公开(公告)号：US20230017394A1

公开(公告)日：2023-01-19

申请号：US17535981

申请日：2021-11-26

申请人： Dennis Wright

发明人： Dennis Wright

IPC分类号： E21B43/12

摘要： A method for reducing gas pressure at or nearby a wellhead, the method for comprising the steps of
Providing an intake for high pressure natural;
Conveying the high pressure natural gas to a motion creating element;
Utilizing the motion creating element to reduce the pressure of the natural gas;
Communicating the turning motion into a power generating element; whereby the high pressure gas leaves the motion creating element having less pressure than when it was conveyed to the motion creating element.

公开(公告)号：US06308897B1

公开(公告)日：2001-10-30

申请号：US09548029

申请日：2000-04-12

申请人： James A. Remington ,  Daniel A. Ivanyo ,  Dennis Wright

发明人： James A. Remington ,  Daniel A. Ivanyo ,  Dennis Wright

IPC分类号： E01B960

CPC分类号： E01B9/60

摘要： A rail brace assembly for bracing a rail with respect to a tie plate. The rail brace assembly includes a brace member, a locking member, a retention member and a spring clip fastener. The brace member has a top surface adapted to engage a head fishing surface of the rail, a bottom surface adapted to engage a base fishing surface of the rail, a front friction surface and an outwardly extending toe. The retention member is adapted to be attached to the tie plate and includes a bore adapted to receive a first end of the fastener and a recess adapted to receive the toe of the brace member to thereby prevent vertical movement of the brace member and the rail. The locking member has a front surface, a rear friction surface adapted to engage the front friction surface of the brace member, and a pair of spaced apart outwardly extending legs which straddle the retention member. A first end of the fastener is inserted into the bore of the retention member and a second end of the fastener biases the rear friction surface of the locking member into interlocking engagement with the front friction surface of the brace member to thereby inhibit lateral movement of the brace member with respect to the locking member.

摘要翻译： 轨道支架组件，用于相对于连接板支撑轨道。 导轨支架组件包括支撑构件，锁定构件，保持构件和弹簧夹紧件。 支撑构件具有适于接合轨道的头部钓鱼表面的顶表面，适于接合轨道的基部钓鱼表面的底表面，前部摩擦表面和向外延伸的脚趾。 保持构件适于附接到连接板并且包括适于容纳紧固件的第一端的孔和适于容纳支撑构件的脚趾的凹部，从而防止支撑构件和轨道的垂直运动。 锁定构件具有前表面，适于接合支撑构件的前摩擦表面的后摩擦表面和跨越保持构件的一对间隔开的向外延伸的腿。 紧固件的第一端插入保持构件的孔中，并且紧固件的第二端将锁定构件的后摩擦表面偏压到与支撑构件的前摩擦表面互锁接合，从而抑制 支撑构件相对于锁定构件。

公开(公告)号：US06225074B1

公开(公告)日：2001-05-01

申请号：US08932072

申请日：1997-09-17

申请人： Dennis Wright ,  David J. Phelps

发明人： Dennis Wright ,  David J. Phelps

IPC分类号： C12Q148

CPC分类号： C12Q1/26 ,  G01N2333/91057 ,  G01N2333/916 ,  G01N2333/924 ,  Y10S435/81

摘要： A direct assay for chloramphenicol acetyl transferase (CAT) has been presented wherein the assay reagent comprises chloramphenicol, an acyl CoA compound, and a tetrazolium salt, and wherein the reagent does not have any added coupling redox enzymes. In one embodiment, the reagent is mixed with the test sample and the presence of CAT is detected by an optical response. In a second embodiment, the reagent is mixed with a test sample containing CAT and the optical response is quantitated by comparison with standards to measure CAT activity in the test sample. In another embodiment, an exogenous electron carrier such as phenazines may be used to enhance the detection of CAT. The assay for the presence or activity of CAT can be used in a high-throughput screening assay or to detect CAT as a reporter gene for measuring the expression of a gene of interest. Kits containing the reagents are also provided.

摘要翻译： 已经提出了用于氯霉素乙酰转移酶（CAT）的直接测定法，其中测定试剂包括氯霉素，酰基辅酶A化合物和四唑鎓盐，并且其中所述试剂不具有任何添加的偶联氧化还原酶。 在一个实施方案中，将试剂与测试样品混合，并通过光学响应检测CAT的存在。 在第二个实施方案中，将试剂与含有CAT的测试样品混合，并通过与标准品进行比较来定量光学响应以测量测试样品中的CAT活性。 在另一个实施方案中，外源电子载体如吩嗪可用于增强CAT的检测。 CAT的存在或活性的测定可用于高通量筛选测定或检测CAT作为用于测量感兴趣的基因表达的报告基因。 还提供了含有试剂的试剂盒。

公开(公告)号：US5670327A

公开(公告)日：1997-09-23

申请号：US279940

申请日：1994-07-25

申请人： Dennis Wright

发明人： Dennis Wright

IPC分类号： C12Q1/34 ,  C12Q1/42 ,  G01N33/535 ,  G01N33/58 ,  G01N33/573

CPC分类号： G01N33/535 ,  C12Q1/34 ,  C12Q1/42 ,  G01N33/581 ,  C12Q2326/92 ,  C12Q2334/52 ,  G01N2333/924 ,  G01N2333/938

摘要： A non-radioactive method of detecting the enzymes beta galactosidase or beta glucosidase directly or for the detection of a ligand and antiligand complex is provided wherein beta galactosidase or the complex labelled with beta galactosidase or a tracer having beta galactosidase conjugated thereto is reacted with 5-bromo-4-chloro-3-indolyl-B-D-galactoside and a tetrazolium salt to produce a colored formazan or a color change indicative of the presence of beta galactosidase, or wherein beta glucosidase or the complex labelled with the beta glucosidase or a tracer having beta glucosidase conjugated thereto is reacted with 5-bromo-4-chloro-3-indolyl-B-D-glucoside and a tetrazolium salt to produce a colored formazan or a color change indicative of the presence of beta glucosidase. Optionally, the galactosidase-galactoside determination or the glucosidase-glucoside determination may further include catalyst phenazine methosulfate (PMS) as a reactant. The preferred tetrazolium salt is dimethylthiazol diphenyl tetrazolium (MTT). A solution or composition of 5-bromo-4-chloro-3-indolyl-B-D-galactoside or 5-bromo-4-chloro-3-indolyl-B-D-glucoside, and a tetrazolium salt, as well as a test kit including the same, is also provided for carrying out the chromogenic method of detection.

摘要翻译： 提供了直接检测酶β半乳糖苷酶或β-葡糖苷酶或用于检测配体和反配体配合物的非放射性方法，其中β半乳糖苷酶或用β-半乳糖苷酶标记的复合物或与其结合的β半乳糖苷酶的示踪剂与5- 溴代-4-氯-3-吲哚基-β-半乳糖苷和四唑鎓盐以产生着色的甲an或指示β-半乳糖苷酶存在的变色，或其中β葡糖苷酶或由β-葡糖苷酶标记的复合物或具有 与其结合的β-葡萄糖苷酶与5-溴-4-氯-3-吲哚基-β-葡萄糖苷和四唑鎓盐反应以产生有色甲an或指示β葡糖苷酶存在的变色。 任选地，所述半乳糖苷酶 - 半乳糖苷测定或所述葡糖苷酶 - 糖苷的测定可以进一步包括催化剂吩嗪甲硫酸盐（PMS）作为反应物。 优选的四唑鎓盐是二甲基噻唑二苯基四唑（MTT）。 5-溴-4-氯-3-吲哚基-β-半乳糖苷或5-溴-4-氯-3-吲哚基-β-葡萄糖苷和四唑鎓盐的溶液或组合物，以及包括 同样地，也用于进行显色检测方法。

公开(公告)号：US20110245311A1

公开(公告)日：2011-10-06

申请号：US12918995

申请日：2010-04-02

申请人： Dennis Wright

发明人： Dennis Wright

IPC分类号： A61K31/417 ,  C07D233/64 ,  C12N5/09 ,  C12N1/20

CPC分类号： C07D233/64

摘要： Disclosed herein are the compositions and methods for a compound of Formula Ia or Ib.

摘要翻译： 本文公开了式Ia或Ib化合物的组合物和方法。

公开(公告)号：US5354658A

公开(公告)日：1994-10-11

申请号：US10344

申请日：1993-01-28

申请人： Dennis Wright

发明人： Dennis Wright

IPC分类号： C12Q1/34 ,  C12Q1/42 ,  G01N33/535 ,  G01N33/58 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/535 ,  C12Q1/34 ,  C12Q1/42 ,  G01N33/581 ,  C12Q2326/92 ,  C12Q2334/52 ,  G01N2333/924 ,  G01N2333/938

摘要： A non-radioactive method of detecting a ligand and antiligand complex labelled with alkaline phosphatase or a tracer having alkaline phosphatase conjugated thereto comprises reacting the complex with bromo-chloro-indolyl phosphate (BCIP), phenazine methosulfate (PMS) and dimethylthiazol diphenyl tetrazolium (MTT) and allowing the reaction to proceed to produce a colored formazan or a color change indicative of the presence of the labelled complex. A solution or composition of bromo-chloro-indolyl phosphate (BCIP), phenazine methosulfate (PMS) and dimethylthiazol diphenyl tetrazolium (MTT), as well as a test kit including the same, is also provided for carrying out the chromogenic method of detection.

摘要翻译： 检测用碱性磷酸酶标记的配体和反配体配合物的非放射性方法或与其结合的碱性磷酸酶的示踪剂包括使该配合物与溴 - 氯 - 吲哚基磷酸酯（BCIP），吩嗪甲硫酸盐（PMS）和二甲基噻唑二苯基四唑（MTT） ），并允许反应进行以产生着色甲an或指示存在标记复合物的颜色变化。 还提供溴 - 氯 - 吲哚磷酸盐（BCIP），吩嗪甲硫酸盐（PMS）和二甲基噻唑二苯基四唑（MTT）的溶液或组合物，以及包含该溶液或组合物的测试试剂盒，用于进行显色检测方法。

公开(公告)号：US08163953B2

公开(公告)日：2012-04-24

申请号：US12426644

申请日：2009-04-20

申请人： Ben A. Bahr ,  Dennis Wright

发明人： Ben A. Bahr ,  Dennis Wright

IPC分类号： A61K31/70 ,  A61K31/27 ,  C07C69/88 ,  C07C271/20

CPC分类号： C07C271/20

摘要： Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Aβ and other protein and glycoconjugate species are provided. Methods for the treatment of neurodegenerative diseases that involve protein accumulation and aggregation in the brain, such as Alzheimer's, Parkinson's and Huntington's Disease, are also provided.

摘要翻译： 可用于促进溶酶体过程，从而改善由A＆Bgr诱导的细胞和功能完整性破坏的化合物; 并提供其他蛋白质和糖缀合物。 还提供了治疗涉及脑中的蛋白质积聚和聚集的神经变性疾病的方法，例如阿尔茨海默氏症，帕金森病和亨廷顿病。

公开(公告)号：US4312645A

公开(公告)日：1982-01-26

申请号：US128505

申请日：1980-03-10

申请人： Stratos Mavros ,  Dennis Wright

发明人： Stratos Mavros ,  Dennis Wright

IPC分类号： B01D46/46 ,  B01D50/00

CPC分类号： B01D46/10 ,  B01D46/46 ,  B01D2273/10 ,  B01D2273/14 ,  Y10S55/25

摘要： A filtering assembly for an air intake duct for a turbine device for normally removing particulate matter entrained in the air being introduced to the turbine device through the air duct. The improved filtering assembly comprises a filter element for removing particulate matter entrained in air passing therethrough which is mounted in the air duct so that at least a section of the filter element is movable between a filtering position and bypass position. More particularly, the filter element is mounted in the air duct so that when it is in the filtering position, substantially all of the air passing through the air duct passes through the filter element and so that when it is in the bypass position, a substantial amount of the air passing through the air duct bypasses the filter. A suitable sensing device is provided for sensing the pressure differential of the air across the filter element in the air duct and a clamping device is provided which normally clamps the filter element in the filtering position. The clamping device is actuable to release the filter element from the filtering position to allow the filter element to move to the bypass position when the pressure differential sensed by the sensing device is above a predetermined pressure difference. In this manner, air flow will be maintained to the turbine, even if the filter becomes clogged or stopped, thereby preventing a situation in which the turbine might otherwise be starved of sufficient air flow.

摘要翻译： 一种用于涡轮机装置的进气管道的过滤组件，用于通常通过空气管道去除夹带在空气中的颗粒物质被引入涡轮机装置。 改进的过滤组件包括用于去除夹带在其中穿过的空气中的颗粒物质的过滤元件，其安装在空气管道中，使得过滤元件的至少一部分可在过滤位置和旁路位置之间移动。 更具体地，过滤元件安装在空气管道中，使得当其处于过滤位置时，通过空气管道的基本上所有的空气都通过过滤元件，并且当其处于旁路位置时， 通过风道的空气量绕过滤器。 提供了一种合适的感测装置，用于感测通过空气管道中的过滤元件的空气的压差，并且提供了夹紧装置，其通常将过滤元件夹紧在过滤位置。 夹紧装置可致动以将过滤元件从过滤位置释放，以使得当感测装置感测到的压差高于预定压力差时，过滤元件移动到旁路位置。 以这种方式，即使过滤器堵塞或停止，空气流也将被维持到涡轮机，从而防止涡轮机可能以其它方式缺乏足够的空气流动的情况。

公开(公告)号：US20060121501A1

公开(公告)日：2006-06-08

申请号：US11251611

申请日：2005-10-14

申请人： Harry Jabs ,  Dennis Wright

发明人： Harry Jabs ,  Dennis Wright

IPC分类号： C12Q1/68 ,  G01N1/31 ,  C12M1/34

CPC分类号： G01N33/54373 ,  B01J20/3219 ,  B01J20/3242 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00722 ,  B01J2219/00725 ,  G01N33/54353 ,  G01N33/5438 ,  G01N33/552

摘要： A method immobilizing molecules on the surface of a semiconductor oxide substrate by forming stable bonds with hydrazine bound to the surface is disclosed. Also disclosed is a FET sensor for sensing target molecules in a solution. The FET is modified with molecular probes immobilized on the sensor surface via hydrazone bonds. The immobilized molecular probes are available to bind target molecules present in a solution and the FET will respond to the binding event.

摘要翻译： 公开了通过与结合到表面上的肼形成稳定的键而将分子固定在半导体氧化物衬底的表面上的方法。 还公开了用于感测溶液中的目标分子的FET传感器。 通过腙键固定在传感器表面上的分子探针修饰FET。 固定的分子探针可用于结合存在于溶液中的靶分子，并且FET将响应于结合事件。

公开(公告)号：US4121439A

公开(公告)日：1978-10-24

申请号：US696114

申请日：1976-06-15

申请人： Dennis Wright

发明人： Dennis Wright

IPC分类号： D04B9/00 ,  D04B9/02 ,  D04B9/28 ,  D04B15/60

CPC分类号： D04B15/60

摘要： In a knitting machine the needle beds and yarn feeders circulate relative to one another. This normally produces a tubular fabric. In order to leave a gap in the tube, a zone of each needle bed is arranged as a non-knit zone. To save yarn the yarns are not normally allowed to float across the gap, but are severed and trapped. To hold the edges straight, periodic yarns are allowed to float across the gap.

摘要翻译： 在针织机中，针床和喂纱器相对于彼此循环。 这通常产生管状织物。 为了在管中留下间隙，每个针床的区域被布置为非针织区域。 为了节省纱线，纱线通常不允许漂浮在间隙上，而是被切断并被捕获。 为了保持边缘直线，允许周期性纱线漂浮在间隙上。