： Dan Frenkel , Adi Kopelevich , Veronica Lifshitz , Tali Benromano , Nofit Borenstein
IPC: A61K38/08 , A61K38/16 , A61K38/05 , A61K38/10 , A61P3/08 , A61P3/10 , A61P9/00 , A61P25/00 , A61P31/12 , C07K14/00 , C07K7/06 , C07K7/08
CPC classification number: A61K38/16
Abstract: Use of an isolated peptide comprising an amino acid sequence being no more than 25 amino acids in length, the amino acid sequence comprising at least one aspartate or a homolog thereof, the peptide having an Insulin-Degrading Enzyme (IDE) inhibitory activity, for the manufacture of a medicament identified for treating a disease selected from the group consisting of diabetes, obesity, hyperglycemia, retinal damage, renal failure, nerve damage, microvascular damage and varicella-zoster virus (VZV) infection is disclosed.
Abstract translation: 使用包含长度不超过25个氨基酸的氨基酸序列的分离肽，所述氨基酸序列包含至少一种天冬氨酸或其同源物，具有胰岛素降解酶（IDE）抑制活性的肽，用于 公开了鉴定用于治疗选自糖尿病，肥胖症，高血糖症，视网膜损伤，肾衰竭，神经损伤，微血管损伤和水痘带状疱疹病毒（VZV）感染的疾病的药物的制备。
-
公开(公告)号：US09757448B2
公开(公告)日：2017-09-12
申请号：US13579817
申请日：2011-02-24
Applicant: Howard Weiner , Dan Frenkel , Veronica Lifshitz
Inventor： Howard Weiner , Dan Frenkel , Veronica Lifshitz
IPC: A61K39/39 , A61K31/739 , A61K38/16 , A61K45/06
CPC classification number: A61K39/39 , A61K31/739 , A61K38/164 , A61K45/06
Abstract: Methods for treating and reducing risk of cerebral amyloid angiopathy (CAA) using nasal vaccination with a proteosome adjuvant.
-
3.发明申请公开(公告)号：US20080241169A1
公开(公告)日：2008-10-02
申请号：US11927606
申请日：2007-10-29
Applicant: Beka SOLOMON , Dan Frenkel
Inventor： Beka SOLOMON , Dan Frenkel
IPC: A61K39/395 , C07K16/18 , A61K35/76 , G01N33/53 , A61P25/00
CPC classification number: C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/6075 , C07K14/47 , C07K16/18 , C07K2317/34 , C07K2317/622 , C07K2319/00
Abstract: A strategy for immunizing against amyloid plaques using display technology. The strategy includes methods, agents, and pharmaceutical compositions for vaccination against plaque forming diseases (e.g., Alzheimer's disease) that rely upon presentation of an antigen or epitope on a display vehicle. The strategy further includes methods, agents, and pharmaceutical compositions for vaccination against plaque forming diseases (e.g., Alzheimer's disease) that rely upon presentation of an antibody, or an active portion thereof, on a display vehicle. Whether antigens or antibodies are employed, desegregation of plaques results from the immunization.
Abstract translation: 使用显示技术免疫淀粉样蛋白斑块的策略。 该策略包括依赖于在显示媒介载体上呈递抗原或表位的针对斑块形成疾病（例如阿尔茨海默氏病）接种疫苗的方法，药剂和药物组合物。 该策略还包括依赖于在显示媒介载体上呈递抗体或其活性部分的针对斑块形成疾病（例如阿尔茨海默氏病）接种疫苗的方法，药剂和药物组合物。 无论是使用抗原还是抗体，均免疫后产生斑块的分离。
-
4.发明授权Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases 有权治疗中枢神经系统（CNS）和神经退行性疾病的自身免疫性疾病的方法公开(公告)号：US08901074B2
公开(公告)日：2014-12-02
申请号：US13813969
申请日：2011-08-04
Applicant: Dan Frenkel , Hilit Levy , Nofit Borenstein , Dorit Farfara , Dorit Trudler
Inventor： Dan Frenkel , Hilit Levy , Nofit Borenstein , Dorit Farfara , Dorit Trudler
CPC classification number: C07K7/06 , A61K38/1709 , A61K47/50 , A61K47/554 , C07K7/08 , C07K14/001 , C07K14/4703
Abstract: An insulin degrading enzyme (IDE) inhibitor for use in the treatment of a disease selected from the group consisting of an autoimmune disease of the central nervous system and a neurodegenerative disease is disclosed.
Abstract translation: 公开了一种用于治疗选自中枢神经系统的自身免疫性疾病和神经变性疾病的疾病的胰岛素降解酶（IDE）抑制剂。
-
公开(公告)号：US20140039581A1
公开(公告)日：2014-02-06
申请号：US14005561
申请日：2012-03-25
Applicant: Uri Oron , Hana Tuby , Dan Frenkel , Dorit Farfara
Inventor： Uri Oron , Hana Tuby , Dan Frenkel , Dorit Farfara
IPC: A61N5/06
CPC classification number: A61N5/0618 , A61N5/0601 , A61N5/0603 , A61N2005/005 , A61N2005/0612 , A61N2005/063 , A61N2005/0645 , A61N2005/0651 , A61N2005/0659 , A61N2005/0662 , A61N2005/067
Abstract: Methods and systems are provided for delivering visible or infrared biostimulatory energy to bone marrow to subjects having or developing Alzheimer's disease. The radiation is delivered to sites remote from the brain at a dose sufficient to cause stimulated mesenchymal stem cells to appear in the brain and degrade β-amyloid. The energy may be coherent light and can be administered transcutaneously, subcutaneously, or via an intramedullary probe.
Abstract translation: 提供的方法和系统用于将可见或红外生物刺激能量递送至具有或发展阿尔茨海默病的受试者的骨髓。 辐射以足以引起刺激的间充质干细胞出现在脑中并降低β-淀粉样蛋白的剂量被输送到远离脑的部位。 能量可以是相干光，并且可以经皮，皮下或经髓内探针施用。
-
Patent Agency Ranking
公开(公告)号：US06703015B1
公开(公告)日：2004-03-09
申请号：US09473653
申请日：1999-12-29
Applicant: Beka Solomon , Dan Frenkel
Inventor： Beka Solomon , Dan Frenkel
IPC: A01K6300
CPC classification number: C07K14/4711 , A61K38/1709 , A61K39/0007 , A61K2039/6075 , C07K14/47 , C07K16/18 , C07K2317/34 , C07K2317/622 , C07K2319/00
Abstract: A strategy for immunizing against amyloid plaques using display technology. The strategy includes methods, agents, and pharmaceutical compositions for vaccination against plaque forming diseases (e.g. Alzheimer's disease) which rely upon presentation of an antigen or epitope on a display vehicle. The strategy further includes methods, agents, and pharmaceutical compositions for vaccination against plaque forming diseases (e.g. Alzheimer's disease) which rely upon presentation of an antibody, or an active portion thereof, on a display vehicle. Whether antigens or antibodies are employed, desegregation of plaques results from the immunization.
Abstract translation: 使用显示技术免疫淀粉样蛋白斑块的策略。 该策略包括依赖于在显示媒介载体上呈递抗原或表位的针对斑块形成疾病（例如阿尔茨海默病）接种疫苗的方法，药剂和药物组合物。 该策略还包括依赖于在显示载体上呈递抗体或其活性部分的针对斑块形成疾病（例如阿尔茨海默氏病）接种疫苗的方法，药剂和药物组合物。 无论是使用抗原还是抗体，均免疫后产生斑块分解。
-
公开(公告)号：US20130183245A1
公开(公告)日：2013-07-18
申请号：US13579817
申请日：2011-02-24
Applicant: Howard Weiner , Dan Frenkel , Veronica Lifshitz
Inventor： Howard Weiner , Dan Frenkel , Veronica Lifshitz
CPC classification number: A61K39/39 , A61K31/739 , A61K38/164 , A61K45/06
Abstract: Methods for treating and reducing risk of cerebral amyloid angiopathy (CAA) using nasal vaccination with a proteosome adjuvant.
Abstract translation: 用蛋白质体佐剂鼻腔接种治疗和降低脑淀粉样血管病（CAA）风险的方法。
-
8.发明申请METHODS OF TREATING AUTOIMMUNE DISEASES OF THE CENTRAL NERVOUS SYSTEM (CNS) AND NEURODEGENERATIVE DISEASES 有权治疗中枢神经系统（CNS）和神经源性疾病的自身免疫性疾病的方法公开(公告)号：US20130130976A1
公开(公告)日：2013-05-23
申请号：US13813969
申请日：2011-08-04
Applicant: Dan Frenkel , Hilit Levy , Nofit Borenstein , Dorit Farfara , Dorit Trudler
Inventor： Dan Frenkel , Hilit Levy , Nofit Borenstein , Dorit Farfara , Dorit Trudler
CPC classification number: C07K7/06 , A61K38/1709 , A61K47/50 , A61K47/554 , C07K7/08 , C07K14/001 , C07K14/4703
Abstract: An insulin degrading enzyme (IDE) inhibitor for use in the treatment of a disease selected from the group consisting of an autoimmune disease of the central nervous system and a neurodegenerative disease is disclosed.
Abstract translation: 公开了一种用于治疗选自中枢神经系统的自身免疫性疾病和神经变性疾病的疾病的胰岛素降解酶（IDE）抑制剂。
-
公开(公告)号：US20100144868A1
公开(公告)日：2010-06-10
申请号：US11795808
申请日：2006-01-22
Applicant: Michael Gozin , Howard L. Weiner , Alon Monsonego , Amnon Bar-Shir , Yoni Engel , Dan Frenkel
Inventor： Michael Gozin , Howard L. Weiner , Alon Monsonego , Amnon Bar-Shir , Yoni Engel , Dan Frenkel
CPC classification number: B82Y5/00 , A61K47/6949
Abstract: Disclosed are novel hybrid compounds having a fullerene core residue, one or more bioavailability enhancing moieties and one or more glutamate receptor ligand residues, whereby the bioavailability enhancing moiety allow the compound to reach an effective concentration in physiological media and pass the blood-brain barrier, as defined in the specification. Also disclosed are pharmaceutical compositions containing these hybrid compounds and uses thereof as antioxidants and/or neuroprotective agents for the treatment of medical conditions associated with oxidative stress and/or neural damage, such as, for example, neurological diseases, disorders and trauma, and hence in the treatment of CNS-associated diseases, disorders and trauma, as well as to uses thereof as antiviral, antibacterial, antiglycemic, antiarrhythmic, antidepressant and antitumor agents.
Abstract translation: 公开了具有富勒烯核心残基，一个或多个生物利用度增强部分和一个或多个谷氨酸受体配体残基的新型杂化化合物，由此生物利用度增强部分允许化合物在生理介质中达到有效浓度并通过血脑屏障， 如说明书中所定义。 还公开了含有这些杂化化合物的药物组合物及其作为抗氧化剂和/或神经保护剂的用途，用于治疗与氧化应激和/或神经损伤（例如神经疾病，病症和创伤）相关的医学病症，因此 在治疗CNS相关疾病，病症和创伤方面，以及其用作抗病毒，抗菌，抗血糖，抗心律失常药，抗抑郁药和抗肿瘤剂的用途。
-
公开(公告)号：US09403030B2
公开(公告)日：2016-08-02
申请号：US14005561
申请日：2012-03-25
Applicant: Uri Oron , Hana Tuby , Dan Frenkel , Dorit Farfara
Inventor： Uri Oron , Hana Tuby , Dan Frenkel , Dorit Farfara
CPC classification number: A61N5/0618 , A61N5/0601 , A61N5/0603 , A61N2005/005 , A61N2005/0612 , A61N2005/063 , A61N2005/0645 , A61N2005/0651 , A61N2005/0659 , A61N2005/0662 , A61N2005/067
Abstract: Methods and systems are provided for delivering visible or infrared biostimulatory energy to bone marrow to subjects having or developing Alzheimer's disease. The radiation is delivered to sites remote from the brain at a dose sufficient to cause stimulated mesenchymal stem cells to appear in the brain and degrade β-amyloid. The energy may be coherent light and can be administered transcutaneously, subcutaneously, or via an intramedullary probe.
Abstract translation: 提供的方法和系统用于将可见或红外生物刺激能量递送至具有或发展阿尔茨海默病的受试者的骨髓。 辐射以足以引起刺激的间充质干细胞出现在脑中并降低β-淀粉样蛋白的剂量被输送到远离脑的部位。 能量可以是相干光，并且可以经皮，皮下或经髓内探针施用。
-
-
-
-
-
-
-
-
-
Search Results
15
records
(took 0.017 seconds)
