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公开(公告)号：US20090269777A1
公开(公告)日：2009-10-29
申请号：US12104410
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Lowell J. Tyner , Ryan F. Workman , Robert N. Ziemann
IPC分类号： G01N33/53
CPC分类号： G01N33/566
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
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公开(公告)号：US20090123946A1
公开(公告)日：2009-05-14
申请号：US12329331
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C07K16/18 , G01N33/573 , G01N2333/58 , G01N2800/347
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
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公开(公告)号：US20100227775A1
公开(公告)日：2010-09-09
申请号：US12784548
申请日：2010-05-21
申请人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , Frank C. Grenier , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Ryan F. Workman , Robert N. Ziemann
CPC分类号： G01N33/6872 , G01N2333/96486 , G01N2400/00 , G01N2800/347
摘要： The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample, as well as to determine the proportion of human NGAL monomer to human NGAL dimer contained in a test sample.
摘要翻译： 本发明涉及NGAL免疫测定和试剂盒，以及在免疫测定和试剂盒中使用结合哺乳动物NGAL的糖基化哺乳动物NGAL和抗体的方法。 除此之外，方法和试剂盒可用于确定测试样品中人NGAL单体的量，以及确定测试样品中包含的人NGAL单体对人NGAL二聚体的比例。
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公开(公告)号：US20090124022A1
公开(公告)日：2009-05-14
申请号：US12104413
申请日：2008-04-16
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Lowell J. Tyner
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
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公开(公告)号：US08846036B2
公开(公告)日：2014-09-30
申请号：US12329357
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Robert N. Ziemann , Frank C. Grenier , Ryan F. Workman , Lowell Tyner
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann , Frank C. Grenier , Ryan F. Workman
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
摘要翻译： 本发明涉及对糖基化哺乳动物NGAL特异的抗体，以及制备和使用这些抗体的方法。
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公开(公告)号：US20090263894A1
公开(公告)日：2009-10-22
申请号：US12329357
申请日：2008-12-05
申请人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
发明人： Larry G. Birkenmeyer , Suresh M. Desai , David J. Hawksworth , Edward T. Olejniczak , Qiaoqiao Ruan , Robert W. Siegel , Sergey Y. Tetin , Bryan C. Tieman , Bailin Tu , Joan D. Tyner , Robert N. Ziemann
CPC分类号： C07K16/18 , C07K2317/34 , C07K2317/55 , C07K2317/92
摘要： The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.
摘要翻译： 本发明涉及对糖基化哺乳动物NGAL特异的抗体，以及制备和使用这些抗体的方法。
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7.发明授权Compositions for detecting antibodies to Babesia microti and methods of uses thereof 有权用于检测巴西微生物的抗体的组合物及其使用方法公开(公告)号：US08283124B2
公开(公告)日：2012-10-09
申请号：US11924131
申请日：2007-10-25
IPC分类号： G01N33/53
CPC分类号： G01N33/56905 , C07K14/44 , C07K16/20 , C07K2319/00
摘要： The present invention relates to one or more peptides which may be used to test for the presence of antibodies to B. microti. These peptide are selected based on the strength and specificity of the human antibody response to B. microti. These peptides alone or in combination have a variety of uses, for example, as a component of a diagnostic assay or kit.
摘要翻译： 本发明涉及一种或多种可用于测试对微生物的抗体的存在的肽。 这些肽基于人抗体对微生物的反应的强度和特异性来选择。 单独或组合的这些肽具有多种用途，例如作为诊断测定或试剂盒的组分。
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8.发明申请NUCLEOTIDE AND AMINO ACID SEQUENCES ENCODING AN EXPORTED PROTEIN 1 DERIVED FROM PLASMODIUM VIVAX AND USES THEREOF 有权编码从PLASMODIUM VIVAX衍生的出口蛋白质1的核苷酸和氨基酸序列及其用途公开(公告)号：US20110311572A1
公开(公告)日：2011-12-22
申请号：US13219802
申请日：2011-08-29
申请人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
发明人： Larry G. Birkenmeyer , Ruthie E. Coffey , George J. Dawson , Suresh M. Desai , Bruce J. Dille , Anthony S. Muerhoff
IPC分类号： A61K39/015 , G01N33/566 , A61P33/02 , C07K14/00 , A61P37/04
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： The present invention is directed to novel polynucleotides and polypeptides directed to EXP1 of Plasmodium vivax, and methods of using these polynucleotides and polypeptides in the detection of P. vivax antibodies or anti-P. vivax antibodies in a subject. The invention finds particular useful application in identifying recent exposure to P. vivax.
摘要翻译： 本发明涉及针对间日疟原虫的EXP1的新型多核苷酸和多肽，以及在检测间日疟原虫抗体或抗-P中使用这些多核苷酸和多肽的方法。 受试者中的间日疟原虫抗体。 本发明在识别最近暴露于间日疟原虫方面特别有用。
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公开(公告)号：US08030471B2
公开(公告)日：2011-10-04
申请号：US12143137
申请日：2008-06-20
申请人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
发明人： Larry G. Birkenmeyer , Anthony S. Muerhoff , Suresh M. Desai , George J. Dawson , Bruce J. Dille
IPC分类号： C07H21/04 , C07H19/00 , A01N25/26 , A01N25/28 , A61K39/015 , A61K39/00 , A61K45/00 , A61K39/40 , A61B5/055 , C12P1/00 , C12P21/06 , G01N33/53 , C12N15/09 , C12N1/10 , C12M1/34 , C12M3/00 , C07K1/00
CPC分类号： C07K14/445 , A61K39/00 , A61K2039/505 , G01N33/6893 , G01N2469/20 , G01N2800/26 , Y02A50/412
摘要： The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial diagnostic as well as therapeutic uses.
摘要翻译： 本发明涉及源自疟原虫种类疟原虫和卵白念珠菌的裂殖子表面蛋白（MSP1）基因的由其编码的核酸序列和氨基酸序列。 这些基因和蛋白质具有许多有益的诊断和治疗用途。
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10.发明申请COMPOSITIONS FOR DETECTING ANTIBODIES TO BABESIA MICROTI AND METHODS OF USES THEREOF 有权用于检测抗生素对微生物的组合物及其使用方法公开(公告)号：US20090111123A1
公开(公告)日：2009-04-30
申请号：US11924131
申请日：2007-10-25
CPC分类号： G01N33/56905 , C07K14/44 , C07K16/20 , C07K2319/00
摘要： The present invention relates to one or more peptides which may be used to test for the presence of antibodies to B. microti. These peptide are selected based on the strength and specificity of the human antibody response to B. microti. These peptides alone or in combination have a variety of uses, for example, as a component of a diagnostic assay or kit.
摘要翻译： 本发明涉及一种或多种可用于测试对微生物的抗体的存在的肽。 这些肽基于人抗体对微生物的反应的强度和特异性来选择。 单独或组合的这些肽具有多种用途，例如作为诊断测定或试剂盒的组分。
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