公开(公告)号：US08718751B2

公开(公告)日：2014-05-06

申请号：US11746156

申请日：2007-05-09

申请人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61B5/08 ,  A61B5/04 ,  A61B5/053 ,  A61B5/085

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/4818 ,  A61N1/36114 ,  A61N1/36542 ,  A61N1/36585

摘要： A heart monitoring system comprises a ventricular sensing stage sensing excitation or contraction of ventricular myocardium, an activity sensor unit determining a signal reflecting a patient's physical activity, a ventricular impedance or conductance measuring module, said modules comprising a current source unit adapted to provide a sub-threshold excitation current to the myocardium and comprising an impedance or conductance measurement unit for measuring the resulting voltage on said electrode at the myocardium, a signal generator module, a filter module, a memory, a control unit adapted to derive single measures |ΣZ| of magnitude of impedance or conductance change over a preset sample time interval, determine the variability TARVI in the impedance or conductance change, compare this variability and the activity sensor output signal with a threshold and recent history, determine if sleep disturbed breathing (SDB) is present, and log the SDB episode in the memory device.

摘要翻译： 心脏监测系统包括心室感测阶段感测心室心肌的激发或收缩，活动传感器单元确定反映患者身体活动的信号，心室阻抗或电导测量模块，所述模块包括电流源单元，其适于提供子 并且包括用于测量心肌上的所述电极上产生的电压的阻抗或电导测量单元，信号发生器模块，滤波器模块，存储器，适于导出单个测量的控制单元。 Z | 在预设的采样时间间隔内测量阻抗或电导变化的大小，确定阻抗或电导变化中的变异性TARVI，将该变异性和活动传感器输出信号与阈值和最近历史进行比较，确定睡眠扰动呼吸（SDB）是否为 呈现并记录SDB剧集在内存设备中。

公开(公告)号：US20080300504A1

公开(公告)日：2008-12-04

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/053

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。

公开(公告)号：US08649864B2

公开(公告)日：2014-02-11

申请号：US11873292

申请日：2007-10-16

申请人： David F. Hastings ,  Xin Good ,  Volker Lang

发明人： David F. Hastings ,  Xin Good ,  Volker Lang

IPC分类号： A61N1/365

CPC分类号： A61N1/362

摘要： An implantable medical device that continuously measures the patient's intracardiac ventricular impedance. Extracts cardiac performance information based on the intracardiac impedance, including amplitude, timing and variability of cardiac contraction function. The device records and analysis trends in the performance information. The device identifies changes, which exceed the selected threshold limits. In the event of an incipient crisis, the device transmits an alert message.

摘要翻译： 可植入的医疗装置，可持续测量患者的心内心室阻抗。 基于心脏内阻抗提取心脏性能信息，包括心脏收缩功能的幅度，时间和变异性。 设备记录和分析性能信息的趋势。 设备识别出超出选定阈值限制的更改。 在发生初期危机的情况下，设备会发送警报消息。

公开(公告)号：US20090099617A1

公开(公告)日：2009-04-16

申请号：US11873292

申请日：2007-10-16

申请人： David F. Hastings ,  Xin Good ,  Volker Lang

发明人： David F. Hastings ,  Xin Good ,  Volker Lang

IPC分类号： A61N1/365

CPC分类号： A61N1/362

摘要： An implantable medical device that continuously measures the patient's intracardiac ventricular impedance. Extracts cardiac performance information based on the intracardiac impedance, including amplitude, timing and variability of cardiac contraction function. The device records and analyses trends in the performance information. The device identifies changes, which exceed the selected threshold limits. In the event of an incipient crisis, the device transmits an alert message.

摘要翻译： 可植入的医疗装置，可持续测量患者的心内心室阻抗。 基于心脏内阻抗提取心脏性能信息，包括心脏收缩功能的幅度，时间和变异性。 设备记录和分析性能信息的趋势。 设备识别出超出选定阈值限制的更改。 在发生初期危机的情况下，设备会发送警报消息。

公开(公告)号：US20090088814A1

公开(公告)日：2009-04-02

申请号：US11863375

申请日：2007-09-28

申请人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61N1/368 ,  A61N1/3682

摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.

摘要翻译： 用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应 感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述 刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图 就说 房室间隔采样并分析所述直方图。

公开(公告)号：US20070265539A1

公开(公告)日：2007-11-15

申请号：US11746156

申请日：2007-05-09

申请人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61B5/04

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/4818 ,  A61N1/36114 ,  A61N1/36542 ,  A61N1/36585

摘要： A heart monitoring system comprises a ventricular sensing stage sensing excitation or contraction of ventricular myocardium, an activity sensor unit determining a signal reflecting a patient's physical activity, a ventricular impedance or conductance measuring module, said modules comprising a current source unit adapted to provide a sub-threshold excitation current to the myocardium and comprising an impedance or conductance measurement unit for measuring the resulting voltage on said electrode at the myocardium, a signal generator module, a filter module, a memory, a control unit adapted to derive single measures |ΣZ| of magnitude of impedance or conductance change over a preset sample time interval, determine the variability TARVI in the impedance or conductance change, compare this variability and the activity sensor output signal with a threshold and recent history, determine if sleep disturbed breathing (SDB) is present, and log the SDB episode in the memory device.

摘要翻译： 心脏监测系统包括心室感测阶段感测心室心肌的激发或收缩，活动传感器单元确定反映患者身体活动的信号，心室阻抗或电导测量模块，所述模块包括电流源单元，其适于提供子 包括用于测量心肌上所述电极上产生的电压的阻抗或电导测量单元，信号发生器模块，滤波器模块，存储器，适于导出单个测量的控制单元| SigmaZ | 在预设的采样时间间隔内测量阻抗或电导变化的大小，确定阻抗或电导变化中的变异性TARVI，将该变异性和活动传感器输出信号与阈值和最近历史进行比较，确定睡眠扰动呼吸（SDB）是否为 呈现并记录SDB剧集在内存设备中。

公开(公告)号：US08064998B2

公开(公告)日：2011-11-22

申请号：US11863375

申请日：2007-09-28

申请人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61N1/368 ,  A61N1/3682

摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.

摘要翻译： 用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应 感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述 刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图 就说 房室间隔采样并分析所述直方图。

公开(公告)号：US07970462B2

公开(公告)日：2011-06-28

申请号：US11754973

申请日：2007-05-29

申请人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

发明人： Sharon Lefkov ,  David F. Hastings ,  Christopher S. de Voir ,  Garth Garner ,  Dirk Muessig ,  Hannes Kraetschmer

IPC分类号： A61B5/02 ,  A61B5/08 ,  A61B5/05 ,  A61N1/00

CPC分类号： A61B5/053 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/4878 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36521 ,  A61N1/36585

摘要： Implantable medical device with an impedance determination unit with constant current/voltage source having current feed terminals connected to electrodes for intracorporal placement which generates measuring current pulses having constant current/voltage, for causing a current through a body via intracorporally placed electrodes, a measuring unit for measuring voltage/current strength of voltage/current fed through body, an impedance value determination unit connected to the current/voltage source and adapted to determine an impedance value for each measuring current pulse, and an impedance measuring control and evaluation unit connected to the impedance determination unit which controls the unit and evaluates a sequence of consecutive impedance values, the impedance determination unit further adapted to determine at least intrathoracic and intracardiac impedance values for same period of time, the intrathoracic values sampled with a lower sampling rate than the intracardiac values.

摘要翻译： 具有恒定电流/电压源的阻抗确定单元的植入式医疗装置，其具有连接到用于体内放置的电极的电流馈电端子，其产生具有恒定电流/电压的测量电流脉冲，用于通过体内放置的电极使电流通过身体，测量单元 用于测量通过本体馈送的电压/电流的电压/电流强度，阻抗值确定单元，连接到电流/电压源并适于确定每个测量电流脉冲的阻抗值，以及阻抗测量控制和评估单元，连接到 阻抗确定单元，其控制所述单元并评估连续阻抗值的序列，所述阻抗确定单元还适于在相同时间段内至少确定胸内和心内阻抗值，以比心脏内值更低的采样率采样的胸内值 。