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公开(公告)号：US20110146678A1
公开(公告)日：2011-06-23
申请号：US13054532
申请日：2009-07-20
Applicant: Graham Ruecroft , Dipesh Parikh
Inventor： Graham Ruecroft , Dipesh Parikh
IPC: A61M15/00 , A61K31/135 , A61K31/56 , A61K31/58 , C07J71/00 , C07J3/00 , C07C215/00 , B32B5/00 , A61M15/08 , B82Y5/00
CPC classification number: C30B29/605 , A61K9/0075 , A61K9/008 , B01D9/0027 , B01D9/005 , B01D9/0081 , C30B1/12 , Y10T428/2982
Abstract: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.
Abstract translation: 本发明提供了一种提高至少一种小于100％结晶的固体材料的结晶度的方法，包括使所述固体材料与其中固体材料不溶或难溶（非溶剂）的溶剂接触; 以及当与所述非溶剂接触时，将超声应用于所述固体材料。
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公开(公告)号：US20120309729A1
公开(公告)日：2012-12-06
申请号：US13503120
申请日：2010-10-20
Applicant: Graham Ruecroft , Dipesh Parikh
Inventor： Graham Ruecroft , Dipesh Parikh
IPC: C07J75/00 , A61P11/00 , A61K31/58 , C07C213/10 , A61K31/137
CPC classification number: B01D9/0027 , A61K9/0075 , A61K9/1688 , B01D1/18 , B01D9/0081 , B01J2/04 , B01J2/18
Abstract: The invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising applying ultrasound to the substantially dry solid material.
Abstract translation: 本发明提供了一种提高至少一种小于100％结晶的固体材料的结晶度的方法，包括将超声应用于基本干燥的固体材料。
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公开(公告)号：US20140228330A1
公开(公告)日：2014-08-14
申请号：US14237085
申请日：2012-08-08
Applicant: Graham Ruecroft , Dipesh Parikh
Inventor： Graham Ruecroft , Dipesh Parikh
IPC: A61K31/40 , A61K31/46 , A61K31/58 , A61K31/522 , A61K31/137 , A61K31/4704
CPC classification number: A61K9/0073 , A61K9/0043 , A61K9/0075 , A61K9/008 , A61K9/16 , A61K9/1688 , A61K31/137 , A61K31/138 , A61K31/167 , A61K31/205 , A61K31/40 , A61K31/46 , A61K31/4704 , A61K31/522 , A61K31/58 , A61K45/06 , A61M15/009 , A61M15/0091 , A61M15/08
Abstract: This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for the treatment of respiratory disease.
Abstract translation: 本发明提供一种药物组合物，其包含两种药理活性成分的共晶组合物，用于通过吸入递送至肺。 本发明还提供一种药物组合物，其包含用于治疗呼吸系统疾病的两种药理活性成分的共晶组合物。
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公开(公告)号：US09278323B2
公开(公告)日：2016-03-08
申请号：US12665019
申请日：2008-06-17
Applicant: Graham Ruecroft , James Robinson , Dipesh Parikh
Inventor： Graham Ruecroft , James Robinson , Dipesh Parikh
CPC classification number: B01J2/06 , A61K9/0073 , A61K9/14 , B01D9/0009 , B01D9/0018 , B01D9/005 , B01D9/0054 , B01D9/0059 , B01D9/0081 , B01J2/18
Abstract: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.
Abstract translation: 一种制备包含至少一种活性主体的结晶颗粒的乳液或分散体的方法，包括使第一流动中的溶剂或溶剂混合物中的至少一种溶质的溶液与第二流动流中的非溶剂接触 其中所述非溶剂和溶剂彼此不混溶，以形成乳液或分散体。 通过合适的方法产生超饱和，并且对乳液或分散体进行超声波照射以介导晶体成核。
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Patent Agency Ranking
公开(公告)号：US08771744B2
公开(公告)日：2014-07-08
申请号：US13503120
申请日：2010-10-20
Applicant: Graham Ruecroft , Dipesh Parikh
Inventor： Graham Ruecroft , Dipesh Parikh
CPC classification number: B01D9/0027 , A61K9/0075 , A61K9/1688 , B01D1/18 , B01D9/0081 , B01J2/04 , B01J2/18
Abstract: The invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising applying ultrasound to the substantially dry solid material.
Abstract translation: 本发明提供了一种提高至少一种小于100％结晶的固体材料的结晶度的方法，包括将超声应用于基本干燥的固体材料。
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![INHALATION PARTICLES COMPRISING A SALT OF 8-HYDROXY-2-[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO] ETHYL]-2(1H)-QUINOLINONE AND A CORTICOSTEROID](/abs-image/US/2010/10/28/US20100269825A1/abs.jpg.150x150.jpg)
6.发明申请INHALATION PARTICLES COMPRISING A SALT OF 8-HYDROXY-2-[[(1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO] ETHYL]-2(1H)-QUINOLINONE AND A CORTICOSTEROID 审中-公开包含8-羟基-2 - [[（1R）-2-（4-甲氧基苯基）-1-甲基乙基]氨基]乙基] -2（1H） - 喹啉酮和角质醇的盐的吸入颗粒公开(公告)号：US20100269825A1
公开(公告)日：2010-10-28
申请号：US12712531
申请日：2010-02-25
Applicant: Daniela COCCONI , Rossella MUSA , Gaetano BRAMBILLA , Dipesh PARIKH , Graham RUECROFT
Inventor： Daniela COCCONI , Rossella MUSA , Gaetano BRAMBILLA , Dipesh PARIKH , Graham RUECROFT
IPC: A61M15/00 , A61K31/573 , A61K9/12 , A61P11/06
CPC classification number: A61K9/008 , A61K9/0075 , A61K31/167 , A61K31/58 , A61K2300/00
Abstract: Crystalline particles wherein each particle comprises a combination of a pharmaceutically acceptable salt of 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone (carmoterol), and a corticosteroid in a pre-determined and constant ratio are effective for the prevention and treatment of inflammatory or obstructive airways diseases.
Abstract translation: 结晶颗粒，其中每个颗粒包含8-羟基-5 - [（1R）-1-羟基-2 - [[（1R）-2-（4-甲氧基苯基）-1-甲基乙基]氨基的药学上可接受的盐 ]乙基] -2（1H） - 喹啉酮（carmoterol），预定和恒定比例的皮质类固醇对于预防和治疗炎性或阻塞性气道疾病是有效的。
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公开(公告)号：US09637840B2
公开(公告)日：2017-05-02
申请号：US13054532
申请日：2009-07-20
Applicant: Graham Ruecroft , Dipesh Parikh , David Hipkiss
Inventor： Graham Ruecroft , Dipesh Parikh , David Hipkiss
CPC classification number: C30B29/605 , A61K9/0075 , A61K9/008 , B01D9/0027 , B01D9/005 , B01D9/0081 , C30B1/12 , Y10T428/2982
Abstract: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.
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公开(公告)号：US09220708B2
公开(公告)日：2015-12-29
申请号：US14237085
申请日：2012-08-08
Applicant: Graham Ruecroft , Dipesh Parikh
Inventor： Graham Ruecroft , Dipesh Parikh
IPC: A61K31/415 , A61K31/40 , A61K9/16 , A61K31/137 , A61K31/46 , A61K31/4704 , A61K31/522 , A61K31/58 , A61K9/00
CPC classification number: A61K9/0073 , A61K9/0043 , A61K9/0075 , A61K9/008 , A61K9/16 , A61K9/1688 , A61K31/137 , A61K31/138 , A61K31/167 , A61K31/205 , A61K31/40 , A61K31/46 , A61K31/4704 , A61K31/522 , A61K31/58 , A61K45/06 , A61M15/009 , A61M15/0091 , A61M15/08
Abstract: This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for the treatment of respiratory disease.
Abstract translation: 本发明提供一种药物组合物，其包含两种药理活性成分的共晶组合物，用于通过吸入递送至肺。 本发明还提供一种药物组合物，其包含用于治疗呼吸系统疾病的两种药理活性成分的共晶组合物。
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公开(公告)号：US20100190760A1
公开(公告)日：2010-07-29
申请号：US12665019
申请日：2008-06-17
Applicant: Graham Ruecroft , James Robinson , Dipesh Parikh
Inventor： Graham Ruecroft , James Robinson , Dipesh Parikh
CPC classification number: B01J2/06 , A61K9/0073 , A61K9/14 , B01D9/0009 , B01D9/0018 , B01D9/005 , B01D9/0054 , B01D9/0059 , B01D9/0081 , B01J2/18
Abstract: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.
Abstract translation: 一种制备包含至少一种活性主体的结晶颗粒的乳液或分散体的方法，包括使第一流动中的溶剂或溶剂混合物中的至少一种溶质的溶液与第二流动流中的非溶剂接触 其中所述非溶剂和溶剂彼此不混溶，以形成乳液或分散体。 通过合适的方法产生超饱和，并且对乳液或分散体进行超声波照射以介导晶体成核。
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