Detection of stroke events using diffuse optical tomagraphy
    1.
    发明授权
    Detection of stroke events using diffuse optical tomagraphy 失效
    使用漫射光镜检测中风事件

    公开(公告)号:US06577884B1

    公开(公告)日:2003-06-10

    申请号:US09598422

    申请日:2000-06-19

    申请人: David Alan Boas

    发明人: David Alan Boas

    IPC分类号: A61B500

    摘要: The invention relates to a method of using diffuse optical tomography and oxygen in a stroke patient, or a patient suspected of having a stroke, to detect ischemic events or bleeds in the brain.

    摘要翻译: 本发明涉及一种在卒中患者或疑似患有中风的患者中使用弥漫性光学断层摄影和氧气以检测脑内缺血事件或出血的方法。

    Calibration methods and systems for diffuse optical tomography and spectroscopy
    2.
    发明授权
    Calibration methods and systems for diffuse optical tomography and spectroscopy 失效
    扩散光学断层扫描和光谱学的校准方法和系统

    公开(公告)号:US06549284B1

    公开(公告)日:2003-04-15

    申请号:US09662862

    申请日:2000-09-15

    IPC分类号: G01N2147

    摘要: The invention features a calibration method for diffuse optical measurements that corrects transmittance measurements between a source and a detector for factors unrelated to sample properties. The calibration method is based on the same set of transmittance measurements that are subsequently corrected by the calibration and used in imaging and/or spectroscopy applications. The calibration method involves a forward calculation for each of multiple source-detector pairs based on an approximate model of the sample, and a minimization of an expression that depends on the forward calculations and the transmittance measurements to determine self-consistent coupling coefficients for every source-detector pair. Once the coupling coefficients have been determined, they can be used to correct the transmittance measurements. If desired, an inverse calculation can be performed on the corrected sample measurements to determine spatial variations in the optical properties of the sample. If necessary, the calibration can be repeated and iteratively improved, whereby the optical properties determined by the inverse calculation in an earlier iteration are used to improve the sample model for the forward calculation in a subsequent iteration.

    摘要翻译: 本发明的特征在于用于扩散光学测量的校准方法,该校准方法校正源与检测器之间对与样品性质无关的因素的透射率测量。 校准方法基于相同的透射率测量集合,随后通过校准校正并用于成像和/或光谱应用。 校准方法包括基于样本的近似模型的多个源 - 检测器对中的每一个的正向计算,以及取决于前向计算和透射率测量的表达式的最小化,以确定每个源的自相容耦合系数 检测器对。 一旦确定了耦合系数,它们可用于校正透射率测量。 如果需要,可以对校正的样本测量进行反向计算,以确定样品的光学性质的空间变化。 如果需要,可以重复和迭代地改进校准,由此通过在较早的迭代中通过逆计算确定的光学性质被用于改进用于后续迭代中的正向计算的样本模型。

    Fetal pulse oximetry
    6.
    发明授权
    Fetal pulse oximetry 失效
    胎儿脉搏血氧饱和度测定

    公开(公告)号:US07047055B2

    公开(公告)日:2006-05-16

    申请号:US10415163

    申请日:2001-01-26

    IPC分类号: A61B5/00

    摘要: A fetal blood pulse oximetry method and apparatus using a first wavelength of light at about 655 to 705 nm and a second wavelength of light at about 820 to 900 nm. Measurements are taken through a mother's abdomen. Processing is performed to extract absorption information related to fetal arterial blood with calculation of fetal oxygen saturation from the extracted data.

    摘要翻译: 一种使用约655至705nm的第一波长的光和约820至900nm的第二波长的胎儿血液血氧饱和度测定方法和装置。 测量通过母亲的腹部进行。 进行处理以从提取的数据计算胎儿氧饱和度来提取与胎动脉血相关的吸收信息。

    FLUORESCENCE-LIFETIME-BASED TOMOGRAPHY
    7.
    发明申请
    FLUORESCENCE-LIFETIME-BASED TOMOGRAPHY 审中-公开
    基于荧光 - 基于生命的TOMOGRAPHY

    公开(公告)号:US20090164130A1

    公开(公告)日:2009-06-25

    申请号:US11917023

    申请日:2006-06-09

    IPC分类号: G01N21/64 G06F19/00

    摘要: Methods, apparatus (100), and computer program products for determining lifetimes and distribution of fluorophores (102) embedded in samples (104). Fluorophores are placed into the sample, light from a source (110) selected to excite the fluorophores illuminates the sample, light emitted from the excited fluorophores is detected by a device (138), and a time-domain analysis is performed on the detected emitted light to determine a three-dimensional distribution of the fluorophores in the sample.

    摘要翻译: 用于确定嵌入样品(104)中的荧光团(102)的寿命和分布的方法,装置(100)和计算机程序产品。 将荧光团放置在样品中,来自选择用于激发荧光团的源(110)的光照射样品,由装置(138)检测从激发的荧光团发射的光,并且对所检测到的发射 以确定样品中荧光团的三维分布。