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公开(公告)号：US09193827B2
公开(公告)日：2015-11-24
申请号：US13819280
申请日：2011-08-26
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译： 使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。 本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。 当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。 这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。 此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。 这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。 本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。
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公开(公告)号：US08562966B2
公开(公告)日：2013-10-22
申请号：US13312224
申请日：2011-12-06
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译： 聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。 使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。 本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。 末端修饰的聚合物特别可用于递送核酸如DNA或RNA。 本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。
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公开(公告)号：US08226934B2
公开(公告)日：2012-07-24
申请号：US12147397
申请日：2008-06-26
申请人： Daniel Griffith Anderson , Amir Nashat , Mitchell John Derosa , David Thomas Puerta , Ronald P. McLaughlin , Bryan Scott Akcasu , Susan Alice Williams , Richard Matthew Ramirez
发明人： Daniel Griffith Anderson , Amir Nashat , Mitchell John Derosa , David Thomas Puerta , Ronald P. McLaughlin , Bryan Scott Akcasu , Susan Alice Williams , Richard Matthew Ramirez
CPC分类号： A61K8/37 , A61K8/8152 , A61Q5/06 , A61Q5/12 , A61Q9/02
摘要： The present invention provides kits and methods for treating hair on the scalp comprising non-toxic compositions providing beneficial effects on hair without employing high temperatures, free radical initiators or rinsing hair after applying the compositions.
摘要翻译： 本发明提供了用于治疗头皮上的毛发的试剂盒和方法，其包括在施用组合物之后不使用高温，自由基引发剂或漂洗毛发，对毛发提供有益效果的无毒组合物。
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公开(公告)号：US20120149630A1
公开(公告)日：2012-06-14
申请号：US13312224
申请日：2011-12-06
IPC分类号： A61K38/02 , A61K31/7088 , C08G63/91 , A61K47/34 , B82Y5/00
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译： 聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。 使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。 本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。 末端修饰的聚合物特别可用于递送核酸如DNA或RNA。 本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。
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公开(公告)号：US08163861B2
公开(公告)日：2012-04-24
申请号：US12354697
申请日：2009-01-15
摘要： Hair treatment compositions are disclosed comprising a β-amino ester compound in a cosmetically acceptable vehicle, such as a spray or cream. In embodiments, the compounds include a polybutadiene moiety. Methods of treating hair with the compositions to impart volume, texture and definition are also disclosed.
摘要翻译： 公开的美发处理组合物包括化妆品可接受的载体如喷雾剂或霜剂中的“ - 氨基酯化合物”。 在实施方案中，化合物包括聚丁二烯部分。 还公开了用组合物处理头发以赋予体积，质地和定义的方法。
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公开(公告)号：US20120009222A1
公开(公告)日：2012-01-12
申请号：US13126260
申请日：2009-10-27
IPC分类号： A61K31/7088 , A61P37/02 , B82Y5/00
CPC分类号： A61K39/39 , A61K31/132 , A61K47/6911 , A61K47/6921 , A61K2039/55561 , A61K2039/55572 , C12N2760/16011
摘要： The present invention provides lipidoids that can be used to modulate the immune response in a subject. Lipidoids are prepared by the conjugate addition of an amine to an acrylate to acrylamide. The lipidoids form complexes or particles with an immunostimulatory polynucleotide, which are then administerd to a subject. Such compositions have been found to stimulate the production of cytokines and increase both humoral and cell-mediate immune response. The invention also provides pharmaceuti-cal compositions thereof and methods for using the same.
摘要翻译： 本发明提供可用于调节受试者的免疫应答的类脂质。 通过将丙烯酸丁酯偶联加成丙烯酰胺制备脂质体。 脂类与免疫刺激多核苷酸形成复合物或颗粒，然后将其施用于受试者。 已经发现这些组合物刺激细胞因子的产生并增加体液和细胞中介免疫应答。 本发明还提供其药物组合物及其使用方法。
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公开(公告)号：US20110280912A1
公开(公告)日：2011-11-17
申请号：US12969558
申请日：2010-12-15
申请人： Robert S. Langer , Ana Jaklenec , Daniel Alan Heller , Daniel Griffith Anderson , Michael S. Strano
发明人： Robert S. Langer , Ana Jaklenec , Daniel Alan Heller , Daniel Griffith Anderson , Michael S. Strano
CPC分类号： C08J5/005 , B82Y30/00 , C08J2379/00
摘要： This invention relates generally to composites comprising a plurality of nanostructures, and methods of making the same. In some embodiments, the composites further comprise a polymer. In some embodiments, the composites may have desirable properties such as, for example, biodegradability, biocompatibility, and/or high tensile strength. In one embodiment, the plurality of nanostructures comprises carbon nanotubes, and the polymer comprises a poly(beta-amino ester). Various methods are provided for preparing the composites. For example, the polymer and the plurality of nanostructures may, in some embodiments, be combined in a layer-by-layer process to form the composite. High throughput methods for preparing composites having different compositions also are provided for screening composites for desirable properties.
摘要翻译： 本发明一般涉及包含多个纳米结构的复合材料及其制备方法。 在一些实施方案中，复合材料还包含聚合物。 在一些实施方案中，复合材料可具有期望的性质，例如生物降解性，生物相容性和/或高拉伸强度。 在一个实施方案中，多个纳米结构包含碳纳米管，并且聚合物包含聚（β-氨基酯）。 提供了各种制备复合材料的方法。 例如，在一些实施方案中，聚合物和多个纳米结构可以以逐层方法组合以形成复合材料。 还提供了用于制备具有不同组成的复合材料的高通量方法用于筛选复合材料以获得所需性能。
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公开(公告)号：US07967702B2
公开(公告)日：2011-06-28
申请号：US10821763
申请日：2004-04-09
IPC分类号： A63B37/12
CPC分类号： A63B37/12 , A63B37/0003 , A63B37/0013 , A63B37/0022 , A63B37/0074 , A63B43/00 , A63B43/008 , A63B69/3655 , A63B2225/60
摘要： In order to provide a golf ball with a water immersion indicator, a golf ball with indicia or a particular recognizable color is overlain with an opacification layer that provides a mask over the indicia or the colored ball until such time as the ball has been immersed in water for a predetermined period of time affecting the ball's performance. The opacification layer when removed or otherwise made transparent, while providing for a change in the appearance of the golf ball upon water immersion, does not need to have a layer or indicia which changes color in reaction to the infusion of water. Rather the opacification layer is either removed or made transparent to expose an underlying colored surface or a surface bearing pre-determined indicia, thus to alter the appearance of the ball when it has been immersed in water for a period of time which affects golf ball properties. The subject system provides an easy way to make indicia visible upon water immersion since one does not have to create the indicia in response to water activation, but rather uncover already-printed indicia due to the removal or transparency of the opacification layer. Opacification reduction or elimination is accomplished through a number of physical processes involving a water-activated binder and either insoluble pigment particles, effervescing bubbles, the use of transparent oils, agglomeration or the complete or partial removal of the opacification layer.
摘要翻译： 为了提供具有水浸指示器的高尔夫球，具有标记或特定可识别颜色的高尔夫球覆盖有在标记或彩色球上提供面罩的不透明层，直到球已经浸入 水预定一段时间影响球的表现。 当去除或以其它方式制成透明的同时提供在浸水时高尔夫球的外观变化的不透明层不需要具有改变反映于水的颜色的层或标记。 相反地，不透明层被去除或制成透明以暴露下面的着色表面或承载预定标记的表面，从而当球浸入水中一段时间以改变球的外观，这影响高尔夫球的性质 。 主题系统提供了一种简单的方法，使水印上可见的标记，因为不必为响应于水的激活而产生标记，而是由于不透明层的去除或透明度而露出已打印的标记。 通过涉及水活化粘合剂和不溶性颜料颗粒，起泡泡，使用透明油，聚集或完全或部分去除不透明层的物理过程来实现不透明度降低或消除。
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公开(公告)号：US20090220436A1
公开(公告)日：2009-09-03
申请号：US12300451
申请日：2007-05-11
CPC分类号： G09B19/24 , A61K8/8152 , A61Q19/00
摘要： Cosmetics represent a world-wide multi-billion dollar industry. The present invention provides technology for polymerizing monomers on skin in situ to produce desired skin characteristics. For example, the inventive system may be used to reduce the signs of aging or to protect the treated skin from UV light. The polymerization of monomers on skin is typically initiated using a thermal or photoinitiatied free radical initiator. In certain embodiments, the monomers are fluorinated thereby producing a fluorinated polymer on the skin upon polymerization. The invention provides monomers, initiators, methods, and kits for use in treating skin with polymers.
摘要翻译： 化妆品代表世界数十亿美元的行业。 本发明提供在皮肤上原位聚合单体以产生所需皮肤特征的技术。 例如，本发明的系统可以用于减少老化的迹象或者保护经处理的皮肤免受UV光的影响。 通常使用热或光引发的自由基引发剂引发单体在皮肤上的聚合。 在某些实施方案中，单体是氟化的，从而在聚合时在皮肤上产生氟化聚合物。 本发明提供用于用聚合物处理皮肤的单体，引发剂，方法和试剂盒。
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公开(公告)号：US09238716B2
公开(公告)日：2016-01-19
申请号：US13428695
申请日：2012-03-23
申请人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
发明人： James E. Dahlman , Avraham D. Schroeder , Daniel Griffith Anderson , Robert S. Langer , Christopher G. Levins
IPC分类号： C08G73/10 , C07D257/02 , C07D273/08 , A61K9/00 , A61K47/34 , A61K47/48
CPC分类号： A61K47/22 , A61K9/0019 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/59 , A61K47/6907 , A61K47/6911 , A61K47/6921 , C07D257/02 , C07D273/00 , C07D273/08 , C07D295/084 , C08G73/10 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/32
摘要： The present invention provides inventive conjugated polyethyleneimine (PEI) polymers and conjugated aza-macrocycles (collectively referred to herein as “conjugated lipomers” or “lipomers”) containing one or more groups of the formula (iii): wherein R3 and R4 are as defined herein. Also provided are compositions comprising the inventive conjugated lipomers, and methods of preparation and use.
摘要翻译： 本发明提供含有一个或多个式（ⅲ）基团的本发明共轭聚乙烯亚胺（PEI）聚合物和共轭氮杂 - 大环化合物（统称为“共轭脂族”或“脂聚合物”）：其中R3和R4定义如上 这里。 还提供了包含本发明的共轭脂族物的组合物，以及制备和使用方法。
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