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公开(公告)号：US20060073148A1
公开(公告)日：2006-04-06
申请号：US11155843
申请日：2005-06-17
申请人： Lioudmila Tchistiakova , Marion Kasaian , Debra Donaldson , Xiang-Yang Tan , Davinder Gill , Macy Jin , Bruce Jacobson , Samuel Goldman , John Knopf , Angela Widom
发明人： Lioudmila Tchistiakova , Marion Kasaian , Debra Donaldson , Xiang-Yang Tan , Davinder Gill , Macy Jin , Bruce Jacobson , Samuel Goldman , John Knopf , Angela Widom
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/24 , C12N5/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
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公开(公告)号：US07501121B2
公开(公告)日：2009-03-10
申请号：US11155843
申请日：2005-06-17
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US07943342B2
公开(公告)日：2011-05-17
申请号：US12358111
申请日：2009-01-22
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US20110262435A1
公开(公告)日：2011-10-27
申请号：US13098668
申请日：2011-05-02
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号： A61K39/395 , A61P11/00 , A61P1/00 , A61P35/00 , A61P37/02 , A61P29/00 , A61P11/06 , A61P31/12
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US20090274705A1
公开(公告)日：2009-11-05
申请号：US12358111
申请日：2009-01-22
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US10059756B2
公开(公告)日：2018-08-28
申请号：US13447091
申请日：2012-04-13
申请人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra , Kristian Pietras
发明人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra , Kristian Pietras
CPC分类号： C07K14/71 , C07K2319/30 , C07K2319/32
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.
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公开(公告)号：US08772234B2
公开(公告)日：2014-07-08
申请号：US13442479
申请日：2012-04-09
申请人： Jasbir Seehra , John Knopf
发明人： Jasbir Seehra , John Knopf
CPC分类号： A61K38/1875 , C07K14/51 , C07K2319/00
摘要： In certain aspects, the present invention provides BMP10 propeptides for use in treating a variety of disorders including heart disorders and other disorders associated with unwanted activity of the mature BMP10 polypeptide. The present invention also provides methods of screening compounds that modulate activity of BMP10.
摘要翻译： 在某些方面，本发明提供用于治疗多种疾病的BMP10前肽，包括心脏病和与成熟BMP10多肽的不想要的活性相关的其它病症。 本发明还提供了筛选调节BMP10活性的化合物的方法。
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公开(公告)号：US08455428B2
公开(公告)日：2013-06-04
申请号：US11982738
申请日：2007-11-02
申请人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra
发明人： Asya Grinberg , John Knopf , Robert S. Pearsall , Ravindra Kumar , Jasbir Seehra
IPC分类号： A61K38/00
CPC分类号： A61K39/39558 , A61K45/06 , C07K14/71 , C07K16/18 , C07K2317/52 , C07K2319/30
摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.
摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 该公开内容还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，以及抑制受体 - 配体相互作用的抗体。
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公开(公告)号：US08367611B2
公开(公告)日：2013-02-05
申请号：US13111393
申请日：2011-05-19
申请人： John Knopf , Jasbir Seehra , Matthew L. Sherman
发明人： John Knopf , Jasbir Seehra , Matthew L. Sherman
IPC分类号： A61K38/00
CPC分类号： C12N9/12 , A61K38/179 , C07K14/71 , C07K2319/30 , C12Y207/1103
摘要： In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.
摘要翻译： 在某些方面，本发明提供用于降低患者中FSH水平的组合物和方法。 患者可能例如被诊断患有FSH相关疾病或延迟或抑制生殖细胞成熟的欲望。
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公开(公告)号：US20120202739A1
公开(公告)日：2012-08-09
申请号：US13453759
申请日：2012-04-23
申请人： John Knopf , Jasbir Seehra
发明人： John Knopf , Jasbir Seehra
CPC分类号： C07K14/475 , A61K38/1841 , G01N33/574 , G01N33/6893 , G01N2333/495
摘要： In certain aspects, the present invention provides compositions and methods for regulating body weight, in particular, for treating obesity and obesity-associate disorders. The present invention also provides methods of screening compounds that modulate activity of GDF3. The compositions and methods provided herein are also useful in treating diseases associated with abnormal activity of GDF3.
摘要翻译： 在某些方面，本发明提供了用于调节体重的组合物和方法，特别是用于治疗肥胖症和肥胖相关疾病。 本发明还提供了筛选调节GDF3活性的化合物的方法。 本文提供的组合物和方法也可用于治疗与GDF3的异常活性相关的疾病。
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