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公开(公告)号：US08562966B2
公开(公告)日：2013-10-22
申请号：US13312224
申请日：2011-12-06
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译： 聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。 使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。 本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。 末端修饰的聚合物特别可用于递送核酸如DNA或RNA。 本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。
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公开(公告)号：US20120149630A1
公开(公告)日：2012-06-14
申请号：US13312224
申请日：2011-12-06
IPC分类号： A61K38/02 , A61K31/7088 , C08G63/91 , A61K47/34 , B82Y5/00
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译： 聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。 使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。 本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。 末端修饰的聚合物特别可用于递送核酸如DNA或RNA。 本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。
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公开(公告)号：US08071082B2
公开(公告)日：2011-12-06
申请号：US11780754
申请日：2007-07-20
IPC分类号： A61K31/765 , A61K9/00 , A61K48/00 , C12N15/11 , C08F26/00
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译： 聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。 使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。 本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。 末端修饰的聚合物特别可用于递送核酸如DNA或RNA。 本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。
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公开(公告)号：US20080242626A1
公开(公告)日：2008-10-02
申请号：US11780754
申请日：2007-07-20
IPC分类号： A61K31/7088 , C08F18/14 , A61P43/00
CPC分类号： C12N15/87 , A61K9/5138 , A61K47/34 , C08G63/6856 , C08G73/02 , C08L79/02
摘要： Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.
摘要翻译： 聚（β-氨基酯）被末端修饰以形成用于医疗和非医学领域的材料。 使胺封端的聚（β-氨基酯）与亲电子试剂或丙烯酸酯封端的聚（β-氨基酯）与亲核试剂反应。 本发明的末端改性聚合物可用于已经发现聚合物有用的任何领域，包括药物递送领域。 末端修饰的聚合物特别可用于递送核酸如DNA或RNA。 本发明还提供包含本发明的端基改性聚合物，制备本发明聚合物的方法和使用本发明聚合物的方法的组合物。
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公开(公告)号：US20090011486A1
公开(公告)日：2009-01-08
申请号：US11682139
申请日：2007-03-05
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
IPC分类号： C12N11/08
CPC分类号： C08J9/0023 , C08G63/20 , C08G63/914 , C08J2201/024 , C08J2207/10 , C08J2367/00
摘要： The present inventions in various aspects provide elastic polymers compositions for encapsulation of cells. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked in the presence of glycerol and a population of cells to form elastic porous polymer scaffolds suitable for cell encapsulation and/or proliferation.
摘要翻译： 各方面的本发明提供了用于封装细胞的弹性聚合物组合物。 在各种实施方案中，通过多官能醇或醚和双官能或更高级酸的反应形成聚合物以形成预聚物，其在甘油和细胞群中存在下交联以形成弹性多孔 适用于细胞包封和/或增殖的聚合物支架。
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公开(公告)号：US20100215708A1
公开(公告)日：2010-08-26
申请号：US12306794
申请日：2007-06-28
申请人： Andreas Zumbuehl , Danial S. Kohane , Lino Da Silva Ferreira , Robert S. Langer , Gerald R. Fink
发明人： Andreas Zumbuehl , Danial S. Kohane , Lino Da Silva Ferreira , Robert S. Langer , Gerald R. Fink
IPC分类号： A61F2/00 , A61K31/7088 , A61K31/713 , A61K31/7048 , A61K9/16 , A61K9/70 , A61P31/00 , A61M25/00 , A61M27/00 , A61M16/04
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/404 , A61L2300/602
摘要： This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in, inter-alia, biological applications, including preventing infection and the treatment of various diseases.
摘要翻译： 本发明涉及涂覆有凝胶，泡沫，膜，颗粒或组合物的基材，材料和装置，其包含多聚酯溶剂和附着于其上的效应化合物，其制备方法及其使用方法， ，生物应用，包括预防感染和各种疾病的治疗。
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公开(公告)号：US20090047256A1
公开(公告)日：2009-02-19
申请号：US11623041
申请日：2007-01-12
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
IPC分类号： A61K35/12 , C08G63/00 , C08G63/06 , C08G63/66 , C08G73/02 , A61K47/34 , A61N1/30 , A61K31/7088 , A61K31/715 , A61K38/02 , A61K35/00
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化的共聚物共聚。
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公开(公告)号：US20120269761A1
公开(公告)日：2012-10-25
申请号：US13428869
申请日：2012-03-23
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。
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公开(公告)号：US09006487B2
公开(公告)日：2015-04-14
申请号：US11453222
申请日：2006-06-14
申请人： Daniel G. Anderson , Andreas Zumbuehl , Elizaveta Sergeyevna Leshchiner (Turkhanova) , Robert S. Langer , Michael Goldberg
发明人： Daniel G. Anderson , Andreas Zumbuehl , Elizaveta Sergeyevna Leshchiner (Turkhanova) , Robert S. Langer , Michael Goldberg
IPC分类号： C07C239/00 , C07C229/00 , C12N15/88 , A61K31/785 , C07B53/00 , G01N33/92 , A61K48/00 , A61K9/16 , C07C229/12 , C07C229/14 , C07C229/16 , C07C229/18 , C07C237/06 , C07D211/26 , C07D233/61 , C07D243/08 , C07D295/12 , C07D307/14 , C07D317/28
CPC分类号： C07D233/61 , A61K9/1617 , A61K47/18 , A61K47/22 , A61K48/00 , A61K48/0033 , C07C227/10 , C07C229/12 , C07C229/14 , C07C229/16 , C07C229/18 , C07C231/12 , C07C237/06 , C07D211/26 , C07D243/08 , C07D295/12 , C07D307/14 , C07D317/28 , C12N15/88
摘要： Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译： 描述了从共轭加成胺到丙烯酸酯，丙烯酰胺或与吸电子基团共轭的其它碳 - 碳双键制备的含氮脂质。 还提供了从市售的起始原料制备这些脂质的方法。 这些含脂质的脂质或这些脂质的盐形式优选是可生物降解的和生物相容的，并可用于各种药物递送系统。 鉴于这些脂质的氨基部分，它们特别适用于递送多核苷酸。 已经制备了含有本发明的脂质和多核苷酸的复合物或纳米颗粒。 本发明的脂质也可用于制备用于药物递送的微粒。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。
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10.发明授权Method comprising contacting tissue with a cross-linkable polyester prepolymer 有权方法包括使组织与可交联聚酯预聚物接触公开(公告)号：US08691203B2
公开(公告)日：2014-04-08
申请号：US13428869
申请日：2012-03-23
申请人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
发明人： Christopher J. Bettinger , Joost P. Bruggeman , Lino Da Silva Ferreira , Jeffrey M. Karp , Robert S. Langer , Christiaan Nijst , Andreas Zumbuehl , Jason Burdick , Sonia J. Kim
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
摘要翻译： 本发明在各方面提供弹性可生物降解的聚合物。 在各种实施方案中，聚合物通过多官能醇或醚和双官能或更高级酸的反应形成以形成预聚物，其被交联以形成弹性可生物降解的聚合物。 在优选的实施方案中，通过用乙烯基官能化预聚物主链上的一个或多个OR基团进行交联，然后进行光聚合以形成弹性可生物降解的聚合物组合物或材料。 优选地，使用丙烯酸酯将一种或多种乙烯基加成到预聚物的主链上以形成丙烯酸酯化的预聚物。 在各种实施方案中，丙烯酸酯化的预聚物与一种或多种丙烯酸酯化共聚物共聚。
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