公开(公告)号：US4297903A

公开(公告)日：1981-11-03

申请号：US143238

申请日：1980-04-24

申请人： Edmund E. Buzza

发明人： Edmund E. Buzza

IPC分类号： F16K11/02 ,  G01N1/00 ,  G01N1/38 ,  G01N35/10 ,  G01N35/08

CPC分类号： G01N35/1097 ,  G01N1/38 ,  G01N35/1004 ,  Y10T137/8158

摘要： A liquid transfer valve including movable valve portions. A second valve portion is movable with respect to a first valve portion to allow a probe to extend therethrough to pick up a sample liquid. Upon probe retraction, the second valve portion is movable to a position which allows the sample liquid to be injected into the valve where it is diluted and carried to a remote detector or delivery point.

摘要翻译： 一种包括可动阀部分的液体转移阀。 第二阀部分可相对于第一阀部分移动以允许探针延伸穿过其中以拾取样品液体。 在探头回缩时，第二阀部分可移动到允许将样品液体注入阀中的位置，在该位置被稀释并运送到远程检测器或输送点。

公开(公告)号：US4007105A

公开(公告)日：1977-02-08

申请号：US595207

申请日：1975-07-11

申请人： Edmund E. Buzza ,  John E. Lillig

发明人： Edmund E. Buzza ,  John E. Lillig

IPC分类号： G01N27/44 ,  G01N31/16

CPC分类号： G01N31/164 ,  G01N27/44

摘要： Titration apparatus for measuring chloride electrolyte in blood samples including a pair of coulometric generator electrodes for titrating the chloride with silver ions to precipitate silver chloride and a pair of amperometric detector electrodes for detecting completion of the silver chloride precipitation. The amperometric electrodes and one of the coulometric electrodes (cathode) are contained in a unitary electrode module which is mounted separately from the remaining coulometric electrode (anode) and which is readily removable for cleaning.

摘要翻译： 用于测量血液样品中的氯化物电解质的滴定装置，包括一对用银离子滴定氯化物以沉淀氯化银的电量发生器电极，以及一对电流检测器电极，用于检测氯化银沉淀的完成。 电流电极和库仑电极（阴极）中的一个包含在与剩余的库仑电极（阳极）分开安装并且易于移除以进行清洁的单一电极模块中。

公开(公告)号：US5213762A

公开(公告)日：1993-05-25

申请号：US862428

申请日：1992-04-02

申请人： Samuel G. Ricchio ,  Delbert D. Jackson ,  Stephen F. Barker ,  Edmund E. Buzza ,  Frank R. Shu ,  John E. Stone

发明人： Samuel G. Ricchio ,  Delbert D. Jackson ,  Stephen F. Barker ,  Edmund E. Buzza ,  Frank R. Shu ,  John E. Stone

IPC分类号： G01N35/08

CPC分类号： G01N35/08

摘要： An automatic chemistry analyzer includes a flow cell mounted so that flow through the cell and tubing connected to the cell is visible from the front of the housing. The electrolytes to the cell are removably plugged into the cell from their rear. The probe aspirating sample fluid into an injection cell is simultaneously washed by diluent and the diluent mixes with the fluid sample. Waste fluid from the flow cell is fed to a basin which then feeds under gravity to a waste drain. A ratio pump is formed by selected syringes which are band driven to deliver accurately prerequisite volumes of reagents to the flow cell. The solution ground to the system is on the inlet line for sample adjacent the entrance to the flow cell of fluid thereby minimizing electronic noise. Only two motive means are necessary, one to effect horizontal and rotational movement of the sample tray, and a second to effect vertical motion of a crane mounted probe operative between sample cups and an injection cell.

公开(公告)号：US5130095A

公开(公告)日：1992-07-14

申请号：US322807

申请日：1989-03-13

申请人： Samuel G. Ricchio ,  Delbert D. Jackson ,  Stephen F. Barker ,  Edmund E. Buzza ,  Frank R. Shu ,  John E. Stone

发明人： Samuel G. Ricchio ,  Delbert D. Jackson ,  Stephen F. Barker ,  Edmund E. Buzza ,  Frank R. Shu ,  John E. Stone

IPC分类号： G01N27/28 ,  G01N1/00 ,  G01N27/403 ,  G01N27/416 ,  G01N35/02 ,  G01N35/04 ,  G01N35/08 ,  G01N35/10

CPC分类号： G01N35/08 ,  G01N27/4163 ,  G01N1/14

摘要： An automatic chemistry analyzer includes a flow cell mounted so that flow through the cell and tubing connected to the cell is visible from the front of the housing. The electrolytes to the cell are removably plugged into the cell from their rear. The probe aspirating sample flud into an injection cell is simultaneously washed by diluent and the diluent mixes with the fluid sample. Waste fluid from the flow cell is fed to a basin which then feeds under gravity to a waste drain. A ratio pump is formed by selected syringes which are band driven to deliver accurately prerequisite volumes of reagents to the flow cell. The solution ground to the system is on the inlet line for sample adjacent the entrance to the flow cell of fluid thereby minimizing electronic noise. Only two motive means are necessary, one to effect horizontal and rotational movement of the sample tray, and a second to effect vertical motion of a crane mounted probe operative between sample cups and an injection cell.

公开(公告)号：US5117870A

公开(公告)日：1992-06-02

申请号：US678825

申请日：1991-04-01

申请人： David L. Goodale ,  Edmund E. Buzza

发明人： David L. Goodale ,  Edmund E. Buzza

IPC分类号： F16K7/06 ,  F16K11/02

CPC分类号： F16K7/065 ,  F16K11/027 ,  Y10T137/86445 ,  Y10T137/87064 ,  Y10T137/87161

摘要： A pinch valve for selectively pinching or releasing a multiple plurality of fluid conduits includes a rotatable single cam as part of a rotor within a stator for locating the fluid conduits. The cam periphery with different lobe surfaces for engaging movable means which is either a plunger or a endless belt which pinch or release multiple fluid conduits. The rotor integrally includes a gear, shaft and flag indicator and is operable by a stepper motor. A backing means about the stator resiliently resists movement.

摘要翻译： 用于选择性地夹紧或释放多个多个流体导管的夹紧阀包括作为定子内的转子的一部分的可旋转单个凸轮，用于定位流体导管。 凸轮周边具有不同的凸角表面，用于接合活动装置，该活动装置是夹紧或释放多个流体导管的柱塞或环形带。 转子整体包括齿轮，轴和标志指示器，并可由步进电机操作。 关于定子的背衬装置弹性地抵抗运动。

公开(公告)号：US3997420A

公开(公告)日：1976-12-14

申请号：US550271

申请日：1975-02-18

申请人： Edmund E. Buzza

发明人： Edmund E. Buzza

IPC分类号： G01N27/416 ,  G01N33/49 ,  G01N27/46

CPC分类号： G01N33/4925

摘要： An apparatus for automatically performing blood chemistry analyses and in particular the determination of the pH, PCO.sub.2 and PO.sub.2 of blood. The apparatus employs a flow cell having pH, PCO.sub.2 and PO.sub.2 measuring electrodes mounted therein adjacent to a sample passage extending through the cell. Sample is collected in a conventional syringe. The needle of the syringe is removed and the syringe cylinder is attached to the flow cell adjacent to the inlet end of the sample passage. Means are provided for automatically driving the plunger of the syringe into the cylinder to convey the sample through the sample passage. A wash solution is then conveyed through the passage to discharge the sample therefrom and thereafter a calibration solution is conveyed through the passage which permits simultaneous calibration of the pH, PCO.sub.2 and PO.sub.2 electrodes. A unique construction of the flow cell and means for mounting the measuring electrode therein allows the use of a single reference electrode which is common to each of the measuring electrodes. Means are also disclosed for allowing flushing of a capillary passage in the flow cell which forms a liquid junction between the reference electrode and the sample in the sample passage.

摘要翻译： 一种用于自动进行血液化学分析的装置，特别是测定血液的pH，PCO2和PO2。 该装置使用具有pH，PCO2和PO2测量电极的流动池，其邻近于延伸穿过电池的样品通道安装在其中。 样品在常规注射器中收集。 注射器的针头被移除，注射器筒体附接到与样品通道入口端相邻的流动池。 提供了用于将注射器的柱塞自动驱动到气缸中以将样品输送通过样品通道的装置。 然后将洗涤溶液输送通过通道以从其中排出样品，然后将校准溶液输送通过该通道，其允许pH，PCO 2和PO 2电极的同时校准。 流动池的独特结构和用于将测量电极安装在其中的装置允许使用每个测量电极共同的单个参考电极。 还公开了用于允许冲洗流动池中的毛细管通道的装置，其在样品通道中在参考电极和样品之间形成液体接合点。

公开(公告)号：US4888998A

公开(公告)日：1989-12-26

申请号：US355077

申请日：1989-05-17

申请人： Edmund E. Buzza ,  Delbert D. Jackson

发明人： Edmund E. Buzza ,  Delbert D. Jackson

IPC分类号： G01N1/00 ,  G01N35/10

CPC分类号： G01N35/1097 ,  G01N35/1004

摘要： A sample handling system including a sample injection cell having an open chamber in turn comprising an upper portion for washing a sample handling probe and a lower portion adapted to reeive the probe for injection of a sample and fluid mixture into a flow analysis device. The cell enables the probe to be withdrawn from the cell and moved to other analysis modules for injection of sample therein. The cell includes a seal between the upper portion and lower portion of the chamber and the probe includes a mating seal near the tip of the probe. A plurality of conduits are formed into the cell for flowing sample and a fluid such as diluent through the cell to a flow analysis device and for filling the cell for washing the probe tip.

摘要翻译： 一种样品处理系统，包括具有开放室的样品注射池，其又包括用于洗涤样品处理探针的上部分和适于将样品和流体混合物注入到流动分析装置中的探针的下部。 电池使探针从电池中取出并移动到其他分析模块，用于在其中注入样品。 电池包括在腔室的上部和下部之间的密封，并且探针在探针的尖端附近包括配合密封件。 多个导管形成在电池中，用于将样品和诸如稀释剂的流体通过电池流动到流动分析装置并用于填充用于洗涤探针尖端的电池。

公开(公告)号：US4463615A

公开(公告)日：1984-08-07

申请号：US280437

申请日：1981-07-06

申请人： Edmund E. Buzza

发明人： Edmund E. Buzza

IPC分类号： G01N1/00 ,  G01N1/38 ,  G01N35/10 ,  G01N35/08

CPC分类号： G01N35/1097 ,  G01N1/38 ,  G01N35/1004

摘要： A liquid transfer valve including a movable valve portion. A second valve portion is movable with respect to a first valve portion to allow probes to extend therethrough to pick up a liquids. Upon probe retraction, the second valve portion is movable to a position which allows the liquids to be injected into the valve where they are diluted, mixed, and carried to a remote detector or delivery point.

摘要翻译： 一种液体转移阀，包括可动阀部分。 第二阀部分可相对于第一阀部分移动，以允许探针从其中延伸以吸收液体。 在探头回缩时，第二阀部分可移动到允许液体被注入到阀中的位置，在那里它们被稀释，混合并携带到远程检测器或输送点。

公开(公告)号：US4149949A

公开(公告)日：1979-04-17

申请号：US922459

申请日：1978-07-06

申请人： Edmund E. Buzza ,  John E. Lillig

发明人： Edmund E. Buzza ,  John E. Lillig

IPC分类号： G01N27/416 ,  G01N33/487 ,  G01N33/49 ,  G01N27/26

CPC分类号： G01N33/4925

摘要： Apparatus for measuring CO.sub.2 in serum with a single pH sensor of the electrolyte flow-through type, the sensor including a gas-permeable membrane selectively passing CO.sub.2 into an electrolyte filled space adjacent a pH sensing electrode for reacting with the electrolyte to produce a pH change therein. The electrolyte space is connected by a conduit to an electrolyte reservoir for flowing fresh electrolyte to and through the electrolyte space prior to a sample measurement. A stainless steel metal electrode directly contacts the electrolyte of constant composition in the conduit upstream of the pH sensor to derive a reference potential thereat. The potential across the pH sensor and the stainless steel electrode is monitored, differentiated, and the maximum value of the differentiated signal measured to determine the CO.sub.2 concentration.

摘要翻译： 用于通过电解质流通型的单个pH传感器测量血清中的CO 2的装置，所述传感器包括气体可渗透膜，其选择性地将CO 2通入pH电极的电解质填充空间中，以与电解质反应以产生pH变化 其中。 电解质空间通过导管连接到电解质储存器，用于在样品测量之前将新鲜的电解质流过和通过电解质空间。 不锈钢金属电极在pH传感器上游的导管中直接接触恒定组成的电解质，以在其上导出参考电位。 对pH传感器和不锈钢电极的电位进行监测，分化，测量差分信号的最大值以确定CO2浓度。

公开(公告)号：US4202747A

公开(公告)日：1980-05-13

申请号：US922458

申请日：1978-07-06

申请人： Edmund E. Buzza ,  Richard C. Meyer

发明人： Edmund E. Buzza ,  Richard C. Meyer

IPC分类号： G01N1/00 ,  G01N33/483 ,  G01N33/487 ,  G01N33/49 ,  G01N27/46

CPC分类号： G01N33/4915 ,  G01N35/1095

摘要： Apparatus for automatically and selectively supplying a blood sample or a wash/calibration solution to the entrance port of a flow cell which measures characteristics of the sample such as pH, pCO.sub.2 and pO.sub.2. A sample filled syringe and a solution supply conduit are supported by respective first and second fluid delivery mechanisms which rotate to move the syringe outlet and the conduit outlet in generally arcuate paths toward and away from the flow cell entrance port. The delivery mechanisms are rotated simultaneously, one toward and one away from the entrance port, by a common drive gear. Seating of the wash solution outlet in the entrance port is upstream of the seating of the sample outlet to ensure complete flushing of sample from the entrance port by the wash solution.

摘要翻译： 用于自动和选择性地将血液样品或洗涤/校准溶液供应到流动池的入口端口的装置，其测量样品的特性，例如pH，pCO 2和pO 2。 样品填充的注射器和溶液供应管道由相应的第一和第二流体递送机构支撑，所述第一和第二流体递送机构旋转以将注射器出口和导管出口沿大致弧形的路径朝向和远离流动池入口移动。 输送机构通过共同的驱动齿轮同时旋转，一个朝向一个远离入口。 入口处洗涤溶液出口的座位位于样品出口安置的上游，以确保样品从入口处被洗涤液彻底冲洗。