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公开(公告)号：US20110160451A1
公开(公告)日：2011-06-30
申请号：US13043391
申请日：2011-03-08
Applicant: Hui CAI , Frank CHAVEZ , James P. EDWARDS , Anne E. FITZGERALD , Jing LIU , Neelakandha S. MANI , Danielle K. NEFF , Michele C. RIZZOLIO , Brad M. SAVALL , Deborah M. SMITH , Jennifer D. VENABLE , Jianmei WEI , Ronald L. WOLIN
Inventor： Hui CAI , Frank CHAVEZ , James P. EDWARDS , Anne E. FITZGERALD , Jing LIU , Neelakandha S. MANI , Danielle K. NEFF , Michele C. RIZZOLIO , Brad M. SAVALL , Deborah M. SMITH , Jennifer D. VENABLE , Jianmei WEI , Ronald L. WOLIN
IPC: C07D403/04 , C07D401/04 , C07D487/04 , C07D471/04 , C07D487/08 , C07D405/14 , C07D487/10 , C07D498/04 , C07D491/052 , C07D239/48 , C07D409/14 , C07D409/06
CPC classification number: C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 描述了2-氨基嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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公开(公告)号：US08937075B2
公开(公告)日：2015-01-20
申请号：US13456165
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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公开(公告)号：US08927555B2
公开(公告)日：2015-01-06
申请号：US13456180
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Abstract translation: 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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4.发明申请THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 审中-公开组胺H4受体的THIENO-ADN FURO-PYRIMIDINE调节剂公开(公告)号：US20120214792A1
公开(公告)日：2012-08-23
申请号：US13456180
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A61K31/519 , C07D491/048 , C07D243/08 , A61K31/551 , A61P37/08 , A61P11/06 , A61P27/02 , A61P11/00 , A61P9/10 , A61P19/02 , A61P1/00 , A61P1/04 , A61P17/06 , A61P17/00 , A61P37/06 , A61P7/06 , C07D495/04
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Abstract translation: 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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公开(公告)号：US07250427B2
公开(公告)日：2007-07-31
申请号：US11168107
申请日：2005-06-27
Applicant: J. Guy Breitenbucher , Alice Lee-Dutra , Danielle K. Neff
Inventor： J. Guy Breitenbucher , Alice Lee-Dutra , Danielle K. Neff
IPC: A61K31/4184 , C07D235/12
CPC classification number: C07D403/12 , C07D235/18 , C07D401/12
Abstract: Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
Abstract translation: 芳基取代的苯并咪唑和咪唑并[4,5]吡啶醚被描述为Cds1的抑制剂，可用作治疗癌症的化学疗法或放射治疗的佐剂。
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Patent Agency Ranking
公开(公告)号：US20110218338A1
公开(公告)日：2011-09-08
申请号：US13084226
申请日：2011-04-11
Applicant: Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
Inventor： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC: C07D403/14 , C07D403/04 , C07D413/14 , C07D405/14
CPC classification number: C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
Abstract translation: 描述了2-氨基嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于治疗由H 4受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫性疾病和瘙痒症。
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公开(公告)号：US08440654B2
公开(公告)日：2013-05-14
申请号：US13456148
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: C07D491/04 , C07D243/08 , A61K31/519 , A61K31/5513 , A61K31/5025 , A61K31/501 , A61P29/00
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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公开(公告)号：US20120208793A1
公开(公告)日：2012-08-16
申请号：US13456165
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A61K31/497 , A61K31/4995 , A61K31/519 , C07D491/048 , C07D495/04 , A61K31/4985 , A61P29/00 , A61P37/08 , A61P17/00 , A61P11/06 , A61P27/04 , A61P11/00 , A61P9/10 , A61P19/02 , A61P25/00 , A61P1/00 , A61P17/06 , A61P27/02 , A61P3/10 , A61P7/06 , A61K31/5513
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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公开(公告)号：US08193178B2
公开(公告)日：2012-06-05
申请号：US12283700
申请日：2008-09-12
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: C07D243/08 , C07D491/147 , A61K31/5513 , A61K31/5025 , A61K31/501 , A61K31/519 , A61P29/00
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Abstract translation: 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这样的化合物可以用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和状况。
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公开(公告)号：US20080194577A1
公开(公告)日：2008-08-14
申请号：US12070051
申请日：2008-02-14
Applicant: Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
Inventor： Hui Cai , Frank Chavez , James P. Edwards , Anne E. Fitzgerald , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Michele C. Rizzolio , Brad M. Savall , Deborah M. Smith , Jennifer D. Venable , Jianmei Wei , Ronald L. Wolin
IPC: A61K31/496 , C07D239/48 , A61K31/505 , A61P37/08 , C07K14/705 , A61P17/00 , A61P29/00 , C07D403/04
CPC classification number: C07D498/04 , C07D239/48 , C07D239/70 , C07D239/95 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D487/10 , C07D519/00
Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
Abstract translation: 描述了2-氨基嘧啶化合物，其可用作H 4 S 5受体调节剂。 这样的化合物可以用于治疗由H 4 S受体活性介导的疾病状态，病症和病症的药物组合物和方法，例如过敏，哮喘，自身免疫疾病和瘙痒症。
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