公开(公告)号：US11104690B2

公开(公告)日：2021-08-31

申请号：US16461902

申请日：2017-11-13

申请人： Merck Sharp & Dohme Corp. ,  Dong-Ming Shen ,  Thomas H. Graham ,  Wensheng Liu ,  Clare Tudge ,  Andreas Verras ,  Jinlong Jiang

发明人： Dong-Ming Shen ,  Thomas H. Graham ,  Wensheng Liu ,  Clare Tudge ,  Andreas Verras ,  Jinlong Jiang

IPC分类号： C07D515/08 ,  C07D409/12 ,  C07D401/12 ,  C07D403/12 ,  C07D231/56 ,  C07D405/12 ,  C07D487/04 ,  C07D417/12 ,  C07D413/12 ,  C07D409/14

摘要： The present invention relates to a compound represented by formula I′: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.

公开(公告)号：US10947222B2

公开(公告)日：2021-03-16

申请号：US16461880

申请日：2017-11-13

申请人： Merck Sharp & Dohme Corp. ,  Dong-Ming Shen ,  Thomas H. Graham ,  Jinlong Jiang ,  Fa-Xiang Ding ,  Clare Tudge

发明人： Dong-Ming Shen ,  Thomas H. Graham ,  Jinlong Jiang ,  Fa-Xiang Ding ,  Clare Tudge

IPC分类号： C07D401/12 ,  C07D409/12 ,  A61P1/16 ,  C07D209/08 ,  C07D409/14 ,  C07D413/12 ,  A61K31/506 ,  A61K45/06 ,  C07D413/14 ,  A61K31/404 ,  A61K31/4439 ,  C07D209/10

摘要： The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, nonalcoholic steatohepatitis (NASH), cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.

公开(公告)号：US09006268B2

公开(公告)日：2015-04-14

申请号：US13702656

申请日：2011-06-06

申请人： John S. Debenham ,  Jinlong Jiang ,  Christina B. Madsen-Duggan ,  Dong-Ming Shen

发明人： John S. Debenham ,  Jinlong Jiang ,  Christina B. Madsen-Duggan ,  Dong-Ming Shen

IPC分类号： A61K31/4545 ,  C07D401/14 ,  A61K31/366 ,  A61K31/397 ,  A61K31/44 ,  A61K31/519 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  A61K31/454 ,  A61K31/506 ,  A61K45/06

CPC分类号： C07D401/14 ,  A61K31/366 ,  A61K31/397 ,  A61K31/44 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  A61K2300/00

摘要： Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.

摘要翻译： 结构式I的化合物是脯氨酰羧肽酶（PrCP）的抑制剂。 本发明的化合物可用于预防和治疗与PrCP的酶活性相关的病症，例如异常代谢，包括肥胖症; 糖尿病; 代谢综合征; 肥胖相关疾病; 和糖尿病相关疾病。

公开(公告)号：US08933113B2

公开(公告)日：2015-01-13

申请号：US13979875

申请日：2012-01-19

申请人： Alejandro Crespo ,  Ping Lan ,  Rudrajit Mal ,  Anthony Ogawa ,  Hong Shen ,  Peter J. Sinclair ,  Zhongxiang Sun ,  Ellen K. Vande Bunte ,  Zhicai Wu ,  Kun Liu ,  Robert J. DeVita ,  Dong-Ming Shen ,  Min Shu ,  John Qiang Tan ,  Changhe Qi ,  Yuguang Wang ,  Richard Beresis

发明人： Alejandro Crespo ,  Ping Lan ,  Rudrajit Mal ,  Anthony Ogawa ,  Hong Shen ,  Peter J. Sinclair ,  Zhongxiang Sun ,  Ellen K. Vande Bunte ,  Zhicai Wu ,  Kun Liu ,  Robert J. DeVita ,  Dong-Ming Shen ,  Min Shu ,  John Qiang Tan ,  Changhe Qi ,  Yuguang Wang ,  Richard Beresis

IPC分类号： A61K31/416 ,  C07D231/56 ,  A61K31/405 ,  A61K31/404 ,  C07D403/06 ,  C07D209/08 ,  C07D209/10 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K45/06 ,  C07D413/06

CPC分类号： C07D413/06 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/405 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K45/06 ,  C07D209/08 ,  C07D209/10 ,  C07D231/56 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06

摘要： Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.

摘要翻译： 公开了式（I）化合物及其药学上可接受的盐，其可用于治疗醛固酮介导的疾病。 还公开了制备式（I）化合物，用于治疗和预防上述疾病和用于制备用于此目的的药物的方法和包含式（I）化合物的药物组合物。

公开(公告)号：US08538690B2

公开(公告)日：2013-09-17

申请号：US12979367

申请日：2010-12-28

申请人： Dong-Ming Li ,  Wei Teng ,  Chi-Ming Lu

发明人： Dong-Ming Li ,  Wei Teng ,  Chi-Ming Lu

IPC分类号： G01C21/26 ,  G01C21/10 ,  G08B23/00 ,  B60K28/00

CPC分类号： G01S19/52 ,  G01C21/3407 ,  G01C21/3697

摘要： A tracking detection and alarm method which is applied to a navigation device use a number of positioning data points retrieved from a navigation module of the navigation device. A number of deflections and a number of average speeds that correspond to the position data points are calculated and generated. A number of maximum deflections are calculated and generated according to the average speeds. When a deflection of a positioning data point is greater than a maximum safe deflection thereof, one is added to a frequency of unsafe driving instances. When the frequency of unsafe driving instances is greater than a preset threshold value, an unsafe driving alarm is activated.

摘要翻译： 应用于导航装置的跟踪检测和报警方法使用从导航装置的导航模块检索的多个定位数据点。 计算并产生对应于位置数据点的多个偏转和多个平均速度。 根据平均速度计算并产生多个最大偏差。 当定位数据点的偏转大于其最大安全偏转时，将一个加到不安全驾驶实例的频率上。 当不安全驾驶实例的频率大于预设阈值时，会启动不安全的驾驶报警。

公开(公告)号：US20130080603A1

公开(公告)日：2013-03-28

申请号：US13284718

申请日：2011-10-28

申请人： Nicholas Michael Simons ,  Corey David Shaw ,  Dong Ming ,  Sugandha SudeshKumar Kapoor ,  Christopher Broussard ,  Richard Alan Mareno ,  Matthew James Ruhlen ,  Tara Kraft

发明人： Nicholas Michael Simons ,  Corey David Shaw ,  Dong Ming ,  Sugandha SudeshKumar Kapoor ,  Christopher Broussard ,  Richard Alan Mareno ,  Matthew James Ruhlen ,  Tara Kraft

IPC分类号： G06F15/177

CPC分类号： H04L67/16 ,  H04L63/0807 ,  H04L63/105 ,  H04L67/1002

摘要： A fault tolerant external application server. The external application server is a web based system that allows a user of a client computing device to work with a file over a network via a general client application communicating with a host. The host brokers the functionality and provides a platform for interacting with the external application server. The external application server is implemented as a server farm. A fault tolerant farm system combines latent configuration replication between farm members, interchangeable farm members, and optional health monitoring to allow the external application server farm to provide on-the-fly configuration while maintaining full functionality without requiring a real time state management database.

摘要翻译： 容错的外部应用服务器。 外部应用服务器是基于网络的系统，其允许客户端计算设备的用户通过网络通过与主机通信的通用客户端应用来处理文件。 主机经纪功能，并提供与外部应用服务器交互的平台。 外部应用程序服务器实现为服务器场。 容错农场系统将农场成员之间的潜在配置复制，可互换的场成员和可选的健康监控相结合，以允许外部应用服务器场提供即时配置，同时保持完整的功能，而无需实时状态管理数据库。

公开(公告)号：US20130030019A1

公开(公告)日：2013-01-31

申请号：US13638991

申请日：2011-04-21

申请人： Thomas H. Graham ,  Dong-Ming Shen ,  Min Shu

发明人： Thomas H. Graham ,  Dong-Ming Shen ,  Min Shu

IPC分类号： C07D401/04 ,  A61K31/4545 ,  A61K31/454 ,  A61P3/00 ,  A61K31/4155 ,  A61P3/04 ,  A61P3/10 ,  C07D401/14 ,  C07D403/04

CPC分类号： C07D401/04 ,  A61K9/4858 ,  C07D401/14 ,  C07D403/04

摘要： Compounds of structural formula (I) are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.

摘要翻译： 结构式（I）的化合物是脯氨酰羧肽酶（PrCP）的抑制剂。 本发明的化合物可用于预防和治疗与PrCP的酶活性相关的病症，例如异常代谢，包括肥胖症; 糖尿病; 代谢综合征; 肥胖相关疾病; 和糖尿病相关疾病。

公开(公告)号：US20120143494A1

公开(公告)日：2012-06-07

申请号：US12979367

申请日：2010-12-28

申请人： DONG-MING LI ,  WEI TENG ,  CHI-MING LU

发明人： DONG-MING LI ,  WEI TENG ,  CHI-MING LU

IPC分类号： G01C21/00

CPC分类号： G01S19/52 ,  G01C21/3407 ,  G01C21/3697

摘要： A tracking detection and alarm method which is applied to a navigation device use a number of positioning data points retrieved from a navigation module of the navigation device. A number of deflections and a number of average speeds that correspond to the position data points are calculated and generated. A number of maximum deflections are calculated and generated according to the average speeds. When a deflection of a positioning data point is greater than a maximum safe deflection thereof, one is added to a frequency of unsafe driving instances. When the frequency of unsafe driving instances is greater than a preset threshold value, an unsafe driving alarm is activated.

摘要翻译： 应用于导航装置的跟踪检测和报警方法使用从导航装置的导航模块检索的多个定位数据点。 计算并产生对应于位置数据点的多个偏转和多个平均速度。 根据平均速度计算并产生多个最大偏差。 当定位数据点的偏转大于其最大安全偏转时，将一个加到不安全驾驶实例的频率上。 当不安全驾驶实例的频率大于预设阈值时，会启动不安全的驾驶报警。

公开(公告)号：US20120128079A1

公开(公告)日：2012-05-24

申请号：US13069370

申请日：2011-03-22

申请人： Dong-Ming Chuang

发明人： Dong-Ming Chuang

IPC分类号： H04B3/02

CPC分类号： H04B3/54

摘要： The present discloses a dynamic transmit power control method for a power line communication (PLC) system. The dynamic transmit power control method includes steps of collecting a data; and adjusting a compliant transmit power spectrum density (PSD) mask according to a non-flat transmit PSD mask and the data; wherein the compliant transmit PSD mask complies with the non-flat transmit PSD mask, which comprises a plurality of reference PSDs corresponding to a plurality of frequency bands.

摘要翻译： 本发明公开了一种用于电力线通信（PLC）系统的动态发射功率控制方法。 动态发射功率控制方法包括收集数据的步骤; 以及根据非平坦发射PSD掩模和所述数据调整适应发射功率谱密度（PSD）掩模; 其中所述顺从发射PSD掩模符合非平坦发射PSD掩模，其包括对应于多个频带的多个参考PSD。

公开(公告)号：US08060036B2

公开(公告)日：2011-11-15

申请号：US12331371

申请日：2008-12-09

申请人： Chi-Ming Lu ,  Dong-Ming Li

发明人： Chi-Ming Lu ,  Dong-Ming Li

IPC分类号： H03C1/62 ,  H04B17/00

CPC分类号： H04W48/20

摘要： A mobile terminal device includes a detector, a transceiver, an analyzer, an execution module, and a connection module. The detector generates a probing request signal. The transceiver receives signals sent from a plurality of access points (AP). The analyzer retrieves a plurality of Received signal strength Indications (RSSI) of the plurality of APs and workload of the plurality of APs by analyzing the signals. The execution module generates a plurality of indices of the plurality of APs based on an analysis results, and selects one of the plurality of indices as a best comprehensive index. The connection module establishes a connection between an AP corresponding to the best comprehensive index and the mobile terminal device.

摘要翻译： 移动终端装置包括检测器，收发器，分析器，执行模块和连接模块。 检测器产生探测请求信号。 收发信机接收从多个接入点（AP）发送的信号。 分析器通过分析信号来检索多个AP的多个接收信号强度指示（RSSI）和多个AP的工作负荷。 执行模块基于分析结果生成多个AP的多个索引，并且选择多个索引中的一个作为最佳综合索引。 连接模块建立与最佳综合索引对应的AP与移动终端设备之间的连接。