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    N-hydroxyamide derivatives and use thereof
    3.
    发明授权
    N-hydroxyamide derivatives and use thereof 有权
    N-羟基酰胺衍生物及其用途

    公开(公告)号：US07868009B2

    公开(公告)日：2011-01-11

    申请号：US11883286

    申请日：2006-01-27

    申请人： Dominique Swinnen ,  Jerome Gonzalez

    发明人： Dominique Swinnen ,  Jerome Gonzalez

    IPC分类号： A61K31/495 ,  C07D295/185 ,  C07D317/34 ,  A61K31/451

    CPC分类号： C07D295/185 ,  C07D317/34

    摘要： The present invention is related to N-hydroxyamide derivatives of Formula (I): and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

    摘要翻译： 本发明涉及式（I）的N-羟基酰胺衍生物：其特别用于治疗和/或预防自身免疫疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多种 硬化症，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。

    Aryl dicarboxamides
    5.
    发明授权
    Aryl dicarboxamides 失效
    芳基二甲酰胺

    公开(公告)号：US07365225B2

    公开(公告)日：2008-04-29

    申请号：US10565557

    申请日：2004-07-20

    申请人： Russel J. Thomas ,  Dominique Swinnen ,  Jean-Francois Pons ,  Agnes Bombrun

    发明人： Russel J. Thomas ,  Dominique Swinnen ,  Jean-Francois Pons ,  Agnes Bombrun

    IPC分类号： C07C53/134 ,  C07C63/04 ,  A01N43/78 ,  A01N37/10 ,  C07D277/20

    CPC分类号： A61K31/16 ,  A61K31/166 ,  A61K31/167 ,  A61K31/426 ,  C07C237/42 ,  C07C255/57 ,  C07C2601/08 ,  C07C2601/14 ,  C07D277/30 ,  C07D277/56

    摘要： The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose tolerance, insulin resistance, hyperlipidemia, hypertriglyceridemia, hypercholes-terolemia, polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of aryl dicarboxamides of formula (I) to modulate, notably to inhibit the activity of PTPs. A is an aminocarbonyl moiety; Cy is an aryl, heteroaryl, aryl-heteroaryl, heteroaryl-aryl, aryl-aryl, cycloalkyl or heterocycle group; n is either 0 or 1; R1 and R2 are independently from each other is selected from the group consisting of hydrogen or C1-C6-alkyl; R4 and R5 are each independently from each other selected from the group consisting of H, hydroxy, C1-C6 alkyl, carboxy, C1-C6 alkoxy, C1-C3 alkyl carboxy, C2-C3 alkenyl carboxy, C2-C3 alkynyl carboxy, amino or R4 and R5 may form an unsaturated or saturated heterocyclic ring, whereby at least one of R4 or R5 is not a hydrogen or C1-C6 alkyl

    摘要翻译： 本发明涉及式（I）的芳基二甲酰胺和其用于治疗和/或预防由胰岛素抵抗或高血糖介导的肥胖和/或代谢障碍的用途，其包括I型和/或II型糖尿病，葡萄糖耐量不足， 胰岛素抵抗，高脂血症，高甘油三酯血症，高胆固醇血症，多囊卵巢综合征（PCOS）。 特别地，本发明涉及式（I）的芳基二羧酰胺调节，特别是抑制PTP活性的用途。 A是氨基羰基部分; Cy是芳基，杂芳基，芳基 - 杂芳基，杂芳基 - 芳基，芳基 - 芳基，环烷基或杂环基团; n为0或1; R 1和R 2彼此独立地选自氢或C 1 -C 6烷基， 亚烷基; R 4和R 5各自彼此独立地选自H，羟基，C 1 -C 6 羧基，C 1 -C 6烷氧基，C 1 -C 3烷基羧基，C 1 -C 6烷基，C 1 -C 6烷基， ，C 2 -C 3链烯基羧基，C 2 -C 3炔基羧基，氨基或R SUP > 4和R 5可以形成不饱和或饱和的杂环，其中R 4或R 5中的至少一个是 不是氢或C 1 -C 6烷基

    N-Hydroxyamide Derivatives and Use Thereof
    6.
    发明申请
    N-Hydroxyamide Derivatives and Use Thereof 有权
    N-羟基酰胺衍生物及其用途

    公开(公告)号：US20080090838A1

    公开(公告)日：2008-04-17

    申请号：US11883286

    申请日：2006-01-27

    申请人： Dominique Swinnen ,  Jerome Gonzalez

    发明人： Dominique Swinnen ,  Jerome Gonzalez

    IPC分类号： A61K31/495 ,  A61P25/00 ,  A61P29/00 ,  C07D241/04

    CPC分类号： C07D295/185 ,  C07D317/34

    摘要： The present invention is related to N-hydroxyamide derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic 5 obstructive pulmonary disease, liver and pulmonary fibrosis.

    摘要翻译： 本发明涉及式（I）的N-羟基酰胺衍生物及其用途，特别是其用于治疗和/或预防自身免疫疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病和纤维化，包括多发性硬化症 ，关节炎，肺气肿，慢性5型阻塞性肺疾病，肝纤维化和肺纤维化。

    Octahydropyrrolo[2,3C]Pyridine Derivatives and Pharmaceutical Use Thereof
    10.
    发明申请
    Octahydropyrrolo[2,3C]Pyridine Derivatives and Pharmaceutical Use Thereof 有权
    八氢吡咯并[2,3C]吡啶衍生物及其药物用途

    公开(公告)号：US20080146806A1

    公开(公告)日：2008-06-19

    申请号：US11658084

    申请日：2005-07-20

    申请人： Dominique Swinnen ,  Agnes Bombrun

    发明人： Dominique Swinnen ,  Agnes Bombrun

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： The present invention is related to octahydropyrrolo[2,3,c]pyridine derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

    摘要翻译： 本发明涉及式（I）的八氢吡咯并[2,3，c]吡啶衍生物，特别是其用于治疗和/或预防自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，癌症，呼吸系统疾病 和纤维化，包括多发性硬化，关节炎，肺气肿，慢性阻塞性肺病，肝纤维化和肺纤维化。