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公开(公告)号：US08639324B2
公开(公告)日：2014-01-28
申请号：US13353515
申请日：2012-01-19
Applicant: Efdal Elferri , Randall L. McPherson , Donald L. Hopper , Gary T. Seim , James O. Gilkerson , Dan Li , David L. Perschbacher
Inventor： Efdal Elferri , Randall L. McPherson , Donald L. Hopper , Gary T. Seim , James O. Gilkerson , Dan Li , David L. Perschbacher
IPC: A61B5/0205 , A61N1/365 , A61N1/39
CPC classification number: A61N1/36585 , A61B5/0464 , A61B5/0538 , A61B5/0809 , A61B5/091 , A61B5/686 , A61N1/3962
Abstract: An implantable or ambulatory medical device can include a cardiac signal sensing circuit configured to provide a sensed cardiac depolarization signal of a heart of a subject, a respiration sensing circuit configured to provide a signal representative of respiration of the subject, and a control circuit communicatively coupled to the cardiac signal sensing circuit and the respiration circuit. The control circuit includes a tachyarrhythmia detection circuit configured to determine heart rate using the depolarization signal, determine a respiration parameter of the subject using the respiration signal, calculate a ratio using the determined heart rate and the determined respiration parameter, generate an indication of tachyarrhythmia when the calculated ratio satisfies a specified detection ratio threshold value, and provide the indication of tachyarrhythmia to a user or process.
Abstract translation: 植入式或动态医疗装置可以包括心脏信号感测电路，该心脏信号感测电路被配置为提供受检者的心脏的感测的心脏去极化信号，被配置为提供代表对象呼吸的信号的呼吸感测电路，以及通信耦合的控制电路 到心脏信号感测电路和呼吸电路。 控制电路包括快速性心律失常检测电路，其被配置为使用去极化信号来确定心率，使用呼吸信号确定受试者的呼吸参数，使用所确定的心率和确定的呼吸参数来计算比率，产生快速性心律失常的指示， 所计算的比率满足规定的检测率阈值，并向用户或过程提供快速性心律失常的指示。
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2.发明授权Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device 有权通过植入式心脏装置的代谢反应检测的心肺功能状态评估公开(公告)号：US08538525B2
公开(公告)日：2013-09-17
申请号：US13371705
申请日：2012-02-13
Applicant: Donald L. Hopper , Bruce Wilkoff , Richard Morris
Inventor： Donald L. Hopper , Bruce Wilkoff , Richard Morris
IPC: A61N1/00
CPC classification number: A61N1/36585 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/3702
Abstract: An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient's functional status.
Abstract translation: 可植入心脏装置被配置和编程以通过评估患者的分钟通气反应来评估患者的心肺功能。 这种评估可以通过计算每分钟通气量的增加变化与测量活动水平的增量变化的比例来计算每分钟通气响应斜率来进行。 然后将分钟通气反应斜率与正常范围进行比较，以评估患者的功能状态。
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公开(公告)号：US20090082823A1
公开(公告)日：2009-03-26
申请号：US11903758
申请日：2007-09-25
Applicant: Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
Inventor： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
IPC: A61N1/365
CPC classification number: A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
Abstract: An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
Abstract translation: 用于递送心室起搏的可植入起搏装置可以被配置为以模拟运动的方式间歇地和可变地减小在心房触发起搏模式中使用的AV延迟间隔。 该设备可以被编程为根据定义的进入和退出条件间歇地切换到可变地缩短的AV延迟模式。
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4.发明申请APPARATUS AND METHOD FOR HEART FAILURE INDICATION BASED ON HEART RATE, ONSET AND TACHYARRHYTHMIA 有权基于心率，ONSET和TACHYARRHYTHMIA的心脏失效指征的装置和方法公开(公告)号：US20080281370A1
公开(公告)日：2008-11-13
申请号：US11744952
申请日：2007-05-07
Applicant: Yayun Lin , Shelley M. Cazares , Donald L. Hopper
Inventor： Yayun Lin , Shelley M. Cazares , Donald L. Hopper
IPC: A61N1/02
CPC classification number: A61N1/3702 , A61B5/02028 , A61B5/02405 , A61B5/0464 , A61N1/3627 , A61N1/36592
Abstract: An indication of an actual or potential heart failure condition is computed. One example includes monitoring a first heart rate preceding a first onset of a first sinus tachyarrhythmia episode. Upon detecting the first sinus tachyarrhythmia episode, the indication is automatically provided using information about the first heart rate and how quickly the first onset occurs.
Abstract translation: 计算出实际或潜在的心力衰竭状况的指示。 一个例子包括监测在第一次窦性心律失常发作的第一次发作之前的第一心率。 在检测到第一窦性心律失常发作时，使用关于第一心率的信息以及第一次发作发生的速度自动提供指示。
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公开(公告)号：US08972007B2
公开(公告)日：2015-03-03
申请号：US11903758
申请日：2007-09-25
Applicant: Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
Inventor： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
CPC classification number: A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
Abstract: An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
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Patent Agency Ranking
公开(公告)号：US08914107B2
公开(公告)日：2014-12-16
申请号：US12784151
申请日：2010-05-20
Applicant: Paul F. Emerson , Gary T. Seim , Michael A. Querimit , Donald L. Hopper , Stephen R. Pitzl , Daniel O'Brien
Inventor： Paul F. Emerson , Gary T. Seim , Michael A. Querimit , Donald L. Hopper , Stephen R. Pitzl , Daniel O'Brien
CPC classification number: A61N1/36521 , A61N1/362 , A61N1/365 , A61N1/37
Abstract: A cardiac rhythm management (CRM) device can extract ventilation information from thoracic impedance or other information, and adjust a delivery rate of the CRM therapy. A tidal volume of a patient is measured and used to adjust a ventilation rate response factor. The measured tidal volume can optionally be adjusted using a ventilation rate dependent adjustment factor. The ventilation rate response factor can also be adjusted using a maximum voluntary ventilation (MVV), an age predicted maximum heart rate, a resting heart rate, and a resting ventilation determined for the patient. In various examples, a global ventilation sensor rate response factor (for a population) can be programmed into the CRM device, and automatically tailored to be appropriate for a particular patient.
Abstract translation: 心脏节律管理（CRM）设备可以从胸部阻抗或其他信息中提取通气信息，并调整CRM治疗的输送速率。 测量患者的潮气量并用于调节通气率反应因子。 测量的潮气量可以任选地使用通风率依赖调节因子进行调整。 通气率反应因子也可以使用最大自主通气（MVV），年龄预测最大心率，静息心率和为患者确定的休息通气进行调整。 在各种示例中，可将全球通气传感器速率响应因子（对于群体）编程到CRM设备中，并且被自动调整为适合于特定患者。
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公开(公告)号：US08515535B2
公开(公告)日：2013-08-20
申请号：US12695895
申请日：2010-01-28
Applicant: Donald L. Hopper , John M. Voegele , Jesse W. Hartley , Avram Scheiner
Inventor： Donald L. Hopper , John M. Voegele , Jesse W. Hartley , Avram Scheiner
IPC: A61N1/00
CPC classification number: A61B5/686 , A61B5/0022 , A61B5/0024 , A61B5/02028 , A61B5/0205 , A61B5/04012 , A61B5/0402 , A61B5/076 , A61B5/0809 , A61B5/0816 , A61B5/0826 , A61B5/085 , A61B5/091 , A61B5/1118 , A61B5/4836 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B5/747 , A61N1/3627 , A61N1/36585 , A61N1/3702 , A61N1/3987 , G06F19/00 , G16H50/20 , G16H50/30
Abstract: Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.
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8.发明申请CARDIOPULMONARY FUNCTIONAL STATUS ASSESSMENT VIA METABOLIC RESPONSE DETECTION BY IMPLANTABLE CARDIAC DEVICE 有权通过可植入心脏装置的代谢反应检测的心脏功能状态评估公开(公告)号：US20120143276A1
公开(公告)日：2012-06-07
申请号：US13371705
申请日：2012-02-13
Applicant: Donald L. Hopper , Bruce Wilkoff , Richard Morris
Inventor： Donald L. Hopper , Bruce Wilkoff , Richard Morris
IPC: A61N1/365
CPC classification number: A61N1/36585 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/3702
Abstract: An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient's functional status.
Abstract translation: 可植入心脏装置被配置和编程以通过评估患者的分钟通气反应来评估患者的心肺功能。 这种评估可以通过计算每分钟通气量的增加变化与测量活动水平的增量变化的比例来计算每分钟通气响应斜率来进行。 然后将分钟通气反应斜率与正常范围进行比较，以评估患者的功能状态。
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9.发明申请Automatic Adaptation of A-V Delay and HR for Heart Failure using Beat to Beat Measures 有权使用节拍措施自动适应心律失常的A-V延迟和HR公开(公告)号：US20120130443A1
公开(公告)日：2012-05-24
申请号：US13357259
申请日：2012-01-24
Applicant: Donald L. HOPPER , Yinghong YU , Allan Charles SHUROS , Shantha ARCOT-KRISHNAMURTHY , Gerrard M. CARLSON , Jeffrey STAHMANN
Inventor： Donald L. HOPPER , Yinghong YU , Allan Charles SHUROS , Shantha ARCOT-KRISHNAMURTHY , Gerrard M. CARLSON , Jeffrey STAHMANN
IPC: A61N1/365
CPC classification number: A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
Abstract: Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
Abstract translation: 描述了调节起搏治疗时间间隔的方法和系统。 对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。 使用调制的定时间隔来提供起搏治疗。
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10.发明授权Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device 有权通过植入式心脏装置的代谢反应检测的心肺功能状态评估公开(公告)号：US08116869B2
公开(公告)日：2012-02-14
申请号：US12139933
申请日：2008-06-16
Applicant: Donald L. Hopper , Bruce Wilkoff , Richard Morris
Inventor： Donald L. Hopper , Bruce Wilkoff , Richard Morris
IPC: A61N1/00
CPC classification number: A61N1/36585 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/3702
Abstract: An implantable cardiac device is configured and programmed to assess a patient's cardiopulmonary function by evaluating the patient's minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient's functional status.
Abstract translation: 可植入心脏装置被配置和编程以通过评估患者的分钟通气反应来评估患者的心肺功能。 这种评估可以通过计算每分钟通气量的增加变化与测量活动水平的增量变化的比例来计算每分钟通气响应斜率来进行。 然后将分钟通气反应斜率与正常范围进行比较，以评估患者的功能状态。
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