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    PHOSPHORAMIDITE NUCLEOSIDE ANALOGS
    1.
    发明申请
    PHOSPHORAMIDITE NUCLEOSIDE ANALOGS 有权
    磷酰胺核苷类似物

    公开(公告)号：US20090136940A1

    公开(公告)日：2009-05-28

    申请号：US12201758

    申请日：2008-08-29

    申请人： Alexei Bogdanov ,  Valeriy Metelev ,  David Tabatadze ,  Paul Zamecnik

    发明人： Alexei Bogdanov ,  Valeriy Metelev ,  David Tabatadze ,  Paul Zamecnik

    IPC分类号： C12Q1/68 ,  C07H19/04 ,  C07H21/00 ,  C07H21/04 ,  C07H21/02 ,  C07F9/06 ,  C12N5/02

    CPC分类号： C07H19/04 ,  C12P19/38

    摘要： Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or several reporter groups, organic molecules, bio-molecules, small molecules or other chemical groups at the internucleoside phosphotriesters. Oligonucleotides including the monomers have a number of uses in therapeutic, diagnostic, and research applications.

    摘要翻译： 描述了亚磷酰胺核苷类似物单体，其前体和包含一种或多种单体的寡核苷酸。 单体可以在寡核苷酸衍生物的自动合成期间使用，并且允许在核苷间磷酸三酯上引入一个或几个报告基团，有机分子，生物分子，小分子或其它化学基团。 包括单体的寡核苷酸在治疗，诊断和研究应用中具有许多用途。

    Treatment of mycobacterium tuberculosis with antisense oligonucleotides
    4.
    发明申请
    Treatment of mycobacterium tuberculosis with antisense oligonucleotides 审中-公开
    用反义寡核苷酸治疗结核分枝杆菌

    公开(公告)号：US20060183676A1

    公开(公告)日：2006-08-17

    申请号：US10478268

    申请日：2002-05-20

    申请人： Marcus Horwitz ,  Gunter Harth ,  Paul Zamecnik ,  David Tabatadze

    发明人： Marcus Horwitz ,  Gunter Harth ,  Paul Zamecnik ,  David Tabatadze

    IPC分类号： A61K48/00

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2310/3517 ,  C12Y205/01019 ,  C12Y501/01001 ,  C12Y603/01002 ,  C12Y603/02004 ,  C12Y603/02009 ,  C12Y603/0201

    摘要： Methods of inhibiting the proliferation of Mycobacterium tuberculosis comprising contacting Mycobacterium tuberculosis with an effective amount of a polynucleotide complementary to an mRNA transcript expressed by Mycobacterium tuberculosis are provided. Typical methods of the invention utilize phosphorothioate modified antisense polynucleotides (PS-ODNs) against the mRNA of M. tuberculosis genes such as glutamine synthetase, aroA, ask, groES, and the genes of the Antigen 85 complex. Optionally, the methods employ multiple antisense polynucleotides targeting different Mycobacterium tuberculosis transcripts. In preferred embodiments of the invention, the antisense polynucleotides are complementary to the 5′ regions of the Mycobacterium tuberculosis transcripts.

    摘要翻译： 提供了抑制结核分枝杆菌增殖的方法，其包括使结核分枝杆菌与由结核分枝杆菌表达的mRNA转录物互补的有效量的多核苷酸接触。 本发明的典型方法利用硫代磷酸酯修饰的反义多核苷酸（PS-ODN）针对结核分枝杆菌基因的mRNA，如谷氨酰胺合成酶，aroA，ask，groES以及抗原85复合物的基因。 任选地，所述方法使用靶向不同结核分枝杆菌转录本的多个反义多核苷酸。 在本发明的优选实施方案中，反义多核苷酸与结核分枝杆菌转录本的5'区域互补。

    SENSOR-LOTION SYSTEM FOR USE WITH BODY TREATMENT DEVICES
    6.
    发明申请
    SENSOR-LOTION SYSTEM FOR USE WITH BODY TREATMENT DEVICES 审中-公开
    用于身体治疗装置的传感器系统

    公开(公告)号：US20120277659A1

    公开(公告)日：2012-11-01

    申请号：US13460418

    申请日：2012-04-30

    申请人： Ilya Yaroslavsky ,  Gregory B. Altshuler ,  Mikhail Z. Smirnov ,  David Tabatadze ,  Oldrich M. Laznicka, JR.

    发明人： Ilya Yaroslavsky ,  Gregory B. Altshuler ,  Mikhail Z. Smirnov ,  David Tabatadze ,  Oldrich M. Laznicka, JR.

    IPC分类号： A61M37/00

    CPC分类号： A61N5/0616 ,  A45D34/04 ,  A45D2044/007 ,  A45D2200/205 ,  A61B18/203 ,  A61B2018/00648 ,  A61B2018/00875 ,  A61N2005/0627 ,  A61N2005/067

    摘要： Controls improve skin and/or eye safety for use of a light based photocosmetic device. The sensors having high spatial resolution and the low probability of sensor failure and improve skin and/or eye safety by differentiating safe and unsafe firing conditions. The system and/or the device is able to identify a topical present on the skin due to characteristics indicative of that topical that are sensed by the system. The topical can be identified by, for example, impedance level, marker(s), and/or multiple characteristics in a multi-phase system. The sensor(s) can improve safety by checking the presence of contact and the uniformity of contact with the identified topical throughout the treatment cycle.

    摘要翻译： 控制改善使用光基光敏装置的皮肤和/或眼睛的安全性。 传感器具有高空间分辨率，传感器故障概率低，通过区分安全和不安全的点火条件来改善皮肤和/或眼睛的安全。 系统和/或装置能够由于系统所感测到的指示该局部的特征而识别皮肤上的局部存在。 可以通过例如多相系统中的阻抗水平，标记和/或多个特征来识别局部。 传感器可以通过在整个治疗周期内检查接触的存在和与所识别的局部的接触的均匀性来提高安全性。

    Phosphoramidite nucleoside analogs
    7.
    发明授权
    Phosphoramidite nucleoside analogs 有权
    亚磷酰胺核苷类似物

    公开(公告)号：US08084589B2

    公开(公告)日：2011-12-27

    申请号：US12201758

    申请日：2008-08-29

    申请人： Alexei Bogdanov ,  Valeriy Metelev ,  David Tabatadze ,  Paul Zamecnik

    发明人： Alexei Bogdanov ,  Valeriy Metelev ,  David Tabatadze ,  Paul Zamecnik

    IPC分类号： C07G3/00 ,  C07H21/02 ,  C07H21/00 ,  A61K48/00 ,  G01N33/53

    CPC分类号： C07H19/04 ,  C12P19/38

    摘要： Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or several reporter groups, organic molecules, bio-molecules, small molecules or other chemical groups at the internucleoside phosphotriesters. Oligonucleotides including the monomers have a number of uses in therapeutic, diagnostic, and research applications.

    摘要翻译： 描述了亚磷酰胺核苷类似物单体，其前体和包含一种或多种单体的寡核苷酸。 单体可以在寡核苷酸衍生物的自动合成期间使用，并且允许在核苷间磷酸三酯上引入一个或几个报告基团，有机分子，生物分子，小分子或其它化学基团。 包括单体的寡核苷酸在治疗，诊断和研究应用中具有许多用途。

    NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES
    9.
    发明申请
    NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES 审中-公开
    治疗耐药性结肠炎及其他疾病的新方法

    公开(公告)号：US20100204310A1

    公开(公告)日：2010-08-12

    申请号：US12556933

    申请日：2009-09-10

    申请人： Paul C. Zamecnik ,  Karen Pierson ,  David Tabatadze

    发明人： Paul C. Zamecnik ,  Karen Pierson ,  David Tabatadze

    IPC分类号： A61K31/7088 ,  C07H21/02 ,  A61P31/06

    CPC分类号： C12N15/1137 ,  C12N2310/11

    摘要： The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of Mycobacterum tuberculosis selected from protein 30, 32A and 32B, and further having 5′ and 3′ palindromic hairpin-forming sequences, said compound being covalently linked to a protein synthesis inhibiting antibiotic via a linker. The invention further provides pharmaceutical formulations of such compounds and methods of use thereof for treating tuberculosis. Other diseases may similarly be treated by tethering and antibiotic which targets a ribosomal protein to an antisense oligonucleotide complementary to an mRNA involved in the disease.

    摘要翻译： 本发明提供了包含寡核苷酸的抗菌化合物，该寡核苷酸具有与编码选自蛋白30,32A和32B的结核分枝杆菌的支链烯基转移酶的mRNA的翻译起始区域互补的序列，并且还具有5'和3'回文发夹形成序列， 所述化合物通过连接体与抑制蛋白质的抗生素共价连接。 本发明还提供了这种化合物的药物制剂及其用于治疗结核病的方法。 其他疾病可以类似地通过将核糖体蛋白靶向与涉及该疾病的mRNA互补的反义寡核苷酸的系链和抗生素来治疗。