公开(公告)号：US20240044788A1

公开(公告)日：2024-02-08

申请号：US18229087

申请日：2023-08-01

Applicant: Ludwig-Maximilians-Universitaet Munich

Inventor： Thomas Huemmer

IPC: G01N21/39 ,  G01N21/64

CPC classification number: G01N21/39 ,  G01N21/6458 ,  G01N2021/391 ,  G01N2201/0853 ,  G01N2201/103 ,  G01N2021/392

Abstract: According to a method for cavity enhanced microscopy, a sample is arranged on a sample carrier of an optical cavity, which is formed by a pair of opposing mirrors. A description defining a lateral motion of the sample during a predefined time interval and a variation of the cavity length during the time interval in a temporally synchronized manner is stored and an actuator system is triggered to move the sample carrier and/or at least one mirror of the pair of mirrors to effect the lateral motion of the sample with respect to the cavity and the variation of the cavity length according to the description. Light is introduced into the cavity and transmitted portions and/or reflected portions and/or scattered portions and/or emitted portions are detected to generate a sensor dataset.

公开(公告)号：US20230280274A1

公开(公告)日：2023-09-07

申请号：US18315427

申请日：2023-05-10

Applicant: Singular Genomics Systems, Inc.

Inventor： Fedor TRINTCHOUK ,  Eli N. GLEZER

IPC: G01N21/64 ,  G02B21/16 ,  G02B21/26 ,  G02B21/08 ,  G02B21/18 ,  G02B27/10 ,  H04N23/16 ,  H04N23/45 ,  H04N23/56 ,  H04N23/84

CPC classification number: G01N21/6456 ,  G02B21/16 ,  G02B21/26 ,  G02B21/082 ,  G02B21/18 ,  G02B27/1013 ,  G01N21/6428 ,  H04N23/16 ,  H04N23/45 ,  H04N23/56 ,  H04N23/84 ,  G01N2201/103

Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.

公开(公告)号：US11686681B2

公开(公告)日：2023-06-27

申请号：US17853449

申请日：2022-06-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Fedor Trintchouk ,  Eli N. Glezer

IPC: G01N21/64 ,  G02B21/16 ,  G02B21/26 ,  G02B21/08 ,  G02B21/18 ,  G02B27/10 ,  H04N23/16 ,  H04N23/45 ,  H04N23/56 ,  H04N23/84

CPC classification number: G01N21/6456 ,  G01N21/6428 ,  G02B21/082 ,  G02B21/16 ,  G02B21/18 ,  G02B21/26 ,  G02B27/1013 ,  H04N23/16 ,  H04N23/45 ,  H04N23/56 ,  H04N23/84 ,  G01N2201/103

Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.

公开(公告)号：US20230194412A1

公开(公告)日：2023-06-22

申请号：US18082739

申请日：2022-12-16

Applicant: VERSITECH LIMITED ,  ADVANCED BIOMEDICAL INSTRUMENTATION CENTRE LIMITED

Inventor： Kenneth Kin Yip WONG ,  Jiawei SHI ,  Mingsheng LI ,  Jiqiang KANG

IPC: G01N21/17 ,  H01S3/067 ,  H01S3/10 ,  H01S3/094 ,  H01S3/00 ,  H01S3/16 ,  H01S3/108 ,  G02F1/39 ,  H01S3/23 ,  H03F3/19 ,  G01N33/483

CPC classification number: G01N21/1702 ,  H01S3/06716 ,  H01S3/10038 ,  H01S3/094015 ,  H01S3/06791 ,  H01S3/1003 ,  H01S3/005 ,  H01S3/1608 ,  H01S3/1083 ,  G02F1/395 ,  H01S3/1616 ,  H01S3/2316 ,  H03F3/19 ,  G01N33/4833 ,  H03F2200/451 ,  H03F2200/294 ,  G01N2201/06113 ,  G01N2201/08 ,  G01N2201/0633 ,  G01N2201/103 ,  G01N2021/1706

Abstract: An optical-resolution photoacoustic microscopy (OR-PAM) system for visualizing water content deep in biological tissue uses an all-fiber 1930-nm hybrid optical parametrically-oscillating emitter. The emitter includes a tunable laser source whose output is amplified by a first erbium-doped fiber amplifier (EDFA). The output of the first amplifier is modulated with a Mach-Zehnder amplitude modulator that receives an RF signal with a nanosecond pulse width and a multiple kilohertz repetition rate. A second EDFA further amplifies the signal and passes it to a fiber circulator that in turn delivers it to a 1950/1550 mm fiber wavelength-division-multiplexing coupler WDM. The coupler introduces the signal to a cavity that includes a spool of highly nonlinear fiber and a Thulium-doped fiber amplifier TDFA. From the TDFA the signal reaches a 50/50 fiber coupler that sends part to a second output TDFA and guides part back to the cavity through a port of the WDM.

公开(公告)号：US20230184681A1

公开(公告)日：2023-06-15

申请号：US17925131

申请日：2021-03-17

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Satoshi YAMAMOTO

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N21/6452 ,  G01N2201/103 ,  G02B21/06

Abstract: In this sample observation device, a reference table in which an optimum light amount of planar light at a measurement sensitivity represented by the product of a light amount of the planar light and a scanning speed is set according to the scanning speed is referred to, and the scanning speed of a scanning unit and the optimum light amount of the planar light that is applied to a sample are determined on the basis of the measurement sensitivity selected by a user.

公开(公告)号：US20190049382A1

公开(公告)日：2019-02-14

申请号：US16079900

申请日：2017-02-23

Applicant: Single Technologies AB

Inventor： Raoul Stubbe ,  Bengt Sahlgren ,  Johan Strömqvist

IPC: G01N21/64 ,  G01N21/51 ,  G02B19/00 ,  G02B21/00 ,  G02B21/26 ,  G02B21/33 ,  G02B27/10 ,  G02B27/14

CPC classification number: G01N21/6458 ,  G01N21/474 ,  G01N21/51 ,  G01N21/6486 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2021/6478 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0833 ,  G01N2201/103 ,  G02B19/0019 ,  G02B19/0057 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0064 ,  G02B21/0076 ,  G02B21/26 ,  G02B21/33 ,  G02B27/1006 ,  G02B27/141

Abstract: An apparatus for imaging a includes an light source for illuminating the sample simultaneously in a line focus or an array of foci; and a sensor for detecting photons emitted or scattered from the sample simultaneously in an array of fields of view. An array of sub-observation volumes in the sample, from which photons are emitted or scattered during imaging, is defined by the volumes in space where the line focus or array of foci from the light source overlap with the corresponding array of field of views of the sensor. A cylindrical sample holder holds the sample at a surface and is rotatably arranged such that at least a portion of the sample can be transported through at least one of the sub-observation volumes by rotating the sample holder. The apparatus can be used in a high-throughput method of imaging.

公开(公告)号：US10077865B2

公开(公告)日：2018-09-18

申请号：US15315878

申请日：2015-06-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Chinedum E. Okwudire ,  Deokkyun D. Yoon

IPC: H01L21/67 ,  F16M11/04 ,  F16M11/18 ,  G03F7/20 ,  G01N21/95

CPC classification number: F16M11/043 ,  F16M11/18 ,  G01N21/9501 ,  G01N2201/103 ,  G03F7/70758 ,  G03F7/70858 ,  G03F7/709 ,  H01L21/67259 ,  H01L21/68

Abstract: A magnet assisted stage system for scanning applications having a scanning table being moveable from a first position to a second position, a scanning actuator operably associated with the scanning table to move the scanning table along a scanning direction from the first position to the second position, and an actively variable magnetic spring system being operably augmented to the scanning table to exert a magnetic repulsion force upon the scanning table in the scanning direction.

公开(公告)号：US20170082617A1

公开(公告)日：2017-03-23

申请号：US15245062

申请日：2016-08-23

Applicant: Reuven DUER

Inventor： Reuven DUER

IPC: G01N33/543 ,  C12Q1/68 ,  G01N21/64 ,  G01N33/569

CPC classification number: G01N33/54373 ,  B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0819 ,  C12Q1/6825 ,  G01N21/6428 ,  G01N21/6454 ,  G01N21/648 ,  G01N33/56988 ,  G01N2021/6439 ,  G01N2201/0696 ,  G01N2201/08 ,  G01N2201/103 ,  G02B6/4226 ,  Y10T436/143333

Abstract: The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.

公开(公告)号：US20160356725A1

公开(公告)日：2016-12-08

申请号：US15116554

申请日：2015-02-04

Applicant: NSK AMERICAS, INC.

Inventor： George Morrison, III ,  Ty Alan Brown ,  Timothy Brian Rood

IPC: G01N21/88 ,  G01B11/00

CPC classification number: G01N21/8851 ,  B62D1/185 ,  G01B11/00 ,  G01B11/24 ,  G01N21/9515 ,  G01N21/952 ,  G01N2021/888 ,  G01N2201/103

Abstract: An apparatus (110) (and associated method) for inspecting a steering column assembly (10) including at least one motorized roller support assembly (118) that is adapted to rotatably support the steering column assembly at least partially along its length, and at least one optical scanning device (158) adapted to optically scan a feature of Interest of the steering column assembly while the shaft of the steering column assembly is rotated for gathering data for identifying one or more deviations from one or more predetermined values for the feature of interest.

Abstract translation: 一种用于检查转向柱组件（10）的装置（110）（和相关联的方法），该转向柱组件包括至少一个电动辊支撑组件（118），其适于至少部分沿其长度可旋转地支撑转向柱组件，并且至少 一个光学扫描装置（158），其适于在转向柱组件的轴旋转时光学地扫描转向柱组件的特征，以收集用于识别关于感兴趣特征的一个或多个预定值的一个或多个偏差的数据 。

公开(公告)号：US09370799B2

公开(公告)日：2016-06-21

申请号：US14876187

申请日：2015-10-06

Applicant: GII ACQUISITION, LLC

Inventor： Michael G. Nygaard ,  Laura L. Poletti

IPC: G01N21/00 ,  G01B11/24 ,  B07C5/342 ,  F42B35/00 ,  G01N21/90 ,  G01N21/95 ,  G01N21/952

CPC classification number: G01N21/952 ,  B07C5/342 ,  F42B35/00 ,  G01B11/2425 ,  G01B11/2433 ,  G01N21/909 ,  G01N21/9515 ,  G01N2201/02 ,  G01N2201/0621 ,  G01N2201/0638 ,  G01N2201/103 ,  G01N2201/12

Abstract: A method and system for optically inspecting a manufactured part at a single inspection station having a measurement axis are provided. The system comprises a fixture assembly which includes a rotatable first fixturing component to support a part in a generally vertical orientation and a rotatable second fixturing component mating with and removably connected to the first fixturing component to transmit torque from the first fixturing component to the second fixturing component. The second fixturing component includes a device for holding the part in a generally horizontal orientation and to permit rotation of the horizontally held part about the measurement axis between first and second predetermined angular positions about the axis. The system also comprises an actuator assembly, a backside illumination assembly, a frontside illumination device, a lens and detector assembly and at least one processor to process electrical signals generated by the lens and detector assembly.

Abstract translation: 提供了在具有测量轴的单个检查站上光学检查制造部件的方法和系统。 该系统包括夹具组件，其包括可旋转的第一夹持部件以支撑大致垂直的方向的部件，以及可旋转的第二夹紧部件，其与第一夹持部件配合并可拆卸地连接，以将转矩从第一夹持部件传递到第二夹持 零件。 第二固定部件包括用于将部件保持在大体上水平的方向并且允许水平保持部分围绕测量轴线围绕轴线在第一和第二预定角度位置之间旋转的装置。 该系统还包括致动器组件，背面照明组件，前侧照明装置，透镜和检测器组件以及用于处理由透镜和检测器组件产生的电信号的至少一个处理器。