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公开(公告)号：US08080646B2
公开(公告)日：2011-12-20
申请号：US12402854
申请日：2009-03-12
申请人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelly Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelly Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US07537762B2
公开(公告)日：2009-05-26
申请号：US11517530
申请日：2006-09-06
申请人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelley Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Shelley Sims Belouski , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , Sirid Aimee Kellerman , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US20100197005A1
公开(公告)日：2010-08-05
申请号：US12402854
申请日：2009-03-12
申请人： Shelley Sims Belouski , Sirid-Aimee Kellermann , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Shelley Sims Belouski , Sirid-Aimee Kellermann , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US09221915B2
公开(公告)日：2015-12-29
申请号：US13282065
申请日：2011-10-26
申请人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like, kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及抗体，其包括结合激活素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分，其功能是消除ALK-1 / TGF- β-1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US20120052074A1
公开(公告)日：2012-03-01
申请号：US13282065
申请日：2011-10-26
申请人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
发明人： Shelley Sims Belouski , Sirid-Aimée Kellerman , Michael Aidan North , Karin Kristina Amundson , Vahe Bedian , Dana Dan Hu-Lowe , Xin Jiang , Shannon Marie Karlicek , James Arthur Thomson , Jianying Wang , Grant Raymond Wickman , Jingchuan Zhang
IPC分类号： A61K39/395 , A61P27/02 , A61P17/06 , A61P31/04 , A61P27/06 , A61P29/00 , A61P31/12 , A61P35/00 , A61P19/02
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like, kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及抗体，其包括结合激活素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分，其功能是消除ALK-1 / TGF- β-1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US08039596B2
公开(公告)日：2011-10-18
申请号：US12365638
申请日：2009-02-04
申请人： Steven Lee Bender , Gerald Fries Casperson , Dana Dan Hu-Lowe , Xin Jiang , Gang Li , Michael Aidan North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven Lee Bender , Gerald Fries Casperson , Dana Dan Hu-Lowe , Xin Jiang , Gang Li , Michael Aidan North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US20070065444A1
公开(公告)日：2007-03-22
申请号：US11517530
申请日：2006-09-06
申请人： Michael North , Karin Amundson , Vahe Bedian , Shelley Belouski , Dana Hu-Lowe , Xin Jiang , Shannon Karlicek , Sirid Kellermann , James Thomson , Jianying Wang , Grant Wickman , Jingchuan Zhang
发明人： Michael North , Karin Amundson , Vahe Bedian , Shelley Belouski , Dana Hu-Lowe , Xin Jiang , Shannon Karlicek , Sirid Kellermann , James Thomson , Jianying Wang , Grant Wickman , Jingchuan Zhang
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译： 本发明涉及包含结合活化素受体样激酶-1（ALK-1）的细胞外结构域（ECD）的人抗体及其抗原结合部分的抗体，其功能是消除ALK-1 / TGF-β -1 / Smad1信号通路。 本发明还涉及源自人抗ALK-1抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗ALK-1抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。
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公开(公告)号：US08399647B2
公开(公告)日：2013-03-19
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US20120009622A1
公开(公告)日：2012-01-12
申请号：US13237502
申请日：2011-09-20
申请人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
发明人： Steven L. Bender , Gerald F. Casperson , Dana D. Hu-Lowe , Xin Jiang , Gang Li , Michael A. North , Jianying Wang , Grant Wickman , Peter Brams , Haichun Huang , Brigitte Devaux , Haibin Chen , Dawn M. Tanamachi , Kristopher Toy , Lan Yang , Tim W. Sproul , Mark Yamanaka
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.
摘要翻译： 本公开提供以高亲和力特异性结合整联蛋白α5和bgr1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。 本公开还提供了使用本文所述的抗α5和bgr1抗体或其抗原结合部分治疗各种癌症的方法。
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公开(公告)号：US09572517B2
公开(公告)日：2017-02-21
申请号：US13700660
申请日：2011-03-03
申请人： Seng Tat Ng , Xin Jiang , Hwee Siong Chong
发明人： Seng Tat Ng , Xin Jiang , Hwee Siong Chong
CPC分类号： A61B5/0816 , A47D15/003 , A61B5/0059 , A61B5/1128 , A61B5/6807 , A61B5/6892 , A61B5/7278 , A61B5/7282 , A61B5/7455 , A61B5/746 , G01L1/242
摘要： A Baby Monitoring Mat is provided having a top mesh layer, a bottom mesh layer, two flexible sheets, and an optical cable. The optical cable can be routed between the top mesh layer and the bottom mesh layer. The flexible sheets are also between the top mesh layer and the bottom mesh layer forming a sensing area. A light source is provided for feeding light from one side of the optical cable to a photodiode for detecting light attenuation at the other end of the optical cable. A processor receives signals from the light source and photodiode and the signals are processed to determine movements and breath counts. The signals are generated based on the light attenuation changes along the optical fiber cable detected by photodiode. A method for monitoring baby on a mat is also provided.
摘要翻译： 提供了具有顶部网格层，底部网格层，两个柔性片和光缆的婴儿监视垫。 光缆可以在顶部网格层和底部网格层之间布置。 柔性片材也位于顶部网格层和底部网格层之间，形成感测区域。 提供光源用于将光从光缆的一侧馈送到用于检测光缆另一端的光衰减的光电二极管。 处理器从光源和光电二极管接收信号，并处理信号以确定运动和呼吸计数。 信号是根据由光电二极管检测到的光纤电缆的光衰减而产生的。 还提供了一种用于在垫上监测婴儿的方法。
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