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公开(公告)号：US07250427B2
公开(公告)日：2007-07-31
申请号：US11168107
申请日：2005-06-27
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D403/12 , C07D235/18 , C07D401/12
摘要： Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
摘要翻译： 芳基取代的苯并咪唑和咪唑并[4,5]吡啶醚被描述为Cds1的抑制剂，可用作治疗癌症的化学疗法或放射治疗的佐剂。
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公开(公告)号：US20090099157A1
公开(公告)日：2009-04-16
申请号：US12031551
申请日：2008-02-14
申请人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
发明人： Michael K. Ameriks , Kristen L. Arienti , James P. Edwards , Cheryl A. Grice , Todd K. Jones , Alice Lee-Dutra , Jing Liu , Neelakandha S. Mani , Danielle K. Neff , Alvah T. Wickboldt , John J.M. Wiener
IPC分类号： A61K31/551 , C07D471/04 , A61K31/5377 , A61P9/10 , A61P37/08 , A61K31/437
CPC分类号： C07D471/04
摘要： Tetrahydro-pyrazolo-pyridine thioether compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译： 描述了四氢吡唑并吡啶硫醚化合物，其可用作组织蛋白酶S调节剂。 这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。
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公开(公告)号：US08367719B2
公开(公告)日：2013-02-05
申请号：US13091772
申请日：2011-04-21
申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillán, Jr.
发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillán, Jr.
IPC分类号： A61K31/34
CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04
摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.
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公开(公告)号：US07939527B2
公开(公告)日：2011-05-10
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/516 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
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5.发明申请COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 有权具有两个双熔体双组分杂化物的化合物作为LEUKOTRIENE A4水解产物的调节剂公开(公告)号：US20100292208A1
公开(公告)日：2010-11-18
申请号：US12778646
申请日：2010-05-12
申请人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
发明人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
IPC分类号： A61K31/397 , C07D417/14 , A61K31/428 , A61K31/454 , A61K31/5377 , A61K31/537 , A61K31/551 , A61P11/06 , A61P17/06 , A61P17/02 , A61P17/00 , A61P3/10 , A61P19/02 , A61P35/00 , A61P1/00 , A61P9/00
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译： 具有两个稠合双环杂芳基部分的化合物及其药物组合物，以及将其用作白三烯A4水解酶（LTA4H）调节剂并用于治疗由LTA4H介导的疾病，病症和状况的方法。
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6.发明授权Aryl-substituted bridged or fused diamines as modulators of leukotriene A ydrolase 有权芳基取代的桥连或稠合二胺作为白三烯A型调质剂公开(公告)号：US08344008B2
公开(公告)日：2013-01-01
申请号：US13091498
申请日：2011-04-21
申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alexandro Santillán, Jr.
发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alexandro Santillán, Jr.
IPC分类号： A61K31/425
CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04
摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.
摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法 ，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。
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公开(公告)号：US20060004039A1
公开(公告)日：2006-01-05
申请号：US11168107
申请日：2005-06-27
申请人： J. Breitenbucher , Alice Lee-Dutra , Danielle Neff
发明人： J. Breitenbucher , Alice Lee-Dutra , Danielle Neff
IPC分类号： C07D471/02 , A61K31/4745 , A61K31/4184
CPC分类号： C07D403/12 , C07D235/18 , C07D401/12
摘要： Aryl substituted benzimidazole and imidazo[4,5]pyridine ethers are described as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.
摘要翻译： 芳基取代的苯并咪唑和咪唑并[4,5]吡啶醚被描述为Cds1的抑制剂，可用作治疗癌症的化学疗法或放射治疗的佐剂。
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8.发明授权Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase 有权具有两个稠合双环杂芳基部分的化合物作为白三烯A4水解酶的调节剂公开(公告)号：US08399465B2
公开(公告)日：2013-03-19
申请号：US12778646
申请日：2010-05-12
申请人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
发明人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
IPC分类号： A61K31/535 , A61K31/47 , A61K31/445 , A61K31/425 , C07D417/14 , C07D417/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译： 具有两个稠合双环杂芳基部分的化合物及其药物组合物，以及将其用作白三烯A4水解酶（LTA4H）调节剂并用于治疗由LTA4H介导的疾病，病症和状况的方法。
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9.发明授权Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US08357684B2
公开(公告)日：2013-01-22
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
发明人： Genesis M. Bacani , Eugene Y. Cheung , Christa C. Chrovian , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener
IPC分类号： A61K31/5355 , A61K31/4985 , A61K31/506 , A61K31/497 , A61K31/4365 , C07D413/14 , C07D239/34 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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10.发明申请Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110159563A1
公开(公告)日：2011-06-30
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： C12N9/99 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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