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公开(公告)号:US20180105517A1
公开(公告)日:2018-04-19
申请号:US15562814
申请日:2016-03-30
IPC分类号: C07D453/02 , B01D9/00 , A61K31/439 , A61K47/26 , A61K9/00 , A61P11/08
CPC分类号: C07D453/02 , A61K9/0075 , A61K31/439 , A61K47/26 , A61P11/08 , B01D9/0027 , B01D9/005 , C07B2200/13
摘要: A process for preparing (3R)-3-[2-Hydroxy(di-2-thienyl)acetoxy]-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide) comprises reacting 2-hydroxy-2,2-dithien-2-ylacetic acid 1-azabicyclo[2.2.2]oct-3(R)yl methyl ester and 3-phenoxypropyl bromide, wherein the reaction takes place in a solvent or mixture of solvents selected from the group of amides and/or the group of solvents with a sulfoxide group. Also provided is a crystalline aclidinium bromide characterized by a powder XRPD pattern having peaks at 7.7±0.2° 2θ, 10.4±0.2° 2θ, 13.2±0.2° 2θ, 13.8±0.2° 2θ, 19.9±0.2° 2θ, 20.3±0.2° 2θ, 20.8±0.2° 2θ, 24.2±0.2° 2θ, 25.7±0.2° 2θ, 26.1±0.2° 2θ, 29.2±0.2° 2θ, 30.8±0.2° 2θ. A pharmaceutical composition comprises aclidinium bromide according to the invention and a pharmaceutically acceptable excipient.
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公开(公告)号:US08771744B2
公开(公告)日:2014-07-08
申请号:US13503120
申请日:2010-10-20
申请人: Graham Ruecroft , Dipesh Parikh
发明人: Graham Ruecroft , Dipesh Parikh
CPC分类号: B01D9/0027 , A61K9/0075 , A61K9/1688 , B01D1/18 , B01D9/0081 , B01J2/04 , B01J2/18
摘要: The invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising applying ultrasound to the substantially dry solid material.
摘要翻译: 本发明提供了一种提高至少一种小于100%结晶的固体材料的结晶度的方法,包括将超声应用于基本干燥的固体材料。
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公开(公告)号:US20070274789A1
公开(公告)日:2007-11-29
申请号:US11440142
申请日:2006-05-24
IPC分类号: B65G53/00
CPC分类号: C08F6/28 , B01D9/0027 , B01D9/0059 , B01J2219/00006 , C08G63/88
摘要: A method of crystallizing a plurality of polymeric pellets includes a step of introducing the pellets into a pneumatic conveying system with an initial average temperature. The plurality of polymeric pellets are pneumatically transferred from the inlet to an outlet with a conveying gas. While residing within the conveying system, the pellets have a sufficient temperature for crystallization to occur. A pneumatic conveying system implementing the methods of the invention is also provided.
摘要翻译: 使多个聚合物颗粒结晶的方法包括将颗粒引入具有初始平均温度的气动输送系统中的步骤。 多个聚合物颗粒通过输送气体从入口气流地输送到出口。 当存在于输送系统内时,颗粒具有足以发生结晶的温度。 还提供了实现本发明方法的气动输送系统。
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公开(公告)号:US3633283A
公开(公告)日:1972-01-11
申请号:US3633283D
申请日:1970-01-06
CPC分类号: F26B5/065 , A23F5/32 , A23F5/34 , A23L3/44 , B01D9/0009 , B01D9/0027 , B01D9/0059
摘要: Drying of liquids is disclosed in which the liquid is sprayed, together with a gaseous fluid such as steams, into a low-pressure zone to cause freezing of the liquid in small particle form, and the frozen particles are then freeze-dried. The liquid may be a biological solution, fruit juice or tea or coffee extract. Apparatus for effecting such drying comprises a freezing chamber, a two fluid nozzle simultaneously spraying liquid and gas into the chamber, a vacuum system with condensers for maintaining a low pressure within the chamber and a freeze-drying chamber.
摘要翻译: 公开了液体的干燥,其中将液体与气体流体如蒸汽一起喷射到低压区域中以使小颗粒形式的液体冷冻,然后将冷冻的颗粒冷冻干燥。 液体可以是生物溶液,果汁或茶或咖啡提取物。 用于实现这种干燥的装置包括冷冻室,同时将液体和气体喷射到室中的两个流体喷嘴,具有用于在室内保持低压的冷凝器的真空系统和冷冻干燥室。
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公开(公告)号:US1347350A
公开(公告)日:1920-07-20
申请号:US21931218
申请日:1918-02-26
申请人: GEN ELECTRIC
发明人: MOORE ROY W
IPC分类号: B01D9/02
CPC分类号: B01D9/0013 , B01D9/0027 , B01D9/0036
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公开(公告)号:US20170275781A1
公开(公告)日:2017-09-28
申请号:US15490444
申请日:2017-04-18
申请人: Circassia Limited
发明人: Graham Ruecroft , Dipesh Parikh , David Hipkiss
CPC分类号: C30B29/605 , A61K9/0075 , A61K9/008 , B01D9/0027 , B01D9/005 , B01D9/0081 , C30B1/12 , Y10T428/2982
摘要: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.
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公开(公告)号:US09637840B2
公开(公告)日:2017-05-02
申请号:US13054532
申请日:2009-07-20
申请人: Graham Ruecroft , Dipesh Parikh , David Hipkiss
发明人: Graham Ruecroft , Dipesh Parikh , David Hipkiss
CPC分类号: C30B29/605 , A61K9/0075 , A61K9/008 , B01D9/0027 , B01D9/005 , B01D9/0081 , C30B1/12 , Y10T428/2982
摘要: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.
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公开(公告)号:US20150210562A1
公开(公告)日:2015-07-30
申请号:US14419591
申请日:2013-02-13
申请人: Sulzer Chemtech AG
CPC分类号: C02F1/08 , B01D9/0027 , B01D9/0059 , B01D61/02 , B01D61/025 , B01D61/08 , B01D61/10 , B01D2311/2673 , C02F1/008 , C02F1/22 , C02F1/441 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C02F2209/001 , C02F2209/02 , C02F2209/05 , C02F2301/08 , C02F2303/10 , C02F2303/20 , C02F2303/22 , Y02A20/131 , Y02A20/132 , Y02W10/30
摘要: A process for desalinating water is disclosed. The process comprises the steps of passing a feed stream of saline solution 2′ in a first desalination step through a reverse osmosis membrane desalination plant 3′ comprising at least one reverse osmosis desalination unit 4′ to form a first product water stream 5′ having a reduced salt concentration relative to that of the feed stream of saline solution 2′ and a first byproduct stream 6′ having an increased salt concentration relative to that of the feed stream of saline solution 2′ characterized in that the first byproduct stream 6′ is passed in a second desalination step through a falling film crystallization unit 7 to form a second product water stream 8 having a reduced salt concentration relative to that of the first byproduct stream 6′ and a second byproduct stream 9 having an increased salt concentration relative to that of the first byproduct stream 6′. The invention further relates to an apparatus 1 for carrying out said process. The present invention further relates also to the use of the process or apparatus 1 for the reduction of the volume of the first byproduct stream 6′ of a reverse osmosis membrane desalination plant 3′, preferably an in-land desalination plant 3′, or in a device or plant or process for producing desalinated water, for salt production, for co-production of power and desalinated water, or for air conditioning.
摘要翻译: 公开了一种用于脱盐水的方法。 该方法包括以下步骤:将第一脱盐步骤中的盐水溶液2'的进料流通过包含至少一个反渗透脱盐单元4'的反渗透膜脱盐设备3'以形成第一产物水流5' 相对于盐溶液2'的进料流减少的盐浓度和相对于盐水溶液2'的进料流具有增加的盐浓度的第一副产物流6',其特征在于第一副产物流6'通过 在通过降膜结晶单元7的第二脱盐步骤中形成相对于第一副产物流6'的盐浓度降低的第二产物水流8和相对于第一副产物流6'具有增加的盐浓度的第二副产物流9 第一副产品流6'。 本发明还涉及一种用于执行所述处理的装置1。 本发明还涉及该方法或装置1用于减少反渗透膜脱盐装置3'的第一副产物流6'的体积的用途,优选地内淡化装置3',或 用于生产脱盐水,用于生产盐,用于共同生产电力和脱盐水或用于空调的设备或设备或工艺。
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公开(公告)号:US20150166909A1
公开(公告)日:2015-06-18
申请号:US14419034
申请日:2013-07-30
发明人: Dylan S. Loudon , Daniel S. Bezuidenhout , Gernot Meyer , Ingo Behrmann , Hans-Jörg Scheidat , Heiko Feitkenhauer
IPC分类号: C10G73/44
CPC分类号: C10G73/44 , B01D9/0013 , B01D9/0027 , B01D9/0031 , C10G2/332 , C10G45/00 , C10G73/02 , C10G2300/1022
摘要: A method of treating or refining a wax includes hydrogenating a feed wax which has an MEK-solubility oils content of more 0.5 weight % to provide a hydrogenated wax. Thereafter the hydrogenated wax is de-oiled to reduce the MEK-solubility oils content of the hydrogenated wax, producing a refined wax or a wax product.
摘要翻译: 一种处理或精炼蜡的方法包括使具有更多0.5重量%的MEK溶解度油含量的进料蜡加氢以提供氢化蜡。 此后,将氢化蜡脱油以降低氢化蜡的MEK-溶解油含量,产生精制蜡或蜡产物。
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